not sure if anyone gives a shit but if you guys are stoned like me during the covid times you can stream pretty much all of the new series on InstaFlixxer. I've been streaming with my gf for the last couple of months xD
@maxwellonyx95593 жыл бұрын
@Winston Jamir definitely, I have been using InstaFlixxer for months myself =)
@johnwong81462 жыл бұрын
This was an incredible amount of interesting information packed in about 13 minutes. You are amazing. Thank you for making this!
@soilmanted2 жыл бұрын
Although Friedrick Serturner later became a pharmacist, when he published about isolating morphine from Papaver somniferum, he was a pharmacists assistant. He did not have enough education to become a pharmacist. There was little to believe he ever would. However once he published, he gained a degree of fame which allowed him to pursue a further education, and eventually he became a pharmacist. Recent archeological evidence suggests that Papaver somniferum was one of the first plants cultivated, at the dawn of agriculture, about 8000 years ago.
@doodad77 Жыл бұрын
Papaver somniferum, enuff said😁pleasant dreams
@tess76564 ай бұрын
Fuckin druggo 😂
@truescotsman41033 жыл бұрын
morphine is an amazing drug i have decades of experience using this drug to survive. i have somatoform disorder with chronic pain and about every 6-8 months i need a tiny dose to correct some imbalance in my endorphine system. after i take 2mg per day for about 5-7 days i still haven't developed a dependence and its job is done. my homeostasis returns and im able to cope and eat and go to work without constant multiple attacks of extreme abdominal pain requiring me to be in bed for anywhere from 4hrs to 2 weeks. the cycle repeats itself so im assuming im depleting my bodies own endorphins and somehow morphine stimulates my body to return to balance after i stop using it. im seeing the dr next week to discuss this effect. i have a feeling that my problem stems from taking 90mg a day of morhphine for about 9 years. changes occurred that are permanent.
@thomasneal92913 жыл бұрын
interesting. thanks.
@christinearmington3 жыл бұрын
Very interesting. Thank you.
@Cbd_7ohm2 жыл бұрын
Absolutely. The drug war is the biggest farce.
@GazB852 жыл бұрын
Your body can replace endogenous opioids, it's tolerance to exogenous mu agonist opioids that are the problem.
@GazB852 жыл бұрын
@@2nostromo You think it tastes disgusting? I think it's bitter, spicy and kinda grassy cause of the chlorophyll. Unfortunately it isn't a cure for your IBS, it just treats the symptoms. When you say 'addicted' do you mean dependent? Cause even doctor's get dependence and addiction wrong. Dependence ie where your body needs the substance and will go into withdrawal without it. Addiction is where you constantly increase the dose chasing the euphoria.
@chillazchillazius76343 жыл бұрын
It looks like as if you put way more effort into the visual storytelling part in this one. I like that approach very much.
@ProfessorDaveExplains3 жыл бұрын
That's because I've got a pro animator working on this series!
@chillazchillazius76343 жыл бұрын
@@ProfessorDaveExplains very nice work! I work in Motiongraphics and 3D Animation and I know how much work that is. He or she is doing a great job and you should keep doing it that way if you can in my opinion!
@cyrenedomogalla51273 жыл бұрын
@@chillazchillazius7634 thanks!
@user-in8bz3kd7d5 ай бұрын
@@ProfessorDaveExplainsBrother, you are a genius, have you ever made oxytocin? I'm very curious about this, how is it extracted from the ergot fungus, I really want to extract it myself, can you teach me?
@Felixkeeg3 жыл бұрын
Merck definitely deserves an episode for himself. The guy had isolated and characterized over 800 pure(!) compounds, which were up for sale at any time. And that was the mid 1800s
@saturn1returns2 жыл бұрын
MDMA came from Merck too.
@GazB852 жыл бұрын
@@saturn1returns Not the original guy but the company did create it during WW1.
@earlj98882 жыл бұрын
@@GazB85 who was? Interesting stuff
@earlj98882 жыл бұрын
That old? MDMA
@yessure57922 жыл бұрын
what a legend!
@santicruz40123 жыл бұрын
This is my favourite series in your channel!
