24 Studies Later: 4 Anti-Aging Skin Supplements that Work

Рет қаралды 76,492

Ай бұрын

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References [Copy DOI into Search Engine]
[1] doi:10.1002/mnfr.201801094
[2] doi:10.1111/j.1346-8138.2010.00827.x
[3] doi:10.3390/polym14050876
[4] doi:10.1111/ijd.15518
[5] doi:10.1016/j.carbpol.2022.120153
[6] doi:10.1684/ejd.2021.4176
[7] doi:10.3390/nu13072220
[8] doi:10.7326/0003-4819-158-11-201306040-00002
[9] doi:10.1097/DSS.0000000000000879
[10] doi:10.3390/nu13092917
Remaining Collagen Peptide Studies: • Does Supplementing wit...
Remaining Hyaluronic Acid Studies: • Hyaluronic Acid: Does ...
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#skincare #agingbackwards

Пікірлер: 560

@mj625 Ай бұрын

Personal anecdote here. I took collagen peptides for more than a year and noticed nothing. I then read somewhere that glycine is the rate limiting factor in how much collagen your body produces. I incorporated glycine into my diet, and there has been a huge difference in my skin. Even age spots (I am 50) have either disappeared or started to fade.Therefore, I am surprised you didn't say anything about glycine. FYI, I take about 4-6 grams per day.

@alexandremidouni8583 Ай бұрын

Collagene is more effective but glycine = more bang for the buck. I take both

@SeminarioMAE Ай бұрын

i thought collagen had glycine

@mj625 Ай бұрын

@SeminarioMAE I think you're right, but in my case it wasn't enough. I saw no benefit until I added additional glycine in supplement form.

@jrmint2 Ай бұрын

I use a lysine supplement (for cold sores) w my collagen peptides, I feel it works for my skin too...where do you get glycine? is it from food sources or pill form?

@miracoli16 Ай бұрын

Very good point!

@Alagachak Ай бұрын

Collagen peptides - chow that powder down Hyaluronic acid w low molecular weight Sun exposure - vampire brigade represent! Astaxanthin - skin elasticiy & moisture =)

@tracymullane8818 Ай бұрын

Absolutely!! I'm a vampire too. Yes, there absolutely needs to be more focus on skin elasticity. Collagen without the elasticity will just give you thicker wrinkly skin like scleroderma, and that's actually the cause of it- lack of elastin. So astaxanthin is super important. On hyaluronic acid, the prevailing science shows high molecular weight hyaluronic acid is healthier due to the low molecular weight causing inflammation. And most supplements out there are the HMW. There are many studies and a brand new one citing ha as a cause of cancer and inflammation so that's not good. People are a bit freaked out about it right now especially those in the medical aesthetics community because of the injectable fillers industry. High blood serum levels of hyaluronic acid are a screening test for colon cancer. If there's no family history of cancer, I would go ahead and take HA supplements, but if there is a history I would be cautious. Elderberry supplements are another excellent source of body moisture for moisture retention.

@raffaelecorrente1123 Ай бұрын

@@tracymullane8818great comment! Please, can you suggest some brands for each supplement?

@FrozenAuroras Ай бұрын

You forgot GLUTATHIONE 🔥🔥🔥

@tracymullane8818 28 күн бұрын

@@FrozenAuroras yup! NAC (N- acetyl cysteine) is a precursor to glutathione. So it's a good idea to look up the effective dose of it and take it as you get older. Taking it with glycine, collagen supplements, along with vitamin C, is a good idea for collagen production. Glutathione has a very short half-life in the body, so the best way to take it is actually through injection, but even then it doesn't last very long. So taking NAC is more efficient, and cheaper. Gly-nac supplementation extended the lives of mice 24%. Doctors prescribe NAC for the lungs- It thins secretions and enables easier breathing. The FDA was thinking about taking it off the market to study it as a drug but you can't take something that occurs in nature of the market. That would be like taking water off the market. Glycine aids in collagen production and is another powerful antioxidant. NAC also cleans out the liver. You're not supposed to use it in conjunction with drinking alcohol- that's how effective it is.

@HarenHarem-zz5dx 25 күн бұрын

For real elasticiy, I'd recommend an elastin supplement (pills, powder, whatever you like). It's still much harder to get than collagen and hyaluronic acid but more companies are selling it now. You can look hydrolyzed marine elastin up.

@astrol4b Ай бұрын

My project of becoming a perfectly smooth human flamingo is still going on

@MorningClarity 28 күн бұрын

🦩

@acchen567 10 күн бұрын

This comment is soo funny

@EduardQualls Ай бұрын

The effects of hyaluronic acid can be amazing. I had two courses of hyaluronic acid injections directly into the synovial fluid of my knees, and the effects were almost immediate and wonderful. All the knee-pain that had been slowly building up over the years went away within a few weeks and hasn't returned. Health insurance is usually gung-ho for these, because these HA injections reduce the number of knee-replacement surgeries, simply because it causes regrowth, thickening and strengthening of the cartilage shielding the boney wear-surfaces within the joint. (The fact that the nurse-practitioner used ultrasound to make sure the needle didn't nick any structures was great, too. The only discomfort was from the extra pressure right after each injection, but that faded after a couple of hours.)

@linda7279 Ай бұрын

Awesome information!! Tk you

@elingrome5853 Ай бұрын

worth trying out high dose VitD3 as well, if u havent...

@_negentropy_ Ай бұрын

Wow! That’s an amazing result! I’m going to look into this.

@ilevitatecs2 Ай бұрын

Unfortunately, I don’t think cartilage regrows from hyaluronic acid injections (actually we don’t even see cartilage regrowth with stem cells!), but it can be a potent anti-inflammatory

@alexandremidouni8583 Ай бұрын

@@ilevitatecs2 intra articular growth hormone is promising

@larrygarms7230 Ай бұрын

+1 for algorithm. With the free knowledge this channel cranks out, you should have 2.2 billion subs!

