The Complement System | The most COMPREHENSIVE Explanation
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2 жыл бұрынThe Complement System. The 3 complement pathways are the Classical complement pathway, the Alternative Complement pathway, amd The mannose/Mannan-binding lectin pathway...Complement proteins (C1, C1q, C4, C3a, C3b, C5a, C5b, C6, C7, C8, C9)...Termknal complement is the membranes attack complex (MAC).
B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist)..
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@MedicosisPerfectionalis 2 жыл бұрын
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@phonytexts2 Жыл бұрын
says it's deleted
@ashleelarsen2233 Жыл бұрын
@@phonytexts2 sweet! 6:30 ho!y sh!t no I can't bear compliments!!!!!
@ashleelarsen2233 Жыл бұрын
Thank you sir!
@Julie.SandhuMD 7 ай бұрын
ALMOST 1 MILLION SUBs !!! YeY
@jaru5836 2 жыл бұрын
if you see a medical student saying im going to study and YET find him smiling while staring his phone or laptop.. .its not always tiktok videos he has been simply Welcomed to the famous world of medicosis perfictionalis❤️
@MedicosisPerfectionalis 2 жыл бұрын
Wow 🤩 Thank you ☺️
@kairi419 2 жыл бұрын
Sir, can I just say that you're carrying me to finish my Medical Laboratory Studies. I'm so thankful mate. You're really helping me achieving a dream here.
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇 This what I love to hear! Good luck 🍀
@libertieaguiba1935 Жыл бұрын
Omg. That’s literally why I’m watching this video haha. My board is coming up soon
@meganevans2003 Жыл бұрын
Same!!
@kellyfoegen7534 Ай бұрын
I just found this, but same!❤
@UnknownPerson-xz2ps 18 сағат бұрын
Can you update me about your degree like how it's going?
@MedicosisPerfectionalis Жыл бұрын
Note: C2a is the old name, now they call it C2b (it’s still the same protein).
@mariyamqazi9829 10 ай бұрын
Got it!
@joelleandaya350 8 ай бұрын
This one answered my question while watching the video because, in our book, C2a is used. Thanks for the clarification
@catherinemundondi4654 7 ай бұрын
C2a didn't change the functions is unknown thts why c2b is mostly considered.
@MedicosisPerfectionalis 6 ай бұрын
Pathology Playlist: kzfaq.info/sun/PLYcLrRDaR8_ef4PE6gduEK-Gpx4lawX2t&si=T45GEAcahgX_TMtB
@aimeemcelvogue9290 2 жыл бұрын
Some of your metaphors have me laughing in the middle of the library- and during exam season too! Thank you for making everything super digestible!
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇 How was your exam?
@miezuni 2 жыл бұрын
whenever im cramming for an exam (it's not like i want/like to cram, our school sched is so tightly packed), i always watch your lecture videos, and im able to understand AND RETAIN the topic SOOOO quickly in my head! thank you so much!! you make studying medicine seem so easy c: and i love the puns too! haha
@MedicosisPerfectionalis 2 жыл бұрын
Thank you so much 😊 Good luck 🍀
@chandramoulis.g7202 2 жыл бұрын
Never understood properly during my college days, scrached my head many times, but now understood in just 5 minutes, wonderful presentation, hope I had a professor like you
@MedicosisPerfectionalis 2 жыл бұрын
Thank you so much 😊 I am honored!
@lunshitang513 2 жыл бұрын
You are such an amazing teacher!!! Could you please do more lectures on immunology? It’s a hard topic but you explain things so beautifully!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you so much 😊 Just wait for the upcoming videos :)
@fanoor2427 2 жыл бұрын
Omg ! The past few days medicosis has been uploading videos that are in line with what I am currently doing at medical school! This is amazing!!
@MedicosisPerfectionalis 2 жыл бұрын
Awesome 😎 Thank you so much 😊
@lina-jg9xb 2 жыл бұрын
I’m taking an immunology test soon and a video by medicosis to get me through this scary lesson is just a life saver!! Thank you so soo much!
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇 Good luck 🍀
@lina-jg9xb 2 жыл бұрын
@@MedicosisPerfectionalis thanks!