@DemDoolies3 жыл бұрын
Sure this dude was super irresponsible with his experiment, but I gotta give him credit for taking the morphine himself!
@masterzoroark66643 жыл бұрын
Well, yeah- gotta have balls to participate in your own experiment.
@GazB852 жыл бұрын
1.5 grains is 96mg Orally for a first timer at a recreational (Somnolent/Nodding.) dose it's only 20mg of morphine. So they would of all been fucked, unless Serturner had a tolerance, which I assume he did. The kid's could have too, considering how common laudanum (Opium Tincture) was back then and everything it was used for.
@tinafoster86652 жыл бұрын
@@GazB85 yes but the vinegar afterwards undoubtedly gave them a hangover which was really What affected them, the guy was super irresponsible with his experiment for not starting with just dried laudanum, n taking the same equivalent, say 30 mg of his dried laudanum to 30 mg of his morphine isolate, and give them to people who are actually suffering from diarrhea which is a lot of what laudanum was expected to do, to just give people opium extract without having any of the medical conditions which people took them for, it seems a little irresponsible for a pharmaceutical chemist LOL
@HauntedHarmonics2 жыл бұрын
@@tinafoster8665 self administration was and is a huge part of medicinal chemistry, and without the self-experiments of chemists like Shulgin we’d likely still be decades behind in the field of chemistry that being said, yeah, it’s important to titrate doses up slowly. just giving yourself and 3 teenagers 50mg of mystery powder and seeing what happens probably isn’t the smartest move lol
@BushyHairedStranger2 жыл бұрын
@@HauntedHarmonics you need to take into consideration the century this was work was happening, context applies to actions conducted. Albert Hofmann is responsible for one of the most important discoveries in World history. His work with Ergot Alkaloids is unprecedented and few Organic Chemists have surpassed his discoveries.
@vishnuprakashbharadwaj32113 жыл бұрын
Hey! Professor Dave, could you make a video on metallurgical processes and isolation of metals?
@toxikspeaks35233 жыл бұрын
Yus! I'm here for it! Pleeaaaseee daaavvveee
@mitch33842 жыл бұрын
I worked in a copper smelter for a number of years, taking molten matte and refining it in a Pierce-Smith Converter from around 50% purity to about 90%. Also ran the anode furnace for a while, which takes copper from 90% to about 99%. If you're interested in that side of it, ask away. Super fun job if you don't mind hard work and heat.
@GazB852 жыл бұрын
How did Serturner 'enrol' the animals? I like how he got the local kids involved. "Hey kid's, wanna try some pure morphine?"
@avael24512 жыл бұрын
Would be awesome to see this series continued into the 20th century by discussing the development of antibiotics and hormone drugs as well as their semisyntheses :D
@ProfessorDaveExplains2 жыл бұрын
That's where it's headed!
@beckypots12 жыл бұрын
I was told that in Iran the dried poppy is brewed into tea, 1 head per 4 people, is this a likely story? Would boiling water extract a paid relieving tea?
@danielgonzalez-yp7hiАй бұрын
Yes
@brittanyjacobson51993 жыл бұрын
Wonderful, very excited to be getting more in this series.
@topiasr6283 жыл бұрын
Very facilitating! Also 👋 distant relative
@ronokplays2 жыл бұрын
Especially the opening, amazing stuff man
@AbhinavSingh043 жыл бұрын
Congratulations for 1.2 million subscribers 🥳
@godara2op5663 жыл бұрын
Thanks man I was feeling less motivated to study science as the science we study is too abstract. Problem solving is more prioritised than communication with the subject. Regards
@zyern28223 жыл бұрын
Seriously.
@xavierperez6739 Жыл бұрын
Excellent video, thank you for making these videos! It’s very thorough and I can’t tell you how appreciated that is.
@10000daddy3 жыл бұрын
Excellent job! This video must have taken a lot of work and time. I was reading about the morphine rule recently and this video has taught me new things.
