I'm disabled and chronically ill, and I can't exercise without permanently worsening my illness, so this kind of research would make a huge difference to me!

It's well used in the bodybuilding community. Usually sold under the SARM category even though it isn't a SARM. You can feel the endurance improvements right away. It honestly feels like magic. I stopped using it as it felt too good to be safe It's also known under the name "Cardarine". They stopped most research on it because of one incident where it's use indicated increased cancer growth in rats

I have chronic excuses that keeps me from exercising. This would be life changing for me.

This would literally change my life. I have chronic illness that makes exercise way more difficult for me. Lots of basic movements actually harm my body so a pill like this could be huge for me. I hope we get this out in the public soon enough

I think this is great invention for people who are unable to workout however I hope this doesn’t become wide spread as a substitute for working out. That’s just going to breed a whole bunch of problems 😅

*A pharmacist has entered the chat* GW501516 is called cardarine (sometimes also called endurobol) it was developed sometime in the 90's by GSK but then dropped before it was brought to market. It's become fairly popular in the fitness industry in the last few years. One of the biggest benefits I've seen on paper and anecdotally is the increase in HDL (high-density lipoproteins) which are generally considered cardioprotective. I'll also mention that the doses of Cardarine that were given to mice that increased cancer risk were astronomically high and far above the minimum effective dose. That study was most likely establishing the maximum tolerated dose which is a very standard practice in drug development and design prior to human studies because you don't want to put a lot of money into developing a drug that is going to kill people and/or get you sued for causing cancer. This drug is no magic pill though and while it does seem to be very effective and the side effect profile very low it probably won't be brought to market for just those reasons. Treating chronic disease is a huge market and currently the money is in the treatment not the cure unfortunately. Couple that with the fact that at this point it is fairly easy to obtain cardarine online already any company that wanted to patent it or a similar version would probably not make much money. If you are interested in how Cardarine works Ryan Russo has a pretty in-depth analysis of it on his channel. I haven't heard of compound 14 before unless it goes by another name but the way it works sounds similar to glucose disposal agents which are also pretty widely available now. It also seems slightly similar to DNP (2,4-Dinitrophenol) which is a very toxic drug used to lose weight so hopefully that's not what it is.

Hey guys! I think I saw you two days ago in my city, Medellin, Colombia, and I was so surprised of seeing you here that I just got super nervous and couldn’t go and tell you how much I admire you! I hope if it was actually you that you enjoyed my city and had a great time. Hugs!!

I would love it as a booster. The worst part of getting into shape again is getting the initial activity and fat burn going. I know once I've been at it for a month or two, it will be easier, but starting is rough. If I could loose weight quicker at the start, it would be a strong motivator.

That seems like a great thing to help people (and animals) who need this, however I really hope we don't mess it up.

I don't think you can imitate all the benefits exercising has by just taking certain pills, since the movement in itself I believe gives a lot of benefits. But if there will be a pill that can do some things that can be achieved with exercise for people who aren't able to, then certainly this could be a good alternative.

I lift, and the major thing about lifting isnt the end game, its about the journey. I personally wouldnt take the pill, but its nice to see being an option for those who would need it. Cant expect someone over 400lbs to just start exercising without major obstacles

I'm a former body building enthusiast and self proclaimed workout addict. A not-at-fault auto accident in 2010 left me disabled and in chronic intractable pain. I developed fibromyalgia and CFS. I DREAM of and still fight for a higher degree of mobility, not because I am able, but because I can actually FEEL my body dying from this sedentary lifestyle I've been forced to live. Night and day from who I was before. Depression, suicidal dips just trying to deal with so much pain and loss of enjoyment of life. Then add weight problems to the mix due to inactivity 🥺 that's where MANY chronic pain/chronic illness patients exist. Medicines like this would benefit our lives in ways we have only dreamt of! I hope they can roll out something affordable and attainable for those who need it most.

One minor correction, the "recommended 150min" is really the recommended minimum. There's strong evidence suggesting more than 150min is better, but 150min is sufficient to confer enough benefit. To say "recommended" can give the false impression that 150min is the optimal amount.

