Methylene Blue is Neuroprotective After Ischemic Injury (Mouse Study)

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Жыл бұрын

Methylene Blue is Neuroprotective After Ischemic Injury
A quick review of the mechanisms demonstrated by methylene blue studies for MB's neuroprotective role in animal models.
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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Dec. 1 2022
Contraindications: www.rxlist.com/consumer_prova...
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core | PLOS ONE
journals.plos.org/plosone/art...
AMPK - Legere Pharmaceuticals
www.legerepharm.com/ampk/
Schematic illustration of the mTOR signaling pathway. AMPK indicates... | Download Scientific Diagram
www.researchgate.net/figure/S...
Model of the AMPK and mTOR signaling network in mammalian cells. AMPK... | Download Scientific Diagram
www.researchgate.net/figure/M...
Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light
www.frontiersin.org/articles/...
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation | Translational Neurodegeneration | Full Text
translationalneurodegeneratio...

Пікірлер: 389

@eileenbrookfield6966 Жыл бұрын

I started taking Methylene Blue on May 1, and my multiple sclerosis bout that I have been going through for two years disappeared. I’m walking and bending my legs. It’s been a miracle for me.

@hypnotherapist2211 Жыл бұрын

This is fantastic news !!! So pleased for you.

@hypnotherapist2211 Жыл бұрын

What brand did you get. And what dosages did you take

@eileenbrookfield6966 Жыл бұрын

I take nine drops a day

@eileenbrookfield6966 Жыл бұрын

I tried to insert a picture of the brands of methylene blue, but it's not working. You must buy USP grade.

@eileenbrookfield6966 Жыл бұрын

Nine drops a day.

@SuperFrankieKimm Ай бұрын

it's working!!! I started taking one 25 mg capsule daily three weeks ago. I've had CFS, brain fog, nerve pain (and many other symptoms post vax) for three years. within a week of taking MB, I began to feel more energetic. I can feel my brain coming back online! I have no nerve pain. I feel better than I have in years. I'm super emotional as I write this; so many people, suffering so badly, finally getting help...it's overwhelming. I love you, dr. been. I feel so much for the people who commented and shared their stories here. thank you all. ❤

@violetiboya Жыл бұрын

I ordered MB based on this video (been watching this channel for 2 years and greatly appreciate all your content!). Today is day 2 and I am blown away at how much better I feel. I was diagnosed with fibro, asthma, etc decades ago...I can think clearly without coffee jitters, my pain level has dropped dramatically and I finally don't feel like I have the flu 24/7. This is amazing! Thank you so much for sharing this information. I would never have learned about MB if you hadn't discussed it! You are greatly appreciated.

@dporrasxtremeLS3 Жыл бұрын

@Ahmed N Keep in touch with your progress. Thanks.

@kusamagaming7375 Жыл бұрын

@Ahmed N I am on 360 mg daily and perfectly fine I reversed my chronic fatigue syndrome, ibs, fibro I am now restored after approxiemntly 3 months I did feel the effects within a week and gradually it went better and better I have so much more energy in gym also as before I was slammed like by a bus!

@gordongroves8519 Жыл бұрын

@@kusamagaming7375 that's a monster dose without getting a herx reaction. You're a champ!

@engineeritt2206 Жыл бұрын

@Ahmed N if liquid start with 2 drops twice a day then build up based on how you feel

@johnmachter40 Жыл бұрын

@@kusamagaming7375no sideeffects?

@randallhesse5011 Жыл бұрын

I'm here just re-researching methylene blue. I thought I remembered that this is the compound to give quickly after having a brain injury to keep the brains ability to recover. I was right, this is the compound every soldier in war should have on hand for his fellow man/ or woman.

@Grace-Upon-Grace Жыл бұрын

Agree for acute brain injury. Dr Been did not give suggested dose for that- only for continuous low dose (5mg once or twice a day). Could you suggest for immediate ischemic stroke?

@randallhesse5011 Жыл бұрын

Good question. That was one of questions I had myself. I never finished my research to find out dosage immediately after a stroke or tromatic brain injury. I would suggest researching this question on the internet, I'd ask for nih (national institute of health) sources.

@philliplamberth4075 Жыл бұрын

Great idea

@randallhesse5011 11 ай бұрын

@@user-ju5rn1pm3h Yes, I believe so. Methylene blue is also good for lots of things at all times. Mitochondrial biogenesis comes to mind. Adenine tryphosphate, AMPK pathways also comes to mind. My mind is a bit foggy right now. You might want to research the drug Etanercept for stroke recovery as well. For microglial and Neuron Neuro genesis look into polygala tenuifolia (he shou wu), polygonum multiflorum (yuan zhi) , passion fruit seeds, cats claw, etc. Their are a few.

@ChristianAffirmation 10 ай бұрын

Their is research that showed a dosage of 16mg everyday helped patients with Alzheimer’s show cognitive impairments per Mark Sloan.

@michelemcneill3652 Жыл бұрын

I have ME and normally get sick all the time. I've been on methylene blue for about 3 months and haven't been sick once.

