A patient with AIDS has bacterial meningitis and is being treated with an antimicrobial agent cleared by both hepatic metabolism and renal excretion. The volume of distribution is 10 L and the half-life for elimination is 7 hours in this patient. If the renal contribution to the plasma clearance of the drug is 8.3 mL/min, approximately what percentage of the drug’s elimination can be attributed to hepatic metabolism?
10%
25%
50%
65%
75%
90%