These ideas are amazing, especially for people with various disabilities that make any form of exercise difficult.

As someone with severe ME, I would be very interested in something like this (once it's gone through the necessary testing). Exercising isn't an option for me as even light physical activity can cause a crash. I do worry about it being pushed as an alternative to exercise because the weight loss industry is predatory.

I feel like this would be so helpful with those that struggle with mental illness as well! So much research to say research helps MH but if you’re so depressed , you can’t get out of bed this could help at least initially I imagine!!

This is really interesting...people with severe obesity could take this drug as a last resort to burn fat fast. That could help to reduce their weight and as a positive reinforcement towards being more active, since they can see the effects of their training sooner

Personally I don’t think I’m the first candidate for a drug like this, but the idea is still exciting to me. I had a couple traumatic events happen when I was 18 and in the span of about 2 months I gained a substantial amount of weight that has affected other aspects of my health since. I’ve lost most of the weight but our bodies fight weight loss so even though I’ve been trying for a long while the last 20 pounds or so has been the hardest part. I know I wouldn’t cary my extra weight if not for my ptsd spike so something like this would be great to help finally shed my reminder gut.

Hell yeah, bring on the exercise pill! I have worked out most of my life and would enjoy continuing even with the pill. The pill would ensure the benefits are not as easily lost with age, as I have a multitude of conditions making exercise more difficult and less impactful as I get older. I am working more than ever so I have less time. I work long hours that is mostly sedentary. I try and diet well, but eating when and what I want isn't always an option... Also I love delicious foods 😋

Damn! It's fall fun and games until the commercial is about to end and you hear the side effects !!! My goodness.

I'm so excited for this!! I'm disabled and unable to exercise due to a rare autoimmune disease, and I gained a ton of weight from being on high dose steroids for a year early in my treatment. Even though my Dr stopped the steroids, I haven't been able to get the weight off due to not being able to exercise. And it sucks because the extra weight has caused so many more problems along side my other diagnoses. A pill like this would be freaking AMAZING, and would absolutely improve my quality of life, even just a small amount. Hopefully I'll still be around by the time something like this is approved for public use!!! 🤞

Lol that contrast got me: First 90% of the video: "Here's a thing that makes you healthy without exercise!" Last 10% of the video: "But you get cancer."

You explain real science so efficiently and with such a great delivery, you absolutely amaze me. Do something with Scishow if you haven't already!

I have always enjoyed your videos and vlogs; they are entertaining, but also educational. Thank you!😀

The exercise pill will be a ground-breaking discovery ! However, I believe it will be a trade-off between the benefits and of course the side effects that will indisputably come along with it. As such, it will be thoroughly regulated by physicians and only be prescribed as a short-term solution to help towards better levels of physical activity in populations who can't get there without. Also, taking a pill will never bring the social aspect that physical activity has. Working out in a crowd motivates quite a lot of people, like with group classes

I would love something like that. I used to be in ok shape but due to a medical issue in my neck, doctors have advised me not to do any exercise that puts impact on my spine. They even told me walking was bad. I ballooned up in weight due to the sudden lack of exercise and have only just started to get control of it some 3 years later.

as someone with chronic fatigue this could actually revolutionise how we approach recovery - at the moment pretty much all you can do is rest and very very very gradually increase exercise by tiny intervals, but if you push too hard you get a set back and if you don't push enough you also are set further back. A pill that could give the benefits of increased endurance, muscle tone, and weight control without posing the risk of further exhaustion would be life changing for those of us with Chronic fatigue and related conditions like POTs - definitely would be super helpful for chronically ill folks like myself. As it is, I take vasoconstrictor to help increase my blood volume to reduce my heart rate to increase my capacity for exercise quicker, but its still extremely slow and in summer I can barely move at all. If it was proven safe I would absolutely consider medication like this

as someone who has chronic illness and exercised-induced symptoms (asthma attacks and syncope episodes), this would literally change my life

Waffles with nutella

Drugs = side effects I would want to know what else GW501516 does to your body. Also, in a longitudinal study, it would be key to know 5 to 10 years what happens after taking this drug.

as someone who is 50% disabled and has a hard time working out because of chronic pain this would be very helpful!!

