What are Autoimmune Diseases and How Do They Develop?

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Күн бұрын

What are Autoimmune Diseases? Autoimmune Diseases are caused when the immune system attacks its own cells. This video is about autoimmunity, how autoimmune diseases develop, and the symptoms they cause. Find out how autoimmune antibodies, B-cells and T-cells get made and how they get activated. Autoimmune cells are activated via molecular mimicry, bystander activation and epitope spreading. Persistent infections can increase the stimulation of the immune system over a person's lifetime and increase the chances of activating autoimmune cells.
Autoimmune Diseases can affect one organ, as in Type I Diabetes or many organs, as in Lupus. More than 100 autoimmune disorders affect 5-10% of people worldwide.
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CHAPTERS:
00:00 What is an Autoimmune Disease?
00:13 Types of Autoimmune Disease
00:38 Autoimmune Disease Risk
00:59 Autoimmune Disease Symptoms
01:15 Autoimmune Disease Diagnosis
01:27 Autoantibodies
01:53 Autoimmunity and Immune Tolerance
02:27 Role of Antibodies
02:33 B-Cell Development
03:14 T-cell Development
04:04 Activation of Autoreactive B & T-Cells
04:10 Molecular Mimicry
04:35 Bystander Activation
05:11 Epitope Spread
06:40 Viral Persistence
06:59 Symptoms Depend on Target Antigen
07:79 Autoimmune Disease Treatment
#ClevaLab #autoimmunedisease #autoimmunediseases

Пікірлер: 60

@ClevaLab 2 жыл бұрын

*Welcome to ClevaLab* - if you like the video, please give it a 👍and subscribe for more videos. Also, if you have any questions, feel free to ask in the comments. Get a *PDF Summary* of this video here: www.clevalab.com/post/what-are-autoimmune-diseases

@cozstar11 2 ай бұрын

If the definition of immune is to be "totally or partially resistant to a particular infectious disease or pathogen" Auto-immune disease seems like a misleading name, why not call it an immune system disorder or ISD?

@lauralott2741 6 ай бұрын

I have multiple autoimmune disorders. Mine started after I had severe influenza and I got another one after I caught Parvo virus B19. My son’s autoimmune was triggered by severe influenza. My brotherinlaw developed type 1 diabetes after he had measles. In my family the trigger seems to be viruses, with a genetic predisposition.

@ClevaLab 5 ай бұрын

Thanks for your comment. I'm sorry to hear that. That's interesting, I'm sure there's a scientist out there who would like to study your family! 🤓

@SureshKumar-gc8rl Жыл бұрын

Such a beautiful explanation. GREAT!!!!!

@ClevaLab Жыл бұрын

Thanks for your nice comment. 🤓 I'm glad you liked it.

@stefani8156 Ай бұрын

Thank you so much for this video! I have an autoimmune disease and this video helps me understand what’s going on.

@ClevaLab Ай бұрын

Thanks for your comment. 🤓

@wakesurfsnow Жыл бұрын

Helpful video! I have a question: I know a number of people who put their autoimmune conditions into remission (& were able to stop medications) with a whole-food plant-based diet. One such person is my cousin. She had severe lupus, but she switched to this way of eating and after 6 months, had negative blood work and no symptoms. She’s been in remission for 5 years. She helped a few of her friends and family members too who are also now in remission. Can you please explain how such a diet could achieve this? Like, how/why does the diet stop the autoreactive T or B cells from attacking the body? I imagine it has something to do with bringing inflammation levels down but I don’t understand how that stops the process.

@ClevaLab Жыл бұрын

Thanks for your comment. 🤓 early data suggests that plant-based diets can improve lupus symptoms (www.ncbi.nlm.nih.gov/pmc/articles/PMC8793314/). However, there is little data on complete diet change and no placebo-controlled double bind studies. Also, as Lupus tends to flare up and then go into remission, it's hard to tell if the change in diet was the cause or if they were going to go into remission anyway for a single case. More research needs to be done on how diet plays a role.

@Jhannan0 Жыл бұрын

inversely, the carnivore diet also heals this so its something about the processed food

@tracysmith245 10 ай бұрын

that is what I did i looked up everything food and drink, and all ultra-processed food not good I can't eat them for a calcium problem I have a hypo attack if I eat junk food fizzy drinks candy tea coffee milk cereal because of wheat bread pasta tinned food things like pizza takeaways only have the odd one of them when i do i feel bad for a week i had kidney failure with lupus when I found out about all this is possible to get better very challenging with family not knowing anything about any of this think it's me being funny. Smoking and being Overweight is a factor to can not get vitamin d dark skin no i can not go out much sun exposure in lupus rash hair loss Calcium Pulls Calcium from our bones from storage banks or can build up as horrible kidney stones,

@emujinbayarsaikhan1631 Жыл бұрын

Thank you for your great work ❤

@ClevaLab Жыл бұрын

You're welcome. I'm so happy you liked it. 🤓 Thanks for taking the time to comment. 👍

@khadidja7987 11 ай бұрын

Excellent explanation thank you

@ClevaLab 11 ай бұрын

You are welcome! 🤓 Thanks for taking the time to comment. I'm glad you liked it.