@user-mn1ql6ky4x Ай бұрын

What is ME and thank you fir your comment

@4406bbldb 4 ай бұрын

I’m 76 now and also vary healthy but 6 years ago I was a metabolic disaster. Now I have even started driving again I stopped 5 years ago to be safe. Been doing low dose MB and my mood and cognitive function is vary improved. There’s more but Mb matters.

@antjeschwarz7874 2 ай бұрын

Great ❤ I'm really impressed ❤ Would you please tell more? What dosage did you take? What else did you do? ❤ from Germany

@hondablack1 11 ай бұрын

As I understand it, one can have a lot of underperforming neurons. If one takes MB , it can 'recharge' those cells, resulting in increased ATP output. Hence reconditioning old brain cells. As I have been suffering from Lyme disease and probably missing a lot of mitochondrial function, I have just ordered some Methylene Blue to experiment. Wish me luck people.

@sansanmatahari36 10 ай бұрын

So.. how it works on your body? getting better?

@hondablack1 10 ай бұрын

Yes. So far, so good. I am experiencing improvements. Unfortunately, I have been knocked back by a fall, resulting in a broken arm. Therefore I am in a lot of pain which sort of muddies the effect of the MB. I'll know better when my arm heals. Basically I am hoping that my balance will be improved. I think that I fell due to poor balance due to the neurological damage to my system, caused by Lyme disease.@@sansanmatahari36

@lauraa2877 10 ай бұрын

Hi, also have Lyme disease and was wondering how MB was working for you?

@hondablack1 10 ай бұрын

Hi Laura, Yes definitely helping. Not sure how things will work out. I need to recover from a broken arm that I encountered at the start of July. Lot of pain you understand. However I think I will be a lot better after recovering from this. I won't know until afterwards, obviously but have high hopes. I am also taking Ivermectin which I know is helping me. I could not walk properly, two years ago, now I can. Lyme is a horrible horrible thing that I have suffered from all my life. People cannot appreciate what we have to endure. I think MB is a help. @@lauraa2877

@darkfieldcarnivore3928 9 ай бұрын

It will bypass a dysfunctional component of energy production in mitochondria. However, it doesn't fix this issue. Lyme is a microbial issue of which MB will kill.

@risecopeman5409 Жыл бұрын

CELEBRATING!! Thanks to people like DrBeen, the commenter's input, the doctors and researchers that have kept open minds, and other high quality youtubers exercising freedom of thought and speech.... MY DAUGHTER'S BLOOD PRESSURE AND HEART RATE ARE NORMAL UPON STANDING THIS MORDING!!!!! I couldn't have figured out what to try or who to work with if it hadn't been for all of you. We will probably never meet, but I am thanking God for each one of you. This horrible thing may not be over, but we are getting there! THANK YOU AL! Thank you especially, DrBeen, for info about FLCCC, Dr. Patterson. Just responding to me helped me not give up even in my worst moments of a heart broken mom.

@arnyarny77 Жыл бұрын

Xan you elaborate? Did methelene blue help with your daughters blood pressure?

@micaonyx5301 9 ай бұрын

She might also benefit from vitamin B1 as well. Watch Elliott Overton eonutrictio on the benefits of B1.

@risecopeman5409 9 ай бұрын

@@micaonyx5301 Your reply is such a confirmation! I have a milder case of long covid and heard about B1 by reading a comment on a DrBeen video. I researched a bit more, especially EO Nutrition, and tried it myself with very good results. My daughter's recovery has had several significant crashes and she is going backwards fast at this moment. I just saw an FLCCC video about sepsis and post sepsis. The protocol includes IV vitamin C and THIAMIN to fix a disregulated immune system and to help the mitochondria. Over the last two days I have deep dived into thiamin research again, and watched newer EO Nutrition videos. Now I have to help my daughter see and understand. She is so discouraged and fatalistic at this point. It is hard to help her without getting into weird relationship zone. She must take ownership of her recovery. Thank you so much for your reply.

@juliafisherlmmortalbeauty9119 Жыл бұрын

I almost stopped taking MB as l have read that it is direct NO blocker. After watching this l have learned it is actually the the opposite!! U are so knowledgeable! I love the way u explain everything in a way l can absorb the amazing knowledge and information that u share! Thank u! Xxx 😊💖 xxx

@GoldenBlaisdale Жыл бұрын

I know this is my third comment, and I apologise if it’s annoying, but another really important thing to take into account is the purity of the MB: There are three different grades of methylene blue: Industrial grade - used to dye fabric Chemical grade - used in laboratory experiments Pharmaceutical grade - used to treat methemoglobinemia, urinary tract infections, overdoses, and considered safe for human use. By the way, the methionine blue that you will find in fish shops for treating fish diseases is not pharmaceutical grade.

@skybox-101 Жыл бұрын

Do you have link to correct MB?

@thorinoakenshield5601 Жыл бұрын

DrB covered pharmacy grade options at the beginning of this video. He’s the best!

@tzvetadaskalova9257 Жыл бұрын

Would you recommend a good quality pharma brand MB?