As someone with major depressive disorder, after I give any exercise regimen a chance, I really benefit from it and love doing it. But finding any motivation at my lowest, along with those unexplainable aches and creaks.... It makes it nigh impossible. This could be a short term or as needed boost that would be revolutionary.

I would take the pill but I wouldn't stop moving. The psychological benefits of challenging yourself and moving out of your comfort zone are equally important for me.

Working out is not just about the gains. Doing exercises is kind of like.. dancing! It makes you happy when you move your body.

This is super interesting! I have a condition called Postural Orthostatic Tachycardia Syndrome (POTS) and one of the best studied treatments for it is exercise. The problem, is that POTS also causes exercise intolerance, and I can only do extremely basic forms of exercise (think walking two blocks max, with a walker), before having a syncopal episode. A drug like this would be insanely beneficial in breaking the self perpetuating cycle my condition has me stuck in.

This has me simultaneously excited and terrified for the future

i can see this being really useful for people who really cant lose weight without drastic measures because their body just Clings to it; people whove had any sort of eating disability in the past, or a lack of access to good food if any food at all, or recent ancestors in the same boat, all tend to have gene expressions that make it much harder to lose weight. and also for people with disabilities who cant move around much, or even if someone just broke a leg, regaining thay muscle after it heals would be much easier. im excited to see what the future holds!

As someone who's chronic pain makes exercise very difficult, this would be life changing.

I could see something like this helping folks who exercise too. I know I don't get the same results from exercise that I saw 20 years ago. That can be very disheartening. I'd love to have something that boosted the effects of my exercise routines.

As someone with a chronic disability that limits the amount of exercise I can regularly do safely this kind of research is incredible and sorely needed

This should straight up be reported for misinformation. Greatly exaggerated.

I would definitely take it! I have problems with my joints and it’s becoming more difficult to exercise much besides just walking.

This is amazing! I exercise alot but this pill would help so many people!

I realy thought this would just be an click bait video but, It is, as always form Asap SCIENCE, a awesome video! Thank you for putting great content on KZfaq!

something like this would be wonderful for physically disabled people who actually CAN'T do most exercises.

This sarm has been out for years, it's called Cardarine. It's fairly popular in the fitness industry. I tried it for a couple weeks and seemed to feel better in general

I'm disabled and almost entirely bedbound, unable to exercise - I would love a pill like this

This is going to be essential for space exploration

I get the feeling a true exercise pill would also cause the same distress exercise causes, there are a lot of neurological adaptations to exercise, exercise triggers stress signals and you get adapted to stress mentally, that's how it kills anxiety and depression; exercise throws lots of hormones afterwards; a true exercise pill would cause distress upon consumption, maybe your muscle fibers tear up too. I think an exercise pill would only be able to partially tap into the advantages of exercise.

For people with diseases like MS and ALS this type of medicine could change lives- especially when it comes to athletes that suddenly can't do what they love anymore. It's not just about losing weight; it's the benefits of exercise that people with illnesses can't necessarily get due to severe lack of mobility.

One of the things in the slides show was the implication that exercise prevents depression, but was that controlled for the fact that a depressed person just might be less likely to exercise?

If it could ever be made without the scary side effects, hell yeah I'd take that in a second! I had VERY early onset congestive heart failure (we're talking diagnosis at 14) that makes tolerating exercise very hard, but something like this could be literally life changing.

Love the science behind your channel!Please can you do a video on epilepsy and seizures?

The one thing I keep thinking through the video is “wonder how many anti vaccines people that are always ‘I don’t know what’s in it’ argument.. will take this pill without thinking about it twice”

As someone with chronic depression something like this would be awesome.

