The Genetics of Bipolar Disorder: Causes, Risks & Testing | Dr. Jehannine Austin |

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CREST Bipolar Disorder Network

CREST Bipolar Disorder Network

Күн бұрын

Neuropsychiatric geneticist Dr. Jehannine Austin offers a fascinating insight into the “bipolar gene” and "bipolar jar", genetic and environmental factors that increase the risk for bipolar disorder, the latest in genetic testing for bipolar disorder, and what you should know before having children as a parent with bipolar disorder. Hosted by Dr. Erin Michalak.
00:00 Intro
01:05 About Dr. Austin
05:43 The "Bipolar Gene"
09:05 Stressful Life Events (Triggers)
14:08 The "Bipolar Jar" (Environment vs. Genes)
18:55 Your Genetic Vulnerability to Bipolar Disorder
22:50 Preventing Bipolar Episodes (Protective Factors)
28:02 Top Protective Factors
30:23 Genetic Counselling
32:20 Genetic Testing for Bipolar Disorder
41:20 Pharmacogenomics (DNA Testing for Medication)
46:51 A Message To Those Planning to Have Children
Dr. Jehannine Austin is the Executive director of the BC Mental Health and Substance Use Services Research Institute and Professor in Psychiatry & Medical Genetics. Dr. Austin is a board-certified genetic counselor and their research work involves studying the impact of genetic counseling for people with bipolar disorder and psychiatric disorders, and their families. Dr. Austin heads the Translational Psychiatric Genetics Group which includes the world’s first specialist psychiatric genetic counselling service. Dr. Austin member of the College of the Royal Society of Canada, and a Fellow of the Canadian Academy of Health Sciences. Dr. Austin’s work aims to make psychiatric genetics relevant to people with mental illness and their families by developing new counseling-based and biologically-based treatments.
More on this episode: talkBD.live/genetics
Translational Psychiatric Genetics Group (TPGG): bcchr.ca/TPGG
National Society of Genetic Counselors: nsgc.org
#talkBD Bipolar Disorder Podcast
talkBD gathers researchers, people with lived experience, healthcare providers, and top bipolar disorder experts from around the world to discuss and answer the most important questions about living with bipolar disorder. All episodes are available on all podcast platforms:
Spotify: open.spotify.com/show/5svD0Dm...
Apple Podcasts: podcasts.apple.com/podcast/16...
Learn more about talkBD: talkBD.live

Пікірлер: 58
@jeanastubbert6749
@jeanastubbert6749 Жыл бұрын
Adverse childhood experiences (ACE scores) are quantitative stressful life events that contribute to psychiatric disorders.
@mscraig5147
@mscraig5147 6 ай бұрын
Such a cop out of the psych community, spurred on by the pharm industry. Lol. Genetics. Passed on. Come to grips with the reality that these things are biological, and that people can and do overcome their poor life experiences which every one of us have. Nature matters. Nurture matters. Nurture will NEVER take away nature. Sorry Charlie. Way it is. Nature, however, CAN out do nurture. There is only so much outside influence can do when there is biological, genetic, neuro divergence. Fact and truth.
@cindysutteranimalsfunny9185
@cindysutteranimalsfunny9185 4 ай бұрын
it’s not that way for everyone. my bipolar is inherited believe it or not!
@mscraig5147
@mscraig5147 4 ай бұрын
And it's an excuse copout to avoid that these things are HEREDITARY and to make people feel weak and sorry for themselves instead of strong
@kathryndaignault432
@kathryndaignault432 2 ай бұрын
@muralikrishnan7586
@muralikrishnan7586 Ай бұрын
Nothing discovered scientifically. Her PhD is futile
@JAI_801
@JAI_801 7 ай бұрын
Never heard of Psychiatric geneticist til now and I'm into it. Thank you Dr. Austin for your presentation and good humor in sharing your research and insights! Makes so much sense to integrate genetics into treatment of bipolar.
@jordanweir4867
@jordanweir4867 Жыл бұрын
Really enjoyed the interview and informative discussion. Thank you. Great visualisations.
