Advil, Aspirin, and Tylenol -- What's the difference?

Рет қаралды 168,613

Күн бұрын

You can get 50% off for the first month for any MEL Science subscriptions (Physics, Chemistry, STEM, MED) if you use the link melscience.com/sBIN/ or the promo code SABINE50. This is a limited time offer and valid only for 1 month.
What's the difference between common over-the-counter painkillers like Advil, Tylenol, Paracetamol, Voltaren, and Aspirin? How do local anesthetics work? Why do opioids lead to withdrawal symptoms and what is neuropathic pain? I'll explain all this in today's video.
The US pain survey I mention at the beginning is this stacks.cdc.gov/view/cdc/107894 and the table for the European Union is here: ec.europa.eu/eurostat/statist...
Data for the healthcare costs stemming from pain are from here: www.sip-platform.eu/press-are...
The table with the risk for cardiovascular events from NSAIDs that I show at 8 minutes is from this paper www.cureus.com/articles/6604-...
The data for the costs from neuropathic pain in the USA that I refer to at 11 mins 30 seconds are from here www.nature.com/articles/535S2a
The CDC guide for how to taper off opioids that I mention at 14 minutes is here: www.cdc.gov/drugoverdose/pdf/...
The Cannabis meta study that I mention at 14 minutes 50 seconds is this: research.monash.edu/en/public...
The report about the construction worker with the nail in his boot is from here: www.bmj.com/content/310/6971/70
The paper about the effects of pain on the endocrine system that I mention at 17 mins is this: www.ncbi.nlm.nih.gov/pmc/arti...
And the paper about the possible link between chronic pain and tinnitus is here: journals.plos.org/plosone/art...
💌 Sign up for my weekly science newsletter. It's free! ➜ sabinehossenfelder.com/
👉 Support me on Patreon ➜ / sabine
📖 My new book "Existential Physics" is coming out in August ➜ existentialphysics.com/
Many thanks to Jordi Busqué for helping with this video jordibusque.com/
0:00 Intro
0:23 What is pain?
2:31 Local anesthetics
3:53 NSAIDs (ibuprofen, aspirin)
8:49 Acetaminophen (paracetamol, tylenol)
10:54 Neuropathic pain
11:41 Opioids
14:29 Cannabis
15:00 Somatic (de)amplification
16:37 Chronic pain
18:25 Unboxing for MEL Science
20:30 Tim's pun

Пікірлер: 1 200

@SAVVALEX Жыл бұрын

As a pharmacist and clinical pharmacologist, I truly have to commend you for this video. You nailed all the fundamentals an average person should know. The amount of study required to achieve this result must have been immense. Well done, once again! 👏

@hikingmallard Жыл бұрын

@M G I don't understand what you mean, would you care to elaborate?

@SAVVALEX Жыл бұрын

@@Matthias_Fischer I'm not a native English speaker, but as far as I know the pronoun YOU may refer to one person as well as many persons. I don't doubt that Sabine may have a team of collaborates, but that doesn't change the fact that a lot of work has to be done to determine what must stay in and what must be left out of a short video, when talking about a subject with tons of literature that isn't Sabine's field of expertise. In addition, I assume you don't doubt Sabine's direct involvement in the presentation of the video, which is, as always, outstanding. I really can't get my mind around the reasons for attacking comments that praise the hard work of people, who offer high quality content free of charge. Kind regards

@emar779 Жыл бұрын

Hi Alexander. What should someone take for pain from pancreatic cancer? E.g. the person is taking paracetamol, tramadol and codeine. The only one with real effectiveness is paracetamol, but 8 in 24 hour period, separated by 4-6 hours each is not enough. Is there anyway to deal with this? Please do let me know, send me a message as it's listed on my profile I think and I'll go into more detail.

@SAVVALEX Жыл бұрын

@@emar779 I'm not trying to dodge your question, but it would be very irresponsible and probably unethical to offer medical advice over the comment section of KZfaq. I'm sure - since there is a diagnosis - that a physician is already handling the situation and, therefore, assuming the responsibility of treatment. I hope everything works out well.

@emar779 Жыл бұрын

@@SAVVALEX Just asking for things to look into that laymen like me don't have access to. Docs run on their own schedules and pain for loved ones does not care for those schedules.

@jamesmule Жыл бұрын

It doesn't get more German than not getting a joke an English person makes, then arguing about the factual accuracy of the joke with him and then preparing and giving a 20 minute public lecture about the general topic of the joke. Grüße.

@paulspice4717 Жыл бұрын

Now that's 🤣🤣🤣🤣🤣funny

@cameronmclennan942 Жыл бұрын

I was on the floor when she revealed the reason for making the video. Best combination of English joke and German-ness I've ever seen

@tarmaque Жыл бұрын

@@cameronmclennan942 Admit it: It was nothing more than an educated Dad joke.

@derekcouzens9483 Жыл бұрын

@@tarmaque i also tell Dad jokes but he never gets them.

@cameronmclennan942 Жыл бұрын

@@tarmaque you sound like a barrel of fun. Probably need about as many tickles as an octopus needs to make you laugh.

@absta1995 Жыл бұрын

As a PhD studying chronic pain, I have to say this video is really good! It would have also been interesting for you to cover how taking ibuprofen + paracetamol together is more effective than taking double of either one.