I was an athlete before being disabled. Meds and slowing down made me gain weight, making exercise even more painful. This video made me cry

love this video and always loved u guys but don’t start click baity thumbnails ☹️

As someone with ME/CFS that is struggling to restore my capacity for exercise since a bone break - something like this might honestly be a life saver

You were amazing on big brother season 4 your speech was iconic

Great video guys!

I wonder if this could be used short-term to help people (like me) who really hate exercising partially because their endurance is so low. So maybe something like this could help get into a rhythm and then you can be taken off the drug

Nikocado avacado will mukbang these pills

As someone who suffers from hypothyroidism, this would be a game changer.

One thing to keep in mind is that dosing equivalents in mice and humans are very different due to their metabolism. They require much more of a drug to receive a similar effect. So the study that showed cardarine to have rapidly caused massive multi-organ cancerous tumors should be more than slightly concerning despite the high doses.

If you think there’s not going to be commercials about this in 10 or 15 years your not paying attention

As someone who struggles to START an exercise regimen, this is great news :D

This sounds nice. It could be used to make up for lack of time. For example, if I had the option to use such a pill (ignoring the side effects) I'd probably still work out but I'd lower the amount of time spent working out with the pill. For people that barely have time for anything much less working out this would help them keep their health in check too. Overlal it sounds interesting and the possibilities seem pretty nice. Hopefully testing, modifications and all that shows it doesn't have super averse effects. It's nice to imagine a future where I can take a pill or pills to makes up for lack of time to exercise but them again an argument can be made that we should set up the world so everyone has enough time to do stuff like that. This would definitely be most beneficial for people that physically can't exercise. Im sure there are plenty of people mentioning their own stories down in the comments.

Love the format. More like the format from a few years ago.

That was fascinating and very well explained. However the list of side effects is a Halloween horror story.

Wouldn't even think about it, helps if you're sedentary but I imagine it might help even if yo do exercise, as it pushes a little extra or you're just at a different baseline because of it so you could do more, maybe all you can do is walk at 3mph but then because of this pull affecting your baseline you manage to go 4 or 5 or 6mph which would in turn have greater benefits (obv up to a point). I assume diminishing returns on the truly very active but yeah, for the cat majority of the people who sit at work at day (drivers, bankers, factory workers, corporate people) this would be I think a great development

I've actually use this drug myself, 10mg daily. I used it primarily to improve my lipid profile as my HDL was borderline out of the reference range (due to my high testosterone) I have to say this drug honestly feels like magic. My cardio is phenomenal and I can eat literally anything I want and my blood work stays good and even when bulking I cannot get above 15% bf (approximately) no matter what and how much I eat.

For anyone actually looking into the drug for "exercise in a pill", this is not what GW50156 or cardarine does. While the endurance benefits can not be understated, cardarine is carcinogenic in doses very close to human doses. While there hasn't been anyone reporting cancer directly related to cardarine, almost every study in rats has resulted in an overwhelming amount of deaths due to cancer. Also as someone who has tried GW50156, really the only benefits are endurance. There are no noticeable body changes besides improved lipids. Be safe.

Shirtless clickbait thumbnail is clickbait 👹🤣

I think I would take a pill that complements my exercise. I don't think any pill could every replace what you gain through effort and sweating. So I'd be ok with a supplement to my exercise, but I would never abandon exercise (gym, inc. cardio and weights) completely

Great videos, thanks 🙂

It's like lowering the difficulty in games. I prefer not to but I'm glad it's there so that people can experience and enjoy it. If this helps people enjoy life I'm all for it.

This pill will be great for clinical depressed people. Since exercising is so hard for us, but not exercising makes our condition worse and exercising helps. Using it to give someone the strength to actually exercise would be really helpful!! Like same with antidepressants, medical prescription is the best way to not use it too much but get the benefits that could help people to have it easier exercising!

It is this even real?