@GoldenBlaisdale Жыл бұрын

@@tzvetadaskalova9257 I think Dr B showed them at the start of the video. I live in the U.K. I didn’t get mine online

@thorinoakenshield5601 Жыл бұрын

I use Biopharm Inc out of Arkansas. 1% USP grade and purchased through Amazon. I’m sure the also have a website directly but haven’t looked.

@MarcusAurelius33036 Жыл бұрын

I love your sense of humor in selling access to your lectures. 1/2 the price of a bottle of MB!!!!

@donnafraenkel7852 8 ай бұрын

Can't recommend this enough ❤i give it to my dog in her water (micro dosing) and her health is back to being like a puppy. She's hipermobile and her joints and bones are very fragile, and since taking it,she not showing signs of any pain or discomfort, and her coat condition has improved. She also has teeth issues and bad breath which has almost disappeared

@lindamalee7902 8 ай бұрын

Can you tell me how you add it? Approximately the amount of water and MB per day? :)

@donnafraenkel7852 8 ай бұрын

@@lindamalee7902 I was just dabbing my finger on it and putting it in the bowl,so the water was just a pale blue and every second refresh was pure water. We also have a mesquito problem and birds drinking from the bowls so it's good for keeping still water clean

@lindamalee7902 8 ай бұрын

@@donnafraenkel7852 Very helpful, thank you! I’m only starting to research, and yours is the first comment I’ve seen about it benefitting your dog.

@donnafraenkel7852 8 ай бұрын

@@lindamalee7902 it's pretty amazing because we have so many parasites and worms which affect dogs on the street and it's rotated because of wildlife and nature so I found that animal sanctuaries and places housing animals should also treat their waters, especially ground water and still water that's sitting

@mikeward9870 Жыл бұрын

Impressive: prevents neural apoptosis, protects mitocondria, and activates neural autophagy (perhaps in other cells too)! (May the force be with you. ;^)

@miriaml.150 Жыл бұрын

Thank you for this fantastic explanation of the mechanism of methylene blue! I agree that every emergency medical professional needs to have a vial of this ready to go. It's not a questionable treatment! And as long as the doses are low enough there would be very small number of times when it wouldn't be safe. I started out in healthcare in 1982 and have learned that mainstream medicine has its benefits, but it certainly has many limitations. I'm not aware of any pharmaceutical that can do this. We all know why that is. I'm talking about there being no profits in it. But that doesn't translate into meaning that there is no use for it because it is astonishing what it can do! I recently stumbled on it looking for something else, as often happens. I decided to use myself as a guinea pig because I have some conditions that I felt it might improve. I don't believe it was wishful thinking when I say that's after one dose got my thinking felt much clearer. As I continue to just take small doses my clear-thinking has persisted! That's saying a lot because I have had depression and anxiety for about as long as I have been a healthcare professional. And I have been willing to try almost anything including clinical ketamine IV treatments which didn't help me at all. That should tell you how desperate I've been. I'm going to kiss my bottle of methylene blue as you jokingly mentioned! Thank goodness it's not a joke. 🎉

@LisaMeCandyMinistry 8 ай бұрын

We have been researching MB for Lupus and auto immune anxiety .. started a low dose once and sometimes twice a day .. no side effects . But noticeable clarity from Lupus brain fog... I am excited. Multiple Dr's and medications.. I do feel a difference .. as we keep exploring I plan to get my Dr's on board to help monitor dosage & bloodwook .. Effects don't seem to last long.. I guess because using such a low dose.. I am pleased .. I want off all pharma medications This MB seems to make this a possibility and no Dr ever mentioned .. I will receive healing Thank you Dr Been

@ketherwhale6126 11 ай бұрын

Methelyne Blue could be used in Sepsis. It works with Alzheimer’s and has probably the capability to help in Parkinson’s like Michael J. Fox.

@donnafraenkel7852 8 ай бұрын

It did as I used it this way and it worked

@user-mn1ql6ky4x Ай бұрын

@@donnafraenkel7852hi. Can you explain details of how it helped you.

@nobodynothing2594 Ай бұрын

@@donnafraenkel7852did you take it for Parkinson’s or Alzheimer’s?

@nobodynothing2594 Ай бұрын

@@donnafraenkel7852and at what daily doses & after how log before you found results? My friend’s mother 73yrs old has Parkinson’s & want to help.

@donnafraenkel7852 Ай бұрын

@@nobodynothing2594 I used it for a torn Auric field.i noticed significant improvement in overall health but I don't have either I have autism so it greatly improved my memory, physical improvement and consciousness awareness, without a doubt

@fragranthills 11 ай бұрын

Your videos are priceless, like a Stradivarius. Your drawings make your comments understandable to non-physicians. I, therefore, bought your lifetime membership and I bought pharmaceutical grade MB. I addition, I bought one for each vehicle in my family.

@kennethbeal Жыл бұрын

Thank you! Today is day 2. Brain fog lifting, it's wonderful!

@michellewahl4756 Жыл бұрын

Glad you took four days off. Glad to see you again love this lecture. Thank you Dr. Mobeen.

@Storm_Lily Жыл бұрын

This is such a beautiful video! I've watched SO MANY MB videos, and this one is easily the best. Thank you!

