The Story of Deciphering the Ribosome - with Venki Ramakrishnan

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Күн бұрын

Nobel Laureate Venki Ramakrishnan shares the story behind uncovering the complex structure of the ribosome and his role in the process, in conversation with Vivianne Parry.
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Nobel Prize winner Venki Ramakrishnan tells the story of the race to uncover the structure of the ribosome, a fundamental discovery that resolves an ancient mystery of life itself and could lead to the development of better antibiotics to fight the most deadly diseases. He will chart his unlikely journey from his first fumbling experiments in a biology lab to being at the centre of a fierce competition at the cutting edge of modern science.
Watch the Q&A: • Q&A: The Story of Deci...
Venkatraman ‘Venki’ Ramakrishnan is a Nobel Prize-winning biologist whose many scientific contributions include his work on the atomic structure of the ribosome.
Venki received the Nobel Prize in Chemistry for his work on ribosomal structure and was knighted in 2012. He is a Member of the US National Academy of Sciences, Leopoldina and EMBO, and a Foreign Member of the Indian National Science Academy. In 2015, he was elected as President of the Royal Society of London for a five-year term.
This talk was filmed at the Ri on 18 October 2018.
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Пікірлер: 47

@michaelogden5958 Жыл бұрын

My first employment out of college was in a biomedical research lab. After maybe a year of fumbling around, I found my stride and came to be a respected member of the community. That lab structure didn't conform to a "just because you have a PhD, you're infallable" point of view. At any rate, I look back with fondness at the cooperation, camaraderie, and results we achieved. This was in the mid-80s. Primitive by today's standards. But a lot of it was bleeding edge at the time. Nice discussion in the video!

@johnwilson4120 2 жыл бұрын

This is just about the best talk I've seen from the RI. Venki Ramakrishnan has the gift of being able to explain complex concepts and ideas in Simple English ... a rare and priceless gift. Not only that he can do it with humour and laugh at himself. A thoroughly enjoyable hour well worth watching ... and I learned a whole bunch about the Ribosome.👍👍👍😎

@roysmallian2889 5 жыл бұрын

Even Charles Darwin made the self-deprecating remark; I was amongst the distinguished class of people who achieved second class honours, at Cambridge. He was clearly, one of the most accomplished scholars of all time who was not limited by his seeming initial prospects.

@Carlzday 4 жыл бұрын

just bought the book (epub)

@arghyabanerjee4702 Жыл бұрын

He is all time my inspiration ❤

@WinrichNaujoks 5 жыл бұрын

Hmmm. She's got the paperback version of the book, but that's not available until October.

@perumallasrikanth5621 5 жыл бұрын

Very interesting talk.

@Vorpal_Wit 5 жыл бұрын

Came here to Decipher the Ribosome, got a poor interview and meandering autobiography instead.

@alainpannetier2543 5 жыл бұрын

Right. learned nothing. Book has more content. Still it's about the hows of the discoveries. Not the whats.

@dbreardon 5 жыл бұрын

Excellent talk regarding the history of the discovery of the ribosome and the scientist who did it. As a biologist, I am already well versed in the structure of the ribosome so this history talk was pretty interesting. If anyone here has read the "Double Helix" by watson and crick, it follows the same type of theme...a story of the history of the discovery of the structure...the ultimate structure determined while drinking beer in the Eagle Pub. I have been to the Eagle Pub on a vacation to England! But I can understand those on here who expected a more biological/structural/function talk. But there are plenty of videos on that subject.

@dhaditya4867 5 жыл бұрын

Just amazing

@recklessroges 5 жыл бұрын

I'm usually a little lukewarm about these book tour "lectures", but this one I thoroughly enjoyed.

@Arctic-fox717 2 жыл бұрын

Super . .

@georgeseese 4 жыл бұрын

Since the Ribosome structure was "uncovered", has it helped anyone to explain how it works? For example, has it shed light on how it counts to 3? A Martian coming down to see what automobiles look like and move still doesn't know how they operate. The word "decipher" means more than seeing what something looks like. If you see a cuneiform document clearly, you still don't understand it until it's deciphered into a known language.

@ravishanker6925 2 жыл бұрын

How do they stack ribosomes to form a crystal? how do they ensure no other items are there in that crystal? How big can be this crystal?

