The Most Beautiful Experiment: Meselson and Stahl

Рет қаралды 162,483

Күн бұрын

Matt Meselson and Frank Stahl share the story of their groundbreaking experiment from 1958 that definitively showed semiconservative DNA replication.
Matt Meselson and Frank Stahl were in their mid-20s when they performed what is now recognized as one of the most beautiful experiments in modern #biology. In this short film, Matt and Frank share how they devised the groundbreaking experiment that proved semiconservative #DNA replication, what it was like to see the results for the first time, and how it felt to be at the forefront of molecular biology research in the 1950s. This film celebrates a lifelong friendship, a shared love of science, and the serendipity that can lead to foundational discoveries about the living world.
0:00 Introduction
2:01 The Spark
4:14 The Very Beginning
5:23 A Gorgeous Insight
7:59 Serendipity
9:45 Three Targets
14:36 That’s Replication
17:49 The Fundamental Things
20:27 Epilogue and Credits
Scientist Biographies:
Matthew Meselson: Dr. Meselson has made important contributions to the areas of DNA replication, repair and recombination as well as isolating the first restriction enzyme. Currently, he is Professor of Molecular and Cellular Biology at Harvard University, where his lab studies aging in the model organism bdelloid rotifers. Meselson is also a long-time advocate for the abolition of biological and chemical weapons. He has received many honors, including a Lasker Award in 2004.
Frank Stahl: Frank Stahl received his PhD at the University of Rochester, where he studied genetic recombination in phage. He performed postdoctoral studies at Caltech, during which he completed the famous Meselson-Stahl experiment, and joined the faculty at the University of Oregon in Eugene in 1959. He is now an emeritus faculty member who enjoys teaching and family life, and the natural wonders of Oregon.
Additional Resources:
More info at our website www.ibiology.org/genetics-and...
See the Explorer’s Guide to Biology for a first-person and in-depth description of Meselson and Stahl’s studies, as well as educational resources associated with their foundational key experiment:
explorebiology.org/summary/ge...
Credits:
Elliot Kirschner (Wonder Collaborative): Executive Producer
Shannon Behrman (iBiology): Executive Producer
Brittany Anderton (iBiology): Producer
Derek Reich (ZooPrax Productions): Videographer
Eric Kornblum (iBiology): Videographer
Rebecca Ellsworth (The Edit Center): Editor
Adam Bolt (The Edit Center): Editor
Gb Kim (Explorer’s Guide to Biology): Illustrations
Chris George: Design and Graphics
Maggie Hubbard: Design and Graphics
Marcus Bagala: Original music
Samuel Bagala: Original music
#scientist #science #scientists #dnareplication

Пікірлер: 224

@Jacubp 3 жыл бұрын

NEVER THOUGHT THEY’RE ALIVE LOVE U GUYS

@gracysharma2796 3 жыл бұрын

Couldn't have imagined to learn this experiment from them. Internet is surely a beautiful place.

@shweta618 3 жыл бұрын

Wow..dont these guys look adorable. And the pic promises to be an entertaining talk

@AnkeetKumar 3 жыл бұрын

I have just started my PhD, It feels amazing to see such great souls.

@DG-xg8vg 3 жыл бұрын

Same here brother! What is your project?

@purabiborah9590 3 жыл бұрын

@Ankeet r u from india

@AnkeetKumar 3 жыл бұрын

@@purabiborah9590 yes, n u?

@purabiborah9590 3 жыл бұрын

I m also from india... In where you are doing PhD

@AnkeetKumar 3 жыл бұрын

@@purabiborah9590 iisc Bangalore

@MifaMila58 3 жыл бұрын

I worked as Matt Meselson's research asst. when he first came to Harvard, 1961 until 1965. He was a great person to work for/with. We used the density gradient technique for further phage genetics studies. The woman I worked for at Caltech, where my husband was an undergrad, Hildegarde Lamfrom suggested Dr. Meselson hire me, a we were going to Harvard too. He wanted someone willing to learn his careful techniques.