@michelemcneill3652 Жыл бұрын

I have ME/CFS and started Methylene blue 2 weeks ago. I have more energy, less brain fog. I take 3 drops =1 1/2mg in morning, 2 drops at noon and 1 or 2 drops in the evening. I'm sleeping better than I have for years.

@drgamzegungor Жыл бұрын

whıch MB you buy.ay want to buy MB ,but whıch one correct form

@RvP6384 Жыл бұрын

26:15 love the way he explains complex things!!

@ms_amanda2714 Жыл бұрын

Thank you 💚 I am starting this today with my flccc protocol for my v. Injury 🤞🤞🤞🤞

@Userxyz-z2d Жыл бұрын

And what hav your results been?

@leifkring6346 Жыл бұрын

How has it worked for you?

@Userxyz-z2d Жыл бұрын

Ive been using MB for over a month & hav not noticed any changes.

@BeYourUniquePotential Жыл бұрын

Hello Dr Been, I love your teaching style. I’ve been taking MB for two weeks now after having a suspected tia/Bell’s palsy last year. I sleep do my well and I feel so much clearer in my mind. Thank you ❤

@mehmetcakir4231 9 ай бұрын

I have just discovered Dr Ben’s channel and he is one of the best presenters that have come across in KZfaq or elsewhere. Fantastic way of explaining how MB works in action and other mechanisms in and around mitochondria. Thank you for your work

@totallyautonomous 10 ай бұрын

🎯 Key Takeaways for quick navigation: 00:13 ⚠️ Dr. Mobeen discusses methylene blue side effects, contraindications, and cautions - important to review before considering use. 05:14 🧠 In ischemic brain injury, methylene blue interferes with p53 activation which reduces apoptosis, providing neuroprotection. 08:58 🧹 It also enhances autophagy, helping clean up cellular debris in injured neurons. 15:08 🩺 The study authors suggest emergency responders could administer methylene blue on-site to protect more acute stroke patients. 23:16 🔋 As an electron cycler, methylene blue can kickstart dysfunctional mitochondria in ischemic tissues by donating and accepting electrons. 29:32 💊 This makes it an antioxidant, anti-inflammatory, energy enhancer, and nitric oxide producer, conferring neuroprotection through multiple mechanisms. 36:13 📝 In summary, low dose methylene blue may help rehabilitate mitochondria, reduce apoptosis, trigger autophagy, and protect tissues in various conditions.

@joeboxter3635 5 ай бұрын

You know all channels should have this sort of summary. I would subscribe to them just because they added this kind of thing!!!

@GoldenBlaisdale Жыл бұрын

I’ve been taking it for a couple of months every day and it’s really made me feel wide-awake and in a happy mood. I did a lot of research, and you have to be careful that you’re taking pharmaceutical grade. I also did a lot of listening and reading around the research of Dr Gonzalez-Lima, one of the main researchers in this area and he has published many of the papers. I heard him mention that when they use it in research, they mix it with ascorbic acid. This helps the absorption because before the body can absorb it, it has to reduce it to leucomethylene blue, and ascorbic acid will reduce it. I wrote to him and he confirmed this to me. (Kind) The other benefit of adding ascorbic acid is that it takes out the dark blue colour which can make your tongue and mouth and teeth go blue. And it takes away a lot of the bitter taste methylene blue is extremely bitter. It does make your urine range from very blue to very green. At first this is disconcerting.

@ms_amanda2714 Жыл бұрын

Thank you! I just took my first drop today, will for sure be adding some ascorbic acid!

@GoldenBlaisdale Жыл бұрын

@@ms_amanda2714 great, as a clarification, the body will do the reduction process itself, apparently so you don’t have to add the ascorbic acid, but by adding it, it makes it much more easily absorbable and has the benefits I mentioned.

@reliableandrew Жыл бұрын

@@GoldenBlaisdale Always good to hear a positive testimonial of MB. What dosage have you taken over the last 2 months?…a drop a day?

@ms_amanda2714 Жыл бұрын

@@GoldenBlaisdale thank you! I was wondering how many months I would have to have a blue tongue for, very timely info

@GoldenBlaisdale Жыл бұрын

@@reliableandrew actually no. I ‘discovered’ MB a while ago but was a bit afraid so did a lot of reading. I’m not suggesting that you do this by the way, but from my reading a very safe, starting dose is actually 10 drops twice a day, and that is what I did, mixed with ascorbic acid. I am now taking as we speak, 25 drops in one dose. I think Dr been mentioned something different, and I have not looked this up again but my understanding is the half life of methylene blue is 12 hours. Therefore if you want to keep the same amount in you should dose it twice a day I have to say it appears true because at about the 12 hour point my urine is becoming more normal coloured. PS the drops are based on 1% solution so each drop contains 0.5mg of methylene blue.

@keithnorris6348 Жыл бұрын

Fantastic painting and brilliant info thanks very much.

