Thank you. I like your clear lecture style. I didn't find myself stuck, trying to decipher sentence one, while you'd moved on to paragraph 20. You know how to talk to laymen.

Beautiful lighthearted delivery of complex information. You made it fun.

Thank you for such an interesting lecture, with such a clear and understandable presentation. Quorum sensing seems to have many potential medical applications, and may help us understand complex cellular interactions within large organisms. Absolutely fascinating.

when I was 12 we never had KZfaq how I wish I was 12 again... homework would be so easy

Awesome for the presentation and for giving credit to everyone at the end!

Amazing to contemplate such a simple grouping of organic chemistry can lead to behaviors as complex as co operative tasking etc . . .life is a mind trip. Great presentation Dr Bassler.

Professor Bassler- Bonnie - You are a gifted teacher. You are the model of what a teacher should be. You obviously enjoy your work, and you enjoy telling me about it in a way that I instantly grasp it and remember it. Vibrio fischeri - See? I remember even the name of the bacteria. How often do laymen come away from an impromptu visit to a biology lecture with the just-learned name of a bacteria imprinted in their minds? I have long believed that we will eventually find all kinds of communication “circuits” in cells, bacteria, and even within the smaller parts of these. There must be feedback systems that aid in evolution itself, beyond the final test of sub-species survival. I think you may have revealed one of the most important systems. We have learned that octopi rewrite their RNA molecules and encode (apparently) something like genetic memory. Perhaps that has a role in evolution, too. But I encourage you to keep expanding your searches for more kinds of intra-cellular and inter-cellular (extra-cellular) forms of communication. I think science has been looking at process as random when in fact it’s very connected, very chatty, and very intelligent in ways we never dreamed of examining. This is incredible! Thank you so much for the video and your clear, concise way of communicating. There is something poetically just, here. Someone studying communication of any sort would be advised to understand communication on our macro-level, so that knowledge gets clearly and accurately conveyed to the recipient. You do Everyone else, take note!

Bonnie Bassler, you're the best, I love the way you do your lectures , wonderful, despit the fact that I'm so bad at english, I can clearly understand your lectures, I cant wait for your next one, it's become kind of endophine generator for me

14 people voted down because they are sad that they don't have a vibrio fischeri bio-luminescence pouch and can be easily tracked by predators.

An excellent presentation. Better than anything on television! Dr. Bassler reminds me of a friend of mind who has a Phd in soil sciences: his enthusiasm is boundless and he makes dirt so very interesting. Question about inter-communication: do bacteria communicate with other bacteria to slow down or speed up their reproductive cycle? I can imagine scenarios where this could happen. But does it? Finally, we once again see that nature invented it first: networking, social media, and majority rule.

Excellent lecture and very informative, I love Dr. Bassler's passion to the topic and bacteria. Please keep up the good work!

Not only the most interesting subject, probably the most important.

Ah! The world of scientists! They like to share their knowledge, their achievements, with interested laymen. Of course we laymen too shall need raise to the occasion to have some basic background awareness of the involved topic. Thanks m'am for this enlightening tour of the 'friendly' bacterias inside me & how they do what they do.

Fascinating ! And so we’ll communicated, thank you for your work

I love this lady. Intelligence is so attractive. Fantastic! Thanks

What a fantastic lecturer!

Amazing. Very interesting. Very clear. Very original content. This is true for the whole channel

this is a great presentation and the background illustrations make it easy to understand.

Ones and zeros. Two words. Language. Thank you. Great passion.

Wonderful speech! Thank you!

Fantastic explanation and delivery. Thank you!

"Quorum sensing" Democracy, Jim, but not as we know it.

Wow, that's actually something new for me. I like the way the scientist explain the whole idea and some outputs, so we know more than "how", but also "what is about". Thank you for the lesson.

