Dr. Rand states that all we have to do is give anastrozole if E2 increases due to once per week injections. So, let me state my experience as a medical professional in integrative functional medicine that specializes in TRT for the last 3 decades. The reason someone may feel better about 50% of the time when doing once per week injections vs every other day or more frequent injections is because of dosing. For example, you give someone 200mg of testosterone and you drive their total T through the roof, lower their SHBG which in turn drives up free T and E2. The patient feels great for a few days and then they do it all over again so they never really feel bad. This protocol may be okay for someone that is healthy and fairly young (not over 50) or so. However, in a patient that is older, you end up with super elevated DHT which can cause major problems with the prostate and significant hair loss, and even acne for some. You also end up with a significant increase in RBC count and hemoglobin/hematocrit levels. The idea is to mimic what the body naturally produces to avoid over conversion in the first place. If you don't feel as good doing more frequent injections it's because you need to either inject more testosterone per injection OR you have other hormones that are low such as DHEA-S and Pregnenolone. Check your SHBG and dose/inject accordingly. If SHBG is high and you are just starting out on TRT then you can dose high once per week and then taper off to EOD or even daily. If SHBG is low and free T is above the range, then you most definitely need to be dosing more frequently, especially if you are overweight or have some liver issues and have problems with conversion of too much T to E2 due to aromatization. Also, estrogen is protective, so knocking it down with AIs will cause your HDL to plummet, cholesterol to increase, along with joint and muscle aches. Another thing is that estrogen helps your body get rid of old blood cells which also helps to keep RBC count in range. Also, if you donate blood you will in turn crash your ferritin levels over time which then results in lower iron levels. This causes your body to release more erythropoietin which in turn increases RBCs. So, if you have elevated RBCs, hemoglobin, and hematocrit, the thing to do is check your ferritin and if lower than 30, supplement with Ferrochel. You can also sleep on grounded sheets which in turn decreases hematocrit and improves blood circulation by reducing RBC aggregation. Taking supplements like Nattokinase and Pycnogenol also work out great especially if you are prone to DVT and your RBC count is in the upper end of normal or out of range. A lot more to this, but just wanted to point out some things.

Definitely less bloat, less acne and feel better when pinning every 2-3 days

Completely disagree, splitting dose 2x weekly, every 3.5 days I feel entirely better than a 1x a week massive blast of test that starts to waiver as the week winds down and I approach my next shot; Twice a week I feel way more “balanced” It also requires less AI use at least on my behalf.

I might suggest letting your blood pressure be your guide. If you’re injecting so much that your BP is high, (with BP meds). Lower your dose, split your dose or what ever it takes. After you adjust, try increasing as you go to build a protocol that works for you.

A lot of guys say that by day 6 after injection they’re feeling down. Also, you skimmed over the biggest argument guys have, and that eliminating the need for an aromatase inhibitor.

I've been on trt for 15 years. Started at 100mg once a week. For the past 10 years I've been pinning twice a week. I felt no difference, but my crit and hemoglobin went back to normal levels. My test ranges for 700 - 900. Please remember "free testosterone " is what matters. My free is in the 20's.

I have experienced exactly what this doctor is warning about and he is absolutely correct in my case. I cut my dose in half but started injecting it twice as often and here is what happened... 1) My libido went down 2) My morning erections ceased happening. 3) My SHBG went up 4) My free testosterone went down All of these things were negative consequences and so I returned to once a week 200mg dosing and everything improved again.

Not really selling the idea of once a week injections is he. "Yeh we will just throw in more drugs to counteract estrogen". No thanks

100mg every 6 days been good for me no issues love it

I started off on once a week injections but then followed the new guidance and switched to twice a week, then every other day, every third day, even every day in an effort to keep hematocrit and estradiol under control. Guess what -nothing worked for that - I always wound up having to take an AI to bring down estrogen and my hematocrit always ran over 51. I recently switched back to once a week injections because I just felt better on it

First of all the dose and thus the frequency of pinning depends on the test and ester you are using. Its going to be different for enanthate and propionate. Test enanthate which is 250mg/ml (180mg actually, rest is the ester, ) will be totally different than test prop which could be lets say 100mg per ml (80mg actual test, rest 20 ester). So if you want around 120mg per week and you are using Enanthate then you ll split 1ml in about 3 equal doses (180/3=60) and use just 2 doses during the week. I dont really know what works best though. One shot with the whole dose or two split shots? I am really concerned about this issue. It appears that its better to split it because of the half life of the drug. Enanthate half life is 4.5 days, so i believe its better to shoot every 4 days so it goes up again and not every 10 days or even worst 14 days.