@GoldenBlaisdale Жыл бұрын

I made a post that I am taking methylene blue and finding it very helpful. There is something that I don’t think was mentioned strongly, apparently from what I have read taking overly high doses can be dangerous even fatal. The low dose, therapeutic affect are exactly that they are found in low-dose. “Methylene blue exhibits very different effects at low doses than it does at high doses. They call this a ‘hormetic dose response,’ where the effects of a low dose are the opposite than at a high dose. “Methylene blue is a safe drug when used in therapeutic doses (

@jules9465 Жыл бұрын

Was there any data on how long someone would take at a low dose?

@Userxyz-z2d Жыл бұрын

Been taking low dose (20 drops per day) and higher dose (100 drops per day), I might as well be taking water. No benefit at all. I hav major inflammation & it doesnt touch it at all. I have CFS, IBS & asthma too- nothing. If anything my breathing worsened on MB. I even bot the powder & mixed it myself thinking the prev (USP) MB i bot mite hav been Mixed wrong altho it stated 1%. High dose herbs do wonders for my inflammation so I was hoping MB was everything these YT drs say it is. Nope.

@vladmirgolobovic518 Жыл бұрын

What substance exactly is NOT fatal when taking in overly high doses? That applies to everything.

@johnmachter40 Жыл бұрын

@@Userxyz-z2dwhich herbs do you take?

@Grace-Upon-Grace Жыл бұрын

Excellent!

@jamesmacdonald5556 6 ай бұрын

I totally agree with others I felt much better, better focus and good mood although even medical grade has trace heavy metals (just barely measurable). When I'm on this stuff even talking to my ex-wife would not piss me off but look at the research on L-threonate (type of magnesium that can pass the blood-brain barrier). This stuff is legal? Gives me a overwhelming feeling of well-being and focus.

@kathyirwin5518 Жыл бұрын

Dr. bean, you are an amazing artist!!! This is also a very interesting topic, thank you.❤

@robertcarter6887 Жыл бұрын

Love your info Dr. Been

@vessietaylor Жыл бұрын

I'm amazed... Thank you 😊 I love your channel.

@earthsoulart 11 ай бұрын

Can dogs take it? My dog just had a stroke. Would it help her?

@philliplamberth4075 Жыл бұрын

Thank you Dr. Been

@NelaCopey2959 Жыл бұрын

Thank you, Dr. Been - you are the best! Methylene Blue Forever in my pocket!

@spanglestein66 6 ай бұрын

I’ve been talking 4mg … 8x 0.5ml drops in a 1/2 a glass of water in the morning on a empty stomach In the morning just before I walk my dogs It most definitely works . It’s quite amazing, energy and focus. A subtle yet undeniable effect. It takes 25-30 for me to notice that it is working If you need a burst of energy and focus… then this is it ❤

@PhilipRawbon-rk8uv 9 ай бұрын

Now this is a real eye opener!!..love it..i'm getting some!

@reg4211 Жыл бұрын

Always been interested in methylene blue as a preventative for acute vasospasm post aneurysm repair.

@awesometulips9427 11 ай бұрын

19:00 how cell autophagy works, role of insulin etc

@TraversFlynn Жыл бұрын

Thank You !!!

@DrHughWegwerth Жыл бұрын

Great lecture Doc!

@janemerrittmckenna2386 Жыл бұрын

Great info!

@Total_Body_Fitness_USA Жыл бұрын

I always thought that MB inhibited NO which is why it is protective in ischemic stroke due to vasoconstriction and increasing BP? Here is an paragraph from a study I found. Nitric oxide generation during ischemia and reperfusion plays a significant role in ischemic and reperfusion injury.[56] There is evidence that MB decreases or inhibits nitric oxide generation that might have the potential effect of neuroprotection in ischemia/reperfusion injury. In order to prove that the endocardial endothelium of Rana esculenta produces an amount of nitric oxide that is sufficient to modulate ventricular performance, Sys et al. measured the changes of stroke volume (as a measure of performance in paced frog hearts) and stroke work (as an index of systolic function) after using MB-induced inhibition of nitric oxide synthase.[43] This reminded us that MB could inhibit nitric oxide generation. Evgenov et al. found that continuous infusion of MB counteracted the early myocardial dysfunction and derangement of hemodynamics and gas exchange by the inhibition of nitric oxide pathway in ovine endotoxemia model.

@dolarrius 18 күн бұрын

I'm so confused so is it increasing or decreasing 🤦‍♂️

@jolantawozniak2132 11 күн бұрын

According to “ The Ultimate Guide To Methylene Blue” by Mark Sloan, methylene blue is the nitric oxide inhibitor. I was in shock that the informations about nitric oxide are focusing on vasodilation, but not on paradox involved with this phenomenon. In small amounts, the vasodilatory effects of nitric oxide can be beneficial. In excess, it can be causative of a whole host of disorders and pathologies. I am glad I purchased the book. Nitric oxide is the body’s backup mechanism for dilating blood vessels during stress.

@ildikosowinski5708 7 ай бұрын

Great presentation !

