Two main categories of antidepressants and how they work

Рет қаралды 21,112

Жыл бұрын

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Пікірлер: 100

@blufaerie Жыл бұрын

Will you do a deeper dive into the different antidepressant meds? Like by name?

@shawnaford5540 Жыл бұрын

I was on an SSRI for years and it was worse then the pain of depression, anhedonia was disabling. Dampened is understatement from my experience.

@user-vt7fo4sq9l Жыл бұрын

Not for arguing, but for addition, ‘cause this will be top comment, I would like to say my experience. I was on Amitriptyline for couple of months after half year severe depression and it helps me after couple days of using it. Increased good mood, no bad thoughts, world become bright and happy again, anhedonia made a step back, but everything still was hard to do. It’s undoubtedly gave me energy to seek the way out of depression. But, honestly, it caused hypomania to me

@sophileh6185 Жыл бұрын

Glad to be on Wellbutrin. Can’t believe my first psychiatrist heard me describe the apathy and other signs my meds weren’t right and just kept increasing it. My second dr knew right away

@gagecarty4290 Жыл бұрын

Always gives us easy to understand explanations of what medications do

@SparklyRaccoon Жыл бұрын

shout out to this short reminding me to take my meds lmao

@DrAndreaFurlan Жыл бұрын

Another great video by Dr. Marks!

@lewa3910 Жыл бұрын

Really interesting explanation of how this drugs work

@DwayneTheMomJohnson Жыл бұрын

I'm on an SSRI and a stimulant. Sadly, Wellbutrin (bupropion) caused me a great deal of issues such as wild mood swings, crying for no reason, insomnia, and süicidāl ideation. Even though I'm often told that Wellbutrin is well tolerated and should help with my ADHD and GAD 🙄🙄 Nope, not for me!!

@LDiamondz Жыл бұрын

I had terrible adverse effects from Wellbutrin, as well. Including kidney problems. I had to go off it quick. Nothing seems to work for me. It sux.

@Finkeldinken Жыл бұрын

Same here! I reacted SO badly to it in the same ways (ADHD here too). Atomoxetine was no good for me either, unfortunately. I get bad skin issues with central stimulants, but at least they have a positive effect on my executive functioning.

@Dabne5587 Жыл бұрын

Google "Tardive Dysphoria" and "Pssd"

@zamandzeya 8 ай бұрын

Thank you, I have struggled with being sedated by anti depressants for a decade

@TheDsgrant79 Жыл бұрын

I'd rather be apathetic than depressed. Prozac changed my life

@JZGreengo Жыл бұрын

Strange, I’d rather feel something than nothing

@missmargmillionaire6421 Жыл бұрын

a lesser of two evils is such a sad choice to have to make

@edelweissdebergbaldrian7696 Жыл бұрын

Being apathetic is no picnic either.🙁

@jeanettewaverly2590 Жыл бұрын

Prozac alleviates my depression without dampening my overall mood. But it gives me insomnia!

@NoRockinMansLand Жыл бұрын

It shouldn't be seen as a permanent solution either

@jw-j8104 Жыл бұрын

Wellbutrin has helped me soooo much. Love it

@pamelabarbato1623 6 ай бұрын

Does it really work? I'm so depressed.dr acts like they don't care

@thepudge6953 Жыл бұрын

Bruh, antidepressants didnt increase my mood but (vyvanse) stimulants did. I no longer pace.

@lething1237 Жыл бұрын

Stimulants were the first antidepressants for a reason.

@cynthiadietzel2388 Жыл бұрын

Decaf coffee can be used to increase dopamine slightly.

@Elektra_7 Жыл бұрын

Without caffeine, useless for the increase of dopamine

@DandyParrott Жыл бұрын

How does that work?

@meredithfriday9682 Жыл бұрын

Effexor saved my life. Had horrible GAD and couldn’t function.

@lizabear7014 Жыл бұрын

Wellbutrin plus lithium saved my life. Bipolar 1 here.

@jefframaki Жыл бұрын

My bf was on wellbutrin and lexapro. His new dr wont give both but he needs it! The combo works for him

@madi6284 Жыл бұрын

I’ve been on Effexor (Venlafaxine) and my dr added Wellbutrin, seems to be common to add Wellbutrin in conjunction to an antidepressant

@AxelLivesForever 8 ай бұрын

Dr Marks, thank you so much!! That’s what I’m on and I’ve tried other medications but I’ve experienced what you described as blunting and apathy!! Like the medications aren’t fixing or helping the right thing.

@WirableCrown1 Жыл бұрын

Wellbutrin was a wonderful crutch. But.. It made me not me, but I wasn't me being depressed, so take that as you will.

@doreenarcher8543 8 ай бұрын

I’ve been taking Wellbutrin for maybe a couple years now. I have major depression and have been on a lot of different meds over the years. This works well . Once initial side effects went away I do really well with it.

@beahappy1today Жыл бұрын

I didn’t know that about Wellbutrin. Very interesting! I love psychopharmacology.

