I agree with the above comments. You communicate clearly and provide not often mentioned insights. It takes time to build a youtube channel. Do not be discouraged by the initial few views. I would very much appreciate you sharing your knowledge.

You keep saying "having APOE gene" rather than clarifying you mean "APOE4" specifically. Everyione has APOE genes, so you can be confusing some.

Thanks

Is there a reason keto and high fat diets come with a caution for apo e4 carriers? I was hypoglycaemic and early experiencing cognitive issues at 40. I’m diagnosed adhd but it significantly worsened with age. All has improved for me substantially with keto. Thank you.

Your information about ketogenic diet and ApoE4 is contrary to the recommendations by Dr. Dale Bredesen. He recommends mild ketosis (70% of calories from fat) with high vegetable intake (70% of food by volume). If you were to update this video, would you update that information or do you still have a different opinion?

I believe we should ALL be eating and having a lifestyle like we have 2 copies of the APOE4 gene. I say get tested I did. I have the E/2 & E/3 combination.

Very interesting, thank you Doctor :)

Dr. Nina, thank you so much for this valuable information. I've been grasping for info about ApoE4 and what I can do to mitigate the health concerns. The DHA supplementation suggestion starting at 9:34 in this video is interesting. I'm not "early in life" exactly (I'm 55) but I'm wondering if I should still take DHA; research seems to point to 2g/day as a decent target. Right after that, however, you mention that we should avoid foods high in PUFAs which confuses me a little bit. DHA is a PUFA I believe, so I'm conflicted about whether or not to take it, as well as foods like Salmon/Mackerel, Walnuts etc. In my other research I find multiple sources that say to greatly reduce Saturated fats to 7% of dietary calories or fewer. Are you saying we should do the same or for these PUFAs? Thank you!

This is a very helpful video. My mom just died of Alzheimer’s and I have already had open heart surgery at age 55. My cholesterol levels were off the charts before my heart attacks (2020 when most of the medical community was shut down) My cardiologist now has had me on an injectable for the last 2 years which concerns me in case I have the APOE4 gene(s). I just contacted my doctor to try getting tested. ❤

Not only did I get to watch my parents decline and die, I inherited APO4 from them both. Everything else is developing as you said, high cholesterol, ridiculously high triglicerides, prediabetic, so I try to be productive and enjoy each day while I still can, even though I soon won't remember it.

Dr. Nina, I am an E4/E4 carrier, and have been doing some research on the subject for some months. Many sources I come across mention limiting/cutting out alcohol. I wasn't a heavy drinker to begin with, but have limited my intake to 2 drinks per week, occasionally up to 4 drinks total a week but spread over two days a week if there is something going on. I don't drink to get drunk, but I just enjoy the taste and it's always been this way for me. I found it interesting you didn't mention alcohol and wondered your thoughts on alcohol intake when it comes to considering dietary restrictions with APOE4?

Very informative, thankyou so much.

Thanks for this. Extremely helpful. I wonder if there is a protective association with apoe4 and Covid. I have one copy, have never been vaccinated, and have not-to my knowledge-contracted the virus. I’m 58, naturally thin, been on a self imposed strict keto diet for 3+ years. I’ve been telling myself that I’m on keto to PREVENT Alzheimer’s, but since recently learning I’m heterozygous apoe4, it looks like it’s time for a diet change. My inflammatory markers are out of range, as are my LDL. Everything you said here resonates. Thank you again for sharing your knowledge.

Thank you soo much for this video. I have the APEO4 gene from both parents. While I have done a lot of reading on the subject, this video is articulated in a comprehensive fashion ... easy to understand. Again...Thank you

I made genetic test 2 years ago. It was just for fun as it was as part package where I also found info about my ancestors... When I got results that I have apoe4/4 it scared me. My great grandmother had alzheimer and as young girl I use to stay with her at home if my aunt needed to go somewhere for couple hours. Now I decided it is better to face this so I am trying to find more information. I am 36 and I already found I need to completely change all my lifestyle. Is here someone who spoke with their doctor about this? I don't know if I should do it or just change my eating habits...

Just read where Biogen dropped the price of their Alzheimer's drug by 50% . Down to 28 thousand and some change a year . Now I know it costs a lot of money to develop and research these drugs and I also know the tax breaks and government grants cut the costs of development substantially so why the outlandish costs to the consumers ? You know , when hospitals refused to use the drug because the cost was inflated to a level never seen before that should say something to every American.. I love Capitalism and firmly believe it is the best system in the world but if we do not as a nation stop rampant price gouging on necessitates like food and medicines and place a profit cap on these companies we should stop funding their research . Maybe when the grants and tax breaks disappear they will get the message that price gouging isn't in their best interest .

Thank you for this, especially the useful information presented in context. I hope you keep this channel going.

Very informative. Thank you doctor.

Thank you for the info. You mentioned the importance of avoiding PUFAs, which are in nuts, vegetable oils and fatty fish. Does that mean to eliminate foods such as walnuts, mackerel and Flax?