@beerpigs9764 Жыл бұрын
I cant get over how good these videos are such a dope playlist i definitely am gonna check out microbiology next
@karyngarrisonАй бұрын
I like your lingo that you Incorporated that's "Dope" , that you said "Dope" 😎.. There are dopamine receptors in our brains and when those things release the feel-good chemicals it's very very very very very very like the chemicals and similar to like feeling really really good or a high from opioids. And then if the opioid over triggers that so much it over releases the dopamine and then when you go back to natural like that's where the withdrawal like will come in but that's why you got to take it at a slow pace but I think I'm just saying like you know that's a little kinky with the you know crazy like bad on the morphine thing that I think it's might be a little bit of a whip on top of you know what I mean but I like it I still say dope too. ANYWAY THAT'S JUST A LITTLE TIDBIT TO SAY HI YOU'RE AWESOME I HOPE YOU'RE ALWAYS BLESSED AND HOPE YOU PROSPER AND YEAH THAT'S WHERE THE WORD IS DERIVED FROM I WISH YOU WELL .
@beerpigs9764Ай бұрын
@@karyngarrison hahaha thank u! 👍
@maxdangers2 жыл бұрын
The mouse was last seen headed in the direction of the local pawn shop with his grandmother's jewellery.
@BushyHairedStranger2 жыл бұрын
Sandoz Pharmaceutical(Novartis) made monumental strides in Alkaloid research. Specifically work with Ergotamines.
@catdurrant5694 Жыл бұрын
First channel that I have subscribed to in the first 10 seconds, purely based on the intro! Bring the science!
@nathanielf483 жыл бұрын
Very interesting although the poppy blowing in the wind is not an opium poppy
@-azerima50393 жыл бұрын
This video is so well made. I think a better title would help it loads.
@choosen11303 жыл бұрын
As a pharmacy student I really find this interesting
@dominiquedoeslife2 жыл бұрын
The fact that you used the term "complex dependency patterns" instead of misusing the word "addiction" tells me that you're both knowledgeable and unbiased. I just subscribed. Psychopharmacology was one of my areas of focus when I went to school for my psychology degree. Your channel is as informative and interesting as any of the classes I took at the private university I attended. (Edited and reposted this, because I'm a grammar nazi and I had made a spelling error in my original comment)🤦🏻♀️
@grantflippin78082 жыл бұрын
"Complex dependency patterns" sounds like something an addict would say to excuse their behavior...
@hankhill33652 жыл бұрын
@@grantflippin7808 both u are right tbh
@BushyHairedStranger2 жыл бұрын
@@grantflippin7808 Heroin is awesome. You’re just afraid to try it because you’re already a slave to your ego. That said & known, if you ever tried Heroin, in place of talking shit about those who have, you’d know the power & the glory of the almighty King of Drugs! Smack City would make you slave numero uno!
@grantflippin78082 жыл бұрын
@@BushyHairedStranger imagine being addicted to hydrocodone (big pharma heroine) for your entire time at high-school. It only ended when my stash was stolen during a break in and had to experience the worst pain I have ever experienced from the withdrawal.
@thomasrodriguez98642 жыл бұрын
Randomly suggested video. I like it.
@VerasakSahachaisaree8 ай бұрын
Superb lecture, Prof. Dave. Thank so much.
@backstreetfan28873 жыл бұрын
thank you for doing these
@CJay-xq7dh10 ай бұрын
You’ve gained me as a sub, what a great, informative video on this topic
@studybuddy94423 жыл бұрын
He knows a lot about science stuff professor dave explains 😘
@ronokplays2 жыл бұрын
I’d like to make content like this later in life. Such a goal
@Gman_40413 жыл бұрын
Such quality content. We love you professor Dave!
@dredank2 жыл бұрын
Did u ever make the narcotics video u mentioned with dia morphine
@earlj98882 жыл бұрын
Thank you for the information. The simple brakedown
@RicoCreations2 жыл бұрын
Great way to present the field in a lay friendly level 👍🏼👍🏼Two thumbs up!
@Guidus1252 жыл бұрын
fantastic video!
