TLR Signalling Pathway

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2 жыл бұрын

Toll-like receptors (TLRs) play an essential role in the activation of innate immunity by recognizing molecules from pathogens like we have LPS from Gram negative Bacteria.
TLR signaling pathways arise from intracytoplasmic TIR domains, which are conserved among all TLRs and these TIR Domains are stimulated and activated by binding of Ligands towards the TLR proteins.
In this pathway we need the following Proteins :
1.Lipolysaccharide Binding Proteins.
2.CD-14
3.MD-2
4.TLR
5.MY D88
6.TIRAM
7.TRAM
8.TRAF
9.IRF.
10.NFKB
11.AP-1
12.IKK
and many other molecules .
From this pathway we get the transcription of Cytokines , Chemokines , Interferons .

Пікірлер: 26

@user-py9re3hv2l 6 ай бұрын

i realllly hate this subject....but you simplfied it as much as possible,great job

@mitamajoomdar9390 2 жыл бұрын

I need this video earlier 😭 but still happy 😊 finally got simplest way of tlr signaling pathway

@muhammadzain-ul-abdeen7521 2 жыл бұрын

Excellently explained, thank you❤️

@michaeleisenberg7867 2 жыл бұрын

Hello Shabir, Very nice animations with different colors and shapes. 👏👏👏

@kaulickmitra6898 2 жыл бұрын

Fantastic explanation,Sir.

@alannahhyland5758 Жыл бұрын

Very clearly explained, thank you very much!

@hussainbiology Жыл бұрын

Glad it was helpful!

@fatemehkolbadi6397 Жыл бұрын

Perfect explanation 👌

@muntazirhasan8494 2 жыл бұрын

Bro excellent job. Totally impressive.

@hussainbiology Жыл бұрын

thanks for appreciation..Glad it helps....✌️

@umerfarooqbiology7083 2 жыл бұрын

very nice and great information

@pikagirl..2420 Жыл бұрын

It was this easy!! Idk what my teachers taught me damn🤦‍♀️ they make things so complex..

@alexei8468 Жыл бұрын

gracias!

@risharajkhowa5060 10 ай бұрын

what an explanation !🥰🥰🥰🥰

@franciswalsh5469 2 жыл бұрын

Very good, thank you

@hussainbiology Жыл бұрын

thanks for appreciation..Glad it helps....✌️

@tonimartin6954 11 ай бұрын

Thank you!

@hussainbiology 11 ай бұрын

You're welcome!

@uttamghosh503 7 ай бұрын

So easy to learn thank you sir

@hussainbiology 7 ай бұрын

Keep watching

@gissie391 7 ай бұрын

How do we reverse damage done by dopamine inhibitors?

@YanpingSoongNora 6 ай бұрын

How is TLR signaling shut off? If TLR signaling is overactivated, which diseases of the four types hypersensitivity reactions would such TLR hyperactivity be associated with?