Transcription initiation in prokaryotes | prokaryotic transcription lecture 2

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9 жыл бұрын

Transcription initiation in prokaryotes - This lecture explains about the prokaryotic transcription initiation. The nucleotide pair within the DNA double helix that corresponds to the web page from which the first 5' mRNA nucleotide is transcribed is referred to as the +1 website online, or the initiation website. Nucleotides preceding the initiation site are given poor numbers and are exact upstream. Conversely, nucleotides following the initiation site are denoted with "+" numbering and are referred to as downstream nucleotides.
A promoter is a DNA sequence onto which the transcription machinery binds and initiates transcription. Mostly, promoters exist upstream of the genes they regulate. The targeted sequence of a promoter is very important when you consider that it determines whether the corresponding gene is transcribed at all times, one of the crucial time, or sometimes. Although promoters differ among prokaryotic genomes, just a few elements are conserved. At the -10 and -35 regions upstream of the initiation website, there are two promoter consensus sequences, or areas which are an identical throughout all promoters and throughout various bacterial species. The -10 consensus sequence, called the -10 region, is TATAAT. The -35 sequence, TTGACA, is famous and certain through σ. Once this interaction is made, the subunits of the core enzyme bind to the website online. The A-T-rich -10 neighborhood facilitates unwinding of the DNA template; a few phosphodiester bonds are made. The transcription initiation section ends with the creation of abortive transcripts that are polymers of roughly 10 nucleotides which are made and released.
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@trinamondal6688 3 жыл бұрын

Sir, I actually read somewhere that the abortive initiation occurs while the sigma factor is still attached to the RNA polymerase. The RNA polymerase in the open promoter complex starts transcribing the DNA but is unable to move forward due to the attachment of sigma factor to it thus releasing the short synthesised mRNAs. This synthesis and release of several short mRNAs produce optimum energy for the release of the sigma factor and RNA polymerase can finally move forward. The time for which sigma factor stays attached to the RNA polymerase is called PCT (Promoter Clearance Time) which is usually 2secs to 2mins in prokaryotes. Just wanted to say, sir I really love your lectures and your teaching style. I've been following you for 3 years now and your lectures have helped me a lot in my BSc. Thank you so much! :))

@nemesisdeimos92 2 жыл бұрын

Reference ?

@thatboiscotty 4 жыл бұрын

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@sweetyroy4339 4 жыл бұрын

Prokaryotic transcription or Eukaryotic transcription Pribnow box or TATA box RNA Polymerase or RNA pol II Signa factor or sigma absent. If it is prokaryotic transcription No TATA box No RNA pol II If it is Eukaryotic, Yes to TATA box Yes to RNA polymerase II No to sigma factor

@janme936 4 жыл бұрын

Yes, you're totally right... Well, do you know which one of Sigma factor and RNA polimarase II binds to promoter first? I already reads some books that explained that sigma factor is binds first to the promoter then give a signal to RNA polimerase to bind in.. But in some animation video it explained that sigma factor binds to the RNA polimerase II then form a complex enzim then atack the promoter to start inisiation process... Which one is right?

@peculiarezindu1043 3 жыл бұрын

@@janme936 I think the video amination is right because the RNA polymerase enzyme has to be activated before it is able to perform in its active state. it is more regulated this way and make more sense. also some textbooks explains like this

@vasudevgautam9385 3 жыл бұрын

And in eukaryotes there is RNA pol. ||| not || which is used to transcription initiation or elongation......pol. || is only work when pol. ||| isnt working or absent eventually.

@neeshantn4701 8 жыл бұрын

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@fatimanisar9776 7 жыл бұрын

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@user-ih8pf4nn3p 6 жыл бұрын

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@aditisarkar7911 Жыл бұрын

Presently I am pursuing master degree in microbiology and our teacher told us to read the entire chapter on transcription. I was very upset before bcoz this chapter was a bit difficult for me, but not anymore. Thank you so much sir

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i am a civil service aspirant and my optional is zoology, your video are very helpful. thanks a lot.