@MedicosisPerfectionalis 2 жыл бұрын
You’re welcome 😇
@NihadTabakhy 5 ай бұрын
I swear this video was good and effective for me, especially since I have a final exam in the immune system, and I did not know how to study this lesson. Thank you for being here, Professor💕💕
@MedicosisPerfectionalis 5 ай бұрын
Glad it helped! I wish you all the success in the world!
@shuttleship 2 жыл бұрын
FINALLY you did it !! what an amazing video covering all horizons (even that bridge thingy) btw some books mention C3 convertase of classical as C4b2a why is that so ?
@MedicosisPerfectionalis 2 жыл бұрын
There is some disagreements on the nomenclature of the complement proteins between different books written in different points in time.
@pamelawu2834 2 жыл бұрын
Awesome content!! Was wondering if I could add another topic on your never ending list of request - a video on haemophagocytic lymphohistiocytosis? Appreciate all the learning you are facilitating here!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you for letting me know!
@ShabirAhmad-pp7yr 2 жыл бұрын
Love your lectures and tone.Especially the tricks for remembring the stuff are awesome.....Love and respect from Pakistan🍀🍀🍀
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@zaaarabd6391 Жыл бұрын
You are an amazing teacher ❤️.. love your videos and how you describe them with so much ease and with such beautiful examples which we can remember
@MedicosisPerfectionalis Жыл бұрын
You are so welcome!
@gracessecret4978 2 жыл бұрын
Sir you're such a life saver! love and respect from Algeria
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@rayaabdullah363 Жыл бұрын
I was thinking why I, as a medical student, study this subject, but after listening to your explanation, I realized the importance of this subject to me as a medical student, thank you Doctor
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@aliahmedqasem1502 2 жыл бұрын
iam travelling the whole world in your channel from anemia to blood indices to this the journey never ends
@MedicosisPerfectionalis 2 жыл бұрын
Indeed:) Thank you so much for watching!
@dimeberechukwu9273 Жыл бұрын
Me too
@nikendwisetyaningrum279 2 ай бұрын
Sir, my lecturer never give this kind of way learning. Like its hard to connecting the dots from things he explained. But ur video really help a lot. Thanks sir❤
@lamialamia5755 2 жыл бұрын
you are a genius i like when you mention philospher in your presentation but what i liked the most how you putting us in the big picture first and how you connect all systems and subjects to make information usfule and having a sence you are an artiste god bless you
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@medicallaboratory4673 9 ай бұрын
I was trying to study it within 3 days and I did not understand it. Now I understood it in just half an hour. You are truly amazing.❤
@MedicosisPerfectionalis 9 ай бұрын
Thank you!
@shaikh.700 10 ай бұрын
The same energy. It reminds me of the time when I studied hematology with you. ❤ Thank you
@MedicosisPerfectionalis 10 ай бұрын
You’re always welcome! I appreciate you! Would you please help me by sharing?
@shaikh.700 10 ай бұрын
@@MedicosisPerfectionalis Already shared with my fellow 💕
@lucytravis9333 2 жыл бұрын
this guy is so whacky but i am HERE for it. Really funny and thorough explanation. thank you medicosis, you might have saved me in this fridays exam!!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you ☺️
@abdelrahmanmohamedmahmoud850 9 ай бұрын
Many thanks from Egypt. Please, continue this work.
@MedicosisPerfectionalis 9 ай бұрын
Thank you, I will!
@AP-ei4jt 2 жыл бұрын
I learned the C system before. Thanks for providing a different perspective!
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@AP-ei4jt 2 жыл бұрын
@@MedicosisPerfectionalis I’m looking into C5b wrt to COVID and clotting in severe hospitalized patients. Amazing how everything ties together eventually.
@OnlyJalenPhd 2 ай бұрын
I’m not a doctor, and I understand that the video includes “a” and “b”. My labs just say low 3 and 4. Not being an MD, your presentation was well written, and easy to follow/understand.
@rajivgayen120 7 ай бұрын
I can't believe you taught me the thing like bread and butter what I was unable to understand for past few months❤❤❤loved this video
@MedicosisPerfectionalis 7 ай бұрын
Thank you!
@theafricanesther5795 Жыл бұрын
Another brilliant video. Thank you for teaching me.
@MedicosisPerfectionalis Жыл бұрын
Glad you enjoyed it!