@nicoletambasco9210 8 ай бұрын

The name brand worked great for me..until it didn’t ..but for a while I did alright in Wellbutrin. Told the doc the generic made my urine smell bad. So they gave me the name brand and I did good on it

@imnotnotgameiacmaniac5327 8 ай бұрын

this is true and kinda crazy. ssris do work but the only mechanism through which they work numbness

@SynasterHax Жыл бұрын

That would explain why my psychiatrists keep trying to put me on Wellbutrin, but it makes my heartburn skyrocket despite already being on two antacids.

@edelweissdebergbaldrian7696 Жыл бұрын

Tell them you don't want to take Wellbutrin because the side effects are too uncomfortable. You have a say in your treatment, you know that right?

@jeanettewaverly2590 Жыл бұрын

I can’t take it because it’s contraindicated in cases with seizures. I had seizures many, many years ago, when I got encephalitis. So I’m not taking any chances with Wellbutrin.

@lil_weasel219 Жыл бұрын

@@edelweissdebergbaldrian7696 in the past at one point when i reported side effects, the psych used language in the report that made it seem like she though i was making shit up they can be pretty paranoid and will sometimes think the patient is making up side effects.

@johnsakeiyia330 Жыл бұрын

I wish you could dive deeper into these antidepressants. You've only mentioned Wellbutrin, hopefully you'll expound more on it and the others such as escitalopram. I am a victim of social phobia and currently under medication using escitalopram. God bless you.

@johnsakeiyia330 Жыл бұрын

@@brandiwestpfahl7539 I'd say it has, to just a little extent though so far. I've used it for two months now and my psychiatrist says I might end up using it for even a year in order to notice a significant improvement.

@edelweissdebergbaldrian7696 Жыл бұрын

So, you suffer with social phobia. Never heard anyone say they were a, "Victim." Interesting use of words.

@smallpseudonym2844 Жыл бұрын

But... she _does_ get into Escitalopram. It's an SSRI. She actually explains SSRI's better than Welbutrin, which doesn't really have a "class" yet so she just named it instead.

@johnsakeiyia330 Жыл бұрын

@@edelweissdebergbaldrian7696 English is not my first language.

@johnsakeiyia330 Жыл бұрын

@@smallpseudonym2844 alright. Maybe she could recommend what a long-time sufferer of social phobia needs.

@kristoffseisler2163 Жыл бұрын

is there any medication that only disables serotonin but doesn't touch dopamine at all?

@LDiamondz Жыл бұрын

I asked my doctor what medication I could take to increase dopamine. She said, "Yeah, heroine. Do you want to try that?" And laughed. This was a few years ago. Are meds that increase dopamine new? Or is my doctor the problem? (Or both?) I thought her answer was inappropriate at the time, no matter what her reasoning.

@smallpseudonym2844 Жыл бұрын

If you listen, she explicitly names a drug that increases Dopamine. You can thus just type "Wellbutrin discovery" and this pops up: "Bupropion was invented by Nariman Mehta of Burroughs Wellcome (now GlaxoSmithKline) in 1969, and the US patent for it was granted in 1974. It was approved by the U.S. Food and Drug Administration (FDA) as an antidepressant on 30 December 1985, and marketed under the name Wellbutrin." It's been around a long time. Depending on where you live, such as the UK, they won't prescribe it, though.

@lil_weasel219 Жыл бұрын

if im not mistaken, caffeine increases dopamine. Like any drug though it causes tolerance.

@smallpseudonym2844 Жыл бұрын

@@lil_weasel219 Not all drugs are created equal. Caffeine is one of the most addictive substances known to mankind. It's also very short acting. Comparing it to long action psychotropic medicines that don't produce the same operant conditioning is disingenuous at best.

@LDiamondz Жыл бұрын

@@smallpseudonym2844 Thank you. I don't think caffeine is a good option, either. Neither is Wellbutrin, as I had severe adverse reactions to it. Maybe there's something else. Would you know of another medication, by chance?

@musthavemoxie Жыл бұрын

Lamotrigine increases dopamine.

@subodhgautam649 3 ай бұрын

Nicely explained.... dopamine is culprit, i believe....but , but, but....Risperidone really affects u gud way..Risperidone makes u feel emotions which u hvnt experienced before.

@Reyvius78 Жыл бұрын

Why even take SSRI then? Or a mix of both if that is possible ofc

@emilysunaz9727 8 ай бұрын

Oh my god. Does this mean that my antidepressants could have been exacerbating my adhd because of the decrease in dopamine? I now take adhd meds as well as my antidepressants and they do help, but damn

@Elektra_7 Жыл бұрын

That's exactly what happened to me. I feel like zombie on antidepressants. I feel empty like don't feel.anything. Being like that it's easy to commit suicide.. You are not a human being with feelings..Thank you Dr for this educational video

@timothylevin2661 Жыл бұрын

Why are mass killers on SSRI's ?