@shomusbiologyofficial 2 жыл бұрын

Thank you

@tamoghnachakraborty50 5 жыл бұрын

There is no 0 site in template strand,the start site is known as +1 site,from where the transcription starts and moves toward downstream region.

@neelamchauhan1604 4 жыл бұрын

Thanks a lot you saved my life by teaching this...I understood it for the 1 St time in a lifetime

@shomusbiologyofficial 4 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@aleenajohny3011 4 жыл бұрын

Thank u somuch sir....u taught me within 30 min....Thank u so much....u r so kind and have good teaching skill...u also clears ever bit of each step of transcription

@shomusbiologyofficial 4 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@fatmakhan4268 6 жыл бұрын

sir... awesome..aap jaisa koi teacher nahi..thankyou 😊😊

@shomusbiologyofficial 6 жыл бұрын

+Fatima Khan you're welcome

@alejandravalenzuela342 8 жыл бұрын

you dont know how muuuchh i loveeee thiiiiis. i spent days reading the textbooks and i finally got it :D

@shomusbiologyofficial 8 жыл бұрын

+Alejandra Valenzuela glad it helped. Stay tuned.

@umairfarooqi7679 4 жыл бұрын

Kamal ka smjhate ho ap thank h so much bht axi smjh ati he👍

@shomusbiologyofficial 4 жыл бұрын

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@chizovlogs.1mviews649 5 жыл бұрын

Thank you very much.....you are always here to help me......once again may our good Lord bless u .....

@Studybuddy023 6 жыл бұрын

broo..too good..... loved it.....it has backoff my fear for genetics

@soumikroy3313 4 жыл бұрын

Actually Sigma factor contain some structural motifs that binds to -35 box. The structural motif is Helix-turn-Helix. Another portion of Sigma factor( Actually Sigma 70) binds to -10 box through a specific alpha helix. This helix contain some Hydrophobic Amino acids and the Hydrophobic side chains facilitates melting of DNA at -10 box by creating Hydrophobic interactions with Nitrogenous bases of -10 box.

@ruhidyusifov5106 Жыл бұрын

You are the best teacher.

@shomusbiologyofficial Жыл бұрын

Thank you so much for appreciating my efforts

@bokemon 9 жыл бұрын

Thanks, you explain it way more clear than the teacher I have for this subject.

@srishtidutta8973 4 жыл бұрын

Thank you sir... For answering my doubts... Never had anyone taught molecular biology to me so nicely. Thanks a lot sir.. 😊

@shomusbiologyofficial 4 жыл бұрын

Glad to hear that you're getting benefit from my lectures

@srishtidutta8973 4 жыл бұрын

😊

@rihamlive 5 жыл бұрын

Bro that was really helpful. Thanks for your efforts in making all that equations comfortable to us.

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@unboxing0021 7 жыл бұрын

Much hardwork ...great lecture ..love ..from Pakistan

@shomusbiologyofficial 7 жыл бұрын

+burki 123 thank you. Glad you liked my lectures

@ilsaanwar7935 3 жыл бұрын

You are just amazing sir thanks alot its my presnentation i got all the important points lot of respect from Pakistan

@zulaikhaduggal2870 7 жыл бұрын

In eu bacteria TATA box isn't present. This sequence is only present in eukaroytes n archae. TATA sequence is TATAAAA . This TATAAT sequence is known as pribnow's sequence. otherwise lecture is awesome

@stephanieg2887 6 жыл бұрын

Zulaikha Duggal really? My genetics book also includes prokaryotes to have tata boxes. It states that eukaryotes have tata boxes along with g/c rich and caat boxes.

@amiralive 6 жыл бұрын

Zulaikha Duggal exactly

@NataliaaLolOO 6 жыл бұрын

And also the RNA pol II is in euk cells not on prok

@rpdath007 8 жыл бұрын

in prokaryotes TATAAT sequence is called Pribnow box which is 10 base pairs upstream from the starting site of mrna synthesis. but in eukaryotes same sequence is noun as HOGNESS box which is 25 base pairs upstream from the the site of mrna synthesis

@mampidutta327 7 жыл бұрын

Praveen Dath not mrna it's upstream of dna

@sonalisunildey4498 5 жыл бұрын

There is nothing called “0” the start point is at +1 position. (From Lewin gene)

@sonikamalhotra2508 5 жыл бұрын

Very good explanation

@anny.--. 4 жыл бұрын

Long live sir. Thank you so much for the lectures.

