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Contraindications to NSAIDs?
Acute or CKD; CHF; peptic ulcer dz; anticoagulation
If not → NSAIDs (indomethacin)
Contraindications to colchicine?
Severe renal or liver disease
Combined with another drug inhibiting cytochrome P450 system
If not → oral colchicine
If contraindications to both, consider oral, IV, IM, or intraarticular glucocorticoids
If two or more joints involved, consider oral, IV, or IM glucocorticoids