NO! WE ARE NOT DOOMED! Brilliantly presented brilliant communication of bacterias could prepare a brilliant post antibiotics future for us. Just listening you has giving a sense of brilliance of light to me. The only darkness moment my heart felt was when I heard the algorithms of me/us and others are so embedded in us even in our and all bacterias, now and since life existed! I sad to my self "Gosh we are doomed! No way there will be peace on earth!". Then my hopeful heart started beating again with the brilliance of your joyful endeavour of making science. And then seeing the gang of the lab, I sad humans will manage to be different and one day we will realize there is only us the earth's dwellers and only by thinking this way we can prevent our vulnerable home from heading towards the bleak end of loosing breath. Thanks for being you friends 😊

That was great. Thanks Bassler Labs

Thank you Prof Bonnie. I enjoy your way and the content of your presentation. I will tell our children and grand children to watch it to increase their knowledge and understanding.

Your presentation skills are exceptional! I would love to learn more from you.

A brilliant and interesting talk - thanks!

Wow! This is really an amazin mechanism. It seems to be a precursor to the molecules used in orientation and differentiation messaging in animals. Stunning idea to use it as a weapon against malignamlnt bacteria. Shame i am in my fifries already. That would really be a great field to work in. Keep up the good work. I love it!

Very interesting and well explained.

Cool! That was very interesting. Good luck to you, too.

Amazing content, thanks for this!

Very interesting video. Thank you.

She also has a Ted Talk on this, in which she goes a little more in-debth on the vibrio fischeri. Amazing lecture

Such a great lecture. I hope millions of people see this. When Pasteur invented the method of cooking milk to prevent bacteria, he started the world on a road that classified bacteria as all bad, and this lecture i hope will start to turn that back around. We see more and more probiotic products sold, and i think over time people will realize that this quorum stuff is "the" important thing, because many bacteria are opportunistic, and sense which way things are going, and so keeping balance and not having them all pounce on us is very important for health. At some point the human body becomes a computer programming problem to study. I am sure that once you have 10 signals you are basically dealing with cellular algorithms. In a cell with only 2 types of sensors that is a pretty simple organism, but what happens when where are 10 inputs. That means 2^10 behaviors, which is 1024. It will be fascinating to see how many sensors they find. And i am still waiting for them to find the "chi" that the chinese talk about so much, the invisible energy that organisms possess, and can be projected from one person to another. That isn't chemical but some kind of radio, so there is another electromagnetic aspect of the cells that hasn't been discovered yet.

Excellent ... well done ...

Thank you for sharing...

Just outstanding....I understood this...amazing.

Love it! Thank you.

I love her. Good presentation

¡Grandee! ¡Me encanta lo que hace Ud.!

This is amazing!!!!

How this may well produce a beneficial therapy is many of the bacteria in your gut are not "good" or "bad", but rather they behave beneficially in under favorable gut conditions and detrimentally under unfavorable gut conditions. And often, Bacteria will be doing both beneficial and detrimental things at the same time, just to different extents. Many existing therapies tend to nullify all or all of a group of bacteria during treatment. This is why after treating some gut / systemic infections, patient need a transplant of good gut bacteria. There is a saying in biology...You can never do just one thing. Biology tends to be very highly interconnected; do one little thing, and it will likely cause multiple other things. A therapy that results from this experimentation may be able to halt precisely the detrimental actions of a particular group of bacteria without interfering with the beneficial actions.

I love your passion for science, your support of your colleagues and your great sense of humor! Plus I learned quite a bit. This immediately makes me think of "My Octopus Teacher" and all the amazing shapes and colors of this amazing creature. It's clear the octopus isn't "thinking about" changing shape or color it's instantaneous. So, is it all one giant, tiny conspiracy of bacteria performing the endless dance?

A very informative lecture thank you

10x more bacteria than me! That's a huge garden to take care of, really.

i love this so much thank you !!

Wow you are great at teaching! I wish my mom was like you. In addition to being a great scientist, I think you'd be a great mom. Capable of teaching kids a ton!

This. Is. F-ing. AWESOME. Real science, fcking love it. Thnx for the video. More thnx for the content of video.

Saw this on the Research Channel years ago as a lecture at HHMI. Edge had a question one year: What do you believe but can't prove. Mine was that every living thing on this planet is aware of itself and its surroundings. Haven't seen anything to disabuse me of that belief.

My watch later list is getting way to jam packed.