@marcmarc172 5 жыл бұрын

I got so excited after seeing the title. ... ... ... What a disappointment. Why not prepare a full lecture, stand up, and talk.

@ScientificReview 5 жыл бұрын

Because she is wearing tiger skin.

@smartwombat9116 4 жыл бұрын

Because, like BBC Radio 4's "The Life Scientific", hearing HOW a scientist got where they are and did what they've done, is interesting and in most cases inspirational.

@mujahidhussaindar8714 4 жыл бұрын

Impetus to basic science needed here in india

@gandautama4141 5 жыл бұрын

Can read the book in Google books.

@BULLAKI 5 жыл бұрын

Probably wearing cheetah was not the best wardrobe choice... we’ve read his book before shooting an interview with him last week at the MRC Laboratory of Molecular Biology, Cambridge (we just published the first part). We found particularly interesting how “politics” played a role in his journey. Worth reading it. I’ve read of people complaining that there isn’t much science in this video... just Google Scholar his name... plenty of articles in Nature, Science, Cell to further explore his contribution.

@ingebrecht 5 жыл бұрын

Those guys growing the blue crystal had better watch their six for Heisenberg.

@mokujin29 5 жыл бұрын

@cbrow44 5 жыл бұрын

Fascinating science, unfortunately not very much of it in this talk. I had to skip through at least half. Wish he'd have just given a lecture.

@liesdamnlies3372 5 жыл бұрын

Jess B At least they get rid of the desk for these.

@tobysemler 5 жыл бұрын

Yep. I don't have time for this.

@Kysen10 5 жыл бұрын

Indeed

@midrangemonroe1 5 жыл бұрын

20:51 "Circling the plughole is what the Americans call it" ...no...

@symmetrie_bruch 4 жыл бұрын

23:01 there´s no lens for xrays? maybe not a classical lens exactly like in a normal camera but there a hundreds of xray lenses sucensfully in use right now. in telescopes and satellites in all sizes. how does he think xray astronomy works if there were no xray lenses? it´s quite interesting actually how they work and i´m pretty sure theres a talk about it right here on this channel.

@joed2392 5 жыл бұрын

It would have been better if she was not on the stage as MC.....! I kept flashing back to scene's from Snowpiercer !!!!

@dipi71 5 жыл бұрын

High praise to have one’s presence compared with that of Tilda Swinton. She was great in »Snowpiercer«. Hell, she was even great in »Doctor Strange«. Cheers!

@georgeseese 4 жыл бұрын

Congratulations in getting a clear picture of these machines. What's known about how a Ribosome is generated? Articles say each of the main two subunits has RNA strings and multiple proteins. What's the genome? Are they all expressed at one time? What are the individual rRNA strings called? What are the bases? How do the strings connect to proteins? A Ribosome has a third subunit called tRNA. We know how mRNA is made. How are tRNA subunits made? What are the bases? Do the bases have patterns as we see in genes (translatable)? How does a string of tRNA transport amino acid molecules? What is the energy source? A lot more "deciphering" is needed.

@gokulgopisetti741 2 ай бұрын

M K Stalin felicitated Nobel Laureate Venkataraman Ramakrishnan. Stalin hosted a grand ceremony on the scale of celebrating Ilaya Raja, Leonel, or a politician like Velu because he had never celebrated a Nobel Laureate. Nevertheless, he wanted to appreciate science in a way never attempted in Tamil Nadu by anybody or the more knowledgeable, English-speaking J Jayalalitha. How did Venkataraman Ramakrishnan feel when a great and popular politician whose father is Kalainar or an artist in literature or litterateur par excellence felicitated him? What was the atmosphere like? What was it like being in the august and imposing presence of one of the walking colossi of Tamil Nadu politics ever since the Dravidian revolution? Was it a proud and glorious moment when a great litterateur par excellence's son himself felicitated him? How would the Hindu newspaper describe such an electrifying moment and atmosphere? Can the Hindu newspaper tell us what hung in the air? Interestingly and intriguingly, what was the audience like? What was it like being at the center of attraction of such a unique audience who were in awe of a scientist even though they have known and seen only celebrities like Illaya Raja, Lionel, or politician Velu? Was it a God's Gift?