Why do Nondepolarizing muscle relaxants cause Fade with TOF monitoring?

Рет қаралды 68,917

Michael Bentley

11 жыл бұрын

Пікірлер: 53

@lbowlesrn 7 жыл бұрын

i NEEDED someone to break this down for me simply and with moving pictures, THANK YOU SO MUCH!!! I ACTUALLY UNDERSTAND THIS NOW!!!

@WooPoo2007 9 жыл бұрын

Thanks for the breakdown and thorough explanation. It truly helped. And while I'm no longer in the Army, hearing "let me orient you" made me crack a smile.

@xDomglmao 3 жыл бұрын

Guy deserves an award for teaching. Would you be so kind to explain the pattern visible after using depol agents?

@dancingwater1582 3 ай бұрын

Clear presentation. Just the right pace. Learning has occurred! Talented, capable and knowledgeable instructor. Great teachers are few and far between. Thank you, Michael Bentley, PhD!

@kirkgiles4136 10 жыл бұрын

An awesome video that was even better when view in sequence w/ the video explaining twitch.

@sonjaherzog5722 8 жыл бұрын

So helpful! Thank you so much!

@leetabgolden 4 жыл бұрын

Thanks for this great brief!

@manuelloera5995 2 ай бұрын

Love the explanation, thank you sir!

@priyalhingrajiya229 2 жыл бұрын

Thank you so much , so much understanding and enjoyable video 👍🏻👍🏻

@sandysara8423 2 жыл бұрын

Very helpful, thank you very much 🙏

@dennerdovandojr.8878 4 жыл бұрын

Great video. Thanks!

@abeltsehay8533 5 жыл бұрын

very helpful, thank you!!

@adeelkazmi9691 10 ай бұрын

Wow…simply amazing or amazingly simple u made it

@MambaCool20 3 ай бұрын

Thank you Sir 🙏🏾

@drmohobaidullah9228 8 жыл бұрын

thank you so much it really helped

@broganthomas2259 5 жыл бұрын

Thank you !!

@brwnbaldie Жыл бұрын

Thank you!

@radhika1218 2 жыл бұрын

Thank you 🙏

@MohamedKandilMD 9 жыл бұрын

That was really helpful Dr. Bentley thank you very much but why do we also see fading pattern in phase II of depolarizing blockers?

@xDomglmao 3 жыл бұрын

same question here!

@pankhuridhawan4393 4 жыл бұрын

Thankyou so much

@emilymoore7897 10 жыл бұрын

Great video, I'm a nurse in the Army Reserves attending Anesthesia school in Pennsylvania! Thanks so much

@seanbernard6000 5 жыл бұрын

Makes me wish I went to USAGPAN

@soulmatesr64 10 жыл бұрын

Very useful

@mastakeaton 10 жыл бұрын

awesome!

@drnykterstein_ 2 жыл бұрын

This video was a godsend! But I dont understand the same thing for the phase 2 of Depolarizing blockers.

@Jagadeesh_Gade39 4 жыл бұрын

So helpful. Tq

@mariotorres2993 6 жыл бұрын

This video really helps a lot to visualize the depletion of Ach. But @ 7:27 the doctor says that Ach has to stay away from pseudo cholinesterase. He should have said that Ach should stay away from True Cholinesterase which is the one that metabolizes Ach.

@AhsanKhan1998 3 жыл бұрын

He says "acetylcholinesterase" Edit: now that I hear it again, it does sound like he says "pseudo"

@alexanderbrigantty3068 8 жыл бұрын

best video ever

@tubakhalid9001 3 жыл бұрын

Magical✨

@Devilishsuki 5 жыл бұрын

Thank you very helpful. Currently studying for the ICU part 1 examination in Australia :)

@xDomglmao 3 жыл бұрын

so...did you pass :D?

@Devilishsuki 3 жыл бұрын

xDomglmao yes! Thanks for asking! Though this topic did not come up for me, it was the subject of one of my practice vivas

@xDomglmao 3 жыл бұрын

@@Devilishsuki Glad to hear that! :D Grats!

@jephh 6 ай бұрын

Sukey I almost stopped watching this video 20 seconds in but because of your comment I watched the whole thing. It is good.

@zipfish123 8 ай бұрын

Great video. I want to draw a parallel to succinylcholine: Is phase 2 block caused by desensitization of the presynaptic nicotinic receptors (rather than direct antagonism as seen with non-depolarizing agents)? I'm having a hard time understanding why this would only occur at high doses.

@paryjameel868 4 жыл бұрын

Thank u I’m pary from iraq

@ElenaRox1994 8 жыл бұрын

why is he wearing army clothes teaching medicine? extremely helpful and clear though! Wonderful simple diagrams~ easy to understand! Thank you!! :)

@chrisopaas4987 8 жыл бұрын

+ElenaRox1994 Because the army also deal with medicine. Actually the wars up trough the years has improved the surgical knowledge and skills that no hospital could ever experience. The military medical branch is a very important branch of the military.

@ElenaRox1994 8 жыл бұрын

Jorge Arizpe wow i see.. thank you!

@khebhh 8 жыл бұрын

Takes a decade to get to the point. Could have been concise and to the point. Anyway thanks for making the basic clear.

@ryanbrunner5622 8 жыл бұрын

what does the presynaptic nicotinic receptor do? you explain the blocker is competing there but what does it NORMALLY do... I feel like thats essential in understanding this, and you dont explain it. for that reason.. thumbs down you just say positive feedback mechanism.. what are you talking about specifically? -First Year medical student

@martinyowa 8 жыл бұрын

+Ryan Brunner....... presynaptic it has acetylcholine a neuron transmitter which attach to post synaptic. the below one in the diagram to open a channel called na/k channel which lead to influx of sodium from out side to inside n efflux of potassium from inside to outside which lead to depolarization

@ane28829 4 жыл бұрын

PREsynaptic receptors move the next set Ach filled vesicles to the “front line” (the edge of nicotinic nerve for preparation) and when another action potential comes and stimulates Ca2+ influx (which destabilizes the proteins that hold the vesicles in place) the “front line” is ready for release into the synaptic cleft. I know this is 4yrs old but I thought this reply may be helpful for others in the future -SRNA

@ane28829 4 жыл бұрын

Ryan Brunner the other response is true for POSTsynaptic nicotinic muscle receptors NOT PRE-. When Ach is released not all diffuses time the motor end plate, a fraction bind to PRE (Pos Feedback Mech).

@xDomglmao 3 жыл бұрын

@@ane28829 Thank you very much!

@pesmobile-progamer1327 3 жыл бұрын

@@ane28829 i think u also need to open a youtube channel U explain superbly