@CRESTBD
@CRESTBD Жыл бұрын
Thank you for tuning in, glad you found this helpful! 👍
@jacotromp59581
@jacotromp59581 Ай бұрын
It's amazing and scary how in 2024 ( when I'm watching this video), we still know so little about the brain and mental disorders. We can fly a human to the moon, put them at the bottom of the ocean, yet the brain is a mystery like the universe. 200 years from now scientists will look back at us today and laugh at how primitive our technology and understanding of the brain is (was).
@thenutritionalhealer7233
@thenutritionalhealer7233 10 ай бұрын
High Fat Diets Oxidize Metals While emotional storms oxidize metals instantaneously, certain lifestyles and diets can have a slower effect. High fat diets have become extremely trendy over the years under the guise that carbohydrates are harmful for us. Trends like these low carb, high fat/high protein diets are not helpful for anyone suffering from bipolar disorder or other mental illnesses. The reason is because too much fat in the diet promotes oxidizing of the heavy metal deposits in the brain, which then causes corrosion. This creates a problem over time and short circuits the electrical impulses, which then causes more manic episodes. The reason you may hear many authors and experts today endorse high protein/high fat diets is because they claim the brain is made of fat. This one of the biggest misconceptions about the brain that is currently becoming popular. This just shows how little the medical community actually knows about the brain if this misguided theory has been allowed to be considered truth. The brain is mostly made of and runs on glucose. There are only tiny traces of fat in the brain because it’s made almost entirely of carbohydrates. In many countries, animal brains are eaten as delicacies. If you have ever tried lamb brain, monkey brain, or rabbit brain, it has a very sweet flavor. This is because brains are made of glycogen (glucose). If someone experiences regular brain fog, or any other malfunction of the brain, it could be because they simply are not eating enough healthy carbohydrates like fruits and sweet potatoes. Instead, they are eating high fat and high protein diets (which are one and the same.) I must mention as well that someone’s high fat diet may not be due to following a trendy regimen. Most Americans and other Westerners who eat standard diets full of oils, meats, cheese, eggs, milk, and yogurt have an extremely high intake of fat. Therefore, keep in mind that a high fat diet may not be intentional, but rather an inevitable consequence of eating in the standard way. The same is true if someone is eating a plant based diet but they’re consuming a lot of oils, nuts, nut butters, soy, or processed vegan foods or eggs and dairy products if someone is vegetarian.
@Shakedown24Seven
@Shakedown24Seven 9 ай бұрын
Eating your biologically proportional (not binge eating or eating whopping servings) servings of well varied and nutritional food is the key. More so important than any specific diet. Strict keto diets are not ideal for my body type; however, if I keep my saturated fat low enough, I do find the keto diet very therapeutic. That being said I’ve used that diet to dissolve a high hba1c. It worked very fast and I was able to feel tranquil throughout the process. Biggest complaint was loss of power during anaerobic activities; however, sex drive was good on keto. I’m beginning to lean towards the thought in which everyone’s struggle with their mental disorders may be quite individual from a biopsychosocial stand point. Thankfully I had my DNA sequenced and I’ll be able to understand certain oxidative stress points etc with better clarity. I think keeping a curious and open mindset allows us to explore different options while we hone in on root causes
@blbrightlights564
@blbrightlights564 7 ай бұрын
Often the signs that your child has bipolar don't show up until they are too old for you to have control over it. And if you and close relatives have bipolar your child or at least one of them will have bipolar and I don't agree that any child could have this condition. If I knew how bad my illness was going to get I wouldn't wish it my worst enemy let alone my precious child. Maybe this is why there seems to be more and more people with this condition. Or maybe it's just ridiculous that half the people haven't got it. Drug companies are having a field day.think very carefully about having a baby with bipolar I worry every day I'm going to get a phone call that my son has taken his life.
@chryssanthistell
@chryssanthistell 6 ай бұрын
Great conversation! I loved the way Dr. Austin encourages women with b.d. who want to have children to have them by taking some precautions!
