The following is an interview with Edward B. Lewis, Thomas Hunt Morgan Professor of Biology Emeritus, at the California Institute of Technology. The interview was conducted by his friend and colleague, Elliot Meyerowitz, George W. Beadle Professor of Biology and Chair of the Division of Biology, at the California Institute of Technology. The interview was recorded at the Kerckhoff Library on the Caltech Campus in Pasadena, California, on November 20, 2001.