@theancientsancients1769 Ай бұрын

You assume by default because he sounds nice he is correct, however many more experienced than this student reject his claims

@kouritasvonkafthor468 Ай бұрын

A typical village lifestyle in Greece All you youtubers confuse and stress us out with what you suggest for health and longevity. My aunt died in 2022 and she was 108 years old, my uncle at 98 years old, my father died at 97 years old and my mother at 93. We all come from Greece, specifically from the island of Samos next to Ikaria. The style of their life, a typical day was as follows. They would wake up in the morning at 6, maybe have a mountain tea or some milk with wholemeal bread and leave for manual work on the estates. Around 10 o'clock they ate some wholemeal bread with a few olives or their own cheese, at noon they rested for about half an hour and usually ate Legumes, pulses, and in the afternoon when the vesper bell rang at about 6 pm they usually left on foot for the village because the donkey was loaded with tools and products. In the evening, light food, Salads, wild greens, Legumes and generally Greek cuisine, all almost their own production. They always used olive oil in the food. in the evening the men would go to the Cafe for a drink, usually wine or ouzo and the women would gather in a house or in the courtyards of the houses and chat about the events of the village. At 10pm everyone went to bed. They didn't eat much meat. They ate fish Eggs and some old hen on some Sundays with potatoes and rarely with spaghetti. They used tomato paste for the sauces they made themselves in the sun and maybe would drink some wine that produce themselves. They had fun at the festivals 4 to 5 times a year and on the religious holidays. We children went with them to the estates and helped on weekends when we didn't have school. I should mention that all the residents in the villages of Samos have more or less the same habits and economic level. Many residents of my home village left and went to the United States of America. I am very sad to say that all 5 of my classmates who left for the USA and adopted the lifestyle there, all died very early very young in their 50's and 60's.

@srezzy1326 Ай бұрын

Sounds glorious that’s for sure. Doesn’t surprise me about American food supply either. Sorry about your classmates.

@unholyquail4560 Ай бұрын

So how much wrinkles do these people have? Exactly They might have had long lives and were not struck by cancer.. doesn't mean they aged pretty. People in the longevity and healthspan part aren't just looking to replicate the results from your family which might also have a genetic component to it like very low occurrence of cardiovascular disease, they are looking to perpetuate the effect of rejuvenation. The absence of aging at all and the absence of decay. This is where you completely miss the mark. Yes we can learn a lot from them. But they didn't have the fix. They still experienced significant bodily decay until failure. They still had reduced quality of life over time and at some points failed in their ability to do things they used to be able to. So your mindset is still in the 2004 of the blue zone studies. We are now looking past those and are trying to find the mechanisms that might improve on those outcomes. Of course modern mankind seems to be moving further away from this as we speak but not everyone when u isolate populations who do get the message. So "youtubers" like Psychionic aren't confused at all. They just have different outcomes of goals projected than you have when using these definitions.

@deansusec8745 Ай бұрын

Very little meat and wine, I dont really want to live to 100 like that.

@studentaccount4354 Ай бұрын

Humans can live into their 120's why did they die so young?

@unholyquail4560 Ай бұрын

@@deansusec8745 It is just because you lack imagination and experience of how it can be without. My glass of Khombucha with a thai plant based dinner checks those same marks. Yet the difference is I am not paying a price for it.

@david-jr5fn Ай бұрын

I know people don't enjoy it but Microneedling is probably the most effective method for increasing collagen and it's much cheaper then ongoing supplement purchasing. Red light therapy also more effective then supplements and more enjoyable than microneedling

@nickmontanaro9638 Ай бұрын

Can i ask Which red light therapy do you use?

@david-jr5fn Ай бұрын

@@nickmontanaro9638 The device I have is a red led mask, it doesn't appear to have a brand name. If you want to buy one just go for the one with the largest amount of LEDs.

@iraschlothi5930 Ай бұрын

Red light therapy can also destroy collagen if it is used too long, I've heard from my skin therapist.

@david-jr5fn Ай бұрын

@@iraschlothi5930 I have never heard of that but you should never exceed 30 mins. Skincare therapists have an interest in convincing clients that if they were to attempt such things by themselves harm will result

@stevenbelzer9768 17 күн бұрын

You’re right, vivaci RF controlled radio microneedle with PRP topical platelet replacement used with SEYPHYL a calcium carbonate “scaffold” RF energy creates new collagen formation . “You can’t supplement your way into better skin . This dude is entirely wrapped up in his academic wheelhouse as a molecular biochemist PhD candidate, he’s intellectually “smug “ and mildly condescending to his audience , masked as an attempt at HUMOR 😂.,

@gregkocher5352 Ай бұрын

While I'm interested in skin repair, my age is 69, I think creams are not my ultimate goal. Recently my dad passed at the age of 97. The one thing that surprised me was how thin and paper like his skin became. It was a miserable experience for him. I suspect that diet will be the only way to improve how my skin strength. I've been on keto for about a year and adding supplements like Omega 3, collagen powder, some vitamins. I recently tried retinol for my forearms and hands as I started showing the thin skin age large bruises. It does help a bit. So I'm actively looking into whole body solutions. Dad's skin issues became a major difficulty. He was mentally fine to his last days.

@jrmint2 Ай бұрын

I think as you get older, its a multifactorial approach, reduce inflammation and increase antioxidants w food, supplements w specific benefits, creams, lotions and serums (and they do work) and sunscreen or sun protection.

@yeahweburnstuff Ай бұрын

Vitamin D is primarily produced in the oil of our skins, this is why it is very important to keep the skin of our elders moisturised. Use CeraVee, it's ceramides are proven to help the skin.

@arihaviv8510 Ай бұрын

Sun protection will be one of the best things you can do

@broccoli7263 Ай бұрын

Look into laser resurfacing for the face at least.

@theancientsancients1769 Ай бұрын

Research Xtend life if trying to start supplements or skin products.

@anode-cathode Ай бұрын

I ignored the warnings about sun exposure when I was younger and now in my 60s I’m paying the price. How I wish I had slathered on the sunscreen and avoided tanning beds.

