Understanding PHI and PSI Angles, Ramachandran Plots, & Newman Projections

Рет қаралды 103,052

3 жыл бұрын

This video was created using models, images, and inspiration from the Proteopedia page: The Ramachandran Principle Phi (φ) and Psi (ψ) Angles in Proteins
proteopedia.org/wiki/index.ph...
REFERENCES:
• Ramachandran, G.N.; Ramakrishnan, C.; Sasisekharan, V. (1963). "Stereochemistry of polypeptide chain configurations". Journal of Molecular Biology. 7: 95-9.
• Prilusky J, Hodis E, Canner D, Decatur W, Oberholser K, Martz E, Berchanski A, Harel M, Sussman JL. Proteopedia: A status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol. 2011 Apr 23. PMID:21536137 doi:10.1016/j.jsb.2011.04.011

Пікірлер: 73

@_jeena 9 ай бұрын

There's no way I'd have grasped the concept of these torsion angles if it weren't for this video. I owe you my life, no jokes.

@gg025 2 ай бұрын

im glad im not the only one

@chakubanga1 2 ай бұрын

Hahahaha. NO Comments. Otherwise the list will get longer 😂😂😂😂

@scruffymakaveli6870 Жыл бұрын

Criminally underrated video. You are awesome.

@gyaneshshukla1946 Жыл бұрын

The best Ramachandran plot explaination on the internet.

@stellyd3752 2 ай бұрын

Dr G N Ramachandran would have been so delighted to see your video if he was still amidst us. He did an amazing discovery and I have tried reading Lehninger, Voet to truly grasp the concept of phi and psi and no book could have done more justice to his contribution than your animated video. Heartfelt thanks.

@goncalosoares8420 Жыл бұрын

been reading my ptts for more than an hour and understood more from these 10 minutes . . .

@rabrojonel Жыл бұрын

I truly did not understand phi/psi angles and Ramachandran plots until watching this video. It was really helpful, thanks!

@mimosveta Жыл бұрын

I don't think those who wrote my book understood them either. like, at no point did they clarify that 6 atoms were co-planar, which to me seems kinda crucial...

@Clockworkbio 3 жыл бұрын

Oh you KNOW it's a good day when there's a new Molecular Memory tutorial!

@adhoccerswings 2 жыл бұрын

VERY clear video, thanks! You'd think "basic" stuff like phi and psi would be difficult to forget but apparently not. My mnemonic; "NCC phi psi"; phi N-CC, psi NC-C. Middle C being the alpha carbon, of course - kinda intuitive and easy to remember since N -> C and "phi psi" is in alphabetical order (h before s; phi before psi)

@MolecularMemory 2 жыл бұрын

Thanks for sharing your mnemonic!

@adwaitdighe4342 Жыл бұрын

cool!...h before s 🤣🤣

@dmajumdar2059 2 жыл бұрын

This is the best video on dihedral angles out there!

@levydo8051 9 ай бұрын

This saved me from hours struggling understanding phi and psi angles

@ogunoluwamayowa4749 3 жыл бұрын

You always have a way of explaining things in an awesome way

@astrobiojoe7283 2 жыл бұрын

This is the best video on dihedral angles!

@jdmccool1 3 жыл бұрын

You do such a great job at visualization that it would be awesome if you could make a video series around group theory. Symmetry is so hard to visualize and I feel you would do an awesome job!

@gabrielqin9687 Жыл бұрын

Hi, is there any recommendation for group theory? I am a math-beginner for a biology major, but currently I need to deal with Euclidean group in molecular symmetry.

@marahsaad9047 Жыл бұрын

Great job, this video allowed me to understand what I have been not understood for 3 years now.

@shafiurrahaman3396 11 күн бұрын

Incredibly helpful video on these dihedral angles, i for one really struggled to understand phi and psi from static 2D images - (for me they seemed to always be 180 in diagrams!). As soon as the image rotated in 3D space it all clicked and the clock diagrams were a nice touch as well for keeping track.

@trixstandflipped 10 ай бұрын

Fantastic video with awesome visualizations. Thanks!

@divyanshdixit933 3 жыл бұрын

Thank you for this, I'll be forever grateful 💓

@yazzydrazzy Жыл бұрын

What an amazing video!!! Thank you so much

@jhankargarg7327 2 жыл бұрын

Both the video and the link provided in description is very helpful Thank you for making my concept clear. It was so confusing earlier

@sathyamurthys9855 4 ай бұрын

THANK YOU FOR THE VIDEO MAKER AND THE PROTEOPEDIA FOR PROVING SUCH DETAILED EXPLANATION

@sudippattanayek6760 2 жыл бұрын

You have done an excellent presentation.

