The Complement System: Classical, Lectin, and Alternative Pathways

Рет қаралды 339,130

Күн бұрын

We are learning about the features of innate immunity, and one that is often overlooked is the complement system. This is a very complicated ensemble of proteins circulating in the bloodstream that activate each other in a specific sequence that results in immune system engagement to kill pathogens. It's quite involved with multiple possible pathways, so this will take a while, but let's dig into this important system now!
Script by Stephanie Melchor
Select images provided by BioRender.com
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Пікірлер: 180

@Liberperlo 2 жыл бұрын

This is the best video on complement I have seen. I'm not an immunologist or even a student. Just a librarian who is fascinated by the immune system. Thanks!

@fidelkipkoech5555 2 жыл бұрын

Wow! You've inspired me...I'm a medical student and find this stuff boring yet you're not even a student but study immunology voluntarily, congrats

@spvillano 2 жыл бұрын

@@fidelkipkoech5555 I've always said, I'll stop learning maybe, just maybe three days after I'm dead. ;) No reason to not study various things, as knowledge is power. Back when I was in the Army (retired in 2010), I ran into not one, but two cases of pheochromocytoma. One was recognized late, the soldier was to begin treatment after field training, but expired from a ruptured AAA. The other, I pieced together what was going on, asked doctor to do me a favor and run a couple extra tests and there it was, he had pheochromocytoma. His problem was quickly addressed and he returned to duty. So, that trivia can and does save lives. Diagnosing things, just Boolean flow really. I do Boolean algebra and regular expressions in my head as part of my job. :) Annoyingly, basic math tends to give me trouble, but that's what calculators or if I had to, fall back to a slide rule is for.

@Dannalasapa Жыл бұрын

@@fidelkipkoech5555 same this is the class I’m hating the most so far but I think it’s mostly bc my prof is absolutely awful

@bjrnaaron Жыл бұрын

Beautiful ❤

@IPlayAces 10 ай бұрын

couldn't agree more- coming from a physician/scientist who's heard many (attempted) explanations of complement systems. this is pure gold. never heard such a clear cut explanation

@sumeet9367 Жыл бұрын

Professor Dave, I am an MS1(first year medical student) and my first block includes immunology. I wanted to say your videos including this complement protein video are more concise than the lectures from my immunology professor. Thank you!

@its_not_lux Ай бұрын

nibba you didn't have to say anything other than 'first year med'. MS1😵‍💫

@emdoubleyew3788 2 жыл бұрын

This makes re-reading my immunology textbook nearly painless. Lovely stuff you have.

@spvillano 2 жыл бұрын

This and similar courses makes things a lot easier to recognize hydrophobic parts and lipophilic parts of some carbon chains. That helps me understand some odd points in the pharmacology of some medications.

@alemantewassie6695 2 ай бұрын

This was the best video I have ever watched about Complement system. Only someone who have left a few minutes left to cover this topic knows how fantastic this work is. Thank you Prof Dave.

@Hannah-yz7gj Жыл бұрын

you don't know how much you helped me understand this topic. i was on the verge of crying going through our readings but this video really clarified a lot of things (for some reason it seemed like our lecturers were also speaking a whole different language while teaching this). thank you so much!

@MissD333 5 ай бұрын

This is really excellent. Also the speed at which you speak is perfect for people who are trying to understand something, other videos I have to pause and re listen because they’re talking too fast, but this is perfect!

@madelinegreene8031 Жыл бұрын

I have an immunology test next week for my first year of grad school--this has been SO much more helpful than anything my professor has said!

@bethuelmutiti2089 Жыл бұрын

I really don't know how my Med School would be without you sir 😭🙏❤️🔥. A Big thanks to you for making my life easy

@whbclaire Жыл бұрын

Thank you so much for this. In my role as a medical writer, I have been doing some programs on paroxysmal nocturnal hematoglobinuria, which is a disease of the complement cascade. This clearly explained a lot of the things I was confused about.

@zhaomengna4800 2 жыл бұрын

Very detailed and direct illustration and description. Learn more from these lectures. Thanks a lot.

@dmskarunaratne80 Жыл бұрын

no words. simplistic way to teach complex theory with best illustrations. thank you. Best video on this topic.

@alinanysiwale2075 Жыл бұрын

This has been really helpful. I've been struggling to understand the complement cascade but with how you've laid everything out, I'm subliming.. .. Thank you so much

@shaqthedoc4376 2 жыл бұрын

dude you just cleared the evolutionary aspect of the complement system, great job👍🏻

@moon_loverr Жыл бұрын

Your videos are amazing, makes immunology easier, making my day😊 Thanks Professor wish u all success.

@adamhartz5483 2 жыл бұрын

Professor Dave.... This video is great. It helped me understand the video much better.