@ameypande6856 2 жыл бұрын

How lucky!

@chelseahaney7973 2 жыл бұрын

This is amazing! What an enriching experience that must have been.

@hope5091 2 жыл бұрын

ava ropui ve

@metipallearuna223 10 ай бұрын

Could these 2 dudes identified an intermediate light/heavy DNA in a mis-sense mutant amt walkingbon a pair of false left handed walking legs in 1965?

@CellRus 3 жыл бұрын

OMG, I learned this in high school. Absolutely beautiful and elegant experiment, and to see the real people behind this experiment brings so much emotion. Now as a cell biologist, revisiting this experiment on here just makes me so proud of being a part of this incredible field of biology. Someone has said to me "the most beautiful experiment is usually the simplest one of all" and this is an example.

@manasmitjena5593 3 жыл бұрын

Wow! Really interesting, only read about them in my Biology book, never thought would hear them speak!

@baranakbas5987 3 жыл бұрын

I love the way how this great experiment started a lifelong friendship 🧿

@roshnidadlani2824 3 жыл бұрын

I literally have goosebumps, i feel great that i chose to study biology. Love you guys..

@swatisharma1668 3 жыл бұрын

wow .. this is intelligence how simply they explained everything with a flow . two gems of biology world, we all are blessed.

@a.basakersoy9402 3 жыл бұрын

Now thinking about it, learning biology indeed feels like the "puzzles" I used to do as a child.

@raeflex1538 5 ай бұрын

Its nice to see that scientists are not boring people. A very interesting duo.

@sonalsingh5698 3 жыл бұрын

Studied their experiment in 11th grade, and i remember how bad i too wanted to perform it by my self. Unfortunately couldn't do it at school level. Watching these guys today, surely made the experiment even more BEAUTIFUL for me.

@tenzin9327 3 жыл бұрын

At their time they thought they were graduate students and looked up to Richard Feynmann and Linus Pauling as great scientists. For students today they are the same for us.

@leonarddobens6070 3 жыл бұрын

recall when a grad student and a professor (David Denison) told us a story about when he was a grad student at Caltech when they came into the grad student lounge with an autorad fresh from the experiment

@nathania6787 Жыл бұрын

their friendship is so wholsome

@sagarikamaitra9619 3 жыл бұрын

I am grateful to know two of our most respected scientists who have confirmed the Watson-Crick model are still amongst us. Studying microbiology in this period of scientific development it’s hard to believe that the founding fathers of the DNA model are still alive, thank you for loving science and helping it grow. Stay healthy, and stay safe. Thank you 😊

@vovadubrovin8834 2 күн бұрын

That's not only interesting. It is also fascinating how their way of life were mentioned. Their friendship is wholesome

@Biswaranjan6373 3 жыл бұрын

On the eve of this Christmas evening, i was reading my Molecular biology book and just after finishing my sub unit , "Semi conservative mode of DNA replication " i opened KZfaq and this was the 1st recommendation video , Am so much fortunate that i am watching these two novel laureates . Respect from India 🤝🤝🤝

@teddiemower5325 3 жыл бұрын

Wow! Just wow. This is the most wonderful thing I've seen in a long time. Thank you for bringing these two together and having them share their work and friendship with us. This is a treasure.

@Ashutoshkumar-iy1kw 3 жыл бұрын

This is so so so beautiful. Wish there was more content like this on the internet. The world is run by the scientists working day and night and not the celebrities dancing with the sharks. Scientists need more respect and exposure.

@aguabranca6480 2 жыл бұрын

It's amazing how Professor Stahl hasn't changed much since I last saw him in 1996! Wish you well Frank and thank you for the opportunity of letting me work in your lab as an undergraduate- It was really a life-changing experience!

@gokayyldz7734 3 жыл бұрын

I never knew that you can find how DNA replicates itself by sometimes sleeping in class. Now I have the courage to do smthng like this

@sonakshisrivastava6958 2 жыл бұрын

This type of video should be shown in schools and universities/colleges to encourage students to research. It feels like two grandpa telling the story of their youth.