@rehabalsaleh166 2 жыл бұрын

Amazing! Thanks a lot! This definitely helped.

@mathiasverbeke9817 Жыл бұрын

A great visualization, thanks!

@anirbanbhowmik1416 Жыл бұрын

Thank you very much for this video! I might have never figured out what these dihedral angles phi and psi actually mean from those textbook descriptions. You know, they should really suggest something like a student should refer to a good KZfaq video for a better understanding, sometimes. And, I don't think not many people understand this concept clearly (even those who've been teaching this). Thank you very much! ❤️✨

@ishakashyap6974 3 жыл бұрын

So so thankful to you...

@tamilbiology5078 2 жыл бұрын

Dr Gn Ramachandran is from my state tamilnadu , India

@Ash-vl5ph Жыл бұрын

Amazing video!!

@franklinpulikkottil7826 Жыл бұрын

Amazing! Concise and understandable ☺️ Thanks a lot. And for the proteiopedia link

@SherKhan0122 9 ай бұрын

Brilliant video. Thanks!

@jessicalv6442 8 ай бұрын

AMAZING!!!!! Thanks!!!

@johnman1626 2 жыл бұрын

Really really osum explanation great work

@ericmartz9100 3 жыл бұрын

Really well done!

@rajatkumarparida4542 9 ай бұрын

thanks a lot for the amazing visualization, and this is helpful to me......

@simonlo2532 2 ай бұрын

Great video!!!!

@herrmanselcher1632 5 ай бұрын

Beautiful, thank you

@doctorumar1700 2 жыл бұрын

excellent PLEASE KEEP THIS CONTINUE

@VenusAndMoon 2 ай бұрын

this video saved my life, thxxxx ❤❤❤❤❤

@jamesbean9396 Жыл бұрын

So damn clear! appreciate

@Theabok853 3 жыл бұрын

Excellent video and explanation

@jkg6491 3 жыл бұрын

From a native speaker, his name is pronounced " Rama-Chunn-Drun/Dran". Also thank you, great video yet again

@jacktietjen 6 ай бұрын

Fantastic!!!

@sayanghosh123 2 жыл бұрын

Great explanation, Thank Youuu

@felixbaez9439 3 жыл бұрын

Excelent video!

@marioncaramel2415 3 жыл бұрын

THANK YOU SO MUCH !

@Thinker-gd8ck 3 жыл бұрын

Thanks for sharing!

@Hyumifu 2 жыл бұрын

thank you so much!!!!!

@thex5772 9 ай бұрын

Thank you soooo much. I subbed

@syedjamal3262 2 жыл бұрын

Great job

@tanushri4236 Жыл бұрын

Wowww 😍

@mahvishathar6483 10 ай бұрын

Thank you .

@infinightsky53 7 ай бұрын

Thank you so much

@divyarana3637 8 ай бұрын

lovely

@soumyaartz8912 Жыл бұрын

Thank you

@HydroZxZInferno 3 жыл бұрын

I wonder if you would be interested in speaking at an event my university is going to hold in connection with the UK Biochemical Society for the students. I have always found your pymol videos to be extremely well explained and clear! please reply if this is something you'd be interested in. Best, Will

@rimplekour3882 2 жыл бұрын

Well done

@tandelchandni1273 Жыл бұрын

yeah thank you

@shujahat_8c 2 ай бұрын

Why do we study this

@Helpnote9987 9 күн бұрын

To figure out the specific rotation of the N-c alpha and c-c alpha bonds of amino acids residues that forms peptide bonds .

@kgranalysis1052 Жыл бұрын

Good video and

@aswinikumar8503 2 жыл бұрын

❤️

@siddheshshewade7063 11 ай бұрын

we are saying that at particular values of phi and psi we have to look down in ramchandran plot and we will get an idea of its secondary structure but the plot u displayed is for alanine so if there is a peptide solely made up of alanine only then it can be true but if we are having variety of other amino acids in our peptide then how can we surely say that at those values corresponding will be the secondary structure. I mean the plot would have to change in that case

@hansenyang4014 Жыл бұрын

Hello I am learning this outside of the textbook for research. Can I ask why the substituents on the nitrogen are 180 degrees to each other? Shouldn't the nitrogen atom also have a lone pair so the substituents have to be 120 degrees or less apart? If this is a convention in some textbooks can someone explain the logic? Thanks very much. Edit: I think I just figured it out. Since the nitrogen is in resonance with the carbonyl, it does not have a lone pair and the N atom is essentially planar with only two substituents. It looks very cursed to have two groups 180 to each other in a Newman projection.