4 Factors that Clear Plaque in your Arteries
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References (Copy & Paste DOI into Search)
[1] doi:10.1016/j.yexmp.2017.01.013
[2] doi:10.1093/eurjpc/zwac309
[3] doi:10.1161/CIRCULATIONAHA.109.879254
[4] doi:10.1016/j.tcm.2018.05.002
[5] doi:10.1016/j.amjcard.2014.08.012
[6] doi:10.3389/fphys.2023.1043108
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#heartdiseaseprevention #heartdiseaseawereness #heartdiseasetreatment
@Physionic 4 ай бұрын
No Amendments & 1 Note NOTE: [Video Summaries and Chapters] I spent 350$ and 5 weeks of work to make this free video. Video summaries and chapters on an 11 minute video hurt retention and hurt the video performance, therefor hurting the channel and my ability to continue this work. If you do not think it is worth your 11 minutes to watch the video and all its context, I understand; however, I ask you understand where I'm coming from, as well. In such a case, I think this brand is not for you - there are plenty of pop science channels to follow - this channel is dedicated to the people who want the depth and context (I appreciate you). So, in short, please do not post video summaries (see channel rules). Thank you. :)
@LingLing-wx4lu 4 ай бұрын
Much appreciated bro , I’m just kidding big fan !
@Lennythewinner 4 ай бұрын
Good morning. I've been watching a video in which Dr Malcolm Kendrick considers an alternative model of what causes arterial plaques, and what things allow them to regress: watch?v=wRjQCG4NU-Y Malcolm also mentions in the video how this alternative model, though acknowledged by a greater proportion of medics and researchers than might appear, continues to be suppressed. I'd be interested in your thoughts and critique of the model, and expect that you and other viewers of yours would be too.🤓 Kind thanks.😊
@user-ij5ky4lr3x 4 ай бұрын
To summarize your anti-video summary comment: Watch the entire video, start to finish, so that KZfaq pays him for his work. Don't post video summaries in comments that might cause potential viewers to leave the video before having viewed the whole thing. Did I get that right? Did I miss anything? Thanks for the excellent content as always!
@src3360 4 ай бұрын
You need other sources of income it seems, outside of KZfaq...
@mellocello187 4 ай бұрын
@@src3360You missed the point. This video cost him a lot of time, and some money, regardless of any other factors. What do you do for free on a regular basis to benefit other people who can probably afford to pay you?
@PInk77W1 4 ай бұрын
Walking is a super power Fasting is a miracle
@charflorida5433 4 ай бұрын
I love fasting!
@justincoats7236 4 ай бұрын
@charflorida5433 I hate it. I believe in it. It's not fun. Maybe you can educate me, so I can love it.
@Gothlore 4 ай бұрын
I thought fasting's only benefit was reducing calories, and that the actual gap in eating was harmful and put stress on the body. Most doctors recommend eating more often, but smaller amounts.
@charflorida5433 4 ай бұрын
@@Gothlore No, int fasting is not about reducing calories. It is about reducing insulin production. And it does not need to be done 7 days a week. I personally don't take the advice of most docs anymore. I suffered for decades with IR and all its symptoms, and docs never told me the cure. I found the cure on my own, int fasting. The "stress" on the body is autophagy, which is extremely healing. Most GPs these days are "pharmecutical reps" not health and diet professionals.
@Gothlore 4 ай бұрын
@@charflorida5433 It's not just what doctors say. There are plenty of recent studies that show reduced lifespan and plenty of other health issues with fasting.
@rmggrm2069 3 ай бұрын
Berberine / metformin Nattokinase / serrapeptase K2 / koncentrated K Omega 3s / Astaxanthin Magnesium glycinate
@ianstern7128 3 ай бұрын
Similar to all your supplements. As well as: 5g VitC, and several other anti oxidents like pine bark and aged garlic, tumeric etc, as well as tocotrienols
@rayvac7743 2 ай бұрын
Ty😅
@hawkforce4295 2 ай бұрын
No one taking Niacin? I added niacin because Dr Ford? Says it’ll help. I switch between flush niacin and non flush niacin.
@davex142 Ай бұрын
Make yourself Chemical Ali... avoid excersise at all costs, take chemicals only :D
@hawkforce4295 Ай бұрын
@@davex142 I for one am unable to exercise properly. Disabled, I’ve had a couple back surgeries and a foot reconstruction from a gunshot wound.
@ZappyOh 4 ай бұрын
Bonus factor: High speed motor racing ... lowering your risk of dying from cardio-vascular problems, by raising the risk of vehicle accidents.
@Santa-ny1yp 4 ай бұрын
Imagine the possibilities of bonus factors.
@videoagogo1 4 ай бұрын
and yet, Dr Peter Attia (who wrote 'Outlive: The Science & Art of Longevity') engages in it, and Ayrton Senna is his sporting hero! ;-)
@pjaworek6793 4 ай бұрын
😂😂. That's been my strategy for eternal life all along. Risk taking! For 1, you are in control, not other things. When other things see how much you challenge yourself, they say, "I think I'll pick on someone else". #2 Know your limits for max safety, discipline!
@deemisquadis9437 4 ай бұрын
😂😂😂😂😂
@deemisquadis9437 4 ай бұрын
You got it!
@SeleckPlays 4 ай бұрын
Thank you for breaking this down so simply! My father had quadruple bypass surgery in his 60s and I have uncles on my dad's side that never made it into their 40s due to heart disease. This information is life-saving to those who take this information seriously enough to make habitual life-style changes. Thank you!
@nimblegoat 4 ай бұрын
They may have had Apo A , you may have it too . A new drug has came out to reduce it I believe. Normally is fixed for life edit mean Lipoprotein (a) - genetically determined and is high risk to a bad cardiac outcomes
@skythundersky1544 4 ай бұрын
What was their lifestyle like?
@jellybeanvinkler4878 4 ай бұрын
@@skythundersky1544they probably followed the USDA Food pyramid. Low fat, high carb. 😢
@nicolatesla5786 4 ай бұрын
Us life exiectacy is the lowest of advanced 30 countries.
@CTF33 3 ай бұрын
@@nimblegoatDo you mean Apo B?
@Liberty73_NA 4 ай бұрын
Very impressed with this presentation. No real fluff. Informative and to the point, AND HELPFUL! Thank you!
@fiery_transition 4 ай бұрын
Your videos are one of the few ones I watch, it's so hard to find well-presented science by a person who is also a scientist. I might not be a scientist in the same field, but having an interest in sports science and nutrition, I cringe at what is being shared around the internet usually... So, what I'm saying is, please never stop making videos 😂
@Physionic 4 ай бұрын
Thanks!