@GolgiGuy102 Жыл бұрын

I really appreciate the evolutionary context. Really outs things into better perspective!

@marinahovakimyan9387 Жыл бұрын

Thank you so so so much! Amazing explanation and illustration! Thank you for your effort.

@allofme835 Жыл бұрын

Love your teaching skills to visual learners. You make studying easier 🥳🥳

@nouf1406 Жыл бұрын

How am I supposed to memorize all of this?

@basiabarbara3365 2 жыл бұрын

Your videos are so helpful to me, thank you🙏🏻

@samreenkomal3837 5 ай бұрын

I've been a subscriber since 2016. It's amazing how easy you make things seem easy for us❤❤❤ Lots of love Professor!!❤️

@birukgossaye2187 2 жыл бұрын

Hey Professor, I understand almost everything you explain so please start makin videos about music theory and all. You're the best teacher ever.

@samgas1219 2 жыл бұрын

He knows alot about the SCIENCE stuff, unfortunately music theory is not a science.

@immune01 Ай бұрын

Very comprehensive with just enough detail for competence but not too overwhelming!

@AlvinturesTV 2 жыл бұрын

Just on time for my quiz on this topic!

@pamtarlow 4 ай бұрын

Great video. I am a pharmacist trying to help my patients with Long Covid and appreciate the excellent education here.

@kedarnathlivedarshanbhakti9715 Жыл бұрын

Saw so many videos.. But finally got clarity in this one

@palantir135 2 жыл бұрын

I had to learn all this a long time ago. Thanks for the update.

@TikoPiko 2 жыл бұрын

@Professor Dave Explains, I have come to purchase your book through my enjoyment of your KZfaq content. I must say that I find it very insightful, succint and a refreshing read overall. I look forward to more from you, as you definitely posess great talent. P.S.: on page 18 there is a helium atom representation with the subtext implying that it is in colour, when in fact at least my edition is grayscale. Just a (hopefully) helpful note.

@abigailwatson3330 Жыл бұрын

Thank you thank you thank you, was not understanding this from textbooks or my lecturers! your videos are the best!

@il3354 2 жыл бұрын

Very well explained. Thank you!

@shria__7870 Жыл бұрын

really made such an intimidating topic so easy to understand! thank you Professor Dave :))

@craigcooper5060 2 жыл бұрын

Really good review of the complement system... Thanks for posting!

@user-wv9jq5bw5i 9 ай бұрын

This amazing! and easily to follow, thank you prof Dave

@robjoemama2466 3 ай бұрын

Excellent video!! I have a better understanding of the Complement system now. I'll recommend this to my classmates to watch. 👏👏👏👏👏👏👏👏👏👏

@karina3133 8 ай бұрын

Extremely good video about Complement, saved me. Thank you!

@israelojo6875 Жыл бұрын

Excellent sir. You are doing extremely well. This is really great and highly explanatory, infact completely.

@reeveeakt7250 2 жыл бұрын

Animal immune system are really well made... Amazing presentation!

@josephntowannobil4571 4 ай бұрын

Superb explanation on Complement System. I love this video

@StoutShako 2 жыл бұрын

WOOOO YEAAAH, BABY THAT'S WHAT I'VE BEEN WAITING FOOOOR WOOOO!

@umanamicheal8089 Ай бұрын

Oodles of thanks, Professor Dave.

@sandaruariyawansa6765 Жыл бұрын

Thank you so much for the explanation!

@datimbangnorminah1956 2 жыл бұрын

Thank you for helping me learn our lesson in Serology

@ahmedeldimllawi5092 4 ай бұрын

ur awesome and this is the best video on complement i have seen

@akubasco 2 жыл бұрын

thanks for making this video.Very helpful.

@santicruz4012 2 жыл бұрын

Thanks professor Dave!

@danjbro 2 жыл бұрын

Well done Dave! 👏🏽

@mayar9078 2 жыл бұрын

Great explanation , thanks 💕

@XtinaThaiFan 2 жыл бұрын

This is amazing. Thank youuuu 😍❤❤

@user-cj8bu7qq4o Жыл бұрын

Great presentation on complement pathway!

@fatimayasir9115 2 жыл бұрын

Really great job, thanks a lot!

@dohagouyd3997 2 жыл бұрын

I would like to give you a huge thank for this video! you saved me fr

@santanudebnath9617 3 ай бұрын

You're doing really good. Best wishes

@drmadhavmehta Ай бұрын

Great video Professor!

@Lulla3sl 7 ай бұрын

BEST EXPLANATION EVER!!

@zahramashhadi4288 2 жыл бұрын

It is very helpful. thank you so much

@user-cw6ut6kb8j 8 ай бұрын

this vid is superb, it's best for understanding

@nuriatnamatovu 4 ай бұрын

Just the best I heard about the compliment system , long live

@nadernayo 2 жыл бұрын

Thanks...Great knowledge..