@cindysutteranimalsfunny9185
@cindysutteranimalsfunny9185 4 ай бұрын
i’ve had exteme episodes all my life! actually tried to kill myself the first time when i was 9 or10. i thought that taking a whole bottle of aspirin woul do the job . all it did was make me sick! inever knew why i was feeling the way i did until i was diagnosed ehen i was42 i have finally discovered myself since then but suffer manic and depessive episodes often! i take meds and seems toalevieveate alrviate a little but i never know when it’s going to happen ! but i try very hard to be strong and find things that hard a no no longer let ones that treat me wrongly
@annedodgson8677
@annedodgson8677 2 ай бұрын
People, what you share helps…please check grammar for accuracy…your story is helpful and could save a life
@annedodgson8677
@annedodgson8677 2 ай бұрын
People, what you share helps…please check grammar for accuracy…your story is helpful and could save a life
@PRNSee9786
@PRNSee9786 3 ай бұрын
02:22 Saturday 22 March 24. Thank you Dr Austi and Dr Michalek. A great talk, making valid practical points. This question was in my OSCE for FCPsych board exit exam. I am requesting Dr's to please share some light regarding "genetic couselling regarding association between a positive 22q 11 deletion😢 and Schizophrenia. Thank you
@FirstmaninRome
@FirstmaninRome 7 сағат бұрын
I just found out. Through documents, ghat my grandmother and great grandmother were committed to Milledgeville institution fornication depression, great grandmother died there. I have autism level 1, I never suspected bipolar in my family, though I've dated 5 diagnosed bipolar girl and married one. 😢 the term sinead O'Connor generational trauma comes to mind. Love sinead, y dad is clearly autistic and with schizotypal features I'd say, he's like all qanon, life is hard, I willing to place more blame on genetics than most people.
@Shakedown24Seven
@Shakedown24Seven 9 ай бұрын
Hello 👋🏼 I enjoyed the video and would be interested to learn more. I’m trying to understand if this service is covered by extended health and whether or not there are any practitioners located in Canada or ideally Vancouver whom practice from a private practice. Seems clinical wait times through referral are lengthy if not all together unavailable for middle aged men Any Canadian contact information would be greatly appreciated. Kind regards
@allicat131
@allicat131 Жыл бұрын
Thank you for this!
@allicat131
@allicat131 Жыл бұрын
the recovery visualization has blown my mind. and taken me ten years to figure out on my own.
@CRESTBD
@CRESTBD Жыл бұрын
❤️ thank you. We also cut out that "bipolar jar" section to a separate video to make it more sharable: kzfaq.info/get/bejne/epOemsea37KYmXk.html
@SiK2712
@SiK2712 10 ай бұрын
Unless I have misunderstood the illustration, what concerns me about the “bipolar jar” is it suggests that even if you have a genetic disposition it is the inability to deal with life stressors that cause the jar to overfill leading to episodes and relapses. I feel this stigmatises the sufferer. I have episodes that come out of nowhere, unrelated to anything environmental or relating to the normal vicissitudes of life.
@susanweinstein4319
@susanweinstein4319 10 ай бұрын
@@SiK2712 Interesting. That's not what I took from the illustration. I'm sure that coping mechanisms have a role but it seems to me that those would be protective factors that would increase the jar's capacity. I think that there must be some people whose jar is essentially full with the genetic factors so that the environmental factors play little role, if any. Based on what you describe, that's how I would visualize your jar. You're right, though: we don't need to have any more stigma against people who live with bipolar disorder!
@SiK2712
@SiK2712 10 ай бұрын
@@susanweinstein4319 You contention that there “must be some people…….” Of which you count me as one, is exactly my point. This wasn’t covered during the illustration and I think people would struggle with that. It goes back to the old trope of “pull yourself together” layering on guilt and stress to an already vulnerable person who’s self worth and self esteem is already in the dumpster. This might be a determining factor that pushes them over the edge. Yes, we must seek to eradicate stigma or any confusion or distress that may be caused by not considering the aspect we have both concluded. I am grateful for your interaction.