@geraldomedrano55583 жыл бұрын
Awesome video!!! Thank you for the lesson
@rylandavis2976 Жыл бұрын
What's with him saying that nicotine is "extremely toxic" I'd love to see a research paper on that if you have a source. It's definitely not "extremely toxic" at least not in it's isolated form. Last i checked there was no evidence that nicotine was even really a real carcinogen although there is evidence that it can promote blood vessel growth in an already active tumor. Nicotine is actually pretty safe in safe doses probably within the ballpark of caffeine "toxicity" which mostly consists of stressing the circulatory system (when not in overdose). I'm pretty shocked that you would say it's "extremely toxic" given your previous toxicity is in the dose speech. We do not evidence for nicotine being extremely toxic at all in isolate forms. Things like nicotine gum show no widespread serious long term complications such as smoking. But if you have research showing different id love to see it
@galileog8945 Жыл бұрын
What "research" do you need? Nicotine is an extremely poisonous compound. Its LD50 is 0.5 mg/Kg, which makes it more toxic than cyanide. It is all relative of course, but as far as chemicals go, very few things are more toxic than nicotine.
@janedesign57585 ай бұрын
Same here, it is not toxic.
@UNIRockLIVE3 жыл бұрын
Learning more with every upload
@opiyumpharma5556 Жыл бұрын
Codiene is not technically not synthetic - It is an Opiate, produced in the poppy alongside morphine and thebaine, However due to the larger demand of codiene, for direct use or for further processing into other opioids, the large majority of morphine extracted from poppys is converted to codiene, around 80 to 90%
@michielvandemeent44542 жыл бұрын
Great vid. One point however; the image at 1:50 shows eight structures, only two of which are actually alkaloids...
@denguevirus1353 жыл бұрын
Waiting for the next video on this series
@Talkwithtina8083 жыл бұрын
Omg, I'm in Mexico and just met a couple that was talking about this same thing.
@sydneyhunt66813 жыл бұрын
Amazing and to the point wish more open spoken words to come 😁
@DakuHonoo Жыл бұрын
woah i watched this due to a meme conversation about morphine and found such quality content, i'm subscribing, video's both informative and very well visually composed
@Eatmorepaper Жыл бұрын
love how when youre talking about semisynthetic derivatives you convert morphine into morphine but its turned sideways
@science_and_anonymous2 жыл бұрын
keynote: An alkaloid MUST contain basic nitrogen. If a phytochemical does not contain such, in the example of a flavonoid such as apigenin, it is not truly an alkaloid.
@davidhalliday61611 ай бұрын
What a phenomenal video, great job
@AndreeaTrandafirFlagshipMed3 жыл бұрын
I am always amazed about the progress of medicine and I wonder how would I react if I could live for a day in different periods of the past but also in the future. I wonder how will our children or grandchildren think about medicine from the 2020s. 😅😂
@masterzoroark66643 жыл бұрын
Some probably will be baffled by the return of some to the make belief cures, but the fast acting to get the Covid vaccines will definetly impress them
@tRumbewas Жыл бұрын
Thanks
@Unraveled3 жыл бұрын
I can't believe how scientists just experimented on themselves and others just expecting to see what happened. Dangerous, but a little funny.
@mohamadbaha67913 жыл бұрын
rat randomly chiling in lab sertuner be like would not that make u a candidate for this experiment?
@deliciousness81832 жыл бұрын
Can anyone point me to the exact process of extracting morphine?
@danielgonzalez-yp7hiАй бұрын
My reply keeps getting deleted 😡
@MilkoAtchev3 жыл бұрын
Regarding the %-ages of morphine that you mention at 5:07 - these are not morphine content in dry poppy pods, but morphine content in raw opium. On average morphine content in poppy pods is ~0.3%. Great content though!👍
@BushyHairedStranger2 жыл бұрын
Milko Atchev the average claims to morphine content % vary wildly in the Poppy as mentioned in the video. There are cultivars that have been manipulated over decades to produce high concentrations in the latex.
@joesteadman3432 жыл бұрын
We went from blind experimentation to building space ships.... I wonder what tech other species have created?
@richardwilliamsiv3778 Жыл бұрын
Wish you had mentioned how aspirin and heroin are synthesized via the same reaction, using an agent that acetylates the starter natural product into what we call aspirin and heroin.