@gru4454 Жыл бұрын

I love your videos this was so so soooo helpful ❤

@ClevaLab Жыл бұрын

Thanks for your comment. 🤓 Is terrific to hear you love the videos. I'm glad they've helped you.

@VizzyInks 9 ай бұрын

AMAZING! Can I ask: how long in history have we as a collective been studying and researching about auto-immune diseases?

@ClevaLab 9 ай бұрын

Thanks for your question. 🤓 I had to google this one! There's a review article on this here: doi.org/10.1002/rai2.12049. A better review is here: doi.org/10.1016/j.autrev.2009.10.007, but is behind a paywall. Paul Ehrlich put forward the idea of autoimmunity and that the body could attack itself in the early 1900s, and initial scientific studies indicated this was correct. But, only a few scientists worked on this theory until the late 1940s. Up to the 1940s, the research focused on the immune system fighting foreign pathogens and allergic reactions. In the late 1940s, hemolytic anemia and lupus were the first autoimmune diseases identified. They were shown to be caused by autoantibodies. It was in the 1960s that the scientific community widely accepted autoimmunity.

@VizzyInks 9 ай бұрын

@@ClevaLab WOW! That is crazy! Thank you for the response. 🤲🏻

@G.I_BRO_SHOW 3 ай бұрын

i read somewhere that autoimmune diseases is connected to vitamin D deficiency and by regular dosage of vitamin D and omega 3 fatty acid help in bringing down autoimmune diseases

@jaysimpson6857 Жыл бұрын

Excellent presentation but diet was considered a culprit for the development of AD at the start but not at the end, anyhow my AD mostly features arthritis, tinnitus and neuropathy which is cured by avoiding wheat, dairy and lectins/nightshades. I often suspect I’m not exceptional because over the years I’ve got to know many people with serious AD classifications and all have always consumed a diet consisting of the best known allergens.

@ClevaLab Жыл бұрын

Thanks for your comment. 🤓 Yes, it's hard to cover everything and still be clear and keep it relatively simple! But, interestingly, there has been a clinical trial that found eliminating meat, lactose (all dairy) and gluten, along with continued drug treatment, reduced pain and inflammation (pubmed.ncbi.nlm.nih.gov/34684536/). So, you are not alone. It's great you could work this out on your own.

@joantrotter3005 4 ай бұрын

@@ClevaLab , I think it's a different trigger for each individual, but food allergies are definitely involved. For me it's corn, but I know someone else who is triggered by bananas and avocado. I have had a reaction to every grain except rice, but it is worse during a flare.

@stillwithu_V Жыл бұрын

Soo useful thank you❤❤❤

@ClevaLab Жыл бұрын

Thanks for your comment. 🤓 I'm glad you liked it.

@ChandraShekar-tc3jf 8 ай бұрын

My brother in law had this condition he had ulcer inside stomach and was diagnosed for autoimmune disease but he is okay and healthy now

@ClevaLab 8 ай бұрын

Thanks for your comment. 🤓 I'm glad to hear that he is OK now.

@J0N1Q_LIOS Жыл бұрын

U deserve more subscribers

@ClevaLab Жыл бұрын

Thanks for your comment. 🤓 Hopefully more people will think so too!

@tejasricreations8962 7 күн бұрын

Is there any relation for mouthful ulcers and this autoimmune disease plz explain

@jsantiago8979 4 ай бұрын

Thank you

@ClevaLab 4 ай бұрын

You're welcome, thanks for your comment. 🤓

@waelfadlallah8939 4 ай бұрын

You are cleva indeed!

@ClevaLab 4 ай бұрын

Haha, thanks for your comment. 🤓 I'm glad you liked it.

@14bqdonk Жыл бұрын

I'm here because 1 of my fav cosplayer, her name is Reakami and unfortunately she have this disease. She is a strong woman :')

@VizzyInks 9 ай бұрын

She's so pretty! What is her disease specifically?

@kateskeys 10 ай бұрын

Amen.

@waterbeyza3769 2 ай бұрын

I am dealing with 2 Autoimmun Disase one is Hashimoto Disase the other is a Rare Autoimmun Disase Morbus Behcet i feel sick all the time not easy

@ClevaLab Ай бұрын

I'm sorry to hear that. It definitely is not easy. 😔

@kristieangel5682 6 ай бұрын

How do you get the HLA-B27 positive gene out of the blood????

@ClevaLab 6 ай бұрын

Thanks for your question. 🤓 The DNA is purified using a DNA extraction kit. The DNA is in the white blood cells in your blood. The gene is then PCR amplified and visualised on a gel or by a qPCR machine.

@kristieangel5682 6 ай бұрын

@@ClevaLab Thanks 👍🏼