What is creatine and how does it work?

Рет қаралды 174,574

4 жыл бұрын

This video presents an overview of creatine along with a detailed explanation of the molecular mechanisms involved with it. It also demonstrates how creatine supplementation impacts the molecular mechanism to provide benefits such as increased strength, increased muscle mass, improved performance and fatigue resistance.
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This video is provided for general and educational information only. Please consult your health care provider for Information about your health.
Royalty-Free Music from Bensound
This video was made by McMaster students Victor Nguyen, Ghazaleh Jafarazadeh-Maleki, Vaithiegaa Mathanarajan and Karan Taghizadeh in collaboration with the McMaster Demystifying Medicine Program.
Copyright McMaster University 2020
References:
Cooper, R., Naclerio, F., Allgrove, J., & Jimenez, A. (2012). Creatine supplementation with specific view to exercise/sports performance: an update. Journal of the International Society of Sports Nutrition, 9(1). doi.org/10.1186/1550-2783-9-33
Guimarães-Ferreira, L. (2014). Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles. Einstein (São Paulo), 12(1), 126-131. doi.org/10.1590/s1679-4508201...
de Souza e Silva, A., Pertille, A., Reis Barbosa, C., Aparecida de Oliveira Silva, J., de Jesus, D., & Ribeiro, A. et al. (2019). Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis. Journal Of Renal Nutrition, 29(6), 480-489. doi.org/10.1053/j.jrn.2019.05...

Пікірлер: 164

@longhorn8459 3 жыл бұрын

Thanks for this man, simple and easy to understand, music is a little annoying but overall great video!

@applebirds1nthefuture646 3 жыл бұрын

Shoulda put polo g

@toddsheppard5411 3 жыл бұрын

@@applebirds1nthefuture646 Shoulda put polo g

@LarmadSomSecuritas 2 жыл бұрын

@@toddsheppard5411 Shoulda put polo g

@phadedlife 2 жыл бұрын

The music is fine and it's not super loud. What lol

@TheArtificialIncome 2 жыл бұрын

@@LarmadSomSecuritas Shoulda put polo g

@MPerfect92 Жыл бұрын

If you’re reading this, I cannot stress this enough: DRINK ENOUGH WATER WHILE TAKING IT. Also, it can cause stomach issues. I once shit my pants at a Halloween party because of creatine. Was not fun.

@sharkfortytwo 10 ай бұрын

lmao

@emil335 9 ай бұрын

Man just shit his pants and blamed it on creatine 💀💀

@kostakuzmanovic2151 3 ай бұрын

@@emil335 maybe it was that gosh darned protein powder lmao

@DogsCoffeeNJesus 3 ай бұрын

Anyone else ever have a dream where they're pooping then they wake up and instantly think they sh!t themselves in bed?

@SubwayLover 2 ай бұрын

@@DogsCoffeeNJesus nah blud that's just you 💀

@louisle9162 Жыл бұрын

I gave the vid a like mainly because this dood put in effort to explain, write, draw, erase, rewrite, redraw, and re-erase throughout the video. this is someone who put in effort. i understood about 10% of it. thanks for the information lol

@jakeburke7651 3 жыл бұрын

Spectacular vid, im researching for my term paper on creatine uptake and usage in cells and this will be a huge help

@Kevin-uh4km 3 жыл бұрын

Finally this is the video I wanted to see

@santiagozuluagagaviria1571 Жыл бұрын

I dont know if you will ever see this, but just the MONO audio channel detail made me like and sub! Well played.

@reshvnzitogueno3899 2 жыл бұрын

Great video, also thanks for putting in the references

@jaebell8804 2 жыл бұрын

Haha I found it funny when he wrote "Yay x2!" Next to the drawing having a smiley face🤣 Great video man. You Break it down well👍

@joehaley2691 8 ай бұрын

Wow, this was so clear! Thanks!

@DrJasim-qp6qb 3 жыл бұрын

Thank you☺️☺️

@gerardkirkpatricksanchez2121 Жыл бұрын

THANK YOU!!!!

@mateus_menezes1 Жыл бұрын

Thanks for the video!

@punkypinko2965 2 жыл бұрын

Thanks!

@deepthawelagedara7793 3 жыл бұрын

thanks, nice video

@percysjohnsonmwapemukubwe.3705 Жыл бұрын

Thanks for the information

@jbaker5964 4 ай бұрын

Fantastic explanation of the chemistry involved 👍many thanks!