@zgmimi1143 3 жыл бұрын

Fascinating interview! I am inspired by their genius, passion, and dedications. Thank you for putting this out.

@AlexDainisPhD 3 жыл бұрын

What a beautiful telling of this story. Wonderful piece!!

@Dispatern 3 жыл бұрын

Thank you so much iBiology for providing this amazing interview with two of my scientist heroes. When learning about semiconservative DNA replication, first at school and then again at university, I never thought I'd be able to see Meselson and Stahl in an interview.

@shanemckenzie8681 2 жыл бұрын

I'm so thankful I came across this! What a great time to be alive! Much love to you fellows heart

@roopshalirakshit9778 3 жыл бұрын

This was amazing...!.. To hear those who were actually behind these experiments speak about it is such a delightful experience!

@sayoksarkar1106 3 жыл бұрын

I am so lucky to have atleast watch them on KZfaq. I wish I can meet them in person. The talk was so enriching with humour, insights from those times and just the pure innocence of them. It made my day!!! Thank you iBiology for this great content. Can't thank you enough. ❤️❤️

@urjakuber266 3 ай бұрын

What a lovely interview!

@yepyep8443 3 жыл бұрын

I hope you could get to interview other known scientists/legends like them :) very nice interview.. it made me remember my super smart 75 year-old professor in my graduate studies :’)

@anuuuujgggb 3 жыл бұрын

I got really emotional watching this video... I've been studying about their experiment all the time and now watching how they look and how their voices are is incredible. Thank you!

@luthfiannisarusdartoputri307 3 жыл бұрын

This interview is also beautiful! Thank you, really appreciate their passionate talk and iBiology team!

@rini6688 3 жыл бұрын

This is amazing!!! I have tears in my eye. Such a wonderful journey. Thank u so much for this video.

@christeenasaju9706 11 ай бұрын

Cant believe such a great video is out here in youtube

@scicommlab 10 ай бұрын

thank you. we hope you check out some of our other films as well.

@studyspace_xd 2 жыл бұрын

Sir, you both are so adorable... Literally feeling on the top of the world cause of being able to learn your experiment by yourself. It not just the experiment it's also the history, scenario interest.. That ended up to the experiment and this is beyond textbooks truely fortunate..

@mkilptrick 3 жыл бұрын

What a beautiful interview.

@nraishanzr3333 3 жыл бұрын

Ugh these men are amazing! what a blessing to hear them talk about their own experiment and see their personalities shine through at the same time!

@jessicafontes877 3 жыл бұрын

Thank you so much for this interview! They're brilliant! Loved to watching them speak.

@stackowoflow 3 жыл бұрын

stumbled across this channel recently and I'm loving your content, thank you

@vedikatalele8367 3 жыл бұрын

These were the most beautiful 22 minutes. I really loved the video and do good to see them alive and talking about how they made it through and introduced the concept of semi-conservative replication to the world. So thankful to these men.

@khushboobhardwaj6061 3 жыл бұрын

You both are the reason to find the research so magical. Thanks for all your contributions to this world.

@jahanvitiwari2945 3 жыл бұрын

We studied them in books at school. And now they are out there. Talking! That's interesting!!

@WM5000-ek9nk 2 жыл бұрын

Yes, i was shocked to find out that they made this interview

@mainakagrawal1925 Жыл бұрын

The intensity with which they felt the beauty of it all must have been so grand. Just hearing them talk about it is so overwhelming that I teared up. Probably because of how well they lend us their senses to be able to soak it all in through their expression.

@DrReginaldFinleySr 3 жыл бұрын

One of my students alerted me to this video. I'm glad he did. Kyle, if you are reading this. Thank you again. What a gem.