@jinyoshida321 5 ай бұрын
And here I am studying immunology, and guy really says do not go to sleep yet... just what I needed 😫
@pamelakihumuro3360 Жыл бұрын
I love Medicosis perfectionalis, it appreciates the ♥️ that I am, the bright colors and illustrations, this is my Science way😁🥰
@MedicosisPerfectionalis Жыл бұрын
Thank you 😊 I am honored!
@kunkundajonan2470 2 ай бұрын
You need to make a video teaching us how you manage to memorize and integrate all this knowledge and some philosophical aspects
@prashanth-py9jc 2 жыл бұрын
Super always I will see all ur videos thank u so much for great videos
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@dge. 2 жыл бұрын
Have been waiting for this!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 😊 Did you like it?
@vishwakhatri3890 2 жыл бұрын
OMG! I LOVE THIS CHANNEL!!!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you so much 😊
@sanchitaroy1272 Жыл бұрын
Thank you so much for the easy explanation sir..But can you tell me what is significance of H2O which is with C3 in Alternative pathway?
@yasminaisyaputri Жыл бұрын
How do you make it so easy to understand?!?!? Thank you it's so helpful !
@MedicosisPerfectionalis Жыл бұрын
Thank you 😊
@tijjanialhmodu9580 Жыл бұрын
You made this easy to understand thank you 🙏
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@RUQAYAHABDULAZIZ Жыл бұрын
how the 2nd exposure we use classical pathway who requires an antigen-antibody complex and in the 2nd exposure there is no antigen antibody complex ?
@salomezhozhadze9071 6 ай бұрын
what is the video of you called about inflammatory mediators? i cant find it thank you for you work tho! im preparinf for an exam
@ShirsJournal 25 күн бұрын
Thank you very much!!!❤ GOD is using you to help countless medical students
@jenneferannestavas4751 Ай бұрын
I just noticed you now but iIlike you already, it helps me more.
@MedicosisPerfectionalis Ай бұрын
I appreciate you so much!
@-Cece 2 жыл бұрын
I like your voice and delivery style!
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@jojocool6027 Жыл бұрын
That was so helpful thank you❤️
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@norahassan8455 6 ай бұрын
You’re amazing.thank you so much :)❤
@MedicosisPerfectionalis 6 ай бұрын
My pleasure!
@DoaaHazem-gf7ez 8 ай бұрын
Thanks a lot for ur video ur explanation is awesome it helps me a lot to understand
@MedicosisPerfectionalis 4 ай бұрын
My pleasure!
@mayukhmitra8820 2 жыл бұрын
When C2 binds to C4b C2a remains forming C4b2a and Cb leaves as anaphylotoxin...Thanks for the lecture u r Lifesaver 🥰
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
@mayukhmitra8820 2 ай бұрын
@@MedicosisPerfectionalis Oh thanks
@ahmedfahmi1927 2 жыл бұрын
Thank you very much from Egypt , could you tell me a book or any source that may help to identify the best investigation for internal medicine diseases ?. We know all investigations for each disease but we can't identify the best investigation .
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏, Ahmed! I don’t think you can learn this skill in a book. What you want belongs to “mundane knowledge” (based on trial and error, personal experience, clinical skills,…etc), and not something that can be taught in a theoretical book, at least in my opinion. This is analogous to a young car mechanic asking another mechanic: “what book do you recommend so that I can recognize the best way to diagnose a car issue.” To which the mechanic answers: “only experience can teach you that.” So the best thing I can say is: “find a good doctor and shadow him…observe carefully…and take meticulous handwritten notes.”
@sahartahlawy4609 Жыл бұрын
You are an amazing person....Thanks very much
@MedicosisPerfectionalis Жыл бұрын
Thank you 😊
@nirwansendraperiera2043 11 ай бұрын
Now it makes perfect sense 👌 🤩🤩🤩love from Philippines 🇵🇭 💕
@MedicosisPerfectionalis 9 ай бұрын
Thank you!
@belaliamelouka9613 Жыл бұрын
Thank you sir for this perfecto explication 💙 But I have a question please The c3 convertase in the classical one , is it c4b2b or c4b2a ??
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same protein). I hope this helps!
@johnbarghout5605 Жыл бұрын
Why C1 Esterase is an inhibitor? DO you mean that if it is present so the first step in inhibited?