@Secret_Takodachi Ай бұрын

I use creatine before my hot yoga & pilates classes, it works wonders for me! As far as staying hydrated goes: I bring about 3 litres of Gatorade to each 1 hour class & go through about 1.5 litres per hour. ❤ I used to hate working out, now I LOVE that post workout whole body soreness. I literally workout every day now & because I'm incorporating low weight workouts into a routine with a lot of stretching & flexibility training: I've never encountered any workout induced injuries! (Also, my instructors are amazing & do a great job at monitoring our form)

@mimithompson3049 Ай бұрын

It works wonders for you before hot yoga by doing what? What do you notice by using that isn't present when you don't use it?

@blusafe1 2 жыл бұрын

Agree with everything except the last part. Creatine is the only extensively studied supplement to definitively increase muscle mass, and is widely considered safe.

@giorodz4161 Жыл бұрын

He didn’t say it wasn’t safe 😂

@RioCuperus Жыл бұрын

It is important to respect the side effects. Coffee can make you twitch just like creatine can make you cramp, and people still use both

@DrewA10 8 ай бұрын

@@RioCuperuscaffeine is way worse for you than creatine monohydrate

@MrWookLoaf Жыл бұрын

Ive been using Creatine Monohydrate for a few months now, not once has it given me cramps, gas, or a feeling of dehydration, although every experience varies to some degree I’m sure. One of the things that had concerned me was reports of hairloss/thinning, but I feel like there was sufficient enough research that had debunked that claim.

@mootness_ Жыл бұрын

how has your water intake per day differed and how much do you drink now?

@MrWookLoaf Жыл бұрын

@@mootness_ There wasn’t a significant increase in water intake, I typically drink about 3 litres a day.

@BabyCEQ Жыл бұрын

@@MrWookLoaf Have you experienced more sweating after intake?

@MrWookLoaf Жыл бұрын

@@BabyCEQ No I haven’t.

@BabyCEQ Жыл бұрын

@@MrWookLoaf ok thanks for your reply

@chinmayeechavan5724 3 жыл бұрын

Nice video

@Willie_Wahzoo Жыл бұрын

skhulootle muscles?

@Secret_Takodachi Ай бұрын

"The mitochondria is the powerhouse of the cell" ❤

@fernandocornett2276 2 жыл бұрын

Wel..iam going to tri it see resutls

@jacobgawronski3134 3 жыл бұрын

Amazing video, appreciate the info!

@shawnbailey1585 Ай бұрын

Yea thx bro nice vid

@RioCuperus Жыл бұрын

Great video, this helps!

@DemystifyingMedicineMcMaster Жыл бұрын

Glad you think so!

@SurferSilver 3 ай бұрын

Any tips on how and when I should be taking creatine? Just ordered now

@DaDonCheeto 2 жыл бұрын

When you take creative make sure to hydrate a lot and most this will not happen

@victornwaokpani4500 2 жыл бұрын

Thanks for this video!

@Beliasa01 26 күн бұрын

Good explanation, but that daycare music though...

@LetsChat Жыл бұрын

3:57 Ooooh. Okay. Perfect graph.

@LpatrickH1107 2 жыл бұрын

Great vid but please, you’re butchering how skeletal muscle is pronounced.

@natashakalashnikov4811 Жыл бұрын

Do u recomend it for women?

@edkzir0001 3 ай бұрын

I liked your video but the music was a little annoying, Thanks for the explanation tho ! Very well

@josetheseventhorcustmachin778 Жыл бұрын

I have kidney problems and the doctor said that I have my creatine too high. So thank you for explaining what that is

@TeamOrdigamer 8 ай бұрын

It's possible your are confusing creatine with creatinine. If you don't take creatine supplements and if you have kidney problems, your doctor was likely referring to elevated creatinine, which is a substance that your body produces which is normally eliminated at the same rate by the kidney. Doctors look at the creatinine in your blood to see if your kidney is working properly (in which case the creatine levels would be in a normal range) or not, in which case your kidneys would filter/eliminate less of the creatinine and thus leave higher concentrations in the blood. I'm not sure what your exact situation is but don't hesitate asking your doctor next time!

@andrewfern7625 2 жыл бұрын

Mitochondria is the powerhouse of the cell

@Ruptured_AU 10 ай бұрын

Where does the creatine monohydrate come from.