Yo i haven’t seen you since big brother Canada loved you on it!.

juuuust the minor inconvenience of CANCER!!!! love how u mention that after SEVEN MINUTES , thumbs up reallly , great science work

I have chronic fatigue syndrome. I can barely move at all, haven't left my home in months, and my muscles are atrophying. A miracle pill like this would be a game changer for people like me. Nobody cares about that, though, they just want to be skinny, and there's more money in appealing to those people.

Y’all, please keep in mind that weight loss is not the benefit of exercise. Like, yea, exercising can be a contributing factor to weight loss, but the reason that exercise is good for you is not because it reduces weight. Reducing weight just happens to be a side effect sometimes. But exercise is soooo good for you for other reasons, and it doesn’t stop being good for you if you aren’t losing weight if you’re gaining weight even. Exercise is for everybody regardless of weight!! It’s probably the best thing you can do for your overall health other than maybe quitting smoking if you smoke. Please do not be motivated mainly by weight loss if you’re trying to get into a new exercise routine. Weight loss is very difficult and if you’re trying to measure your success with a new exercise routine by how much weight you lose, you’ll probably struggle more than you need to and you might burn yourself out just because you aren’t seeing the results you want, meanwhile you’re missing all the other benefits going on. You can improve your health with exercise and still stay the same weight or even gain weight at the same time, and exercise is STILL good for you. Weight loss is not the definition of improving health

As a person who has exercise intolerance due to Mitochondrial Myopathy, I would love to try something like this as I have major muscle weakness and am overweight.

Wow, I used to take Cardarine in 2013 lol. Wild to see it here presented this way. I stay away from AAS, PEDs, SARMs, Prohormones, etc these days - but I think they have a ton of real world uses. As another commenter pointed out about the other compound and its similarity to 2,4 DNP, I would avoid that like the plague. Everything can be used in moderation, but just one bad reaction, and whew.

This is huge. Many people are stuck in their diets or lifestyles, and this pill could be the key to helping those people transition to happier, healthier outcomes.

The point of exercise is not only for physical health but mental health. The feeling reward after finishing a marathon or tough workout. A pill doesn't replicate that feeling. A pill could be a supplement but certainly not a replacement for going for a brisk walk or physical activity.

Fascinating!! Thanks for sharing 👍 😊 😀

neeeeed this. wonder when/if it'll ever come out

Did you miss the part where long term use can cause cancer? That's kind of an important side effect to not mention up front...

Sugar coating steroids huh?

Put a smile on my face. ASAP ❤️ always

I would love to hear more about long term effects and how these benefits could potentially help with things like genetic dispositions for high triglyceride levels, cholesterol, etc.

this would be great for my depressive episodes

The effect of exercise for me includes exhaustion and long term pain, and increased tightness that results in crackling and crunching noises when moving. I hardly get out of bed or walk around the house ever since I was 13. Hopefully the pill doesn't cause the adverse effects of exercise, but if it caused only the beneficial effects, I'd probably have to use it.

There are a LOT of positive applications for this: post-surgical, the progressive muscle loss of being elderly, people with mobility-reducing conditions, people who are genetically predisposed to put on weight regardless (think Prader-Willi Syndrome). This is good news, if the side effects are identified and addressed.

I fainted when Mitch flexed.

Another use case for this is bridging fitness across periods of injury. I'm usually very fit, rock climbing and mountain biking. But I broke my ribs a year ago, and recovering from that sucks. I lost a lot of fitness in that time, and unfortunately my mental wellbeing is basically positively linearly correlated with my physical fitness. Using future PEDs like this could potentially be very helpful. I've also got a transhumanist streak, and if we can stimulate the adaptations that exercise causes with a drug, then let's do it! Just because something is natural doesn't mean it's better.

I haven't seen past 2 minutes of this video, but it reminds me of that one time in Diary of a Wimpy Kid when Greg was talking about how one day everybody would be frickin ripped and the special people are the ones that aren't.

It may not give all the benefits of exercise, but it could do wonders in keeping the general populace, that’s usually busy with work and doesn’t have exercising as a hobby, physically healthy.

I love naming a doped up mouse after doped up Lance armstrong.