@fukpoeslaw36133 жыл бұрын
I'm thinking of extracting furanocoumarines from grapefruit juice, I already asked my green grocer what he charges for 15 kg of white grapefruit (far to much: 37,50 euros) but how can I do that best?
@Gruwg2024 Жыл бұрын
“Sir Robert Robinson” what a legendary name
@thekeymaker-ey5rk11 ай бұрын
Amzing doco 👏👏👏
@SirElbert3 жыл бұрын
Thank you Prof. Dave
@index1htmlАй бұрын
Great work ❤
@BRIANOKEEFFE12 жыл бұрын
4:57 not opium poppy pod. Some other strain. Glitch in the,
@dandylandpuffplaysminecraf87442 жыл бұрын
Flanders poppy is one name. They grew in the trench warfare fields after the Great War. The field of Flanders were barren, poppies need light for the seeds to germinate so they outgrew all other plants creating a red field. The blood red poppies came to symbolize the war dead and wounded veterans. Paper poppies are worn on 11/11.
@rastodulla10833 жыл бұрын
Nice video, but you should correct information about poppy pods morphine content. Your numbers are probably correct for opium latex, but not for pods. Average dry poppy pods contain less than 1% of morphine (0.5% is common), only special breeded varieties could be up to 2%.
@sydneyhunt66813 жыл бұрын
Do you know how much calcium hydroxide to use ph ect before adding ammonium to get free base I find it all interesting stuff and yes I think the dead poppy heads have the levels you say
@rastodulla10833 жыл бұрын
@@sydneyhunt6681 In theory, morphine is not very soluble in water at pH 9.1 and should precipitate from a solution. But in practice, things are almost always different.
@sydneyhunt66813 жыл бұрын
@@rastodulla1083 I looked at loads of papers lol I get it needs ph 9.1 but how much or how high ph do you go with calcium hydroxide before you lower it with ammonium to 9.1 that information seems to be very hard to find lol anyway thanks buddy for getting back
@rastodulla10833 жыл бұрын
@@sydneyhunt6681 i saw somewhere online that it should be 11. iirc for decreasing pH back to 9, ammonium chloride should be used, not ammonium.
@chris73brown Жыл бұрын
Awesome. Thx for this
@shatteredreality19872 жыл бұрын
It is truly amazing how God has blessed humanity with every single thing we need to survive. Yet some will say it is all just luck of the draw.
@ProfessorDaveExplains2 жыл бұрын
If we didn't have the things we need to survive, we wouldn't be here to think about it. It's like a puddle of water remarking at how convenient it is that it's sitting in a hole of precisely its own shape. Please exercise better logic.
@patldennis3 жыл бұрын
Tour has all of his sycophants convinced we isolate raw materials for synthetic DNA from natural sources bc we have no other alternative, rather than bc even though we can, it's just cheaper and easier to use a shortcut. I predict that for the ones that wander over here without paying attention this video will only fan the flames.
@ProfessorDaveExplains3 жыл бұрын
Fortunately precisely none of them are interested in learning anything so they avoid my academic tutorials like the plague.
@brannonmcclure69702 жыл бұрын
That is so informative. I am wondering about narcotics as well. Could we find other substances to medicinal interest? The night is short… .
@HitmanR979 ай бұрын
Dude, nice video!
@flyback_driver Жыл бұрын
9:07 yeah back in the day I used to take diacetylmorphine and eventually convert it into 6-acetlymorphine. I suppose I was conducting my own biochemical studies but jokes aside don't do heroin kids.
@kg-Whatthehelliseventhat10 ай бұрын
Good day, Would you mind replying to me? I could use some help with what you stated in your comment.
@user-jh6cg2rx6n19 күн бұрын
Odd a plants defence is to save it not make u dependant UNLESS thats the plants plan ......
@AL4M12 жыл бұрын
Great video !
@shaswatsatyam3 жыл бұрын
Thank you Professor dave for all your hard work.
@nicholaseachus59378 күн бұрын
I want to make it
@pritammaji6702 жыл бұрын
Morphine is one of the best secondary metabolites🔥🔥🔥
@traepetersen6199 Жыл бұрын
I can't believe they won't let you Fullscreen this
@lsd25records3 жыл бұрын
awesome video ... thanks.