@DoomFinger511 5 ай бұрын

Animal protein

@andrekelvin2318 4 ай бұрын

@@DoomFinger511 False. it's from chemical compounds Sarcosine and Cyanamide and it does not contain any animal by-products

@Floornob 2 жыл бұрын

Love the vid but I believe it’s pronounced skell-et-all like skeleton, because it on our bones

@Lownwolf-sm5py Жыл бұрын

You are wrong it is pronounced how he said it in the video

@PoopScooper10000 2 жыл бұрын

Make audio louder plz. O have my volume maxed and still have a bit trouble hearing it

@JoshuaAllcornEsquire 3 жыл бұрын

Why are you saying skeletal that way

@mikejungle 2 ай бұрын

Had to scroll down this far to ensure I wasn't the only one cringing at 'skeh-leetle'

@rich1701 2 жыл бұрын

Was it really necessary to put cat video music on this video?

@aftabuddinahmad6764 Жыл бұрын

Why your sound is very low?

@earlcoles5215 2 жыл бұрын

How long should I take creatine monohydrate every single day before taking a break?

@juliusholstein2376 2 жыл бұрын

Should be taken daily - no break needed.

@earlcoles5215 2 жыл бұрын

@@juliusholstein2376 so you are saying after taking it ever single day for 6 months straight, I should continue without stopping?

@juliusholstein2376 2 жыл бұрын

@@earlcoles5215 yes. no problems. Look up some research and see for yourself :) best of luck on da gains-

@EldergodUK 4 жыл бұрын

Creatine is awesome. I use kre alkalyan tho

@elasticpotato2974 Жыл бұрын

I use tren

@dfjdskf9234j4fisd 9 ай бұрын

Is he trying to say skeletal?

@shortkeys73 3 ай бұрын

"Skleetal muscles" duh!

@adrianwalsh7823 2 жыл бұрын

Very informative, but the music is very distracting making it hard to hear the voice over

@jacksonlamme Жыл бұрын

I'm just wondering whether skel-e-tal muscle was read properly 🤔

@ColinBlenis 9 ай бұрын

It was not.

@jacksonlamme 9 ай бұрын

I'm just messing brother good work 👏

@nolanredding8809 2 жыл бұрын

skeletal muscles, skeeleetle muscles

@rehmanpetsofficial4327 2 жыл бұрын

Can creatine cause hair loss?

@aarondrent5884 2 жыл бұрын

@nitramgt9308 2 жыл бұрын

Its all about your genetics

@Yazzymor Жыл бұрын

Good video but you can barely hear the guy if you’re not in a completely quiet room.

@user-sl4ul4nc3t Жыл бұрын

Yo dat walmart creatine gives me dem sharts

@sulblazer 2 жыл бұрын

Wait...are you purposefully pronouncing skelatal muscles as Skilittle muscles or is that a gag?

@deCrayonn 3 жыл бұрын

please speak up…turn the music off if you gonna be that low.

@fbi8792 3 жыл бұрын

Skelitel muscles

@ResQRaces 2 жыл бұрын

Hahaha yeah… idk what’s up with that

@Stethacanthus 2 жыл бұрын

Disconnect when reading?

@owenrobinson7226 4 ай бұрын

Skel Leetle muscles

@neillondon8709 11 ай бұрын

You've got sugar in that spoon .. I know it 😂

@hybriddude007 2 жыл бұрын

All benchers in your gym lifting massive weights are on creatine

@joeshmoe7967 Жыл бұрын

Possibly, but it is not necessary to build strength. Most people supplement to speed up gains. All else being the same, a person would not get significantly stronger just because they took creatine. I have train off and on for years. Supplements have benefits but are not entirely needed.

@gluteusminimus2134 Жыл бұрын

I find the music very annoying and distracting. Otherwise good video.

@jhd6118 2 жыл бұрын

Great video and explanation. The music was awful and distracted from the material

@cjblade4977 2 жыл бұрын

Trying to convince my parents to let me use creatine.