@deemisquadis9437 4 ай бұрын
Keep looking around, don't stop here.
@fiery_transition 4 ай бұрын
@@deemisquadis9437 While I'm not sure what you are trying to say, I do follow other authors as well, who I also deem it worthwhile to spend my time on. And if there's something I'm really interested in, I know how to research things myself. But the majority of my time is spent on computer science as that is my vocation, since I'm not made of infinity.
@cyberfunk3793 4 ай бұрын
@@Physionic I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation and heart health and perhaps even reverse plaque. Some sustabces that come to mind are: -AMLA (lowers LDL as much as statins in one study) -Citrulline, AAKG -EDTA (chelation) -Nattokinase, Serrapeptase -B3 -Pomegranate -Garlic -Omega 3
@cyberfunk3793 4 ай бұрын
@@Physionic I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation/heart health and perhaps even reverse plaque. Some sustabces that come to my mind are: AMLA, Citrulline, AAKG, EDTA, Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic.
@pjaworek6793 4 ай бұрын
You're #1 for informative health videos Nick! Thanks for bringing everything together for us.
@douggodfrey6521 4 ай бұрын
Great Makeup Kid
@uber_l 4 ай бұрын
Stress leads to high BP, and jobs causes most stress. So if you want to be healthy do not work
@veronicaheaney3464 4 ай бұрын
🤔Unfortunately, lack of money also increases stress.
@CeresKLee 4 ай бұрын
Find work you love and you would never work again at a shit job. I not was so lucky.
@pkmkb007 4 ай бұрын
Goal should be to work enough to invest in income producing assets so that your money works for you.
@anonanon7553 4 ай бұрын
make money but also stay frugal and don't spend on stupid stuff. dont buy the latest iphone, the best clothes, best car yada yada yada
@carlyndolphin 4 ай бұрын
@@pkmkb007I’m 44 been investing all my life in property and global ETF. I could retire tomorrow. I’m always stressed 😣
@LockFarm 4 ай бұрын
I had a stent fitted a couple of months ago as an otherwise active and healthy 53 year old - so finding realistic, evidence based information on recovery and appropriate lifestyle choices has been vital to me. Thank you for sharing this and your channel content in general. I find the supplement area most challenging as that's where the most 'fake science' and fitness influencer content hangs out - but might make some decisions on those once I've implemented the core recommendations that are consistently made. I've lost ~15% body mass over the last four months, transformed my diet and am slowly building up exercise levels with the help of the Doctors. The hardest part is not being able to directly measure the consequences of these changes since our health service minimises follow up to periodic basic blood tests. I know I'm fitter and lighter, but don't know how far that is benefiting me as someone who has a heart disease diagnosis.
@RickinICT 4 ай бұрын
Do you have independent labs where you are? Over here in the States, we have a variety of independent labs (private pay, of course) where we can go and get practically any kind of lab work done, including NMR particle profile tests, etc. It might be worth looking into, they aren't free, but they aren't terribly expensive for a test you'll only need to have performed once or twice a year to keep tabs on your progress.
@misterbd9641 2 ай бұрын
Had 2 stents fitted a week ago after having a heart infarction aged 53. Sadly nothing was given to me diet related, nothing.
@TheVafa95 Ай бұрын
Basic multivitamin works for me, surprisingly after a few months of taking it, caused removal of my old and new nail fungi.😮
@RoseMary-gl4ee 4 ай бұрын
I love that you explain why a logic is correct, and why a logic is mistaken (when it is)
@christaylor9656 4 ай бұрын
This video is greatly appreciated, thanks so much for the content ❤
@WhereOceansMeeet 4 ай бұрын
I was always told K2, Magnesium, Omega 3, D3, Alpha Lipoic Acid, and Vitamin C help clear it. I take them all.
@onder8374 4 ай бұрын
Generally speaking, ,why Im unsubscring from this channel now- , (where he never mentions Tryglicerid is the main problem for this plaques, (carbs) and not LDL which is produced mostly by liver and it is , the main part of lipoprotein mechanism , and it is not cholestrol, it is the carrier to cells..which is MUST for body. and neve rmentions, 2:14 shows `Oxidized LDL` but never mentions what is this and hox oxidization is caused by blood Glucose, :-) , and never mentions Glucose is the root of fat storage mechanism (loose weihgt issue ) so anyway, those supplements are fine, ```but by the way, need to stay away ``mainstream channels` (always told ) to you if mainstream info , is probably showing the wrong direction
@benjames1497 4 ай бұрын
@@onder8374 I like your ideas here. Can you prove any of it?
@Samrod-nj8wk 3 ай бұрын
@@onder8374 thanks for the misinformation bro
@user-rm2mo7gb5w 3 ай бұрын
Excersise Prevents This Plaqing
@Dancky2 3 ай бұрын
@@onder8374talk but can't prove when other guy asked, just a talk talk talker
@shawnogg8208 4 ай бұрын
Clear, Concise. Brilliant stuff. Thank you!
@easyacademy8110 4 ай бұрын
Hi Physionic I watched many many video on reversing plaque and this video is the best i.e. most logical and clearly explained !!! I used to be in the research field and I know your explanation is very well justified!!! 💗💗
@SuperAngelic5 4 ай бұрын
Thanks so much for the information. Great presentation!
@ralphgelwicks3679 4 ай бұрын
Thank you for this great research info and for sharing it with us! 👍🏻
@DaryndaJonesOfficial 4 ай бұрын
Great video and info! Thanks! I love all of your analyses.
@karmadave2000 4 ай бұрын
I just found and subscribed to your channel because this topic is of great interest to me. At about 3:50 you mentioned that to clear arterial plaque, having low blood LDL is thought to be important. That is my personal primary reason for taking twice monthly injections of Repatha. In a few months I will complete a 78-week regimen. I discovered that early clinical reports are showing that Repatha can cause a reduction of arterial plaque by as much as 20%. When I asked my cardiologist about the reports, he said he knew about them too. When I remarked that this could be a game changer for me, he agreed. My LDL cholesterol has been about 17 for over a year. After a year, my systolic BP dropped from about 125-140 to 100-115. I am hopeful that when I am finished with Repatha my cardiologist can at least semi-quantitively determine if my plaque burden has become lower. And perhaps you can find more current information about the relationship between ultra-low blood LDL and plaque reduction. Thank you for your excellent video.