Thank you.

great. what you found sounds very similar to the neuro-transmitter messaging system I researched decades ago.

curing disease, bacteria universal language, you are right, it might explain how our human cells evolve talk to eachother, human cells talking with bacteria, may be like frogs can be a good sign that the pond is healthy, some group of bacteria could be a good sign of our health, its beautiful, thank you Bonnie

9:00 How is this not trending at number one!🥰

This BLEW MY MIND! boom

This is one explanation for cancer and vindicates the theories from the early 1900s that stated that cancer is ultimately the condition of cells that should be communicating ceasing do so. As a result, they lose track of the fact they belong to a collective, and behave individualistically, growing a new colony and essentially a new organ. Luckily, if our immune systems are well fed and our inflammation reduced or eliminated so that signals can get through all layers of tissue, most of the time, our brain in coordination with our good cells prevent any wayward rebels from making it far, using the collection of phytochemicals they have collected from our diet, as well as the tricks they have learned from previous infections. If this system breaks down, we can develop allergies by attacking stuff that we shouldn't due to false associations in the immune system, and then inflammation, and then cancer. That was considered a fringe theory for almost an entire century, but now science mainstream is shifting towards it recently.

Mysterious and magical. For sure

Well, that was exciting.

Godspeed, folks.

Very impressive lecture! I am studying QS molecules too. Someday, I would like to talk with you.

Very interesting analysis well presented. ... Fascinating idea that even bacteria are bilingual when most Americans can't even cope with the concept of California being bilingual.

Floral wars, a germ signal corps. Great angle Bonnie real potential.

Is there any winding twisting road that would have led from quorum-sensing to in-group preference in animals?

I'm so glad there are people smarter than me !

but is it really communicating with them or programming them? wonderful presentation.all the best.

Question: From an evolutionary perspective, wouldn't it be more advantageous for a bacteria to develop the ability to "read" the environment for the universal communications molecule, but not create autoinducer 2 themselves? This way they could remain a silent "spy", able to read the environment for other bacteria, able to compare the ratio of autoinducer 2 to autoinducer 1, but without tipping off other species of their presence? Any bacteria that could mask their presence to other species would presumably have an advantage.

Such smart squids.

Hey, they "don't" make bio lectures that "aren't" boring.

I was wondering if anyone knows how to grow bioluminiscent bateria or maybe even algae? I tried before but it failed, but i would like to try again so does anyone have any tips or ideas of what kind of fish to use best and where i kind find those fish. what sea are they from etc?

Fantastic lecture, so well presented and with such enthusian. Well done, an admirable job. If I could make one comment, why speak of animals, plants and humans. Slightly redundan it seems,, since humans are nnimals, yes? Still, I guess given the unfortunate fact that in the US there is a sizabe number of people for whom biology and evolution are anathema, some caution is necessary.

They will evolve, and that might lead to bugs that are more resistant to attack than our current superbugs.

Excellent work and wonderful presentation, by the way I imagine that the bacteria specific chemical "WORD" for quorum sensing may be used to identify the presence of that specie in a culture ....

WOW It all just happen on its own

maybe English isn't her native language, but she misuses "shadow", she means "silhouette". The squid uses counter-illumination, to hide it's silhouette when predators look up towards it's body, so the squid lights the bottom of itself to match the moonlight, and starlight behind it. en.wikipedia.org/wiki/Counter-illumination FTA: "Marine animals of the mesopelagic (mid-water) zone tend to appear dark against the bright water surface when seen from below. They can camouflage themselves, often from predators but also from their prey, by producing light with bioluminescent photophores on their downward-facing surfaces, reducing the contrast of their silhouettes against the background. " link.springer.com/article/10.1007/s00227-003-1285-3 FTA: "Prior hypotheses have assumed that sepiolid squids in general utilize the bioluminescence produced by their V. fischeri symbionts for counterillumination, a behavior that helps squid camouflage themselves by matching down-welling moonlight via silhouette reduction."

The maximum resolution of this video is only 480, and it’s really too bad.. we can barely see any clear things..

Japan is trying to discharge radioactively contaminated water into the sea, and I'm curious about this part.

can we genetically tag bacteria groups w bioluminiscence ?