@riccosu3599 2 жыл бұрын

Lol same they think creatine is the same as roids

@aarondrent5884 2 жыл бұрын

@@riccosu3599 i just bought it and its on its way without telling thewm imma just telkl them it gives me protein or something like that lol

@Matthew-we3ir 2 жыл бұрын

same

@orionfarah3976 2 жыл бұрын

Same😭😭😭

@joeshmoe7967 Жыл бұрын

If you are young enough to need your parents permission, you don't need creatine. If you are a teenager, your body is already in a an anabolic state due to increased hormone production. You need just 3 things to build strength and muscle. 1) A good consistent training routine. 2) Good nutrition. Enough calories to grow and enough protein. I will also include enough water. Even slight dehydration has a negative effect on training. Muscles is mostly water. 3) Recovery, meaning enough time away from training and enough good quality sleep. Easy enough to research training and nutrition. Supplements really have nothing to offer until you are seriously following 1, 2, 3. You are better off having a really solid baseline, before supplementing. The only supplement at your stage is a good protein. You can get it from food, but shakes following work outs do help. - Cheers

@thesaurusrex7919 Жыл бұрын

I could of did without the annoying music, overall great video though

@ricogold_ 2 жыл бұрын

Can barely hear you

@Whosyourdaddy21 Жыл бұрын

For most people you can avoid all the negative side effects by drinking lots of water. When I was using it daily I was drinking 1 gallon of water everyday at 150 lbs body weight and never had a cramp.

@vinnyrubino4284 3 жыл бұрын

Alright this is an amazing video but who the fuck says skeletal like that

@DoomFinger511 5 ай бұрын

People with degrees in medicine and biology

@auggiecontreras8068 2 жыл бұрын

One guy "almost died" 😄

@vivianteekel6165 Жыл бұрын

skuh-lee-tul muscles

@slipstream7324 Жыл бұрын

hey, be nice

@tristanmolina894 Жыл бұрын

Definitely a loading phase for about 2 weeks is the way to go. When I was a teenager I didn’t understand what a loading phase was so I took 10g of creatine for months!!! I got huge. At 18 I benched 375. But the second I got off of it. I got small lol

@bigconor999 Жыл бұрын

Yea that’s why I don’t think I’m ever gonna start taking it

@reed3330 Жыл бұрын

That’s not how it works

@DoomFinger511 5 ай бұрын

That's BS it's not steroids. Physically, creatine makes people retain more water and look slightly bigger. Loading is unnecessary. You can just take 5g a day for a month and achieve the same full saturation you would by loading for 2 weeks but without the side effects.

@bigfoottamer Жыл бұрын

great video but the music you are using is the main theme for "cuckold simulator" which got a giggle out of me.

@smokeysoldier8590 Жыл бұрын

Jack Murphy simulator

@bigfoottamer Жыл бұрын

@@smokeysoldier8590 funny enough jack murphy was added to cuck simulator

@proelitemode3666 2 жыл бұрын

Adenosine tri phosphate to Adenosine diphosphate

@negvey 3 ай бұрын

bro that music is so annoying, good explanation, but god damn, couldnt finish at how bad that tune was

@dr00skee47 Жыл бұрын

Skeletal. SKEL. Et. Al. Like SKELETON

@quandaledingle8960 2 жыл бұрын

Too quite

@forceful373 Жыл бұрын

Man you talk so slow, had to watch on 1.5x

@jakester5272 9 ай бұрын

why are you whispering??

@sal1021 Жыл бұрын

thanks man, i was so close to taking it . thank god i still love my kidneys

@fourdubs4 Жыл бұрын

Did you even pay attention? There’s no risk at all. It’s not bad for your kidneys it’s harmless

@DoomFinger511 5 ай бұрын

So I'm assuming you either have a preexisting kidney condition or have a problem listening.

@trevorratliff1403 Жыл бұрын

you say "Skeletal" really weirdly....why do you pronouce it like that? ?scolitle what is that ?"

@downshift7300 2 жыл бұрын

Long term use will sadly damage your kidneys

@benjamingadelangsted-aggre8860 2 жыл бұрын

could you please link some studies?

@downshift7300 2 жыл бұрын

@@benjamingadelangsted-aggre8860 its on my personal experience brother

@niels7446 2 жыл бұрын

@@downshift7300 how do you know

@jak743 2 жыл бұрын

@@downshift7300 Nah you took steroids and blame creatine :D Theres plenty of studies disproving the myth of creatine affecting kidneys

@joeshmoe7967 Жыл бұрын

I disagree, unless one has an underlying issue with kidneys. Sensible supplementation will not be a problem for most people. Having said that, I also believe great gains can be had with zero creatine supplementation. I have used it and had periods of not using it. Gains DO come faster with some supplements.