@DeusExMachina50 Ай бұрын

Are you looking like microwaved bacon?

@anode-cathode Ай бұрын

LOL no. Actually I look younger than most my age as I’ve always been physically active, healthy diet, no smoking etc. But how I wish I had more elasticity. I’ve been a vegetarian for the last year but will make an exception for collagen peptides. I’ll try anything at this point.

@DeusExMachina50 Ай бұрын

@@anode-cathode Have you look at using Tretinoin and red light therapy?

@Draziell Ай бұрын

@@anode-cathodein a few years, you will probably regret going vegan more than ignoring the warnings about sun exposure...

@user-qq5du7iv4t Ай бұрын

Lol I get sun every day and always will

@Botanifiles Ай бұрын

I would absolutely love a video on the supplements / regiments you employ as a result of your scientific research.

@ericsonhazeltine5064 Ай бұрын

His supplement stack is reported - check his other vids

@jrb.m.9543 Ай бұрын

@@ericsonhazeltine5064let us know what brands and supplements they are

@JNWG79 Ай бұрын

Thanks! I love when you address skin health topics. Very helpful in a sea full of contradictory info without science to back it up. Appreciate your channel!

@suj1201 Ай бұрын

My my my, look who is fast approaching 200K subs! I love the success you've had - incredibly well-deserved, Nicolas! Happy for ya :)

@detocquevi11e Ай бұрын

I watched this video with interest, not due to interest in improving skin condition, but rather because I have Ehlers-Danlos, and I look for info on anything collagen-oriented. I will however, say that when I increased my vitamin C intake from 250mg supplement/day to 2g supplement (spread over the day), that in addition to many other benefits, the quality of my skin improved markedly... a much more healthy sheen, color, hydration, not to mention a cessation of unexplained bruising. I enjoy your channel, regardless of how personally pertinent the info may be to me!

@nickmontanaro9638 Ай бұрын

Same here type hypermobile. I'm going to try this thank you. 🙏 Howong did it take to start seeing a marked difference?

@detocquevi11e Ай бұрын

@@nickmontanaro9638 I'm hEDS too. I take Trader Joe's Chewable Orange, which has ascorbic acid/sodium ascorbate blend, which I have no idea whether it makes a difference, but am not going to muck around with success, and is cheap too. I started seeing multiple improvements in myalgia (which was really brutal for years), brain fog, anxiety, and a few other typical vitamin C deficiency symptoms within a couple days. Noticeable improvement in skin in 2-3 weeks. That was about 3 yrs ago, so has been sustained. I also take 2g/day of lysine spread through the day (important especially for the C to be spread out also (500mg every 4 hrs), I find best results on empty stomach, but some might not tolerate that well), and a multi-mineral with higher bioavailability than the cheapest stuff. I take a few other things too, but the C/lysine/multi-min have made the biggest diff, including assistance with ligament/tendon healing. Hope something helps you!

@detocquevi11e Ай бұрын

@@nickmontanaro9638 Welp, KZfaq deleted my lengthy reply... will recompose it when I get time. Short answer, a couple days for myalgia, brain fog and other stuff..... a couple weeks for skin.

@donnagerber2911 Ай бұрын

Careful with high dose C- can cause kidney stones

@user-nv6ho9lk4u 14 күн бұрын

Hi, just wanted to say be aware of vit c over 250 mg can cause oxalate kidney stones, this happened to me and Iignored the studies I saw. Worst pain ever so really be aware

@janetashforth7368 Ай бұрын

Incredible information, as usual!

@user-ji5xv5kv9y Ай бұрын

The Nambour sunscreen study showed no signs of aging in 4,5 years in the daily sunscreen group. But keep in mind this study was done in Australia where even in winter the uv index is 6+. Differences between daily and occasionally sunscreen could be less or insignificant in countries with much lower uv indexes.

@JosephJohn-fb9wx Ай бұрын

This was a good honest video. In addition to the above, regular exercise, hydration and the consumption of clean foods seems to help, at least it has for me.

@Mixednuts21 Ай бұрын

Thanks so much Nic. Interesting as always.

@jab5444 Ай бұрын

I certainly hope that the placement of the sun behind your head in an aura/halo appearance was done on purpose. It was hilarious and made my day.

@robertbrowning2 Ай бұрын

Very informative! Thanks

@HocDolliday Ай бұрын

Please do a video about colostrum. I’m curious what the science says about its benefits.

@ThomasAT86 Ай бұрын

Thanks for another great video. Thosen really grounds me and make me think thrice about adding another supplement.

@nazarakopyantc514 Ай бұрын

Broooo you have become so big! I remember how you had only 200 subs! So happy for you!

@Physionic Ай бұрын

Thanks :) I deeply appreciate it

@nazarakopyantc514 Ай бұрын

@@Physionic from rational learner with love! 💞

@joebartles3986 Ай бұрын

Bruuuuu

@d.a.5982 11 күн бұрын

@@Physionic You definitely deserve it! The information you provide is fantastic.

@janineclemons746 Ай бұрын

I started taking astaxanthin years ago to save my vision and it worked. I got IBS really bad after covid and started taking collagen to repair the tissue. I didn't notice tremendous results. Then I found out that taurine is required for college in production. Are taurine levels start reducing in our 30s when we also begin showing signs of aging. I've added l-taurine and feel there's a difference.

@rainerblessing923 Ай бұрын

Great! I use every four of them :)

@japandi7098 28 күн бұрын

This video is a treasure trove of info! I've been using red light therapy for a while now, specifically a panel from Future Form Official, which my dermatologist recommended. It's not just affordable but incredibly effective. I've noticed a significant improvement in my skin complexity and a reduction in wrinkles. I never thought such a simple addition to my routine could yield such noticeable results. There’s a lot of scientific literature backing red light therapy, which gave me the confidence to try it. Big thanks to everyone sharing their experiences and tips here-so helpful!