@snehamandal5376 3 жыл бұрын

I had read about ur experiment in my biology text book....really awesome to listen to ur experience and witness u both together....thank u so much for this video ❤️❤️

@shinobu.1191 3 жыл бұрын

I was unaware that they're alive, it's such an honour to see you sir! Regards from me, big fan of your work! Thank you so much for this video. I'm very grateful to encounter this video.

@harib383 3 жыл бұрын

We usually see black and white photos of scientists in text books! God already blessed us all to watch this most beautiful video! 😍😍

@mai-lo8222 3 жыл бұрын

Would you please consider posting a full version of the interview? I would love to listen to all of the jokes and laughter! Thank you.

@Riya_Sharma_2024 3 жыл бұрын

Just wow...glad to listen to these 2 geniuses...they seem best buddies & so nostalgic remembering all that stuff...just observe their great sense of humour... it's delightful to see them explain all that in person... how beautifully presented...! Thanks 😇❤️ Please bring more such interesting scientific videos.

@huayapam 3 жыл бұрын

Great talk, and beautifully edited! (AndI I love that the llamas made the cut!).

@niabryant406 3 жыл бұрын

I stumbled across this talk looking for inspiration for my own online teaching and saw your comment - hope you're well Jean! I still have one of your drawings on my office wall! Good memories of Eugene OR.

@huayapam 3 жыл бұрын

@@niabryant406 HI Nia! Nice to hear from you, in this roundabout way! I'm doing well, though sad we couldn't come visit the family, this summer..I was fortunate to have squeezed in a visit in February, before Covid hit, while they were filming this video. Hope you are doing well, too, and that you found some inspiration here for your work! If you are ever in Mexico, come visit us in Oaxaca!

@user-sz5it4wm9f 2 жыл бұрын

Wow, I never thought that I learned this experiment from them, thanks ibiology for uploading this great interview.

@talysa_ 3 жыл бұрын

Great story and interview. Thanks, iBiology!

@valdavis4778 4 ай бұрын

Brilliant! 😄. I feel so fortunate to have found this video and the channel behind it. I have attempted to be a science communicator my whole life. I don't have all of the math, but I do have the intrinsic fascination with the nature of reality and our universe.... Thank you!

@baileydavenport2651 3 жыл бұрын

this is such an amazing video, experiment, and pair of scientists! and they're so wholesome too!

@shweta618 3 жыл бұрын

Thank you from the bottom of my heart ibiology. You just made my day!!

@satakhipanda9354 3 жыл бұрын

My day couldn't be any better than this, watching our legends alive, healthy and reminiscing their journey of experiment! 🤩 I feel so lucky to be a biology student!

@adaniltoprak7662 3 жыл бұрын

I am fascinated. Thank you for this great interview

@hrimkarbuch1327 3 жыл бұрын

This should be named 'The most beautiful Video'!! I am not able to comprehend Messelson, Stahl, Temin and Feynman in the same room!

@eileensmoke6848 3 жыл бұрын

So intelligent yet! Amazing conversation..they Sure are still with us!! Thank you for sharing!!

@pavithrasekar8289 3 жыл бұрын

Thanks a lot ibiology It's really amazing to see and hear these words of legends.. Proud to be a geneticist

@caseroj6020 3 жыл бұрын

What a thoroughly enjoyable video! I had so much fun watching it. Biology is cool and it has always been cool. I am glad these guys were around to contribute to our collective understand of life.

@Lluis.Montoliu 3 жыл бұрын

Excellent and inspirational video. Thanks for producing it and sharing. Must-see for anyone loving research, particular the younger generation.

@bhavishapatel8459 2 жыл бұрын

You both are our inspiration ❤️ Never thought I would be able to hear this explanation directly from Meselson and Stahl .... Really I am lucky and grateful 💫🙌💝

@hadihoseinzadehsalaleh269 3 жыл бұрын

WoW! I haven't been this surprised since seeing a talk from Dr. Watson on your channel! makes you think, most of what we know about biology is fairly recent.

@tenzinrabga1959 2 жыл бұрын

the most beautiful interview!

