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Trazodone is an antagonist or blocker of serotonin, H1, and alpha-1 adrenergic receptors. Trazodone can be used to treat major depressive disorder by modulating serotonin signaling in the brain. It can also be used off-label to treat insomnia due to its strong sedative effects. A major adverse effect of trazodone use is priapism, which is a painful erection lasting more than four hours independent of sexual arousal. Trazodone can also cause hypotension, serotonin syndrome, and nausea.
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