@2011crackers Жыл бұрын

Very important there can be serious side affects with MB and anti-depressants be careful check with yr doctor firdt

@nobodyhere2820 Жыл бұрын

It leaves the body in 5 hours but accumulate as well with the half-life. What is accumulating? What does accumulating mean? Are there any harmful substances in it that accumulate? Where may this accumulation occur in the body? 40% excreted through urine. Please detail the remaining 60%. Great informative talk! Thank You.

@szymonbaranowski8184 Жыл бұрын

be more mindful about this 40% going through kidneys I guess

@johnmachter40 Жыл бұрын

well 60% are used up by the body i guess

@danatalia714 Жыл бұрын

I listened to the video - judging by the mechanism proposed in this video, wouldn't methylene blue also help the heart during ischemic lesions? That could be, in principle, the same pathway.

@skybox-101 Жыл бұрын

Wow! That would be amazing.

@geoattoronto Жыл бұрын

Good point. Anything that helps the cell use oxygen protects against heart attack. Great deduction!

@JennySimon206 Жыл бұрын

Omg your painting is amazing.

@sarojtampira632 Жыл бұрын

Thanks!

@SuperFrankieKimm 2 ай бұрын

thank you so much, dr. been. I'm beginning a protocol that includes methylene blue - to see if I can finally overcome the CFS I've been living with since the spike protein entered our lives. feeling a bit of hope...again.

@renwickconolly2839 Жыл бұрын

I remember reading many years ago that...cannabis that contains THC was also known to be neuron sparing in situations that involved a disruption in oxygen.

@jazzmoon77 11 ай бұрын

There was a study done by an Israeli university on cannabis for protection following a stroke. That was late 90s so I’m sure there are many others since.

@janemerrittmckenna2386 2 ай бұрын

Love your art!

@raytrack3552 10 ай бұрын

Wow!!! This shish is amazing!!!!

@scarsdog777 Жыл бұрын

Fascinating

@carloscarion1748 Жыл бұрын

I just fell in love with you. Very very informative wonderful video, thank you

@janemerrittmckenna2386 2 ай бұрын

Thank you

@horstraedel9010 6 ай бұрын

Thanks!❤

@davepeterschmidt5818 Жыл бұрын

Methylene Blue stops mtor? I didn't know that. That concerns me, particularly for older folks for whom sarcopenia (muscle loss) is an issue. Mtor is what builds muscle. There has to be a balance where mtor is activated. Knowing this, I think I'm going to change the way I take MB. Instead of taking it every day, i think I'm going to take it intermittently, perhaps 3 days every two weeks to kick myself into increased autophagy for a period of time. Then stop so mtor can resume normally for the next 10 days.

@johnmachter40 Жыл бұрын

good idea.

@Grace-Upon-Grace Жыл бұрын

Dr Been - FLCCC recommends to take one day off every six days. Prob good for kidneys to give a break as well.

@francisbertolini2538 Жыл бұрын

Wonderful information. The more I know the less I know. Thank you Dr. Been.

@amiedelapena4108 4 ай бұрын

Started using MB as strips just put on tongue and absorbed

@githasingh9010 Жыл бұрын

Thank u so much Dr Been God bless u i just love easy natural medicine

@johnmachter40 Жыл бұрын

MB is in no way natural.

@jazzsnare Жыл бұрын

So it sounds like this should only be used when having a TIA or outright stroke? Does it make sense to take it just due to aging, and if so, how much? Would it be useful during a heart attack or only stroke? Did he say at the end that this would help all cells, not just neurons? Why does he say to use 5 mg per day, whereas most advocates say that a small dose is actually 5 mg. per Kg, which would mean 77 mg. per day for a 170 pound man? That is considered a low dose by Dr. Gonzalez-Lima, one of the foremost researchers on MB? Are we sating that MB helps only when the electron chain is dysfunctional (say, due to TIA), or that it is helpful even in the absence of cellular, electron-chain insult?

@Grace-Upon-Grace Жыл бұрын

Jazz Dr Gonzalez says 0.5 to 1 mg per kg. Not 5 mg/kg. He said 4mg/kg would be highest for low dose use.

@gloryrow100 4 ай бұрын

The notion that our cells ,so complex created themselves from muck is absurd!

@Grace-Upon-Grace Жыл бұрын

Could someone say how much to take for immediately after a stroke- not for chronic use? Thank you.

@meowashley7979 Жыл бұрын

I love it

@jonesywails8382 Жыл бұрын

I’m currently taking 3mg or 6 drops of .05% twice a day. Total 6mg daily. A relatively low dose, or average from the video. I am 64 and weigh 160lbs. How will this affect nitric oxide levels, since those are supposed to be good for dilation of blood vessels? Is this considered a negative effect? Thank you.

@paulbork7647 Жыл бұрын

Thanks Mobeen. It seems that this applies to neurons through the body and not just the brain. It seems long term use of methylene blue can cause problems with inappropriate prevention of cell deaths, such as during infections. Thanks again for the fine video and teaching.

@ovidiudrobota2182 Жыл бұрын

If taken in high doses, right? If you take lower doses long-term, it doesn't cause problems I guess.

@kusamagaming7375 Жыл бұрын

I disagree my friend is sucessful businessman and it was he who introduced me to it, he used to suffer with cfs/me but found that MB, cordyceps, sulbutiamine and ozone terapy did wonders for him to recover, MB is on he's number one list since, he's been on it for years without side effects, if you suffer with CFS your life is hell!