@user-fw4mr7rz1g 4 ай бұрын
I have a question on the part that say bridge between innate and adaptive for first and second exposure looks same which one need antigen antibody complex
@meeromeer8812 Жыл бұрын
The 2nd exposure (no immune complex)! How can this activate the Classical pathway?
@athithibenny3674 Жыл бұрын
Does a always leave the cascade ? In my textbook in some places b leaves and a stays altering the convertase formula iyk what I mean 😕
@aarthi6089 Жыл бұрын
you’re saving my grades. thankyou so muchhhhhh
@MedicosisPerfectionalis Жыл бұрын
You’re very welcome 😊 Would you please help me by sharing?
@ddsylvia5654 Жыл бұрын
You guys are good, you make me laugh while learning
@MedicosisPerfectionalis Жыл бұрын
Thank you 🙏
@soniagrindstaff2416 2 жыл бұрын
Love your videos 🌼 😁
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 😊
@trixiigalore 2 жыл бұрын
Love ur videos!
@MedicosisPerfectionalis 2 жыл бұрын
Thanks a ton!
@rasha1026 Жыл бұрын
thankuuuu for that breakdown!
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@coldencostumes2396 5 ай бұрын
Thanks for the most beautiful and excellent explanation
@MedicosisPerfectionalis 5 ай бұрын
You are very welcome!
@rimsellami5593 Жыл бұрын
Simply, Thank you.
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@danzatriceesotica4502 Жыл бұрын
I have a question? I received my Complement C4a blood test, it is extremly high 1100.1 Could you please explain why? Thank you
@Jackoline6 Жыл бұрын
Sir I think the C3 convertase in lectin and classical pathway is C4b2a, not C4b2b. Thank you for the great video btw!
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same protein).
@nomidiaaitbaziz7886 Жыл бұрын
never thought immunology could be that cool !
@MedicosisPerfectionalis Жыл бұрын
Thank you so much, Nomidia! I appreciate you! Would you please help me by sharing?
@wafaaibrahim2490 Жыл бұрын
So useful .. so interisting
@MedicosisPerfectionalis Жыл бұрын
Thank you 🙏
@sohanirahman720 3 ай бұрын
thank you so much for this
@nathalienicole1252 2 жыл бұрын
Love your videos! I believe C2a is the one that takes part in C3 convertase not C2b…
@MedicosisPerfectionalis 2 жыл бұрын
This specific protein was called by different names by different textbooks in different eras of history (C2a and C2b).
@Nathii-xl6bp Жыл бұрын
sir, can you educate me in this?? Most of the text books even my uni lecture notes say that C4b and C2a combined and produce C3 convertase.. But in your video you have explanied all the "a" parts are leaving the cascade?? what's the correct one? I'M CONFUSED??
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same protein).
@leefordsaidi8272 Жыл бұрын
Isn't C2 an exception thus 2a will join the MAC?
@humairaemma3701 Жыл бұрын
you made me so adaptive to your videos i dont Understand any pther person's explanation!!! can u make videos on gynae obs more for post grad?
@MedicosisPerfectionalis Жыл бұрын
Thank you so much! I am currently working on a complete Ob.Gyn HighYields course that will be uploaded to my website at the end of February 2023: www.medicosisperfectionalis.com/
@humairaemma3701 Жыл бұрын
@@MedicosisPerfectionalis omg thanks!
@azamahanita4109 4 ай бұрын
Best channel ever 👌
@MedicosisPerfectionalis 4 ай бұрын
Thank you so much!
@sarahahmad4147 Жыл бұрын
thanks for sharing your nice information
@MedicosisPerfectionalis Жыл бұрын
Most welcome 🙏
@silvere.9265 8 ай бұрын
Thank you for making my life easier….and that MAC and Attack..😂😂😂
@MedicosisPerfectionalis 4 ай бұрын
My pleasure!
@hamidrezaashayeri7783 Жыл бұрын
Excellent video Only a small mistake: C3 convertase components in classic and lectin pathway are: C4b2a NOT C4b2b
@BaderWesteros Жыл бұрын
It was named c4b2a until scientists decided to change to c4b2b for “consistency” reasons
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
@mouadguerrouaz3539 6 ай бұрын
great explanation🙌🙌👏👏👏
@MedicosisPerfectionalis 6 ай бұрын
Glad it was helpful!