@shomusbiologyofficial 4 жыл бұрын

You're welcome

@JasvirSingh-cn7bb 3 жыл бұрын

It's really helpful for all students😭 of science

@shomusbiologyofficial 3 жыл бұрын

Thank you

@bijayalaxmipani6441 2 жыл бұрын

Amazing session Sir 🙏

@shomusbiologyofficial 2 жыл бұрын

Thank you

@Suba1905 7 жыл бұрын

in ur older lectures u were so cute......now the reaction on 5.01 is awesome,,,, thanks for ur lectures...

@abubakarbashir7951 9 жыл бұрын

Very helpful, please keep doing the good job.

@fal236 6 жыл бұрын

You made my life easier, thank you!

@shomusbiologyofficial 6 жыл бұрын

Nice to know.

@hamnarehman2087 3 жыл бұрын

Awesome concept u have ...👍

@shomusbiologyofficial 3 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@philicyou8962 4 жыл бұрын

thank you so much sir for making these amazing video...its really very very helpful for me

@shomusbiologyofficial 4 жыл бұрын

Glad to hear that you're getting benefit from my lectures. Please subscribe and share

@raymellu4291 5 жыл бұрын

The sigma factor is released in E. coli due to abortive initiation, as scrunching occurs, energy is made and it causes it to be released from the core enzyme. Not sure if this is the same in other proks and euks

@lidiyaivannikova5464 7 жыл бұрын

Wait what? My slides say TATA box is only in Euk, and the TATAAT was called Prinbow Box in Prok? 😟

@khannagma7553 7 жыл бұрын

Lidiya Ivannikova ya correct

@addamlee8616 6 жыл бұрын

TATA box only in prokaryotes and yes it is called Pibnow box also.

@Shuborna112 6 жыл бұрын

Prinbow box is also called as tata box... Due to that tataat sequence

@sharvittibroussard6960 5 жыл бұрын

the TATA box is actually used in transcription. The RNA polymerases binds with with along with the TBP. thats in eukaryotes. Dont think so deep about it in prokaryotes . if it was a test question I would still say the TATA box is utilized only in Eukaryotes for transcription

@pritampal6743 7 жыл бұрын

thanks for teaching transcription and translation....now the concept is clear....plzz upload more videos like this....thank you

@zainabfatima7952 5 жыл бұрын

very well explained sir. sir u really have a very good trick to make a very very very difficult topics soo simple and this thing is like soo rare coz i haven't seen anyone except u that explained this topic soo clear 😊

@vagmiparmar6680 3 жыл бұрын

Thank you so much sir, for making my learning easy.

@shomusbiologyofficial 3 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@gayatrishingnapurkar6304 Жыл бұрын

You're gonna save my semester 😭

@shomusbiologyofficial Жыл бұрын

All the best

@Kazuya2002 3 жыл бұрын

Honestly a life saver! Thankyou so much!:)

@shomusbiologyofficial 3 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@k-miz3683 6 жыл бұрын

I love ethe video truly helpful for my biologui exam... love the biologui specially the prokaryotic one.. The opening of the oric is really inspiring also the dna polimerase is funny with the hand... jejejejjejeje

@mirzaamir4994 8 жыл бұрын

Thanks Shomu! It is much easy to understand than our beloved teacher's lecture.

@maryamssohaib 5 жыл бұрын

U r amazing... Ur lectures help me alot... Thank u so much for amazing videos

@shomusbiologyofficial 5 жыл бұрын

Thank you for appreciating my efforts

@yam-vv6re 7 жыл бұрын

what a life saver you are, thanks!