@patriciawebb5579 Ай бұрын

Thanks!

@Physionic Ай бұрын

Thank you, Patricia!

@caramia4789 Ай бұрын

Awesome video. Your thoughts on retinols?

@barbaras3206 Ай бұрын

I believe. RetinA!!

@marshallsaltzman9924 Ай бұрын

OTC is child plays compared to Tretinoin in terms of efficacy

@PS-vk6bn Ай бұрын

Nice channel, you got a new subscription 🙂

@Physionic Ай бұрын

Welcome!

@Kestrel_Edmonton Ай бұрын

Thank you for mentioning UV as a major factor in aging. I don't take collagen or do much in the way of skincare, but I do slap on sunscreen faithfully and credit it with so many people telling me I look 10+ years younger than I am. I try to stick to mineral sunscreens, which I understand to be better? Maybe you can do a video on sunscreen sometime? It is summer in the northern hemisphere now.

@xmyxymx Ай бұрын

Well and I’m 40 and nobody gives me more than 28. People don’t believe my age they ask for my ID. Never used sunscreen unless I was at a beach baking between 12-3pm. I’m against sunscreen, I hate it with passion, it makes my skin feel terrible, I don’t use it at all, I make sure all of my makeup up and skincare products are sunscreen free. I love the sun and expose my skin to sun regularly, in fact it’s my daily task to get sun exposure daily for at least 30 min. My skin looks great for my age, never had any procedures done, not planning on any adjustments, not planning on using poisonous sunscreen anytime soon. Regardless of the bs studies funded by corporations I can’t see any damage by the sun, and if anything, the benefits that I get from the Sun outweigh the possible hypothetical sun damage.

@campersruincod6134 Ай бұрын

@@xmyxymxgood for you, but n=1. Anecdotes don’t trump evidence. Perhaps you’re genetically gifted in this area…

@jrmint2 Ай бұрын

mineral sunscreens work...but does not work better than chemical sunscreens which offer higher protection, they often use adjuncts that lower inflammation or sunscreen boosters to get the higher numbers. But they work well enough, for ppl that if it is your first choice, its good enough. There is no bad choice if that's the formulation you prefer.

@xmyxymx Ай бұрын

@@campersruincod6134 you mean the same type of evidence that kept insisting that vaccines are “safe and effective” or the evidence that fat is bad for us? Or perhaps the evidence that cholesterol in eggs makes your cholesterol go up and clog up your arteries ? Or.. I could go on and on the entire day with all the “evidence” that makes no sense but fills big pharma’s phockets. It could be a combination of things, if I eat actually healthy diet, not the diet recommended by the govt., if I don’t smoke, don’t drink alcohol, don’t take drugs etc, if my immune system works fine and my body manages to get the benefits from the sun while counteracting the negatives then that could be the reason why. I can’t tell I have particularly good genetics, I have white skin and I live in Australia- a country with high melanoma rates and other skin cancers. People bath themselves in sunscreen day and night yet the rates keep goin up.. something doesn’t add up here. Then we find science that the sun actually doesn’t cause many types of skin cancers and it’s in fact the lack of the sun that cause some of the bad ones. But of course you won’t find any of this info if you use google or other mainstream channels of information, you’d have to dig deep on pubmed to learn this. So yeah, perhaps, my comment is the only comment you came across that would give you an impression of n=1 anecdotal “evidence”, but the actual evidence is overwhelming. I didn’t stop using sunscreen for no reason, I followed the actual science. But you keep using your sunscreen and convince yourself it’s making you look younger 😌👍👍👍

@ballinout92 Ай бұрын

@@jrmint2what chemical sunscreen doesnt burn eyes? Every single chemical sunscreen ive used made my eyes tear up

@littlevoice_11 Ай бұрын

Was there a particular molecular weight for the collagen? Did you find marine or bovine is more effective and do you recommend types 1 and 3? Any reflections of UC-ii for health are usually reported for joints more than skin

@Fair-to-Middling Ай бұрын

Since astaxanthin seems to be an unusual anti-aging supplement, how would we find the best dosage?

@vawiley4 Ай бұрын

I’m on the Lion’s Diet currently. What’s interesting is that I don’t sunburn, just tan. I used to get crispy so fast on the Standard American Diet. It’s a strange, but awesome benefit

@markwhite6782 17 күн бұрын

Holy shit I'm on Ketovore

@silvana8737 14 күн бұрын

Tanning is also a sign of skin injury.

@markwhite6782 14 күн бұрын

@@silvana8737 I know but to me it's worth the injury. I never burn but I do tan well.

@monkiesbanana321 14 күн бұрын

I heard of this on reddit 10 yrs ago so this confirms it's real

@MJ_X2 13 күн бұрын

I experienced this too when I was vegan. At the time I thought it was from all the vitamin E I was eating but now I think it's more a function of eliminating processed food than a specific diet like carnivore vs vegan or whatever. ButI tend to think any benefits from specific diets comes from eliminating processed/manufactured foods.

@Camis419 Ай бұрын

Great video!!!!!!

@davidtrevatt Ай бұрын

I'd like to see the effect of collagen supplements on repairing ligaments, tendons and cartilage.

@hilohahoma4107 Ай бұрын

How do I stay looking young ? I follow the genius advice on Physionic of course.

@Esico6 Ай бұрын

Just don’t get burned in the sun. Also moisturize after.

@Jjoevme Ай бұрын

Any brand recommendations by anyone for hyaluronic acid? I generally go with Donotage but their hyaluronic acid is high molecular weight

@kurtniznik8116 Ай бұрын

@Physionic I recall reading about a study showing reversing of wrinkles with a rapamycin cream (not sure how it was prepared). Do you know anything about this, and would it make a difference to use cream if one is already taking rapamycin as an anti-aging supplement?

@evanrosenlieb8819 Ай бұрын

Hello Physionic -- really appreciate your work -- one slight pushback though. There's been some recent work on other benefits of sun exposure to skin, such as on NO production. Of course, that doesn't mean the benefits outweigh the costs, but its not all just about vitamin D. I'd love for you to do a video on this field of research!