@cindysutteranimalsfunny9185
@cindysutteranimalsfunny9185 4 ай бұрын
i d wish tere were more people chatting here
@blbrightlights564
@blbrightlights564 7 ай бұрын
If there isn't a genetic factor how come you have generation after generation of family members who have bipolar?maybe we might have a discovery of seeing the proof of bipolar in the future.
@mscraig5147
@mscraig5147 6 ай бұрын
It IS genetic. 100%. True, real bipolar disorder is passed on, or induced via head injury that damages the HPA axis. It's genetic. Biological. Medical.
@cindysutteranimalsfunny9185
@cindysutteranimalsfunny9185 4 ай бұрын
i ypunderstand completely? my mother had it i have it, my oldest sister has it and my son has it! anybody tha says it’s not hereditary is a fool and doesn’t have bipolar. it’s just as well, i am not speaking tomy daughter again afte she said forthe last time that it doesn’t exist! i was very ill when she said you’re not sick! sick is when a person is just about to die! i had to be put on antibiotics, i was so ck i was sick for almost four weeks had a long manic episode, couldn’t sleep and very severe headaches! almost as bad as a migrain! and she was yelling at me when i tred to talk to her! i’m just not going to speak to her again.😢 i kinda wish she had bipolar and ill as i was! just for a short time! maybe she would undcrstand what i feel and have some compassion! i never once have treated her this way, i can’t believe she is that way! she is a registerednurs and works in a hospital! i sometimes wonder if she’s that way to the patients. that wasn’t the first time she’s done this kind of thing to me, and i call it emotional and mental abuse. i know what that is like! i’ve been in relationships sand so called friendships like that, i know what it’s like!😢 that’s why i don’t trust auymore and i dont ha a friend. 😢 oh well i know i have to be strong and find something that makes me feel good, right?
@mscraig5147
@mscraig5147 4 ай бұрын
It's hereditary. It can be shown and proven. The meds are just so intense and long term, why would the med industry want anyone knowing that? Same like cancer
@cybercab
@cybercab 9 ай бұрын
Fascinating discussion. Though to be honest I’d be very concerned to do this kind of thing in Canada. If you’re bipolar and are having a baby is the advice to end that fetus? In Canada in 2021 3.3% of all deaths were doctors intentionally ending the life of their patient. Will doctors add this to the list of people who should want death? It’s concerning.
@cybercab
@cybercab 9 ай бұрын
The marble analogy is really good. This might help people understand the situation.
@blbrightlights564
@blbrightlights564 7 ай бұрын
I feel the family history is very important and it takes time to build up the whole picture of someone's condition watching and recording the patient over a few months to label a person with a serious disease and give them very strong drugs are not a good move.
@ShirleyAnnPetrillo-oj7sc
@ShirleyAnnPetrillo-oj7sc 8 ай бұрын
Polygenetic Risk Score. There must be a number of Mutated Genes that are common among those diagnosed with Bipolar Disorder OR those who have many symptoms which might be something else like Endocrine System malfunction or Digestive System issue WHAT are these mutated genes ? MTHFR, MTR, COMT WHAT Labs offer Polygenetic Risk Tests ? Isn’t it much more difficult to counsel without genetic analysis ?
@FirstmaninRome
@FirstmaninRome 6 сағат бұрын
Yeah, my ex-wife heard from a youtube amateur that she could take meds while pregnant, and when the psychosis returned and our lives were destroyed.
@blbrightlights564
@blbrightlights564 7 ай бұрын
Don't you think the bipolar diagnosis has become too popular and half the cases may not be serious contenders it might be one off breakdown or phycosis or induced by drugs.
@littlewoodchopper2659
@littlewoodchopper2659 5 ай бұрын
I blame my bipolar on my relatives. I was diagnosed at 15 but pretty sure i had it by 3.
@26sleepyerik
@26sleepyerik 5 ай бұрын
Same I was diagnosed at 15 years old but I knew their was something different about me since I was 7 years old I blame my parents and environmental issues
@di_decaire
@di_decaire Ай бұрын
From what I know - 1 granddad, my dad. and my brother (who literally drove me out of my family home). Very traceable. Can it be sex-linked?
