What is PCSK9 and how PCSK9 inhibitors work? (Mechanism of action)

No video

What is PCSK9 and how PCSK9 inhibitors work? (Mechanism of action)

Рет қаралды 15,120

Күн бұрын

A concise 5-minute overview of PCSK9 and its inhibitors. Learn how PCSK9 plays a role in cholesterol metabolism and the cutting-edge medications targeting them.
#pcsk9 #cholesterol
Web: heartcare.sydn...

Пікірлер: 27

@debigdogk9563 10 ай бұрын

God bless you for teaching and sharing ❤❤❤❤❤

@littlejoeUTube 9 ай бұрын

Thank you! I have been researching for a few months (family history and ASCVD, in spite of many years of vegan whole foods eating, daily exercise of running and/or resistance training, meditation, etc, etc). Lp(a) of 192 and a current stent have me seeking more data about treatment options. This is definitely the clearest explanation I've find to date re PCSK9 inhibitors.

@heartcaresydney 9 ай бұрын

Thank you. Glad it was useful

@user-in2uj2vr2n 11 ай бұрын

simple and nice way of explaining! thank you!

@heartcaresydney 11 ай бұрын

Thank you

@AbelDelCastilloWest 4 ай бұрын

Thank you so much. Compendious information regarding to an important topic

@crushingt1d Ай бұрын

The flow chart says to use this really only as a last resort. Why? Seems really effective.

@shelbyfaaron739 3 ай бұрын

Absolutely brilliant! Thank you so much as your video helped me understand a part of my cardiology class which seemed complex, until you made it extraordinarily easy to understand. I appreciate the extra details and definitions that also helped me better grasp other concepts! - a med student from France

@heartcaresydney 3 ай бұрын

Glad it helped you🙂👍

@ellianaredick6817 8 ай бұрын

Thanks for the simple explanation of PCSK9 proteins and inhibitors. Amazing what Pharma can target with todays therapies.

@heartcaresydney 8 ай бұрын

Glad it was helpful!

@debigdogk9563 10 ай бұрын

Very informative, thank you thank you and thank you ❤❤❤❤❤

@heartcaresydney 10 ай бұрын

Glad it was helpful!

@ibrahemalkeratah8584 10 ай бұрын

Thank you ❤

@quality6823 4 ай бұрын

عالی بود، آقای دکتر. سپاسگزارم. بیمار با Lipoprotein "a" به مقدار ۴۹۰nmole/L❤😂

@heartcaresydney 4 ай бұрын

I'm glad you liked it. A Lipoprotein a [Lp(a)] level of 490 nmol/L is extremely high, putting the patient at a very high risk of future cardiovascular diseases, such as heart attacks or strokes. Unfortunately, we don't yet have a specific treatment for Lp(a), but we recommend statins, aspirin, and significant lifestyle changes to reduce the risk. Currently, there is no treatment on the market that specifically targets Lp(a), but this is expected to change in the near future. PCSK9 inhibitors can reduce Lp(a) by about 20%, and inclisiran by about 25%. heartcare.sydney/inclisiran/ heartcare.sydney/pcsk9-inhibitors/

@nflaum1997 3 ай бұрын

This is wonderful, but it appears to me, according to the video, now you have a bunch of PCSK9 proteins bonded to antibodies floating around in the plasma (@3:21). What happens to these bodies as they build up over time? Can they form clots of their own? Are they ever broken down. Etc. It seems to me that a lot more research needs to be done before this is hailed as a miracle solution.

@heartcaresydney 2 ай бұрын

The PCSK9-Ab complex is removed from the bloodstream via macrophages in the Reticuloendothelial System (RES).

@suechan-ic6cg 5 ай бұрын

Excellent video! I understood the mechanism ! What are the side effects of this drug?

@heartcaresydney 4 ай бұрын

PCSK9 inhibitors are considered safe and effective for most people and no serious or life-threatening side effects have been reported. The main side effects are related to injection site allergic reactions and occasionally flu-like symptoms. heartcare.sydney/pcsk9-inhibitors/

@sumanreddybobbala6150 10 ай бұрын

Plz share next video on incliseran MOA

@heartcaresydney 10 ай бұрын

will post next week

@cuongly6685 7 ай бұрын

Is it true that the PCSK9 inhibitors cause fatty liver? TIA.

@heartcaresydney 4 ай бұрын

No, PCSK9-inhibitors are not linked to "MAFLD" (Metabolic Dysfunction-Associated Fatty Liver Disease).

@skf369 8 ай бұрын

Notice the absence of any mention of diet and lifestyle changes, the role of insulin resistance on metabolic health and the lack of a causal link between LDL and heart disease - this video demonstrates how your doctor is actually taught by big pharma: it’s just drugs, drugs and more drugs always drugs…… I recommend watching David Diamonds videos discussing the side effects of statins, how they cause diabetes which is the number one cause of heart disease and kidney disease, and how the CORRECT dietary habits and exercise can actually solve the root conditions and produce true health and longevity in most people. But of course no one is getting rich on that message

@heartcaresydney 8 ай бұрын

Thank you for your comment. I want to clarify a few aspects of the video to address your concerns: * This video is specifically about PCSK9 inhibitors and how they work. Its purpose is to educate viewers about this particular type of medication. However, it doesn't aim to cover all aspects of managing cardiovascular disease, such as diet and lifestyle modifications. * PCSK9 inhibitors are for established CAD patients, such as those with a history of heart attack, bypass surgery, or familial hypercholesterolemia. These are for secondary prevention in high-risk individuals, not primary prevention in low-risk people. * I always advise my patients to adopt a healthy lifestyle as the primary approach to heart health (heartcare.sydney/how-to-prevent-a-heart-attack/). However, it's essential to recognize that there are patients who, due to various circumstances, may not be able to engage in these lifestyle changes fully. Additionally, there are individuals who, despite leading a healthy lifestyle, remain at high risk for premature CAD due to genetic or other risk factors. In such cases, medical therapies like statins and PCSK9 inhibitors become a necessary part of their treatment plan to manage risk effectively. * Lastly, remember that taking medication is a personal choice and not an obligation. You can choose not to accept them if you feel they are not for you.

@charlesfuchs 4 ай бұрын

You seem ignorant, LP(a) does not change or get lowered by diet or exercise. Its genetic