@nivlakhera9 Күн бұрын

Hi take sunlight before 9 am best is sunrise you get your infra red - good luck

@dawnelder9046 Ай бұрын

I started taking Hydraulic Acid for my knees after a fall on my knees. Made a big difference. Took a few months. The exercises I was given only helped about 10 percent after 2 months. The Hydraulic filled in the other percent.

@senorpepper3405 Ай бұрын

Dang auto correct

@_zantetsuken_ 11 күн бұрын

Motor oil supplementation reverses all of my wrinkles.

@gsomethingsomething2658 7 күн бұрын

@@_zantetsuken_ But you feel _terrible!_

@_negentropy_ Ай бұрын

Thanks Nic! Love the study results breakdowns. Lots of sunscreen misinformation out there, for those interested, biochemist Dr. Michelle Wong is a great resource for sunscreen science (among other skincare science).

@Physionic Ай бұрын

Yes, she’s excellent

@maximshukanov3267 Ай бұрын

What do you think about creams based on hydrolyzed collagen and elastin? Absolutely zero benefit or is there still some benefit from them?

@thegreaterconundrum 19 күн бұрын

If I remember correctly there have been multiple older studies looking at collagen in topical formats and it showed basically what toxicologists and formulators suspected, which is that collagen is too large to pass through the skin and stimulate new collagen synthesis. You still find it in creams today because it happens to be a really fantastic moisturizer.

@vickisue Ай бұрын

Hello! love your channel. Do you know about or have an opinion on the suppliment called Helocare? Supposed to maintain skins ability to protect against free radical aging. I've been taking it , but it is pricy. Hoping it's beneficial!

@JerzeyBird Ай бұрын

Re: Vitamin D supplementation vs. sun exposure, I work with overweight/obese, diabetic and heart disease patients, and even though they all supplement because their levels of D are low, supplementation does not increase their levels. It seems that this is due to its tendency to store into adipose tissue. I have also seen many labs of folks who are not obese or have any condition, but have tested low for D, and their Vit D levels are also not increased with (correct dose and form) supplementation. Once you've seen hundreds of labs over a career, it becomes clear that the theoretical replacement of Vit D through supplementation does not occur in a significant number of people.

@Vn-ye3km Ай бұрын

So you recommend sun exposure? Doesn't that also get into the adipose tissues?

@irhapsody2010 Ай бұрын

I think that depends on what type of vitamin D it is. There's different types and my understanding is that you need D3 not D2 which is what is typically prescribed. There's also other vitamins that must be taken along with Vitamin D as it works better and it helps with absorption. Do a search on KZfaq and you'll find videos that go more in depth, into the science.

@rebeccadee4107 Ай бұрын

I was informed that you have to take it with a fat because it is fat soluble. I always take mine with a fat, but haven't been tested for my levels so I'm not sure.

@simsammalinao1823 Ай бұрын

So, reduce fat stores in the body.

@Ruudwardt Ай бұрын

Good catch. But you are likely wrong about the adipose tissue eating up the vitamin D. I am lean fit and muscular - vitamine D levels are low and supplementation appears to have low or no effect. Perhaps fish oils or foods containing it would lift my number - haven't tested it recently to know.

@Terence.1 Ай бұрын

Collagen and coffee is a nice combo.

@superboy-qq6fx Ай бұрын

Mr Physionic, I know you are usually not a guide to brands and are more focused on the compound. But could you please tell which collagen would work. A marine, bovine or porcine or is type 2 the answer ? And if there is a specific brand you recommend.

@gabrielbenito9832 17 күн бұрын

excelente video, astaxantina não sabia!!

@xenofontzaras1112 Ай бұрын

Danke!

@Physionic Ай бұрын

Thanks!

@mike_zander Ай бұрын

what sunscreen do you use?

@djayjp Ай бұрын

14:53 Pretty weird how the reported SD and CI of all the studies were wildly different, but then the error bars are all the same width....

@sundiataq Ай бұрын

But I love the sun :( On a more serious note, I'd love to see more in depth discussion on the effect of skin color on UV-induced skin aging. I'm brown skinned, and get about a one to two hours of sunlight a day. I need my vitamin D... I live in Ghana where most people are very dark skinned, and the vast majority of Ghanaians never use sun screen, yet, many people who spend hours in the sun every day barely show signs of skin aging and skin cancers are very rare here. How much protection do different skin tones really afford us, especially for those of us who are neither very light-skinned or very dark-skinned?

@vicz8899 Ай бұрын

You have built in sunscreen.

@sundiataq Ай бұрын

@@vicz8899 yes, I know, but I find statements online like: "dark-skinned blacks have a natural skin protection factor (SPF) of up to 13", but is that true, then why is SPF 30 recommended if dark skinned blacks barely experience UV-damage, and what does that mean for lighter skinned blacks? Do we have SPF 6,5 o is it more complicated than that?

@vicz8899 Ай бұрын

@@sundiataq There probably is "some" benefit to dark skinned blacks using SPF. It won't hurt. But the sunscreen makers also want to sell more product. My neighbor is black, she is 62 and smokes cigarettes. Not a wrinkle on her face. Her mother is at least 20 years older and smooth skin too. Lighter skinned would probably benefit more than darker skinned.

@christianlamb2276 Ай бұрын

Take a look at L theanine,L threonine, and L methionine.they are major players in skin rejuvenation,but they must be taken with B6,B9, and B12.

@MrDjhealth Ай бұрын

how about ceramides capsules supplement for skin hydration? also some make claims red light therapy drastically reduces skin damage from UV or the sun.

@betzib8021 Ай бұрын

Ceramides are terrible for arteries

@curlyhairdudeify Ай бұрын

Use sunblock. Red light therapy is good, but it isn't a miracle cure if you have roasted your skin with baby oil under the sun.