@secretsoul6882 3 жыл бұрын

It so sweet to see these two intelligent men discussing about discoveries, memories...so sweet, inspiring as well...loved it. Thanks for sharing

@PatriciaDavidNunes 3 жыл бұрын

Thank you! Amazing interview.

@strawberry7385 2 жыл бұрын

This is beyond beautiful. Thank you all.

@OfficialRajSingh 3 жыл бұрын

I am a high school sudent in India and while studying i found this video. Really appreciate your work .Respect.

@akshayv.deshpande9384 3 жыл бұрын

WOW...!!! I teach biology and I have read their experiment countless times. Listening their early days and work is surely inspiring for young researchers. Thank you iBiology.

@jagannathsahoo3172 3 жыл бұрын

I always see there pics in books and thesis , It nice to watch both of him in a live frame . World's most beautiful Experiment. ❤

@thompsonmarinho4095 2 жыл бұрын

Amazing interview! Very inspiring!

@marytheresa2354 3 жыл бұрын

Thank you iBiology for providing this video👍🙏🏻...it's wonderful and very inspiring for the new science (especially biology) aspirants...❤️

@krishnaprasadr9579 3 жыл бұрын

Literally one of the finest interviews. ✨

@yarencnar5413 3 жыл бұрын

Great video!

@shashwotrisal8323 3 жыл бұрын

I mean....Meselson, Stahl, Fynmann, Watson, Creek all these great people at a place....what an atmosphere must have been there...one can only imagine now.🔥❤️🙏

@daadaa6356 3 жыл бұрын

it makes me so happy that these guys are still around :D

@esn832 3 жыл бұрын

Thanks for this beautiful video!

@sharanyasinha3979 3 жыл бұрын

Wow I found this unexpectedly and GOD I'M SO GLAD! Not everyday you get to listen to two of the most greatest scientists of all times in biology, and that too such candidly! 😍I loved EVERY part of it! 😍❤️❤️

@aaronmills6103 3 жыл бұрын

I teach these lovely gentlemen's discovery to students in a small town in the UK. They have no idea, but a class full of British kids know about them.

@vanipatrikar6525 3 жыл бұрын

can't believe this ,:i read about them in my biology book .God bless them..

@ugurcicekci6001 3 жыл бұрын

great interview

@markvandersluis7463 3 жыл бұрын

This is a wonderful and well-explained video

@vishnugopakumar8807 3 жыл бұрын

absolutely wonderful vid!

@baranakbas5987 3 жыл бұрын

It is a great chance to learn about their experiment directly from them!

@berguidf 3 жыл бұрын

Loved it. One of the best videos anywhere.

@boraozden9018 3 жыл бұрын

What a pleasant experiment indeed. Truly inspiring.

@arunkumars6257 3 жыл бұрын

The results spoke themselves! 🤩

@singhmilandip 3 жыл бұрын

Benchmark experiment in Biology...And to be able to see the two most eminent persons behind this experiment is a privilege.

@GhanshyamKumar-mw1ql 3 жыл бұрын

I'm excited to get more information.

@arreywaah100 3 жыл бұрын

Happy to see you.

@Rumi_s_r 3 жыл бұрын

Awesome, eagerly waiting for other scientists from biology.

@danhatechav 3 жыл бұрын

Love this! Please, more like this! So well done. Bravo!

@bhavanarai4605 3 жыл бұрын

Being a Biology student, I just love watching them and yeah it's awesome listening to them 😊

@rockapedra1130 3 жыл бұрын

Loved this video! Great science and wonderful friendship.

@amitkumardash2008 3 жыл бұрын

Thank you so much for the video. We are Thankful their beautiful and lovely experiment. It's a very pleasant feeling to see them. May they live for a long...... .

@vijaysoni3110 3 жыл бұрын

In my high school genetics fascinated me most, I mean it sill does and I used to get lost while reading all those fundamental experiments, but now listening these stories, it's a whole new feeling. PS: Thanks to ibiology. I'm really happy after watching this👍.