@Paraselene_Tao 2 жыл бұрын

I'm so glad that you're making these lectures. I considered months ago that the US population (from high school and up) needs to learn how the immune system works. If we know how the immune system works then we will all understand and agree on something like a vaccine. Thank you for spreading this information.

@spvillano 2 жыл бұрын

Indeed, the problems with COVID seems to be that leukocytes are being infected, interfering with their response, while innate responses are also being blunted. By the time the immune system notices that the infection was unaddressed, it went into scorched earth mode (to oversimplify it by a lot) and that's the cytokine storm of COVID-19 and the Spanish Flu.

@whbclaire Жыл бұрын

You are so spot on! If more people understood immunology, we would haver far fewer ridiculous conspiracy lies circulating about vaccines!

@chihchengh 2 жыл бұрын

Really good!

@umanamicheal8089 Ай бұрын

Very explicit and comprehensive.✌️👍👍

@janeszz 2 жыл бұрын

Hey, really like your videos, especially the ones where you debunk conspiracy theories. I recently saw something about Tesla's radiance energy curcuit. It is suggestet that this would be able to supply everybody with free energy but companies dont want us to know about it because we should pay for their energy. Maybe that could be a video idea. Keep on the great work!

@Monicalala 2 жыл бұрын

Thanks for the complement

@saeyeon4404 Жыл бұрын

this is amazingggg thank you!

@beaniebaby_rei 2 жыл бұрын

You're a God send

@jessicalv6442 10 ай бұрын

Save my life!!! Thank you!!!

@indiabiologyexplains5013 Жыл бұрын

Professor dave I learned a lot from this video, but I have just one question. I know that there are a variety of proteins that regulate the complement system. Some of these proteins like C1 inhibitors displace and inactivate many proteins. however, Do any bacteria produce these proteins as a defense mechanism

@sishabell8474 Жыл бұрын

Thank you professor ✅👍🏻

@sarahmsoh5482 Жыл бұрын

How can one fail to subscribe. Best video on Complement

@ClashergodClashergod 3 ай бұрын

great video

@yourfriends 7 ай бұрын

Amazing video

@synasanchouli8511 2 жыл бұрын

Your videoes better than faradars immunology course

@myteeboi7021 2 жыл бұрын

Prof Dave, Could you please make a video on test for gases in chemistry.

@ubaidullah1611 Жыл бұрын

Wow loved it

@TheMiz319 Жыл бұрын

Great video.

@alexisc5358 2 жыл бұрын

This has been so helpful. MY TEXTBOOK uggg!

@chrisopaka10 Жыл бұрын

So currently, 12/10/2022 has C4b2b been officially adopted and is now officially used or is C4b2a debatable?? Prof please?🙏🙏

@humairahabiba4364 21 күн бұрын

Thank you so much

@minashin1562 7 ай бұрын

My man has the best intro ever 👍

@Wiktoria-vo6vg Жыл бұрын

great job!!!

@SaeedaKuvadia Жыл бұрын

better than my uni lectures!!

@Daniellemovie 4 ай бұрын

Super helpful!!!!!

@saswatipatra Ай бұрын

Can't thank you enough..🙏🏼

@salomezhozhadze9071 7 ай бұрын

best video EVER

@sandervdcp3513 Жыл бұрын

thy so much! so clear

@user-qc5lx6yn4k Жыл бұрын

Thank you very much❤❤

@bakrimalek4696 2 жыл бұрын

Thank you❤

@shaneignatius9538 Жыл бұрын

Thank you sir🙏

@poornimam5597 4 күн бұрын

Thankyou thankyou sooo muchh !!!

@anandkishor2791 Жыл бұрын

Thnx for this video

@lexthevi 11 ай бұрын

Damn Man just explained the gibberish in my Professor's slide perfectly. Ready for this exam now.

@HobosRockEmTrashCans 2 жыл бұрын

Best video ever

@Champol Жыл бұрын

Excellent video! so helpful. I have one important question: do these processes work like shown with viral pathogens? These examples showed microbes with a cell wall (I think?) but I don't know if virus wall works the same for this purposes.

@sndhakal1 Жыл бұрын

good point! Not sure if the complement system is as effective against viruses as it is with bacteria and fungi. Anyone shed some light?

@AsstProfDrMerojAJasem Жыл бұрын

thank you

@almaalcala3887 2 жыл бұрын

Thanks!

@teresajadia3291 Жыл бұрын

I am a licensed medical technologist and I'm studying for my second license this coming October. Complement system always ALWAYS aggravate the shit out of me. This lecture gave me atleast an idea what to remember 😅