@curtissharris8914 Ай бұрын

Astaxanthin

@nutech1810 Ай бұрын

Use HLA

@barbiekat6352 17 күн бұрын

@@betzib8021References if you have them, please?

@the_primal_instinct Ай бұрын

I rarely go outside and have a very pale skin naturally so I think my face skin makes me look 10 years younger. Spend your time in the sun 3 times a week 15 min each for vitamin D, and avoid the sun otherwise. Obviously never do solariums nor get sun tan.

@chuclkles58 Ай бұрын

Will the strong antioxidant activity of Astaxanthin hamper the benefits of resistance training??

@smarzig Ай бұрын

Years ago I watched some KZfaq video about hyaluronic acid and I was taking it for a long time and people told me how amazingly youthful my face looked. I stopped taking it and a bunch of years later I actually look older than I should now

@denislemenoir 14 күн бұрын

Great video! What about vitamin b3?

@TekMoliGy Ай бұрын

Do a video on supplemental silica and aloe Vera for collagen production. There are studies about it

@jrmint2 Ай бұрын

Yes! I've used both, I think silica is so underrated, and I dd use aloe vera for years...but still bring it back into rotation.

@heidikamrath1951 Ай бұрын

I use silica (Biosil) but have not heard of using aloe Vera as a supplement. Very interesting!

@TekMoliGy Ай бұрын

@@heidikamrath1951 yea i don't remember how i found out about supplemental aloe vera but i did find studies showing supplementing with it internally increased collagen production and pretty much no one mentions either of these on youtube along with collagen peptides and hyalauronic acid that everyone mentions.

@ijh7192 Ай бұрын

@@jrmint2how do you use the aloe vera? Externally on skin or do you drink it? Thanks in advance.

@jrmint2 Ай бұрын

@@ijh7192 orally, pill form.

@homesignup Ай бұрын

yay thanks for the collection :D.. I take them all....and with regards to the last note, ergothioneine, I'm going back on Cordyceps - good for 7 or 8 health functions.. and includes ergo, and great for a good night's sleep too. Check it out!

@barbiekat6352 17 күн бұрын

Brands you use please?

@homesignup 16 күн бұрын

@@barbiekat6352 I just take Swanson. It's 3rd party tested but its very inexpensive compared to the other brands. I buy everything in bulk 2-3 times a year.

@seban-jackedweeb5513 Ай бұрын

Thank God you said it bro, yes! Guys, you've completely missed the point and need help if you're worried about these supplements...without even consistently using sunscreen and using chemical exfoliation.

@barbaras3206 Ай бұрын

Glycine. Proline. Hydroxyproline. Water with hyaluronic. SUN BLOCK. HAT.

@betzib8021 Ай бұрын

What kind of chemical exfoliation?

@elingrome5853 Ай бұрын

My 2 cents living here in Southern Europe with about 11 months of sun a year; Most of us are deficient in VitD3; the most important hormone for overall health and the immune system... blocking out the little sun we get with sunblock seems unwise...just take care in the midday sun, wear a shirt... and avoid seed oils which also contribute to sunburn...

@roba.8907 Ай бұрын

@@betzib8021They most commonly use some combination of glycolic acid, lactic acid and salicylic acid which helps exfoliate, reduces pore size/appearance of fine lines, and improves skin tone, texture and clarity (brightness). The most convenient ones are single use pads/peels and they should be paraben free such as m-61 PowerGlow peel and many other quality brands. They work great with immediate results and consistent use will help new collagen formation. MD approved

@seban-jackedweeb5513 Ай бұрын

@@betzib8021 topical and at home, like glycolic acid, salicylic acid, lactic acid, etc. You know, the second thing dermatologists say is so important and only second two sunscreen. Exfoliation increases collagen synthesis, increases skin cell turnover, clears pores, etc. If you're worried about anything related to skin without sunscreen and exfoliation, you've missed the forest for the fungus on the floor. It's like worrying about sugar,...when you don't even exercise enough.

@littlevoice_11 Ай бұрын

To conclude... please share dose ranges in the summary or in a punned comment 🙏

@batlin Ай бұрын

11:40 "and the sun is good because it's natural" -- it's good that Nic calls this out. Other things that are natural (and therefore good): wasps, uranium, syphilis... BTW my patented skin-rejuvenating blend of syphilis-infected uranium wasps should be on store shelves soon.

@kennethbutzer4467 Ай бұрын

You really ran with that lol

@anyajohnson4471 13 күн бұрын

The sun is good because we evolved in it. It is required for vitamin d and for vascular function. Getting sun is correlated with longevity.

@batlin 13 күн бұрын

@@anyajohnson4471 that's dependent on dose -- too much and you get skin damage, aging and possibly cancer. Most of the research suggests sunscreen doesn't have much impact on vitamin D production, so you can get most of the benefits with less risk.

@Fair-to-Middling Ай бұрын

How does one know if the hyaluronic acid supplement is low or high molecular weight?

@Vn-ye3km Ай бұрын

It should be mentioned in the label . Not sure if any otr means are there to determine that

@jarnohealth Ай бұрын

Where is the supplement vid u said u put in description?

@charlieparkeris Ай бұрын

What about supplemental vitamin A as in retinol? It does wonders for my skin.

@jrmint2 Ай бұрын

which vitamin A are you taking? caroenes? or the active form? what's your regiment? I'm always interested in what others do for their skin. Thx!!

@charlieparkeris Ай бұрын

@@jrmint2 Retinyl Palmitate. 25,000IU per day. I'm aware of the "risk" of that dose, and am 100% comfortable with it. The difference it makes to my skin is incredible. Body and face acne, from terrible, to gone. The red, sort of slightly rough skin I would get on my neck, behind my ear and sometimes along my hairline, gone. And skin so clear it gets commented on. This is along with my skincare routine of daily SPF, and nightly alternating 0.1% tretinoin, with 20% azelaic acid. But those topicals alone won't take my skin to the level of adding retinyl palmitate. I have had success with substituting the retinyl palmitate with a regular daily dose of good quality cod liver oil. Which provides a much smaller dose of vitamin A, but seems to be just as effective. The reason I don't stick with that, is because I travel a lot, and it's easier to travel with and acquire retinyl palmitate abroad, than it is high quality cod liver oil. Beta-carotene supplements are not an alternative, they have no effect on my skin. There was a recent study that looked at tretinoin topical application, vs tretinoin topical application + 50,000IU vitamin A daily, comparing the signs of aging. And the vitamin A group had a superior outcome after 12 weeks.