@valeriecuan4189 Жыл бұрын

How do I get ozone therapy and how much MB?

@kusamagaming7375 Жыл бұрын

@@valeriecuan4189 depends where you live normally in us and Canada is around 200 for s session in EU is anything between 50/150

@christinewoodland5127 Жыл бұрын

@@valeriecuan4189 do an internet search for functional medicine doctors that offer ozone therapy

@Exodus26.13Pi 10 ай бұрын

From elite athlete to dying of obesity BACK to real health. Below is my life's work distilled. 🎉 Recovery: Inclined Sleep Therapy is free & an ancient practice CPAP Exercise: *Rebounder* proven in the 1970s as the most efficient exercise still. Unique health benefits. Food: Lean poultry, onions, & sweet potatoes replace unhealthy calories Dentist gum cleaning Supplements: Threonate magnesium, vit.D, creatine, taurine, NAC, *methylene blue-not w/ ssri, & fibers TENS for vagus nerve

@bonniedavis9076 10 ай бұрын

If MB cleansing cells, is it helpful to clear our gout crystals?

@elisabethlavoie7655 Жыл бұрын

Would that protect other ischemic events like acute myocardial ischemia for example?

@geoattoronto Жыл бұрын

Of course it would, from better use of oxygen.

@leifkring6346 Жыл бұрын

Spike protein will likely be causing a dementia explosion in elderly, which we already can see signs of. Can Methylene Blue help with detoxification of SP and restoration of circulation and mitochondrial function in the brain?

@jsanders9975 Жыл бұрын

Not sure, but a lady in the comment section said it cured her MS.

@gg-wk2ww 10 ай бұрын

Nattokinase and ivm destroy sp ,either and both

@marksimons4108 8 ай бұрын

@@jsanders9975which one?

@coopercooper8406 9 ай бұрын

What about MB depleting nitric oxide?

@andrewfinlay5160 Жыл бұрын

I believe metformin also activates P-53...

@samwuzzy 6 ай бұрын

Don't forget to earth with Methylene Blue.

@annadrozhinski4410 Жыл бұрын

Hi Dr been. Thank you so much for all the incredible information you give. About the low dose orally, it's 5ml of 1% solution?

@johnmachter40 Жыл бұрын

5mg

@hondablack1 10 ай бұрын

5ml of solution would provide 50mg of MB

@evanlfishbein439 5 ай бұрын

Is not cellular apotposis beneficial some of the time? I though this is why people recommend fasting (ie 24-48 hours) -- in order to get rid of poorly functioning cells.

@topfingers Жыл бұрын

Would it be safe to combine low-dose MB with other autophagy-promoting mechanisms (such as intermittent fasting and/or low-dose rapamycin and/or fisetin)? Would it render any of these superfluous?

@Grace-Upon-Grace Жыл бұрын

Idk about rapamycin, fisetin, but MB both accepts and donates electrons. Do they also do that?

@topfingers Жыл бұрын

@@Grace-Upon-Grace Rapamycin seems to do its thing through mTor inhibition; I'm not sure what the mechanism is for fisetin. Generally, there seem to be multiple paths and dependencies, so causes and effects are difficult to understand or predict.

@billgardiner8396 5 ай бұрын

What is the role of diertary organic sulfur substrates such as onions, garlic, turmeric in supporting MB activity? ( I prepare leuco-MB and dose fasting at 2 mg/kg of gross body weight). I noticed on a day adding back those items to my diet, among others, reduced overnight water productuon and improved sleep

@redcairox6374 Жыл бұрын

Doctor it would be great if you would lend your support to some brands or options for MB as amazon options have both "saved me" and "this is not for humans it hurt me" reviews on so many things!

@mjmeans7983 Жыл бұрын

Maybe I missed something. The study says MB was given by IV to the animals at 1mg/kg. What would the dosage be if given orally instead of by IV to achieve the same blood concentration?

@celtickitc Жыл бұрын

Start low first 5 days then move up gradually. We're using:. 0.5 ml of 1% solution twice a day

@gita2000n 5 ай бұрын

I read an article that BM is killing E-Colie bacteria In UTI. I have suffered for years from UTI . I am going to try. I will let you know the result.

@user-mn1ql6ky4x Ай бұрын

How did it work out

@CJ-lj9fb 11 ай бұрын

Does adding vitamin C to the water to counteract the staining decrease or modify the efficacy of the methylene blue?

@aurasensor 10 ай бұрын

Vitamin C is removing the blue colour. Supposedly works just as well. I don't know studies that prove this though.

@mirellasa4949 5 ай бұрын

My same question. 🤔

@c.holman739 Жыл бұрын

Thank you Dr Been....I keep reading that MB is suppose to limit or stop NO production or keeps NO from being produced too much or something like that. Is that true?

@Grace-Upon-Grace Жыл бұрын

C Holman methylene blue helps with needed nitric oxide (donates electron to Cytochrome C oxidase 4), BUT it also accepts an electron if inducible nitric oxide synthase is too high (self induced -iNOS). I may not be explaining it the best, but it helps if not enough and if too much in our cells.