@anode-cathode 4 ай бұрын
17 LDL? Is that a typo?
@karmadave2000 4 ай бұрын
Before Repatha taking 15 mg simvastatin. 1/4/23 Start Repatha 2x/month +10 mg /day simvastatin 1/9/23 LDL 42 3/16/23 LDL 17 8/8/23 LDL 21 11/13/23 LDL 16 I meet medical criteria for taking Repatha so covered by insurance. Plaque reduction not reason it was prescribed. Hope this helps. @@anode-cathode
@karmadave2000 4 ай бұрын
@@anode-cathode Not a typo. Over 12 months the numbers were: 1/9/23 - 42, 3/16/23 - 17, 8/8/23 - 21, 11/13/23 - 16, 1/3/24 - 29. You're likely unable to get LDL that low without a PCSK9 inhibitor like Repatha. And my cholesterol has never been high so high LDL patients may not get that low. But PCSK9 plus a statin still will be dramatic.
@imhassane 4 ай бұрын
@@anode-cathodethere are people who have 0 ldl genetically.
@karmadave2000 4 ай бұрын
@@anode-cathode No. PCSK9 inhibitor. Google it. I hope Nic will leave this reply up long enough for you to see that I did not ignore you. Bye!
@frankbitzer6748 4 ай бұрын
I very much appreciate your efforts and your videos! Keep up the great work!!!
@meggarstang6761 3 ай бұрын
Thank you for this information. I value your channel very much and appreciate the effort it takes to create accurate and meaningful content. 💕
@max190364 4 ай бұрын
So great full for your knowledge sharing thanks!!
@MarksThinkTank 4 ай бұрын
This subject is crazy interesting and relevant to an ever growing number of people, including me. Please follow up on this!
@Physionic 4 ай бұрын
Thanks, Mark!
@earlpaulich3396 4 ай бұрын
Thank you for this clear, concise helpful information.
@RobertaPeck 3 ай бұрын
Another absolutely brilliant articulation. From one who spent a lifetime teaching, I want to say, you are truly a master teacher!
@tiwidub8809 4 ай бұрын
Fantastic explaination as usual. Many thanks. ❤❤❤
@MadRat70 4 ай бұрын
Its worth watching more than once because its a lot to digest in one run.
@NoLimitsNatty 4 ай бұрын
Thank you for all the information 👍🏽
@harold18659 4 ай бұрын
I am grateful for your work and your talent/gift. Material things are necessary while we live. The intention of why we do things follows us even when we leave here. Doing things with an intention of helping someone guarantees physical provision here and contentment over there.
@willbrink 4 ай бұрын
As efflux of LDL (ApoB) into the artery wall is gradient driven, it makes sense BP is an essential component of the process.
@lucretiasulimay1968 4 ай бұрын
Caught your conversation with Gabrielle Lyons yesterday . I have been taking creatine for a few weeks now after I saw the information you gave on your show . I just turned 65 🎉. Dr Andrew huberman just asked people who they would like to see having a conversation with him , and I mentioned your name I hope you don't mind 😊!! By the way you have a great sense of humor , and no I'm not giving up my social security number 😊😊 have a beautiful day thank you for all your research !!
@Physionic 4 ай бұрын
I appreciate the kind words - thank you :)
@Welshwildthing 4 ай бұрын
I would love to see this too!🙏🏻
@melt2947 4 ай бұрын
That's a great idea
@PhilWhelanNow 4 ай бұрын
Id love to see Huberman in conversation with his recent ‘monogamous’ partners about his proclivities, and their sexual health.. but it’ll be hard watching. 💀
@winwinmilieudefensie7757 4 ай бұрын
Huberman is a quack like most joe roganites
@frankarcobello3149 4 ай бұрын
Thanks for the great talk, loved it
@xband 4 ай бұрын
Great channel! I’m interested in how you choose a review topic? It’s a great service to you’re performing going through these studies. Thanks!
@yogimaster1 4 ай бұрын
I periodically take a full spectrum of proteolytic enzymes including 2000 FU of nattokinase per day. Proteolytic enzymes are fibrinolytic, or they break down fibrins, which are proteins that are components of arterial plaque and scar tissue. Another component of arterial plaque is calcium and this must be addressed along with the other recommendations. Vitamin K2 and an herb called chanca piedra are two of the best ways to reduce arterial calcium.
@cyberfunk3793 4 ай бұрын
I have started nattokinase also. You might want to study the dosages of Nattokinase but be careful because too much can also have serious side effects, because it's a blood thinner afaik. In the one study I saw, they only received results with 10 000 FU, and doses like 2000 FU didn't do anything, so if you haven't read it yet, Google it.
@32Brandonp 4 ай бұрын
You’re correct. He missed the mark with the outmoded faulty cholesterol hypothesis.
@LorenziniLuigi-gl1mg 4 ай бұрын
Sir good evening from Italy. Can you recomand NATTOKINASE for me? Thanks
@yogimaster1 4 ай бұрын
@@LorenziniLuigi-gl1mg If you have blockage of your arteries then nattokinase is one of the things I would recommend. As I mentioned, I would also address the calcium in your arteries. As a final note, long term water fasting has been shown to reduce arterial blockage. These along with a proper diet and exercise is what I would recommend.
@LorenziniLuigi-gl1mg 4 ай бұрын
@@yogimaster1 I thank you very much. I Will take NATTOKINASE AND VIT. K2. Many greeting from Rome to America.
@garjog1 4 ай бұрын
LOVE this analysis! Thanks Nic.
@Physionic 4 ай бұрын
Thrilled to hear it :)
@zanzabar7878 4 ай бұрын
Thank you for all your hard work
@ajr3350 3 ай бұрын
Brilliant Presentation. Clear and informative. Thank you.
@josephbenjamin6426 4 ай бұрын
DAMN!! I’ve watched 100s of health videos (especially after my ❤ attack last year) and NO ONE has explained atherosclerosis and blood pressure as well as this! To add to my understanding, I’d like to see a discussion on how obesity affects inflammation.
@SeanFisher 4 ай бұрын
Would L-Citrulline or L-Arginine aid in providing nitrous oxide to arteries, as you stated was helpful?
@Welshwildthing 4 ай бұрын
This is especially of interest for me as something I worry about, I exercise lots but I also have health anxiety! 😅Thank you!
@Natashaleah9 3 ай бұрын
Thank you so very much, I appreciate this information so much.
@QKVCS 4 ай бұрын
CAPSAICIN CAYENNE PEPPER
@konstipisti 4 ай бұрын
Love the gasp sound effect :)
@CG-zm9oj 4 ай бұрын
Brilliant article really enjoyed that thank you
@supernova1976 4 ай бұрын
This is brilliant, thank you 💪
@peetsnort 4 ай бұрын
Excellent. Im 64 and I have been looking after my endothelial lining for 6 years. Starting with the building blocks . Zinc Manganese Copper I swear its what keeps me cold free.especially with th big C breathing disease I never got it. I didn't roll up my sleeve for a needle. I just took extra vitd3 in winter. Olive oil and totatal avoidance of canola/rapeseed. Very very difficult because its in EVERYTHING on the supermarket shelf. THEN lots of walking or swimming .swimmings best for not damaging my weak joints and tendons. I have now stopped drinking by 90 percent. Same for SUGARS.....thats a proper bad food . SO GLAD SOMEONE IS TALKING ABOUT THE ENDOTHELIAL. what also happens when you breathe HARD through your nose is the natural production of the same gas you get from viagra......nitrous Need i say more.
@user-yj3fv8yu5q 4 ай бұрын
A discussion with Dr Malcom Kendrick would be excellent
@mestrinimaster3602 4 ай бұрын
Feel better! Nice vid
@AstroLaVista 4 ай бұрын
I really appreciate both the research, and how you communicate the findings to us lay folk! I'll keep on doing the Triathlons then by the sounds of it🏊♂🚴♀🏃♂
@stelmili 4 ай бұрын
I love the infographics and animation stuff, makes things clear. Also I noticed you've been showing a bit of wit/humour in your videos lately which I think is great, it really breaks the monotony and helps with my short attention span haha. As for the video, so besides reducing LDL there's no much hope in reducing plaque? Are people on keto diets doomed?
@Physionic 4 ай бұрын
Thanks - I appreciate it. As for your questions - there are some potential additional things, but I'm currently still investigating them, so I'll release more content on them in the future. Keto users are not doomed - it's still possible , in my estimation. One just has to focus on the right types of fats.
@simonround2439 4 ай бұрын
Not everybody experiences a rise in LDL on keto diets. According to recent research, the leaner you are the greater the rise in LDL on keto.
@givemethejob3293 4 ай бұрын
Would it make you feel better if keto followers were doomed? Its people eating ultra processed crap fake foods that are doomed and thats sad too.
@TCBytom 4 ай бұрын
Ok. Author of this interesting video hasn't mentioned single the most important factor shaping first 3 described contributors. - insulin resistance. I.R. is central factor affecting all mentioned mechanisms. HDL level is highly controlled by insulin level - the higher insulin concentration is - the lower HDL is. The higher insulin is - the higher concentration of fasting trigylcerides (which are far more atherogenic than LDL) . High TG also makes HDL to not work... Insulin per se is central proinflamatory hormone. The higher insulin concentration - the higher mentioned cytokines and chemokines concentration is observed. Insuin is primary driver of hypertension - responsible for about 90% cases of this disfunction. When you lower your insulin in majority cases hypertension gets withdrawn. Vitamin D3 and K2 are important factors in atherosclerosis prevention. The rerason for this is that when body has low status of these vitamins macrophages can't digest this oxidized molecules (VDR receptor is not activated) and K2 is required for effective HDL in reverse transport of cholesterol. And third issue - macrophages in order to digest need activate autophagy (this is so called sine qua non requirement), but they can't do it when insulin is high (insulin hampers or even stops completely it). So when insulin is high, macrophages tend to form foam cells (instead leaving endothelium) and eventually die. Summming up. LDL is the least important factor involved here (with exception when it is very high > 180 mg% or simultanously TGs are high twoo). LDL blood concentration is also the least controllable by diet. In contrast HDL can be easily raised up 100%, TG can be easily lowered from 300-700 mg% to 130 mg% - none of these two is achievable by drugs to this extent...
@prestomattwine 4 ай бұрын
What’s the best way to increase HDL and lower triglycerides, other than a healthy diet? I suffer from both. I am very insulin resistant and my lipids doubled on low carb diet. It helped a1/c levels from pre diabetic to low 5’s. Weight stalled in 220’s-230’s. I now stopped saturated fats, upped more protein and eat more seafood and started weight lifting along with walking and biking. Weight loss is resuming again, so I hope I’m heading in the right direction.
@mikeroll9868 4 ай бұрын
What has really helped me is the things you are doing. I started taking creatinine and taurine. These are really helping build my muscle with the resistance exercise. The LDL shooting up on a low carb diet is a natural expression of switching to a more fat based metabolism. Don’t worry your LDL will stabilize. I take a low dose of Crestor and also niacin . The niacin will reduce LDL , raise HDL and help lower triglycerides. I do time restricted eating 8 he eating window and walk before eating breakfast. Keep doing what you are doing and your insulin resistance will go down. Especially if you lose more weight. Fatty liver and pancreas are implicated in metabolic disorder and insulin resistance which are closely related to diabetes and CVD risk . Both are the highest risk factors. Watch Dr Roy Taylor’s video on his fat tolerance and diabetes video. His diabetes research involved his patients losing weight to reverse their type 2 diabetes. No doctors are checking blood insulin levels of CVD patients except for a few. As stated above high insulin seems to be the primary cause of CVD and lowering it is helpful. I am sure time will show that Poor metabolic health characterized by high LDL. Low HDL and high triglycerides are a symptom of insulin resistance. Statins although they reduce LDL also are anti inflammatory which may account for the primary benefit not lowering LDL. . My theory is that plaques are your body trying to heal itself from contractions inflammation caused by all of the associated risk factors, the continuous inflammation leading to An uncontrolled inflammatory response causing Reprures of immune response leading to stroke and heart attacks. A decrease in NO seems to be related to as expressed by this NO expert. kzfaq.info/get/bejne/gbGknMKSl9vGmKM.htmlsi=k3xraCASuJy851J_
@TCBytom 4 ай бұрын
@@prestomattwine Too little information to give decisive answer. But I can give some general tips. 1. it is observed that adding just as little as 30 grams of complex carbohydrates to a meal can restore (lower) LDL levels (you didn't mention what kind of lipids you have above recomennded levels). So maybe ketogenic diet is not the best option for youi and around 70-100 grams of carbs per day would be better option. 2. HDL is low when Triglycerides are high and these are high when insulin is high and/or you eat much of (poly)ybsatyrated fats omega-6 or oxidized - trans fats present in seed oils. Choose olive oil as an addition (up to 50-70g per day). 3. eggs and fish help raise HDL provided that TGs are correct.... 4. hypothyroidism may keep high LDL, high TG and low HDL. Level this if you have issue (don't forget about deficiencies of selenium even if TSH is correct). 5. Give a chance for 24-36h (water/electrolyte) fasting once or twice a month. You're generally on the right track. But it takes time - sometimes even 1-2 years. You need fasting insulin < 8 or even
@prestomattwine 4 ай бұрын
@@TCBytom Thanks for the reply and good advice.
@fazole 2 ай бұрын
@@prestomattwine Do you eat dairy? My weightloss stalled at 210 despite low carb, IF, circuit weight training and low sugar consumption. Once I stopped eating even organic yogurt I lost more weight. 205 at 6'2", but 10 yrs ago, IF and a daily 30 minute swim got me down from 215-190 in 3 mos. Now 55 yrs.
@SiriusStarGazer 4 ай бұрын
good information. The first thing i check in a video is the length of time. If it is between 1 to 22 minutes , I am incline to watch, anything beyond that has to be something that I am totally interested in and the presentation is captivating. This video was ideal, short , to the point and informative!
@9kat53 4 ай бұрын
One of the great things about podcasts/youtube videos is that, in contrast to broadcast outlets, there is plenty of time to present a true deep-dive. Instead, an option for you might be to limit yourself to 22 minutes (or however long you choose) and then come back later for more and then come back again for even more. This way, you still get the *all of the deep-dive info but spend only as much time as you can or want to spend at a given time. KZfaq/podcasts = such a great way to learn quite detailed info for almost free, yet people ask for shortened videos, which means less detail. Why?? Just watch for 22 minutes and come back later. Deep dive = deeper understanding of complex topics. Well worth whatever extra time true understanding takes.
@arrakis8320 4 ай бұрын
Todos tus videos son fabulosos, no me los pierdo, son la mejor manera de aprender y aprovechar el tiempo educandonos. Saludos desde México y gracias por el enorme esfuerzo que pones en cada video. Suscrito.
@brforsberg 4 ай бұрын
doesn´t increased plack cause bood pressure to rise? so the correlations probably indicates the effect of plack on blood pressure and no vice-versa as you suggest
@GeorgeHanson-eg1sp 4 ай бұрын
What about Berberine, TMAO, Mediterranean and Vegan diets? Don't they reduce plaque?
@Mercury1955 4 ай бұрын
Great info thanks!
@easyacademy8110 4 ай бұрын
Physionic I would like to ask are you refering to soft plaque or stabilised plaque to be exact. TQ
@kennethyuman1940 4 ай бұрын
The latter 2 of the 4 factors are no doubt important. The effect of LDL is questionable, but it is a much bigger discussion. Regarding blood pressure, starting at 5:48, I'd propose the inverse relationship: clearing of plaque lowers blood pressure as the artery becomes less rigid and more elastic. With less plaque, we expect the pulse pressure, {sys - dia}, to drop. Lower blood pressure is the effect or consequence of clearing plaque. Separately, would you dive into the mud of supplements for plaque clearing? Kyolic, lumbrokinase, nattokinase, pomegranate juice?
@ebutuoyYT 4 ай бұрын
Any decent evidence for Vitamin K2 being of benefit for artery health / plaque reduction?
@andrewevans8456 3 ай бұрын
In my case it helped. I had a calcified mitral valve indicated in an echo cardiogram. Started taking K2 and high k2 foods such as grass fed butter and 2 years later my valve was no longer calcified.
@MikeG-js1jt Ай бұрын
You gave an incredibly super remarkably clear bullet-pointed explanation of the atheroma creation and probable reversal process, I have listened to a lot of folks trying to explain it, but I found this to be the clearest of any I can recall, in fact it was so clear it makes me believe that I actually understand the processes of both.
@Physionic Ай бұрын
Thanks, Mike. Kind of you to say.
@StevenBrener 4 ай бұрын
Is there a threshold that LDL would need to be reduced to for plaque reduction?
@giannidiolosa8804 4 ай бұрын
Berberine Niacin K2 NATTOKINASE
@goingtothesunhwy. 4 ай бұрын
Why Berberine?
@MR-fn7rw 4 ай бұрын
There is evidence that it decreases LDL and triglycerides and increases HDL. There is also evidence that it decreases inflammation and helps in blood sugar regulation.
@user-dv4fr6pr8b 4 ай бұрын
Niacin plus Berberine..?
@user-dv4fr6pr8b 4 ай бұрын
I have been tsking Berberine for about 2 months now. It amazingly cleared up my blocked colon caused by shingles. And gives me great energy so I can work like 40 yr old at my age of 82..😅
@chriswallace5638 3 ай бұрын
Yes. D3+k2 + nattokinase + berberine or metformin + B3 + intense exercise (get blood pressure max for short time)
@muttleyZZZ 4 ай бұрын
Super useful and really well presented. Subscribed
@Physionic 4 ай бұрын
Thanks!
@ambrsanford3703 4 ай бұрын
I'm at a very healthy BMI, have great blood pressure, statins have reduced my LDL to almost low levels, and I've also been eating a healthy, primarily plant based diet. I do however have familial hypercholesterolemia which seems so far to be an independent factor. Is there perhaps hope for me reducing my arterial plaque?
@cyberfunk3793 4 ай бұрын
I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation/heart health and perhaps even reverse plaque. Some sustabces that come to my mind are: AMLA, Citrulline, AAKG, EDTA, Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic.
@burtondavis4218 3 ай бұрын
Add lumbrokinase - 30 times stronger than nattokinase
@cyberfunk3793 3 ай бұрын
@@burtondavis4218 tnx for the tip, the first time I heard about that. Surprising that there are so many potentially beneficial compounds without prescription that I never even heard of yet.
@wednesdayschild3627 4 ай бұрын
My cardiologist told me he sees thin people with perfect bp, blood sugar, who exercise. He likes to lower ldl below 50. He also say air quality and plastic increases heart disease. He never checks for fractionated cholesterol. Stress tests are not recommended unless a person is having symptoms.
@vtrials9577 4 ай бұрын
Always enjoy your in-depth analysis of these subjects. A possible subject for your further studies might be white blood cell counts as they relate to CHD. You might find Some interesting results. Thanks for all you’re doing.
@Physionic 4 ай бұрын
I have an in depth video on inflammation and CHD, if you're interested.
@o-r-i-o-n Ай бұрын
Love your in-depth content. Thanks!
@petertownsend252 4 ай бұрын
Is this calcified hard plaque, soft plaque, all plaque, or unknown/undetermied type?
@larryc1616 4 ай бұрын
What does it matter? Hard plaques cause heart attacks and soft plaques cause strokes
@rayzerot 4 ай бұрын
@@larryc1616I think the general discourse is that hard plaque is more difficult to remove so Peter was asking if the video applied to hard plaque or only to soft plaque
@Malcolm-Achtman 4 ай бұрын
Do a stress test (mentioned at 10:05 in this video). They are not necessarily reliable. In Sept 2015 I did a stress test with my cardiologist and after finishing it he obviously liked what he saw and told me any insurance company would write me a policy for $1,000,000. And yet, I had just done a CAC scan and my score was 737, which is high (I was 66 years old at the time). Bottom line... triple bypass surgery 8 months later (May 2016).
@Malcolm-Achtman 4 ай бұрын
@@DK-pr9ny No medications. Lipid values in Sept 2015 (in mg/dl): Total Chol 212, Trigs 64, HDL 47, Trig/HDL ratio 1.36, LDL-C 152. Also HbA1c 5.4%.
@RickinICT 4 ай бұрын
@@Malcolm-Achtman I'm surprised they didn't want to put you on statins with an LDL-C that high. Otherwise, the numbers don't seem horrible. It would have been interesting to see a particle profile on you for that time period, to see exactly what size/types of LDL you primarily had. I think you're a good example of why there's a growing consensus that the standard lipid profile tests don't really tell the whole story - or even tell lies that give a false sense that everything is A-OK.
@Malcolm-Achtman 4 ай бұрын
@@RickinICT The closest advanced lipoprotein test I had (time-wise) relative to my bypass surgery in May 2016 was a SpectraCell advanced Lipo Panel done in July 2016. First, the regular lipid results were (in mg/dL): Total Chol 199, Trigs 59, HDL 47, Trig/HDL ratio 1.25, LDL-C 143. Also HbA1c 5.1%. Now for the particle results (in nmol/L). Total LDL particles 950 (ref. range is 900 or less), Remnant Lipoprotein 62 (ref. range is 150 or less), Small Dense "LDL III" was 351 (ref. range is 300 or less), and Small Dense "LDL IV" was 90 (ref. range is 100 or less). So basically I was within or sometimes a bit above the reference range with respect to particles. As far as statins go, my doctors wanted me on them since the "dawn of time" but I always refused them. My doctors still want me on statins today, especially now that my LDL-C is in the 250 - 270 mg/dL range. But I won't take statins and I get the final say.
@soniaforkas1415 4 ай бұрын
My husband was having some chest pain and his doctor ordered a stress test. He was told that his heart was fine after the stress test and sent home. His pain got worse and turns out he was having a heart attack during his stress test .... still don't understand how that wasn't picked up
@Malcolm-Achtman 4 ай бұрын
@@soniaforkas1415Amazingly disturbing.
@MattC2085 4 ай бұрын
Great video! I'd be interested to know what role triglycerides play in all this. Is that part of the inflammation component? Thanks!
@mellocello187 3 ай бұрын
This is a great video. I will add, no one ever talks about fluid dynamics. Most sites of arterial occlusion are at bifurcations: femoral, carotid, eg, (I worked in a hospital department where we did those exams) and are no doubt exacerbated by high blood pressure. Not sure what one would do with that info other than to take steps to lower BP.
@acke26 4 ай бұрын
The BIG question: Is LDL causal? Increased LDL could be the body's response to inflammation. We know LDL is involved in cell building/repairing processes. Question 2, what's causing the inflammation in the arteries in the first place?
@Physionic 4 ай бұрын
Have many videos on the topic
@rayzerot 4 ай бұрын
Even if LDL isn't casual for atherosclerosis, it absolutely accelerates the problem. While it could be that inflammation is the root cause, higher levels of LDL still causes higher level of plaque deposition- more LDL is present to respond
@mattermat1925 4 ай бұрын
Oxidised (damaged) LDL is causal, ordinary LDL is not. Oxidised LDL is directly pro-inflammatory to endothelial cells and in addition it is taken up by macrophages in an uncontrolled way, which is why they then swell up to become foam cells.
@mesterferenc2688 4 ай бұрын
@@mattermat1925 Ten years ago this was science.
@mattermat1925 4 ай бұрын
@@mesterferenc2688 What is it now? A conspiracy theory?
@damon123jones 4 ай бұрын
Ivor Cummings already solved this directly,and its really a great series to watch. researchers are lost still in focusing on cholesterol.. . . its diet and its sugar not fat.
@onder8374 4 ай бұрын
his slide at 2:14 shows oxidized LDL, where it cant find its way in Lipoprotein mechanism, LDL is life. also never mentions about Tryglicerides :-D .which is the problem. and carbs. LDL is mostly produced by liver. ..also.problem is oxidzing it. (which Glucose is the reason)
@theonetrueshibe9567 4 ай бұрын
So great to hear about Atherosclerosis reversal. I was always curious about this as my family has history of it. I myself also had high ldl previous years. What should I do to lower ldl and apoB besides weight lost
@MrPokerblot 4 ай бұрын
Great vid. Well explained
@jeffg4686 4 ай бұрын
Others: Magensium supplementation - not much - don't combine with blood thinners Vitamin K2 Nattokinase - blood thinner (don't combine with other blood thinners) bioflavonoids - often blood thinners (don't combine with other blood thinners) Inositol ACV Omegas - flax oatmeal - keep calcium low(ish) during therapy
@petecabrina 4 ай бұрын
Nattokinase and Serrapeptase need some serious studies done, if they can actually break down arterial plaque like some claims that are out there it is nothing short of a miracle. Usual old story, I know who guy who reversed supposed irreversible heart disease with these enzymes, and of the occasional doc recommending them for the clotting which seems to be 'going around' lately.
@cyberfunk3793 4 ай бұрын
@@petecabrina I'm taking nattokinase too now, in one study they found it effective at a higher dose 10 000 FU, but don't just start taking it because it can have dangerous side-effects at those higher doses. Substances I'm interested are: AMLA (lowers LDL as much as statin in one study), Citrulline, AAKG, EDTA (one guy has video on youtube how he supposedly used it to lower his plaque, but the issue is how to get it to bloodstream), Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic, Omega 3.