@blbrightlights564
@blbrightlights564 7 ай бұрын
These stresses that have an affect on our state of mind don't they stem on childhood experiences sexual abuse , neglect .yes moving hse is stressful but are you saying that could have an affect on your mental well being?
@user-ph9fg6mm3j
@user-ph9fg6mm3j 5 ай бұрын
It’s genesis relates to anxiety and depression and what’s the difference between bipolar and A&D when it comes to genetics
@cindysutteranimalsfunny9185
@cindysutteranimalsfunny9185 4 ай бұрын
what is a.d.?
@user-ph9fg6mm3j
@user-ph9fg6mm3j 4 ай бұрын
@@cindysutteranimalsfunny9185 I just abbreviated anxiety and depression by saying A&D
@user-kc2wq9my3j
@user-kc2wq9my3j 6 ай бұрын
I soooo hope I come back to this to properly comment. Not at 2.50am and on a good day for me. LOVED the history video but THIS jar crap is complete b.s., COMPLETE!! Jar full brings on an episode LOL. Protective rings LOL I hope I come back and rip apart all these 'assumptions' What an insult to my experience, intelligence and disorder.
@PRNSee9786
@PRNSee9786 3 ай бұрын
@ 0Dear KC Even when we disagree with points made by others, we still need to be careful on how to respond and mind our language! We can disagree , but let's do so with respect, restrain. Professionalism !
@FirstmaninRome
@FirstmaninRome 7 сағат бұрын
In America you can't get treatment, this country is the largest mental institution in the world, if hasn't driven you mad, you diffinately are asleep ingredients while standing up.
@James-ik8fn
@James-ik8fn 4 күн бұрын
Nope
@user-wt6qf4sw9m
@user-wt6qf4sw9m 3 ай бұрын
Same sex marriage,metabolism.
@thenutritionalhealer7233
@thenutritionalhealer7233 10 ай бұрын
How to Detox Heavy Metals The good news is there are ways to remove the heavy metals that are behind bipolar disorder. The most important step to take is to incorporate the five heavy metal detox foods I shared in Medical Medium and my other books into your life every single day. This is not any old heavy metal detox you might read about online or hear from your practitioner. There is a great deal of misinformation out there that can lead you to try something which doesn’t actually work. This detox, the Medical Medium heavy metal detox, does work. If you truly want to heal from bipolar disorder, these foods will help you get there. Cilantro, Atlantic dulse (a sea vegetable), spirulina, barley grass juice powder, and frozen or fresh wild blueberries (or wild blueberry powder if you can’t find fresh or frozen) all work together synergistically to safely and effectively carry out the heavy metals from your body like no other foods, practices or detoxes you might hear about do. While all of them are detoxifying foods on their own, the synergy of the five together is what ensures total elimination. Many people who have been incorporating these five foods have enjoyed the Heavy Metal Detox Smoothie because it is a simple way to get them all in at once and the five foods must be enjoyed daily within a 24 hour period of each other. However, if you prefer to consume these foods in other ways over your day, feel free to get creative. Find out more about the heavy metal detox on my blog. I will just make one note about the blueberries because many people get confused about which ones to buy. While cultivated blueberries have many wonderful benefits and health supporting properties, they are put to shame when compared to the wild blueberry. Wild blueberries are much smaller and have much deeper deep blue/purple skins. They are so packed with nutrients and healing properties that simply including these alone can be helpful if that is all that you can do today. Wild blueberries help remove heavy metals from the body, not cultivated blueberries. Wild blueberries are most commonly found in the freezer section of your grocery store, and, thankfully, they are available in most grocery stores around the United States these days. Be sure to buy the blueberries that are wild so that you can properly complete your five foods to detox from heavy metals daily. Other Important Healing Foods For any kind of disorder involving the brain, it is crucial to consume plenty of electrolytes from natural sources. Drinks like coconut water, fresh squeezed lemon or lime in water a few times a day, and pure cucumber juice provide vital electrolytes that help repair the brain and protect you from some of the effects of adrenaline being released. It is incredible what these simple elixirs can do for those who struggle with bipolar, depression, and anxiety. In fact, if you are with someone during an emotional experience, like getting bad news or being in an accident, and you have the ability to do something helpful, consider offering them one of these drinks instead of a simple glass of plain water. The electrolytes and