@iaincampbell2509 Жыл бұрын

I've recently been changed from 150mg Sertraline/day to Cymbalta 90mg/day. Cymbalta has simultaneously been worse and better. The sexual side effects of Cymbalta are horrendous, almost as bad as citalopram. I'm sleeping much better that I have in years though. Brain zap withdrawals if I forget to take one are really bad. Would wellbutrin be a better option? I've asked for Vortioxetine, but was denied.

@Elektra_7 Жыл бұрын

Wellbutrin causes insomnia

@iaincampbell2509 Жыл бұрын

@@Elektra_7 well, that sucks.

@smallpseudonym2844 Жыл бұрын

@@iaincampbell2509 Wellbutrin only has that effect in some folks. I may have just been lucky, but have only had minor side effects. Slight weight loss, which wasn't unwelcome in my case. And slight uptick in libido. After the disaster (for me) that was SSRI's (rapid weight gain, panic attacks, complete loss of libido and appetite), Wellbutrin was a breath of fresh air. Within a week or two of taking it, I regained a significant capacity to focus (dx with ADHD/Anxiety), eliminated long bouts of "brain fog", and reduced my previously perpetual fatigue. While it doesn't seem to directly treat the emotions that come along with my anxiety, it has treated a lot of the more crippling symptoms of it. It has allowed me to be able to function normally, in particular the energy to exercise and the ability to work properly. That has created a positive feedback loop instead of the previously self-destructive anxiety coping mechanisms (In my case anxiety-related avoidance wreaked havoc on just about every aspect of my life). It's ultimately all related to the imbalance that's causing your problem to begin with. Clearly my issue was Dopamine and Norepinephrine, not Seratonin.

@iaincampbell2509 Жыл бұрын

@@smallpseudonym2844 thank you for sharing, I have an appointment with my psychiatrist tomorrow. I will see what she recommends

@gabby9808 Жыл бұрын

Cymbal ya made feel too tight … my brain and my body . Don’t know how to explain ….

@adamandsteve13 Жыл бұрын

What if I already feel apathetic?

@spiritosa0123 8 ай бұрын

wellbutrin

@michaelstapelberg7751 8 ай бұрын

yup.. and sometimes yon can get seratonin syndrome... NOT NICE!! literally the worst explosive bowel movements of your life! i stopped taking mine and within a week my gut calmed right down! of course they i became all nihilistic again! but thats is better than pebble dashing you toilet!

@martinklein2201 Жыл бұрын

Don't use any psychiatrics medication unless absolutely necessary. They have ruined many lives

@smallpseudonym2844 Жыл бұрын

They saved mine. Take your baseless assertions elsewhere.

@lil_weasel219 Жыл бұрын

@@smallpseudonym2844 none of their assertions are unfounded. They say unless necessary. Thats kind of a no brainer dont you think?

@smallpseudonym2844 Жыл бұрын

@@lil_weasel219 The phrasing "absolutely necessary" is purposefully vague. I've seen where this goes. They then deny that it's actually necessary for anyone except those who are violent and basically need to be incapacitated. I have seen it used by paranoid anti-psych-med twits and folks who denigrate those who needed meds to recover. It's stigma, and it's gross. So no, he can screw off with the dog whistles.

@martinklein2201 Жыл бұрын

@@smallpseudonym2844 yeah like me trying Paxil and ended up not being able to feel emotions towards something/someone since then even though I took it like for one week and then stopped. You can start thinking about antidepressants if you have your life, diet and hobbies in check and have no other choice

@gabby9808 Жыл бұрын

I agree they’re horrible . But is worst feeling depressed, fearful and negative . Is a hate love relationship…. I don’t think about medication I just swallow them . I’m not the same person as I was once . I was happy , love to party I wanted to work to succeed in life . Now everything is just nah ok ! Don’t party , don’t smoke , don’t drink , don’t go out , everything is like a flan 🍮 I even like to be in bed by 6 pm .

@blackpoolbootz2790 Жыл бұрын

Didn't know this. Wellburtarin isn't available in UK :-(

@edelweissdebergbaldrian7696 Жыл бұрын

Everyone is different in how they respond to medications. It would be great to find the perfect fit, sometimes you find what you can live with.

@blackpoolbootz2790 Жыл бұрын

@@edelweissdebergbaldrian7696 yea agree it's good to find a medication that provides some relief (on venlafaxine here and works well).

@edelweissdebergbaldrian7696 Жыл бұрын

@@blackpoolbootz2790 Have been on that for years, the only thing that works. I was put on Wellbutrin years ago and I was so depressed I thought I was going to die.

@silviakhan1073 Жыл бұрын

Would be great to learn what each of all medicines do, side effects and related suicidal risks for everyone to be alert. I started taking Pamelor for migraines my throat started getting dry by the time I reached the third dosage. Got up to half of the second prescription and stopped taking it cold. Did notify my doc. also probable weight gain I didn’t get to notice. Many migraine sufferers also take some of these prescriptions. Good to know. Thanks! I don’t want to take any unless really desperate. Don’t like stuff playing with my mind. Some can be affected with suicidal thoughts🥲.