I was into this until the common knowledge fail at around 4 minutes. Bacterial to human cells are about 1:1, not 10:1. Of course the deep-dive study that revealed that "common knowledge" to be false is pretty recent, but still... Kinda hard to watch the rest and assume the information is legitimate :-/

Darwing knew what he was creating. Same goes for genius of geniuses The Shining Einsteing.

This is going to be the ultimate human life hack. "give me the pill to activate the: "want to study, work out every day and be healthy" i need a boost"

I was tested and was found was this horrible Helicobacter pylori (H. pylori) it made my taste bud go crazy and still after treatment thing don't taste the same

Leaving aside the debunked "10 to 1" claim... that intra-species chemical is curious as they're way too similar to be coincidental... looks like it could be a driving force for speciation.... once a bacteria splits with a mutation on the gene producing the chemical, it becomes "cut off" from the rest of the group, causing it to begin a new group which will behave differently, and thus, react to future evolutionary pressures differently, driving a widening in the original genomes from the point of the original split with the mutation. Although I guess there would have to be some overlap if that were the case, where the receptor gene is duplicated allowing for a mutation on that gene first, so when the chemical producing gene is mutated, it already has a receptor for it... then gradually, it would lose the gene for the pre-mutation receptor... or something!

All babies have their own babies/ pets

feedback mechanism

Great subject, but I see some major mistakes. The theme, of the mistakes, is something like an interest in making progress, having understanding, causing us to underestimate complexity, like "aha! the earth is flat!". Start with this question and a reason for that question: 1) why are you so certain that a "cell" is a meaningful term, and what exactly is a cell that our body is not a "cell" and 2) (reason for question) look at your language when you say "the bacteria recieves and enzyme and "knows" to turn on and turn off genes ))))....... in other words, great work, yes bacteria communicate, but look deeper into the _scope_ of _what you do not know_ then you well see a bit better what a "bacteria" really is, which is much, much more than what you call a "cell"

Molecule chain = language. Mind lit up.

I thought bacteria produce toxins as a bi-product of metabolism or eating not from communucating.

What de you know about the VIRUS? Could be asociation betwen fungus- bacteria- virus.. for be in safe? I mean they make a team for help common? Its posible?

Number of bacteria cells in our body is about the same as number of our cells, not 10:1.

🗽

To me, it feels wrong to be seeking applications of this new knowledge to benefit our species, too early. This is a requirement imposed by for-profit capitalism. It is amazing that bacteria have developed quorum sensing so they can exist alone or in groups. How would they even "know" groups exist? How could they formulate tasks that benefit other life forms or how they could help create symbiotic relationships? And the more questions we ask, the more new questions are generated.

Handy template for use by all future generations: •Scientists once believed______________; •But we now know_____________________. It will never not be applicable.

The squid illuminates himself to became invisible? 🤔 🤔 🤔

Nitrous oxide induces a behavioral response (laughter) when it is detected by several brain regions. I am guessing that production of nitrous oxide by some brain cells is associated with our becoming consciously aware of something that we were, up to that point, only subconsciously aware of. Comedy is related to surprise. The behavioral response associated with our sense of humor provides its own quorum-sensing function: When many people laugh, we have a different psychological response than if we hear one person laugh. Fix civilization: gaiabrain.blogspot.com/2015/12

Hmmm, 4 billion years. That means, according to scientists, that based on our sun's shrinkage rate, that it would have been bigger than the orbit of the 1st 3 planets, yes, including Earth. Not sure how that adds up in their minds.

Very informative ... but why am I missing bacteria in my gut ... and have all sorts of digestions issues!!! I'm afraid to eat food ...

Yo! I'm bugging!

Wouldn't it be nice to get a pay check a couple of times a month to talk about this stuff?

some1 wrote :"this is kinda boring. Only eating, offspring, eating..." Well I think, Homo Sapiens does the same thing. No more. No less!Sapiens just covers that with Fantasy=Story=Myth=Religion=Soul=Love and this is a mechanism of evolution. Like florescent Squids doing craziest of light-show, we do, let's say, poetry! And believe to be something extraordinary...At the end we also die naked, alone and decomposing. Exactly like the Bacteria do.