Simply put............it's different for everyone. Why do you think he said it helps 50% of the time? That means the other 50% works for them also. It's just a process that needs to be figured out for each individual. And saying that you don't need AI is BS. Some people can get away with not using them but others really need them. There is no one-size-fits-all when doing TRT.

⁠Cypionate has a good half life at 8 days after injection. So if you take 200 mg on day 1 (let’s say Sunday), by the following Sunday (7 days later) you should have a little more than 100 mg of cyp in your system. So when you take that weekly shot, your baseline test is not what you originally had when you first started, but rather what is still active in your system.

I respect all opinions here. Personally, knowing the half life of a singular injection I like twice a week. Funny I do suffer from OCD too. I do right side Sunday and left side Wednesday.

I'm doing test cyp every day micro administrations , feel the best this way I don't need any aromatase inhibitor

I do mon and thur shots. I tried once a week and i did notice my libido was higher with once a week shot.

Love how we got janitors at Applebees in the comments saying this DR doesn’t know what he’s talking about. This guy is literally a testosterone EXPERT lol.

My blood pressure spiked the first few days of my TRT, I had to break it up 2x a week to keep normal BP levels

I don't know anyone that's had a negative result from 2x injections a week. I know several people that have had negative results from a single injections (sensitive nipples, sluggishness on days 5-7, etc).

Unbelievable this is not what I have experienced whatsoever. I believe your advice is a danger to many men trying to feel normal again

This is an easy fix. Just do it WZ/MW3 style. You can swap weapons from your loadout, but the swap doesn’t take effect until after you Rez or end of rounds.

Trt ten years now. I like enanthate 80mg twice a week. Once a week is fine but twice a week seems like everything is even more balanced. Every two weeks is too long. Over 200mg a week I start to get side effects.

I've been on TRT at 1 cc a week 200 mg, of testosterone cypionate for 9 years now. I do one shot a week and I feel great My sex drive is good I wake up at wood everyday and get wood for no reason sometimes four five six times a day or more. My energy levels are great and that's at 58 years young. But everybody's different but like I said one shot a week and I'm good, good luck to everyone and God bless you doctor.

Why on earth would anyone opt to take an ai instead of just dosing more frequently? When I started with TRT I did one weekly shot and my E2 went really high. By doing it twice a week I don't have that issue.

Good stuff! But the reasoning behind splitting injections is most likely because people go heavy on coffee. Coffee releases dht, lowers shbg, stimulates cortisol and estrogen. (If you ever take 200mg of caffeine and a cup of black coffee the reason why you get 10x more boost from coffee is because it releases free T, lowers shbg, and increases DHT, Estrogen and Cortisol (often balanced by dht inhibitory stress effect). This creates far more adrenaline and estrogen. ) Then when you eat a meal and push everything inside of cells (from outside stimulus - neurotransmitters+hormones, to inside - production/effect), the body becomes slower from cortisol and sensitivity feedback loop and metabolism slows down. So not only you use up more Test from release in the blood, but now anything that is being released later in the week is not enough to keep the energy going. So replenishing more frequently gives few spikes rather than a big 1. And if you add sugar to coffee you release even more hormones, even more estrogen, which later turns into cortisol breaking down all T… Diet is a major factor. This Doc works with professionals alike, and may give his advice to different individuals, BASED on blood numbers

Every other day... i can tell you with 100% honesty IT WORKS !

I take testosterone Cyp. Every 3 days 65mg is that ok it seems to be working well

This is insane advice.

Terrible protocol. 2x per week and dump the AI.

T has had more negative than positive results for me. Peptides work better for me. Again this is me. I did feel better when i split them up. I think this is a personal thing as we react differently. I also used Depo-T and felt better on that one, but again still negative. my main negative was mood swings, hit me one day and we are brawling, i get that real :fight" mode instead of flight. i didn't like that. to me, the negatives outweighted the positives, but man, some of the positives were just so awesome, it scared me at time, talk about feeling 25+ years younger... NAD+ and MOTSC i feel do a little better for me, but again, to each his own

100mg every seven days and at peak I am at a 1200ng level. Feel fine through the week it all depends on the individual. I was at 105ng prior to TRT. Thank god for TC…

Stop repeating this video… we get it

I've tried once a week and twice. Couldn't feel a difference. 150 mg test cyp shot on Monday morning then 3mg aromasin taken on the Tuesday.

Tried numerous protocols. SubQ ED and EOD was without a doubt the worst. Twice a week IM is perfect, for me.

#MorePlatesMoreDates

Clinics often use Anastrozole ….surprising you seemed in favor….Most docs who seem to know don’t think it’s good and in fact can be toxic. What do u think?

Never take advice from a professional that can’t do shirt laundry 🧺

1x per week vs 2x per week I feel the same

I see alot of people disagree which is fair but remember he's seen probably thousands of people. Personally I think it's in your head too. Chasing numbers. Testosterone isn't dopamine. That would make more sense to translate to how you feel so quickly.

I am on TRT from urologist he has me taking 200mgs of testosterone Cypionate ever 2 weeks. My levels went from 213 to 906 in 1 month. The issue I'm having is my anxiety is off the charts I believe it's from testosterone going up and down making my mind on a roller coaster. I think q times a week or 1 time a week is a better dosage for me but the doctor says that's to much well then how do I combat this issue?

Don't agree at all with crushing estrogen. We need healthy levels of estrogen so atleast twice a week to keep that at a healthy range

That makes 0 sense... saying just go on and take more drugs to compensate... It's all about how much SHBG you have ... which he didnt mention... what kinda of doctor is this?

I can only assume that this doctor likes to hear his own voice as he offered 1 piece of advice and then said he can’t explain why

I take a small dose daily and it’s way better. And the few people I know who changed from weekly to daily have said the same thing

I can certainly imagine the sub cutaneous injection would absorb less reliably and less controlled simply from the lack of blood flow through fat tissue. The entire reason you inject directly into muscle to begin with

I take 1cc 200 mg every 7 days once per week injection. I have split it up into 1/2 cc 100mg injection on Tuesday and 1/2cc 100mg on Friday. There’s no difference. If anything I feel worse by splitting it up. 200 mg once a week injection is what works best for me. Besides test cypionate peak last 7 days and actually last up to 14 days but one injection every 14 days will have a roller coaster effect.

What dose are you guys taking per week ? I'm taking 160mg... 2 times a week. 80 Monday and 80 Friday

Very happy to hear this. I was prescribed twice a week subQ. So far, I haven't felt a difference. I was diagnosed with a prolactinoma and have been running 81ng/dL for years without realizing it. :/ Hopefully the subq works over the next few days. If not, I may ask to switch to intramuscular and weekly instead of twice weekly.

I went from 1 dose a week to 3.5 days to every other day. I spent a lot of time on all three. I like every other day. Dose had to go down from 200mg to 105. I keep a steady high normal level, which means less acne, and no need for an AI because levels are within range, and I still have the benefits

One injection per wk works just fine for me. And believe it or not 60 mgs per wk works good as well. Very good sex drive and fairly even. Good results at the gym too. As a small time older bodybuilder I am happy with the results I get from such a small dose which BTW is all can handle without having blood work go bad.

I disagree, I have tried everything from weekly to daily and for me the best is 3 x week. I feel better on 3x a week than even 2 x a week .. however everyday i noticed no improvement

I can't tell the difference between once a week and multiple times a week. After several weeks the blood levels build up and become more consistent anyway.

So,,,,,Once a week??? Or probably best to do twice a week?? Does anyone really know🤷‍♂️

He’s the only guy or doctor on KZfaq who says once a week is better. Wtf

If your chasing perfect bloodwork frequency is better If your chasing the highest highs, less frequent higher dose is better Create a log and write down how you feel each day, then you will know your frequency

I take 200mg shot a week my blood test came back with my t level was 1003 I’m 46 years old is this to high I feel good but my dr. Thinks it’s to high I don’t think it is I take my shot once a week what do u recommend

Randolph mclain is a celebrity in Argentina

I recently switched from once week injection to every other day injections, and it’s been fantastic for me actually, I would do once week injection and feel amazing again and the next day feel okay but not great and the next day feel like garbage so you can imagine how I felt on day 6-7 ( horrible). I’m still doing IM injections just because idc about sub Q TBH , rotating between deltoids, ventral glutes, regular glute area, and biceps if I have to and so far it’s been great, the only thing I’ve noticed is my estrogen levels have shot up significantly since switching to every other day, so I’ve gotten some arimidex and letrozole for that reason and I hate to have to take them cause they make you feel like straight garbage zombie mode when you’re on either, not taken together obviously .

Need a little thought here. Doc wants me to start at 160 a week. Seems a bit high to me. Total T 563, Free T 38.