@shummu1458 6 жыл бұрын

really this video is very help full. thanx a lot sir for making this video it helps me a lot

@jagrityesingh4940 7 жыл бұрын

ur lecture is being so useful in my study...i use to watch almost all your vedioes related to my study.

@shomusbiologyofficial 7 жыл бұрын

+jagritye singh thank you for watching the lecture. Glad you liked the.

@shomusbiologyofficial 7 жыл бұрын

+jagritye singh thank you for watching the lecture. Glad you liked them

@SciencePluss 2 жыл бұрын

Ek dum crystal clear

@shomusbiologyofficial 2 жыл бұрын

Thank you

@souravganguly9557 5 жыл бұрын

It's truly a blessing for us to have such a helpful teacher !! Thanks a lot Sir for making these complex topics to easy to understand...plz keep continuing..

@shomusbiologyofficial 5 жыл бұрын

Glad to hear that you are getting benefit from my videos

@anindyachaturbedy7574 7 жыл бұрын

man you really are the best, I repeat the best

@Showkat_Dar 3 жыл бұрын

Very Helpful Thank you.

@shomusbiologyofficial 3 жыл бұрын

You're welcome

@tarikulislamturjo327 3 жыл бұрын

What may I say!!! You really know how to do it.

@shomusbiologyofficial 3 жыл бұрын

Thank you

@chayadharani6315 4 жыл бұрын

Thank you so much. It's very use full

@shomusbiologyofficial 4 жыл бұрын

You're welcome

@angelsrolltheireye 4 жыл бұрын

Thank you so much...I found it really hard to understand the initiation process..and you explained so well so thank you

@shomusbiologyofficial 4 жыл бұрын

You're welcome. Glad to hear that you're getting benefit from my lectures

@ashmittajayakumar7476 6 жыл бұрын

Amazing lecture, sir! Everything makes complete sense. Thank you.

@vitthal_donadkar 5 жыл бұрын

Why did you write RNA pol II in prokaryotic transcription?

@sradhanjalimohanty3929 Жыл бұрын

Thank you for explanation vry easy

@shomusbiologyofficial Жыл бұрын

You're welcome

@exploringworld5860 6 жыл бұрын

sir.... u made it very clear..thank you so much its soo helpfull.

@shomusbiologyofficial 6 жыл бұрын

+Saba khan glad to hear that you are getting benefit from the videos

@syedafatimanaz8337 7 жыл бұрын

SIR MAY YOU LIVE LONG WITH BEST OF HEALTH AMEEN :]

@varunmangal9993 5 жыл бұрын

verry gud video shomu beta, ur parents ar very proud

@Munzz1097 4 жыл бұрын

Thank you so much for helping me in making notes. 😊

@shomusbiologyofficial 4 жыл бұрын

You're welcome

@shyannealexeipaz4151 8 жыл бұрын

where does the ternary complex specifically formed? is it after the promoter region? at the start site itself? or after the start site? thank you

@milipadhan7946 4 жыл бұрын

Tq sir..for teaching very well...

@shomusbiologyofficial 4 жыл бұрын

You're welcome

@dr.s6233 6 жыл бұрын

TATAAT is in prokaryote and TATA in eukaryote. it differs in distance in nucleotides from the start point..like in prokaryote -10 sequence has the consensus TATAAT also known as pribnow box...and -30 is for TATA in eukaryote also called as TATA box

@walaaibrahim5123 4 жыл бұрын

Thank you so much your a life saver 💐

@shomusbiologyofficial 4 жыл бұрын

Thank you. Glad you liked my lectures

@captainpharma1315 8 жыл бұрын

welll donee i mean everything is crystall clear thanx for d video n keep uploading

@varungarla 8 жыл бұрын

hi sir there is two question i want to ask regarding amino acid and nucleic acid Q1. the rise and pitch of B-DNA are 0.33 nm and 3.40 nm, respectively. about hoe many helical turns are there in a fragment of 1 mm in length ? Q2. lysine is an amino acid with three ionizable groups. these are the alpha COOH amino acid and nita amino groups with pKa values of 2.2, 9.2 and 10.8 respectively. the isoelectric point (pI) gor lysine is: