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A Potential Solution to Sickle Cell Disease: CRISPR-Cas 9

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Demystifying Research McMaster

Demystifying Research McMaster

Күн бұрын

CRISPR-Cas9 is an emerging technology that can be used to treat diseases through genome modification. It represents a recent and promising advancement in genetic manipulation. This video will explore the use of CRISPR-Cas9 as an emerging technology to treat sickle cell disease (SCD). The video will first introduce CRISPR-Cas9 and SCD. It will then delve deeper and provide a comprehensive breakdown into a unique procedure of utilizing CRISPR-Cas9 to treat and cure SCD in a patient. The video will then conclude with the advantages and disadvantages of using CRISPR-Cas9 to treat SCD.
Timestamps:
Introduction: 0:00 - 0:25
What is CRISPR Cas 9: 0:25 - 1:33
What is Sickle Cell Disease: 1:33 - 4:11
How can CRISPR be used to treat SCD: 4:11 - 7:08
What are the advantages and disadvantages: 7:08 - 8:31
Conclusion: 8:31 - 8:44
This video was made by McMaster University students Wenjun Jiang, Khushi Patel, Marc Gonsalves,and Amir Atcha in collaboration with the Demystifying Research McMaster Program.
This video is provided for general and educational information only.
Copyright McMaster University 2023
Some elements were Created with BioRender.com
References:
Ashmore‐Harris, C., & Fruhwirth, G. O. (2020). The clinical potential of gene editing as a tool to engineer cell‐based therapeutics.Clinical and Translational Medicine,9(1). doi.org/10.118...
Bauer, D. E., & Orkin, S. H. (2011). Update on fetal hemoglobin gene regulation in hemoglobinopathies.Current Opinion in Pediatrics,23(1), 1-8. doi.org/10.109...
The Complete Guide to Understanding CRISPR sgRNA. Synthego. (n.d.). www.synthego.c..., C., Manzo, J., & Tkacenko, A. (2021).PDB101: Molecule of the month: Fetal hemoglobin. RCSB. pdb101.rcsb.or...
Curtis, S. A., & Shah, N. C. (2020). Gene therapy in sickle cell disease: Possible utility and impact.Cleveland Clinic Journal of Medicine,87(1), 28-29. doi.org/10.394...
Gersten, T. (2022).Graft Versus Host Disease (GVH). Pennmedicine.org. www.pennmedici...
Golberg, A., & Rubinsky, B. (2013). Mass transfer phenomena in electroporation.Transport in Biological Media, 455-492. doi.org/10.101...
Inusa, B., Hsu, L., Kohli, N., Patel, A., Ominu-Evbota, K., Anie, K., & Atoyebi, W. (2019). Sickle cell disease-genetics, pathophysiology, clinical presentation and treatment.International Journal of Neonatal Screening,5(2), 20. doi.org/10.339...
Kupferschmidt, K. (2023, March 13). Gene-editing summit touts sickle cell success, while questions on embryo editing linger. www.science.or...
The Lancet Haematology. (2019). CRISPR-Cas9 gene editing for patients with haemoglobinopathies.The Lancet Haematology,6(9). doi.org/10.101...
Mangala, A., Ehsan, M., & Maruvada, S. (2023).Sickle Cell Anemia. StatPearls.McSweegan, E. (2023, October 23).Necrotizing fasciitis. Encyclopædia Britannica. www.britannica...
Molteni, M. (2023, March 7). With CRISPR cures on horizon, sickle cell patients ask hard questions about who can access them. www.statnews.c... Center for Biotechnology Information. (2022).Sickle cell anemia. Statpearls. www.ncbi.nlm.n...
National Library of Medicine. (2021). Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease (CEDAR). clinicaltrials...

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