Very interesting 👌

For me I figured out beyond a shadow of a doubt … my body doesn’t respond to pins less than .2 ml at once , regardless of the weekly dose or frequency

Can someone suggest or point me in the right direction in terms of how much I test I should be injecting as an athlete for enhanced athletic performance?

I have always injected every 7 days and it has been easy.

I got my first injection yesterday and my ass cheek is traumatized

I use to inject every two weeks and went to once a week. I really could not tell the difference.

anyone use hcg here? i hear you need to do it 2 a week.. i rather just do it once.. does it matter? say 1000 iu weekly as protocol with 100 mg cyp per week as trt

Soooo.... on one hand we have a guy who micro doses in an effort to mimic the natural production of testosterone and to try to avoid spikes in hormones so he can minimize the amount of drugs he puts in his body so the body can work a naturally as possible. On the other hand we have this doctor who states that pinning is an evasive procedure so he rather a guy pin once a week... causing potential spikes in the hormones and causing the patient to add other drugs to the protocol. What? I don't get it. Can someone help me on this?

Why is this channel now an ad for trt? Especially this doctor with a dubious history and background.

Can I take natural supplements (Tongkat Ali/Fadogia Agrestis ) to offset the side effects of microdosing TRT?

Or just split the dose and not have to shove more meds into your body. And there's a LOT of people that will say they had issues on 1x week and feel better on split doses.

The dock was saying, taking anastrozole and injecting once a week. How much anastrozole is recommended? Thanks

I would trust Dr Rand he’s been doing this for years with thousands of patients

Went from once a week to twice and don’t feel as great honestly I even broke out idk

what does this mean conversion to astrogen? is that like female hormone?

The problem with having testosterone spikes is that it causes erythrocytosis in many patients

i am 57 and i take sustanon 250 once per month, could i go once per week?

Well if it’s not about the numbers but instead symptoms. Swelling and fluid retention. And weight gain

If I done 1ml or 200mg per week for 12 weeks and trained at gym would I develop a Good mucle and build ? ( in gym 5-6 day a week ) . Aslo will it ruin my normal sec drive as I’m taking this just for physique purposes ? .

What's his thoughts on 1 pin every 3 months nibdo 1000mlg is the trt choice we have in the uk on the NHS

It’s amazing how many answers don’t get answered in these videos. They just want to get us interested and take the money. All I ever wanted to know was how much and how often do I take HCG. But nope. That is way way way to hard of an answer to give. So you get people like me just winging it. Thank you doctors. “In the name of health” right lmao yeah ok.

Hell yeh I feel better with 2 or 3x a week

i give my patients TRT Sustanon 1000 per month, so if i only give them 250 then it's once a week.

Using an AI doesn't he doesn't mean blast it. If you were to take 100mg once a week 1mg of arimidex the day after the shot should do you fine

Lost me at use more anastrozole….that’s absolutely ridiculous

So instead of splitting your dose up to reduce estrogen he just wants to prescribe an AI which will cause even higher estrogen 🤔

Stop going after stuff that you saw in a video or because a bodybuilder told you so. Why don't you just do what your doctor says and see if you feel good and call it a day

Why use anastrozole with side effects instead of changing the frequency?

Horrible statement. "Stay on 1x week and take an AI". If you can avoid an IA you should....

Love the dock. Disagree with once per week. More frequent the better

I was literally getting ready to say this guy has no idea what he's talking about and then noticed all the comments were saying the same

He's biased because he's pinning enough to fuel a horse. Twice a week is where it's at.

It's individual based. Not everyone's body functions the same. So many diff variables. This guy is clearly giving the wrong information.

Does dim or calcium d glucarate shuttle the estrogen to the favorable 2 hydroxy pathway versus the undesirable 16 hydroxy? I cannot find anyone or any website for the correct answer? Any thoughts?

what do you take to thin the blood under TRT and at what dose ?

Frequency depends on your SHBG level

Hcg evry week for life

Dr. Rand McClain I have a question, I’m on Jatenzo (237 mg twice daily) and my peaks are around 800-1000 ng/dL, (SHBG 20) and my troughs are usually around 300 ng/dL at 12 hours. My question is why do I feel the same all the time if my levels are dropping low?

This makes me question his other advice.

150mg every 5 days of cypionate

I do every other day injections and it eliminates ALL the side effects I was having doing 1 200mg shot per week of test cyp. side note = back acne WAS horrific lol and yes this is my wife's account, im 37yr old male lol