@thomk3282 Ай бұрын

Do you drink green tea? What are your thoughts about it?

@onpointux Ай бұрын

I'm one of those watchers who you wouldn't lose with the statistics stuff! :) Perhaps there are more like me. How about a one-off show on statistics needed for interpreting studies?

@lukenukem1207 Ай бұрын

Don’t know if you take video topic recommendations, or if this would interest you, but curious what you think of the studies pertaining to protein intakes effect on kidney health!!

@lala38196 Ай бұрын

How many kDa should the hyaluronic acid have? Most supplements seem to have 500 to 700...

@JessicaHopeHarvey 23 күн бұрын

Thank you so much for true scientific data. I’m so tired of cosmeceutical companies presenting ridiculous, decontextualized data with no statistical power as “evidence” when in fact it’s just a marketing scheme. Thank you!

@HarenHarem-zz5dx 25 күн бұрын

Hydrolyzed elastin peptides are needed in addiction to collagen and Hyaluronic acid. It's getting fairly easy to find elastin as a supplement (comes in pills or powder form)

@simonscott5104 11 күн бұрын

💉

@AR-qn9mq Ай бұрын

I'd be interested to hear what you recommend in a sunscreen please. Some scary stories out there about zinc oxide and no sunscreen being in contact with skin without causing other problems

@annvassallo2604 Ай бұрын

I wont leave my bathroom without at LEAST 50 on. Ever. I developed melasma in my late teens from sun when i was a kid, and since i was 18, I don't go anywhere without it on

@teru797 Ай бұрын

I just wear a hat lol

@heidih3048 Ай бұрын

Which sunscreens are your favorites, and why? I hate the feeling of sunscreen on my skin, especially my face. But I know it is important to wear..

@annvassallo2604 Ай бұрын

@@heidih3048 I actually really like Scinic Super Mild Sun Essence 50 + pa. It's a Korea brand, and it's wonderful.

@fibonacci3138 Ай бұрын

Hi, I'm not the original commenter. But I love Bioré kao aqua rich. They sell it on amazon, stylevana(where I get it from) and various other places. It's a Japanese Sunscreen and it seeps right into my skin, the 2019 version is my favourite, that one disappears completely after rubbing in, i am mentioning this because i think Bioré still produces it(the 2019 version). But the newer version is still good.

@MadLadsAnonymous 19 күн бұрын

Try: Face - LRP UVMune 400 Creme Hydratante (eBay or Care To Beauty) Body - Bioderma Pediatrics Pump Spray (Care to Beauty) Protect yourself with a high PPD sunscreen.

@su2sa1li4 Ай бұрын

Fasting for autophagy would help skin aging?

@jacquietarr7280 Ай бұрын

Yes

@knay2297 23 күн бұрын

genuinely asking, isn’t there a thing as too much antioxidants which blunts the benefits of exercise?? also i’ve seen dermatologists suggest taking polypodium leucotomos supplements to help with preventing sun damage but not a alternative to sunscreen, how would that compare to astaxanthin?

@noosphericaltarzan Ай бұрын

H. acid applied on my skin certainly has a cosmetic effect. Honestly, the biggest effect I have seen thus far is from essential oils. But also my greatest experimental catastrophes, which is why I think it is not widely recommended. But if you are serious about it, you should start researching which phytochemicals have various effects on collagen production, autophagy, antioxidants, and especially which ones kill off pathogenic bacteria and fungus that have colonized most westerner's skin (nasty). Once you have a short list, find carrier oils that bring benefits and complement the oils. Then use the oils in small patches first to see if you have bad reactions (and you will to some of them). Keep daily notes and that will actually help you figure out which ones work for you.

@vchafab Ай бұрын

I have found the same. I have tried every product imaginable but recently switched to a castor/rosehip/frankincense mixture and wow my skin has improved so so much.

@noosphericaltarzan Ай бұрын

@@vchafab I like frankincense+patchouli+sunflower carrier oil. Recently I have been taking my chances with cinnamon+patchouli+sunflower oil. I have immune system issues so my main goal is creating a kind of barrier defense, and cinnamon is very effective, yet very dangerous if you have many mast cells sitting in your skin. However, cinnamon will kill the bacteria that causes acne in a week or so when nothing else would. Ylang ylang has effects slightly different from frankincense.

@ballinout92 Ай бұрын

@@noosphericaltarzan What other oils are good for thickening skin and anti aging? I like tamanu

@noosphericaltarzan Ай бұрын

@@ballinout92 ylang ylang has effects. The cosmetics and pharmacology fields pay for quite a lot of research into these oils. You can find the data on all of them in publicly available research papers. What I suspect, though, is that the efficacy of an oil is unique to each person, so that while an oil might on paper be very effective at something, it might not be the best for you. You have to use the research to make informed guesses about what could work for what you are trying to accomplish, keep detailed notes with objective metrics to track, and weed out the oils that aren't as effective. Also learn to use the ones that have side effects but are very effective (for me that is cinnamon). There's no universal answer to give other than a short list of the top candidates to experiment with. I would also point out that addressing colonization by bacteria and fungus goes a very long way. Most Americans have very poor hygiene and are walking around with ongoing colonization by staph and candida pretty much all the time. This slows down the repair and replacement of collagen I think since your body is dealing with the infection on the skin instead of synthesizing new skin. There are also dietary considerations. I don't eat meat. I eat a lot of fruit and vegetables. I supplement with all the precursors amino acids and vitamins to making collagen. I activate my ampk signalling pathway very often in training. There are many things that go into it.