@Talkwithtina8083 жыл бұрын
God created the earth so we could live off it.🙌🏾
@tajinderbir76903 жыл бұрын
Hi
@kali66512 жыл бұрын
No, he didn't. No such thing as God. Sad to see you believe in god when the bible explicitly states you are allowed to own and beat slaves.
@PaulBrown-uj5le2 жыл бұрын
God doesn't exist, it's all nonsense and if you don't understand that you're stupid.
@joshuahickson49762 жыл бұрын
@@PaulBrown-uj5le go back to Reddit
@mattwaldren7 ай бұрын
I recommend having a small pause or break throughout your videos, perhaps by separating the video into three separate parts/sections/chapters. Otherwise, to the viewer/listener, the video can come across as a gushing, unending torrent of information for 12+ minutes. Just trying to help. Otherwise, love the videos.
@TehGoldd6 ай бұрын
Can you teach us how to hypothetically get pure morphine from dry Poppy pods
@willsgarden67402 жыл бұрын
Amazing video
@Sketch19943 жыл бұрын
Who really believes bleeding opium when your skin is cut is good defense mechanism?
@dredank2 жыл бұрын
So cancer has existed since man? Are there plants also carcinogenic to animals?
@flyback_driver Жыл бұрын
What if he had given the vinegar too soon and produced 3-acetamorphine or diamorph. I know it's technically not anhydride but what if...
@lostSempaiWissame2 жыл бұрын
Sooo interesting
@user-ts7sn8mh5g2 ай бұрын
سلاممیتوانیدفیلمازساختهروعینبگزارید
@angelicazambrano2 жыл бұрын
Interesting, I wonder who had the bright ideas to chase the dragon for fun?
@Meike1642 жыл бұрын
I can harvest opium in my back yard. I have a lot of pretty poppies
@campbellmorrison854027 күн бұрын
I never realised morphine was so close to codeine
@I-kd3cz5 ай бұрын
thanks!!!!🎉
@00bean002 жыл бұрын
Dr , where is the thumbnail painting from? I would really like to find these
@garywood58823 жыл бұрын
Professor Dave, could you do a vid on how to synthesize alpha methylphenethylamine ... asking for a friend...
@iridiumFalcon3 жыл бұрын
I second this.. also asking for a friend
@danielgonzalez-yp7hiАй бұрын
I 3rd this …, asking for myself 😂
@asraksabah36733 жыл бұрын
Good
@Avery_____2 жыл бұрын
I ❤️ Heroin
@vongirlvnpnk Жыл бұрын
🤣🤣🤣at least ur honest
@s0umyendustudies3 жыл бұрын
And your hairstyle became like Newton 😍😂
@panosvrionis85483 жыл бұрын
Power rangers said its morphine time.... Now I get it🙄🙄
@KarlosEPM3 жыл бұрын
Mighty morphine
@panosvrionis85483 жыл бұрын
@@KarlosEPM 😎😎😝
@DIGITALVHS3 жыл бұрын
I love perpetually through the history of pharmacy and the discovery of drugs the chemist always seems to bioassay their product. I always think it's very neat they just eat the drug to find out what it's like for themselves. You can always say more than a rat I guess. And then there's albert Hoffmann
@amritheshk71513 жыл бұрын
Awesome
@mcplesk87653 жыл бұрын
I wonder i youll ever do a series “debunking creationism without science”
@thomasneal92913 жыл бұрын
if you examine the accepted consensus academic theology surrounding ANY religion, they all debunk creationism within the religions they study directly from the writings inherent to begin with. really. so you can in fact reject christian/muslim/hindu creationism directly from theological positions, as well as from a scientific one.
@thomasneal92913 жыл бұрын
...but you're not going to get that here, because Dave's interest and background is in science, and that's the way it should be.
@godara2op5663 жыл бұрын
@@thomasneal9291 yes bcuz his channel is based on this topic of science breaking away will lead in confusion. But I believe science that we study today primarily is based upon things and our surrounding. We really haven't focused or taught ourselves well enough the most abstract capabilities of humans (the ability to communicate ,decrypt our intuition and express our intuition,self consciousness and so on