@timeless1908 10 ай бұрын
why do you have that there is no antigen antibody complex under second exposure? I thought that was supposed to be for the first exposure.
@narmin9529 10 ай бұрын
i think there is a mistake in slides
@mohitsultansingh1063 2 жыл бұрын
Bro C3 convertase and C5 convertase k formula me 2b ki jagah 2a nhi aayega kya?as in case of C2 the bigger fragment is specified as C2a
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
@user-ju8te4rn5d 4 ай бұрын
Thank you!!! :)
@MedicosisPerfectionalis 4 ай бұрын
You're welcome!
@rayahrababah9183 2 жыл бұрын
Thx very good ❤️🔥❤️🔥❤️🔥
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@necipfazlay4059 Жыл бұрын
10:50 That WAS beautiful. Love your videos, maybe I should like them too..
@MedicosisPerfectionalis Жыл бұрын
Thank you 🙏
@ABC-fv7ow 2 жыл бұрын
Superb !
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 😊
@DrIA- 5 ай бұрын
12:44 C5b it’s a part of the MAC and the MAC will attack , I love it 😂
@MedicosisPerfectionalis 4 ай бұрын
:)
@darshankhatri2683 10 ай бұрын
Best explanation of the complement system
@MedicosisPerfectionalis 10 ай бұрын
Thank you 🙏
@lynaberr2704 5 ай бұрын
Thanks I was really not in the mood for another huge lecture to do, talking about the little spice ( jokes u made xD )
@MedicosisPerfectionalis 5 ай бұрын
Glad I could help!
@user-rm6sq8cv7d 2 жыл бұрын
Sir , I am from Yemen, could please tell me do you have all internal medicine videos, and how can i get all your full video
@MedicosisPerfectionalis 2 жыл бұрын
Yes! Go to “playlists” here on my KZfaq channel.
@74.santhoshkumar.m80 2 жыл бұрын
Thank u man✌️
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@isaacforextrader4249 2 жыл бұрын
Well explained
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 😊
@etudemed974 2 жыл бұрын
Thank you ❤
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@anujajayan5171 3 ай бұрын
Thank you so much sir
@MedicosisPerfectionalis 3 ай бұрын
Most welcome!
@zhikar9220 8 ай бұрын
Thanks a ton
@MedicosisPerfectionalis 8 ай бұрын
Most welcome!
@nathan2964 Жыл бұрын
Hi Medicosis! Is it not C3 Convertase supposed to be C4(B), C2(A)? Thanks btw!
@nathan2964 Жыл бұрын
Im confused coz there are references that say C4B C2B. :|
@MedicosisPerfectionalis Жыл бұрын
C2a is the old name, now they call it C2b (it’s still the same protein).
@Drharry908 5 ай бұрын
Medicine makes perfect sense here !
@MedicosisPerfectionalis 4 ай бұрын
Thank you!
@Drharry908 4 ай бұрын
@@MedicosisPerfectionalis Sir 🙌
@MoonLight-kt3mb Жыл бұрын
I enjoy your videos medicosis 😂😂
@MedicosisPerfectionalis Жыл бұрын
Thank you so much 😊
@dr.nanci. Жыл бұрын
thanks so muchhh
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@nora06646 Жыл бұрын
Thank you.
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@blueguppy1737 Жыл бұрын
Hope we can have a tip for immunoassay
@MedicosisPerfectionalis Жыл бұрын
I am afraid I didn’t understand!
@blueguppy1737 Жыл бұрын
@@MedicosisPerfectionalis I mean a explanation about the immunoassay
@swami6444 9 ай бұрын
Great👍👏😊
@MedicosisPerfectionalis 4 ай бұрын
Thank you!
@Snehalyf 5 ай бұрын
i wanna see your face. u r just a best medical teacher for me
@MedicosisPerfectionalis 4 ай бұрын
I appreciate you so much!
@pamelakihumuro3360 Жыл бұрын
Guys, we have the Best Teacher Ever. 😁🤣🤣 I know he didn't just say that, she gone men, she gone 🤩🤩OH YES HE DID, OH YES HE DID!!
@MedicosisPerfectionalis Жыл бұрын
:)
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