The following is an interview with Victor A. McKusick, University Professor of Medical Genetics, Johns Hopkins University School of Medicine, Baltimore. The interview was conducted by his student, friend and colleague, Judith G. Hall, Professor of Pediatrics and Medical Genetics at the University of British Columbia, Vancouver. The interview was recorded at the American Society of Human Genetics Annual Meeting at the Millennium Biltmore Hotel in Los Angeles, California on November 4th, 2003.