@jeffg4686 4 ай бұрын
@@petecabrina - There ARE EXISTING good studies actually. Nattokinase alone has proven pretty decent. With a full therapy with other things like omegas, magnesium, inositol, healthy diet, and exercise, you could likely clear your arteries completely. They just have a timeline for everyone as part of their societal agendas. Especially for the POOR. You see how long the Lords of the stock market are living... I saw a friend die of some buffoonery (crap at the hospital with infections and blood pressure dropping - crap like that) as he was IMPROVING from his pancreatic cancer. Arterial plaque is composed of numerous things, but much is calcium/cholesterol deposits stuck to it. If you get calcium on the low side, and cholesterol on the low side, and use nattokinase to break up fibrin, things start coming back into solution - like an equilibrium. Just like if you get metals out of your gut, they also come out of your brain - eventually. Chlorella is my recommendation there if you aren't allergic (a small percentage are)
@darrenvail8726 Ай бұрын
K1 is the blood clotter, not K2. K+ is potassium. Many people are confused by this.
@cyberfunk3793 Ай бұрын
@@darrenvail8726 "The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing"
@kdw75 4 ай бұрын
I am a believer in Nattokinase. I started taking it a few years back.
@Physionic 4 ай бұрын
Content releasing soon on that one
@TTS410 4 ай бұрын
Excellent video !
@zolof911 4 ай бұрын
If the endothelium is compromised due to years of sub-clinical hypokakemia, could this cause or contribute to plaque formation? As I understand it, potassium helps endothelial health and lowers blood pressure. Seems like the recommended daily amount of potassium has been raised recently.
@rajpatel9497 4 ай бұрын
I have lost weight, blood pressure is down, exercise regularly BUT LDL increased very high (Lean mass hyper responder). Any comments?
@MR-fn7rw 4 ай бұрын
Doubt it . Are you on a carnivore diet?
@rajpatel9497 4 ай бұрын
Ketovore@@MR-fn7rw
@user-ck4ui3vk2k 4 ай бұрын
I envy your ability to chew large chunks of data from different RCTs and give it to us in an understandable 10 min video. Special mention on those sarcasms that catches me off guard when I'm comprehending you at 2x.
@MarcKatzMD 2 ай бұрын
Great video man
@inthemarketfor 4 ай бұрын
Distended gut..can it be caouse by taking collallen. Creatine,taurine,alcar,l-lisine ? Or any proteine powder?😅
@postscript123 4 ай бұрын
Sauna at 174 degrees, 20 min, 4 x a week. Studies out of Finland (heard from Dr. Rhonda Patrick). Join the ymca to use one. You don't have to be rich.
@ebaab9913 4 ай бұрын
Link?
@BluesDoctor 4 ай бұрын
Great study on sauna!
@akhusal 4 ай бұрын
It seems there's a user bias: It's usually wealthy who use a sauna, and they have healthy lifestyles.
@postscript123 4 ай бұрын
I go to the ymca under a family membership to use a sauna. You don't have to be rich.
@Barnstable11 4 ай бұрын
I went carnivore and then transitioned to keto a while back. I lost weight, my blood pressure dropped, my HDL shot up to near 100, my inflammation markers went to about as low as can be measured, and due to better joint health I have been able to do more HIIT. HOWEVER, as a lean mass hyperresponder, my LDL went up considerably. It seems counterintuitive to me that this dietary change would bring so many benefits that correlate with better cardiovascular health and potential for reversing athersclerosis, but then would cancel all that out with higher LDL. Is it possible that it's not the level of LDL persay but the type of LDL (large or small particle, more or less oxidized etc.) that is crucial?
@ianbryant 4 ай бұрын
I think the weight loss did more for you than the carnivore. Limiting saturated fat (which is high in animal foods) helps to clear the arteries.
@paulaoyedele2081 4 ай бұрын
@@ianbryant...huh?
@user-ey4fl8zg6n 4 ай бұрын
Claiming LDL and cholesterol causation is fake science ,including saturated fat.
@maxwatermeyer4406 4 ай бұрын
As far as l know and all the studies l read till now…the cholesterol hypothesis is just that…in the absence of vascular inflammation there can’t be any plaque progression…because there is no injury or any LDL that can be oxidised. Thats just my 2 cents.
@rayzerot 4 ай бұрын
@@maxwatermeyer4406And just where are these people that are avoiding the inflammation and avoiding the atherosclerosis? The average person has their first fatty streaks in their arteries by age 13. Anyone in an industrialized nation gets inflammation from just pollution in the air, nevermind people's relentless stress and other environmental contributors. Unless you're eating an extremely anti-inflammatory diet, lowering LDL levels is the most effective way to avoid atherosclerotic buildup.
@emil5884 4 ай бұрын
Love your videos! Really good work!
@bogse 4 ай бұрын
So, based on this if you lift weights and gain lean muscle mass and your weight increases (even you get leaner) that bad for your cholesterol/arteries since you weight more now?
@clarkside4493 4 ай бұрын
Wim Hof Breathing helps.
@kirbychamberlin8683 Ай бұрын
Should have received his 🥇 Nobel prize, a genius.
@jasonbromano 4 ай бұрын
Another optional step might be nattokinase supplementation. There are a couple studies showing plaque reduction after nattokinase intervention. However, it must be at a high enough dose. The two studies I have seen that showed reduced plaque used doses of 6000FU/day and 10,800FU/day. And it may have synergistic effects in combination with red yeast rice. Just some other things to consider. More research and data is needed, of course.
@yogimaster1 4 ай бұрын
I periodically take a full spectrum of proteolytic enzymes including 2000 FU of nattokinase per day. Proteolytic enzymes are fibrinolytic, or they break down fibrins, which are proteins that are components of plaque and scar tissue. Another component of arterial plaque is calcium and this must be addressed along with the other recommendations. Vitamin K2 and an herb called chanca piedra are two of the best ways to reduce arterial calcium.
@rayzerot 4 ай бұрын
Red yeast rice contains a chemical that drug companies turned into a prescription medicine. The medicine lowers cholesterol so it makes sense that it would help with plaque
@mesterferenc2688 4 ай бұрын
@@yogimaster1 10000 FU may be needed.
@arihaviv8510 4 ай бұрын
Yes it's a statin @@rayzerot
@hughjones77 2 ай бұрын
Thank you! If we go back to the atheroma, though, yes the immune cells are responding to the LDL, but, doesn't inflammation play a role here? But, don't we need a fifth step? Reduce inflammation by reducing carb/sugar/processed food/seed oil intake?
@clintonpiercy6651 4 ай бұрын
Thanks for this video I have high LDL and have been worried about this but not much resources online point to solutions.
@jeffreyscottfishman 3 ай бұрын
watch Dr Berry, Dr Bikman , Dr ovadia, Nick Norwitz from Harvard, Paul Mason , Dr David Diamond (professor and neuroscientist) Dr Chafee and DR Shawn Baker and Dr Nadir. These are just a few to start with who will tell you everything you need to know. They are not your typical mainstream that are involved with big pharma.