@DanielleLegacy Жыл бұрын

Is it better than triggering autophagy through fasting?

@danielstapler4315 11 ай бұрын

You could do both.

@user-xp3yy9yu6q 10 ай бұрын

Does methylene blue help treat panic attacks and extreme fear?

@ericmaclaurin8525 Жыл бұрын

So, an electron buffer like bone is for PH?

@hiris1903 Жыл бұрын

Would this be useful for a brain bleed as well, or just ischemia?

@musimedmusi8736 Жыл бұрын

Brain bleed causes cell damage, no? The pressure from the blood, i.e., hematoma, exerts pressure on blood vessels, restricting blood flow, i.e., ischemia, as well, does it not? So, wouldn’t MB be helpful in brain bleed as well?

@hiris1903 Жыл бұрын

@@musimedmusi8736 I don't think MB is okay if the bleed is active, because the nitric oxide release would dilate vessels and increase bleeding. If the bleed has stopped it should be okay. In an emergency situation it is hard to know if a stroke is just a TIA, a larger blockage, or a bleed. So maybe a scan is needed first, but of course that causes a delay in treatment. Maybe if blood pressure is not high you can assume it's ischemia and give MB, but I'm not sure.

@sylibb 9 ай бұрын

Great vid thanks. I have bought 1% solution. It says 5 to 10 drops twice per day but I can't work out to just drop it in my mouth or do I dilute it in water?

@csb1143 4 ай бұрын

Put in a small amount of water. Start slow and work up

@fionmor4893 11 ай бұрын

I'm wondering if MB should be taken with or without food?

@marksimons4108 8 ай бұрын

Take it with a tea spoon of olive oil as it absorbs better with fats!

@TJ-jq9bz Жыл бұрын

How much should I take?

@JTDesign1 Жыл бұрын

Dr I have a spinal cord injury between T2-T5 as a lesion caused by one acute attack known as Transverse Myelitis. I'm in chronic pain and constant fatigue. My doctors got me on Gabapentin and then Duloxetine (SRNI) all for pain. It is not working. I'd like to ween off of them, and I'm curious about the mechanism of Methylene Blue versus my current cocktail. The impact of methylene blue on neurotransmitter levels is multifaceted. While it can inhibit the breakdown of serotonin and norepinephrine by inhibiting MAO, it can also have other effects that modulate neurotransmitter activity. For example, methylene blue has been shown to interact with various receptors and enzymes involved in neurotransmitter regulation, which can influence their overall levels and activity. Do you think it is fair to extrapolate that MB use, while reducing my fatigue, MIGHT also reduce this false pain signal I'm getting from my lesion site?

@geoattoronto Жыл бұрын

Try it. It is very safe and effective. Let us know.

@JTDesign1 Жыл бұрын

@@geoattoronto Been taking 15 drops for a little over a week with some fatigue relief, but no noticable pain reduction. But overall, I cannot see any reason not to keep taking it as long as it does not mess with my gut biome.

@drgamzegungor Жыл бұрын

Hi DR Been,I'm a doctor from TURKEY,Ilisten your videos always and want to listen your lectures .what must I do for this

@cigdemdurucan2399 4 ай бұрын

Mrb hocam

@joprocter4573 9 ай бұрын

How or where do you buy it from please?

@curlyhairdudeify 6 ай бұрын

I take fish grande methylene blue it is safe for wounded fish, their delicate eggs, and baby fish. So it is safe enough for me take. I find it cheaper than human marketed methylene blue. And I do feel good after taking it.

@kdccmb 6 ай бұрын

No, it has heavy metals & other contaminates. Use only 99% purity pharmaceutical grade.

@dellassociates8431 23 күн бұрын

It's only advice for humans to take the pharmaceutical grade. That form of methylene blue is not suitable for human consumption.

@dennismixon9028 8 ай бұрын

What grade of Methylene Blue to you sale? Do you offer Reagent grade or ACS grade? Thank you for your time.

@Davidinski Жыл бұрын

Is this part 2? Did I miss something? How about a short explanation of what it's for before discussing side effects.

@etherealmeals 2 ай бұрын

I live in Denmark and med approach here is quite conservative. I take semaglutide for type 2 diabetes and gabapentine for post stroke nerve pain. Can I still take a low dose methylene blue?

@chrissy1953 7 ай бұрын

I use drops of MB for depression. It helps a lot but I never know how many drops is best. I’m 120 lbs.

@lafemmekiki 11 ай бұрын

I've been trying to find information (that I can understand) about taking NADH and MB? I'm reluctant to take them on the same day. I haven't come across anything that states a negative interaction with NADH, however, there are medical papers on the effects of MB and NAD/NADH. Just wondering if anyone has an answer for me. Thanks.

@89msjellybean 10 ай бұрын

I still haven’t gotten any information, even after writing to doctors promoting MB and companies that sell NADH. Disappointing.

@1rocknroy 3 ай бұрын

Ask an AI for a well formatted reply.