glucose will help counteract the storm that is happening in the brain and protect and restore brain tissue. Another source of electrolytes is the right kind of B12, which contains both adenosylcobalamin and methylcobalamin. Mineral salts are amazing secret powerhouses for brain recovery. Drinking a glass of plain celery juice every morning can help you heal from the emotional storms you have experienced due to bipolar disorder. Many vegetables are high in mineral salts as well, especially spinach and other leafy greens. Healthy sugars from fruits are essential to healing disorders in the brain. As we discussed above, the brain is made almost entirely from glucose. If you starve it too long from the right kinds of glucose, you will be setting the stage for a manic episode to occur. This is why it’s so critical to focus on healthy high carbohydrate foods such as all fruits, potatoes, sweet potatoes, and winter squashes, as your main source of calories when healing from bipolar disorder. Some doctors may prescribe high protein, high fat, low carb diets and for some the symptoms may improve initially, but eventually an even bigger episode will occur because you are being starved of glucose. As I shared earlier, glucose is needed for the brain to cool down so that when another trigger happens it helps to protect your from the emotional storm happening in the brain. Triggers are inevitable because the only predictable thing about life is that it is unpredictable. While you can do your best to set up emotional boundaries and live a low-stress lifestyle, there will still be things that cause emotional storms and surges of adrenaline. This makes being prepared by getting your brain the food it needs to protect itself even more important. Instead of withholding these precious sugars from your brain, begin to incorporate more fruits, sweet potatoes, regular potatoes, raw honey, and winter squash. Bananas are one of the secret weapons against bipolar disorder and should not be underestimated. Dates are an amazing way to get glucose to the brain quickly. Try not to restrict your fruit, especially bananas, in any way. No matter what you may hear about bananas being bad, I have seen them save lives. Restricting your fruit intake is like refusing to feed your brain what it needs to truly heal. In truth, someone with bipolar or another neurological illness requires far more glucose to support the brain than someone who has no health issues. Fruits as meals, snacks, and alongside greens throughout the day are very important. Potatoes, sweet potatoes and squashes with your evening meal are also incredible. Any kind of young greens can be amazing tools against bipolar disorder. Eat sprouts and microgreens of all kinds because the mineral salts in them have a different healing quality when they are in that stage. Baby spinach, radish sprouts, broccoli sprouts, and kale microgreens are examples of amazing vegetables you can put into your salad, juices, or smoothie to help in recovery, or simply top steamed potatoes and baked sweet potatoes with a big handful. Also, include radishes and asparagus, which have unbelievable properties to fight bipolar disorder. Asparagus helps to repel new metals and toxins from taking up residence in the areas where heavy metals once were as you remove them through the heavy metal detox. Radish greens are one of the most powerful leafy greens on our planet and also help to remove heavy metals. Read more about the healing properties of these foods in Life-Changing Foods. Keeping your fats low, as I have discussed above, is essential. If you eat animal foods, try to reduce your intake to once a day or every other day because they are some of the highest sources of fat. If you’re vegetarian, it’s important to remove eggs and dairy in your diet (read why in any of my books). If you are vegan, try not to overdo too many plant sources of fats such as avocado, coconut, nuts, and oils. While these plant fats are not bad foods, in fact they can be quite healing, you want to be mindful of your intake because too much fat in your system makes it harder for the toxic metals to leave your body. Additionally, by keeping your fat intake low, you are creating more room on your plate for the most healing foods like fruit, potatoes, vegetables, and leafy greens, not to mention your heavy metal detox foods or smoothie every day.
@camillegodwin6398
@camillegodwin6398 5 ай бұрын
Why would you assume bipolar is from heavy metals? That’s oddly specific. It’s genetic, that’s why you see multiple people in families all the time.
@thenutritionalhealer7233
@thenutritionalhealer7233 5 ай бұрын
thats one of the drivers pathogens and toxic loads and leaky gutpubmed.ncbi.nlm.nih.gov/?term=bipolar+microbiome
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