@erikjanse3994 4 ай бұрын
My friend, an anecdotical example that indicates just the opposite: 5 years ago I did a CT-scan resulting in a CAC-score of 148. I already lived very healthy more or less during my whole life. After the relative high CAC-score of 148, I started to take a statin (my LDL-level reduced with 30%) and started to live even healthier: now more or less fully cutting out ultra-processed food (eating a Mediterranean diet), and increasing the amount of sports (now 5 days a week, 2 to 2,5 hour per day in the gym, consisting of 1,5 hour resistance training and 0,5 to 1 hour cardio (either zone 2 or zone 5 training). My blood pressure is normal 120/80. My weight is 80 kg with about 12% fat percentage. After 5 years living with this regime I did again a CT-scan resulting in a CAC-score of 572, i.e. a more then 300% increase over 5 years. So it looks like I am the exception all those scientific studies performed.......
@joemonroe9456 4 ай бұрын
Could be a vit k deficiency
@nicktriplett9331 4 ай бұрын
Do you have a family history of cardiovascular disease?
@madstork91 4 ай бұрын
Curious, have you tried K2 MK-7?
@Malcolm-Achtman 4 ай бұрын
Cardiologist Dr. William Davis often mentions people (like you) who discover their CAC is rising 25 - 30% per year despite taking statins. Apparently, some studies have shown that statins increase coronary calcification. But putting that aside, Dr. Davis looks at other more relevant factors. He has seen good results when people avoid all wheat and grains, keep their carb consumption under 15 grams per meal, no snacking between meals, limiting postprandial (after-meal) glucose increases to as little as possible (he calls this the "no-change" rule), optimizing their vitamin D3 (25-hydroxy) to 60 - 70 ng/mL, optimizing their thyroid health and testing it properly (6 tests required for that), using fish oil supplementation - although that's lower on his priority list - but he encourages fish oil especially if you have high Lp(a), and finally, something he is putting much more focus on these days, managing gut health using his numerous do-it-yourself strategies.
@brocklastname6682 4 ай бұрын
CAC only measures calcified plaque, which is stable. It tells you nothing about soft plaque. A more comprehensive angiogram might give you more info. (I'm not a doctor)
@SomeKidFromBritain 4 ай бұрын
When you say "weight loss", specifically fat loss right?
@Santa-ny1yp 4 ай бұрын
Of course, almost nobody wants to lose muscle and water. Many people are offended by the term fat loss. Rather than deal with complaints, most people just use weight loss. It's dumb but that's the society we live in.
@tmtoplak222 4 ай бұрын
In my case, the more weight and fat I lost the higher my LDL went. Had lower LDL at 190 lbs and 15% body fat than I do mow at 176lbs and sub 10% body fat.
@cristobalarriagada8141 4 ай бұрын
@@tmtoplak222it MAY be the factor that you being in a fat % lower than your body will want stresses it causing higher ldl. Other factors such as quality of sleep, environental stress and mental health are strong stressers of your body and may worsen your blood markers. Sorry for the english im from Chile S. A. I hope this can help adress some areas!
@Bjorn_R 4 ай бұрын
@@tmtoplak222 sub 10% is not exactly healthy either.
@evanlouis8853 4 ай бұрын
Do you eat meat?
@philiptruitt 4 ай бұрын
Thank you!
@ghostindamachine 4 ай бұрын
Great info!
@Physionic 4 ай бұрын
Glad it was helpful!
@jimmcmahon7561 4 ай бұрын
Kind of with you, except for the ldl levels. Oxidized LDL is bad, but if it's not oxidized, it's fine and even very healthy.
@mithrandir491 4 ай бұрын
heart disease is basically a diabetic disease - inflammation, foam cell activation, endothelial dysfunction. Lipoproteins have very little do with, they are more of a side-effect rather than the cause.
@Physionic 4 ай бұрын
Is that why non-diabetics with low inflammation, but high LDL still develop heart disease? 😋
@christopherrobin361 4 ай бұрын
@@Physionic Inflammation is the baddy here.
@mithrandir491 4 ай бұрын
@@Physionic Right....and if you exercise there is a greater chance of your plaque breaking up and causing a heart attack than there is of you reducing your plaque. Now why would you want to reduce your plaque instead of treating the underlying causes is beyond me, especially when its providing much needed arterial stability? atherosclerosis is a symptom of a hidden disease not the disease itself.
@tracymullane8818 4 ай бұрын
@@Physionicthere is a school of thought that says the LDL and cholesterol is recruited to patch endothelial cell damage- damage from diabetes and inflammation- and I think that's what this responder is referring to. In this way it could be interpreted that the arterial plaque is indicative of diabetic damage to the endothelial cells.
@tracymullane8818 4 ай бұрын
www.ncbi.nlm.nih.gov/pmc/articles/PMC8615779/
@bv2999 4 ай бұрын
My non-study supported hypothesis on a contributing factor as to why exercise decreases blood pressure is that raising BP during exercise places a stretching force on the arteries which "exercises" the arteries and keeps them flexible. So as your pressure fluctuates during the day the arteries automatically accommodate the added pressure by stretching a bit. Same blood volume plus more pipe = lower pressure. Like two rubber bands made the same day if one is used from time to time and the other just sits in a draw for 10 years when both are then given a good stretch of equal amounts the exercised one stretches but the dried up stiff one just snaps.
@LowHangingFruitForest 4 ай бұрын
Has anyone looked at the effect of long term fasting on plaque?
@ZappyOh 4 ай бұрын
Fasting is stressing your body in many ways. I would imagine LDL skyrocket in the first couple of days, as every drop of fatty acid is sucked out, leaving only shrunken empty vessels in circulation.
@arthurschuler8906 4 ай бұрын
Yes,if I remember it right in Leerboek Cardiologie by professor Meyler it is stated that in the Second World War the Germans did autopsy on murdered Jewish inmates who had succumbed after a time and they had no atherosclerosis! The book stated that much atherosclerosis normally was highly present in this group. By the way, professor Meyler was of Jewish descent. So extreme hunger will reduce plaque is my conclusion...... Greetings from the Netherlands
@arthurschuler8906 4 ай бұрын
Inmates of concentration camps I meant
@Physionic 4 ай бұрын
Not that I'm aware, but I'd love to see it.
@robertbizzarro8586 4 ай бұрын
@@ZappyOhcompletely wrong.
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