@Txevenstar4889 Ай бұрын

What were your oil catastrophes?

@JuliaKirsty 19 күн бұрын

What about the amount of these supplements you need to consume in order to see results? Like how much mg per kg of bodyweight? (Or is per kg of lean body mass a better way to measure?) I am asking from a fitness and health perspective. Because these supps also are called beneficial if you work out a lot and want to support muscle growth, the health of your ligaments, tendons and cartilage. Of course it does incorporate skin and connective tissue too. What about that? Do you know anything about it? I know hyaluronic acid and collagen can be injected into the cartiledge if it is damaged and CAN induce growth. But I also know that cartiledge is nourished during compression and release, not when being in a resting (or stiff) position, basically because it doesn't have its own blood supply. To sum up my question: Is that "information" that the intake of supplements containing collagen and hyaluronic acid beneficial for all of the things mentioned above, legit or is it nonsense? Plus: Noone ever told me how much should be taken in order to cause actual benefits to show up or happen. Here in Germany this all still seems to be rather experimental than based on knowledge, I think we're FAR behind in the health department tbh. That's exactly why I am asking.

@ColbyBarradas Ай бұрын

Are you uploading your Omega-3 video soon?

@ferdinandfocus489 Ай бұрын

Any concern about astaxanthin increasing mortality like supplementation of other antioxidants?

@mikegracia1475 Ай бұрын

I didn't know antioxidants increased mortality? Any links for that?

@ferdinandfocus489 Ай бұрын

@@mikegracia1475somehow it’s not letting me paste links, but u can look up the Cochrane study on supplementation with vitamin A and E

@Mestre_tainha Ай бұрын

I think this issue is only with synthetic vitamin E and beta-carotene.

@mark2073 Ай бұрын

What about castor oil??

@richardbreeze7898 Ай бұрын

Where do you stand on Polypoduim. Its veiwed as a skin specific antioxidant. There seems to be some evidence for that.

@Physionic Ай бұрын

Haven’t looked into it, unfortunately

@richardbreeze7898 Ай бұрын

@@Physionic Have a look. It's meant to be a skin specific antioxidant and there is some evidence to that effect. I take it.

@DarthNoshitam Ай бұрын

I add a scoop of collagen to my daily whey protein shake, but part of me thinks I'd be better served by just using two scoops of whey. What do you think?

@kylechristianson7667 Ай бұрын

Do both. I do 2 scoops of whey with 1 scoop of collagen. Some ceylon cinnamon and a bunch of wild blueberries 💕

@DarthNoshitam Ай бұрын

@@kylechristianson7667 I'd need to buy a bigger blender to accommodate all that lol

@deeprollingriver52 Ай бұрын

Whey is horrible source of protein.

@TheCetarius 13 күн бұрын

How much Kollagen should you take per day?

@keithschmolze7653 6 күн бұрын

Any suggestions on brands and dosage for all 4?

@pubwvj 14 күн бұрын

I do not like sunscreen due to the chemistry. I wear hats, cloths, avoid the mid day (10-2), sun, use the shade all as much as possible. I have very little skin aging at 62. The most exposed skin (hands, calves/shins, face) does have more aging that the non-exposed. But it is very minimal. Good genes likely help.

@davidthornton2788 9 күн бұрын

Do you consume Hyaluronic Acid or out it directly on your skin?

@jimwood1062 11 күн бұрын

Red light and Methylene Blue have a tremendous effects on collegen and skin development. And most sun block lotions have very hazerdous chemicals in them. Yes too much sun is not good, but daily sun exposure has a significant impact on mitochonrial production and health.

@marcobartz1879 Ай бұрын

Have you looked into glycine supplementation together with nac? Like 5g nac 15g glycine?

@Physionic Ай бұрын

I have videos on GlyNAC

@terminator3728 Ай бұрын

@@Physionicgood videos to boot!

@marcobartz1879 Ай бұрын

@@Physionic yes I watched that, though I believe there is solid evidence for that having a decent effect on skin aging. Especially in older people. I was expecting to see it mentioned here.

@carmenzammitti-hn1zj Ай бұрын

What foods are best to raise my low body fat

@jp7357 Ай бұрын

I guess my Astraxanthin is going to my skin not my eyes .. I can’t see the insider link mentioned.

@linda7279 Ай бұрын

😂

@curtissharris8914 Ай бұрын

I put it on my face for UV protection next thing I know I got the DMV to remove my eye glasses restriction.

@aaaaaa-aaaaaaaaaaaaaaa Ай бұрын

Im surprised you didnt mention a time machine.

@Physionic Ай бұрын

Not enough data

@reinerheiner1148 Ай бұрын

But what about astaxanthins effect on training adaptations? Its antioxidant effects could be decrease adaptation.

@tomcarl8784 Ай бұрын

Would love an episode on sunscreen advantages vs dangers given that at a high enough dosage it’s maybe emerging as a carcinogen? Or some are? It definitely has me nervous about the idea of slathering it on daily.

@01peace Ай бұрын

This seems to be highly exaggerated. Also, skin cancer is far more likely that cancer from sunscreen ingredient

@hazelsheridan1869 15 күн бұрын

Mineral based sunscreen might be an option?

@BR525 Ай бұрын

Been doing orange juice enemas since I was 24, no wrinkles at all. I truly think this is the best way to drink from the fountain of youth.

@carolmaplesden916 Ай бұрын

Hummm i used to do enemas I've done all kinds but it never accerd to me to do vit enemas thanks for the tip

@BR525 Ай бұрын

@@carolmaplesden916 it was just a joke, Carol. Don’t actually do it.

@carolmaplesden916 Ай бұрын

@@BR525 Yeah haven't you heard of vit IVs I think it could be good

@salmanuel4053 Ай бұрын

Glad to say I take all of these, and take in what my friends say is too little sun. But you know what else friends say? That I have good skin. And one doesn't do this in the vain hope of physical appeal. Doing what is good for your tissues will probably also be good for your organs and cartilage!