@SabineHossenfelder Жыл бұрын

I didn't know! Thanks for pointing out!

@jaceacekalgoorlie Жыл бұрын

Why not just take a stronger one?

@edgray4471 Жыл бұрын

Yes but under doctor direction. A few years ago fractured my wrist. Rather than prescribe pain killers the doctor told me to take a specific combination of advil/tylonol/aspirin. Worked very well and only had to take for a few days.

@kindlin Жыл бұрын

@Dodala Duhananda Inda Bhude Not gonna lie, but my record is like 8. Was a fun night. Don't try this at home.

@w0mblemania Жыл бұрын

Be careful of Ibuprofen though. It worsen tinnitus, and may actually help cause tinnitus. You do NOT want chronic tinnitus. So, take the minimum ibuprofen you need.

@aleleeinnaleleeinn9110 Жыл бұрын

It would take a physicist to remind us that cocaine ran wall street in the '80s. Your sense of human is as incredible as your ability to explain science logically, coherently, and intelligently. THANK YOU.

@zam6877 Жыл бұрын

I am sure you meant "humor" But I am truly inspired by with "the sense of human" we need more of that in the US 😔 Thanks

@aleleeinnaleleeinn9110 Жыл бұрын

@@zam6877 You are correct. I was thinking of Einstein (yeah that guy again) who did have a sense of human and a very strong sense of social justice. But I did mean humor. Which is also sadly lacking in the US.

@terencemichaels Жыл бұрын

Yes a very informative and entertaining video and funny to boot.. As for cocaine and Wall Street, hubris personified...recent tests found this awful drug all over Britain's Houses of Parliament, which explains so much of the deceit and bombast and inflated egos that consuming it entails. I speak from bitter personal and see all the indications.

@tomfly3155 Жыл бұрын

I have a good sense of Human too😎🙊

@Karagoth444 Жыл бұрын

16:30 You nailed that delivery

@erielhonan Жыл бұрын

In this episode, Sabine gets a sunburn and spends the rest of her vacation researching the drugs she’s taking for it 😊

@cookieDaXapper Жыл бұрын

@@rollo8523 Thank you for the intel. PEACE.

@gryrvn Жыл бұрын

SAVAGE..🙂

@limiv5272 Жыл бұрын

That tan line was surprisingly distracting

@SabineHossenfelder Жыл бұрын

I appreciate the concern, but it's not a sunburn, I just tan quickly. Having said that, I noticed too late I was showing off my tan lines. So, well, guess I'll have to either wear this top less or more often in the summer.

@erielhonan Жыл бұрын

@@SabineHossenfelder - I was attributing my own habits to you 😊. Something: happens Me: googles things that happen

@Demothones Жыл бұрын

Finally, a subject I know a lot about. I teach this to military medics. Great video, Dr. H.

@curiodyssey3867 Жыл бұрын

She's absolutely brilliant

@studibakre Жыл бұрын

So you teach them that motrin and water cures everything? 🤣

@Demothones Жыл бұрын

@@studibakre That is the joke but no, I teach advanced medical skills.

@studibakre Жыл бұрын

@@Demothones so.. two motrin? 🤣

@Demothones Жыл бұрын

Pharmacology and microbiology are absolutely fascinating subjects. The science behind analgesics is particularly interesting. It’s also interesting what we don’t know. As you learn more about the subject you realize that much of what we “know” about microbiology and pharmacology is theoretical. We have strong theories about how some of this works but they are still theories. We cannot fully confirm or deny them. I understand that we have theories about cosmology and quantum mechanics that we cannot confirm or deny. They involve things that take place on a massive scale, or a subatomic one and they can be rare and/or remote from us. The fact that there is so much about our own bodies that we don’t know is much stranger to me. I understand why but it still seems strange.

@picolo121 Жыл бұрын

You are the best polymath teacher I have ever seen. I wish we see more biology here.

@SabineHossenfelder Жыл бұрын

Thanks for the feedback!

@saschahofer413 Жыл бұрын

No please no, here were provided much of High Quality Physics stuff an its getting worse from Video to Video. Sehr geehrte Frau Hossenfelder nicht dass sie andere Themen nicht sehr klar und verständlich ausdrücken. Aber Physik ist neben Mathematik die Königsdisziplin, wer über Bienen, Gender-Gaga oder irgendwelche Pharmapillen Bescheid wissen will soll sich einen solchen KZfaqr/in suchen.

@Graham_Wideman Жыл бұрын

@@saschahofer413 "Dear Mrs. Hossenfelder not that you do not express other topics very clearly and understandably. But physics is the supreme discipline next to mathematics, if you want to know about bees, gender gaga or any pharmaceutical pills, you should look for such a KZfaqr."

@saschahofer413 Жыл бұрын

@@Graham_Wideman Thank you for your translation into Lingua Franca.

@Graham_Wideman Жыл бұрын

@@saschahofer413 Hahaha. You mean: "Chère Mme Hossenfelder pas que vous n'exprimez pas d'autres sujets très clairement et de manière compréhensible. Mais la physique est la discipline suprême à côté des mathématiques, si vous voulez en savoir plus sur les abeilles, le gender gaga ou les pilules pharmaceutiques, vous devriez chercher un tel KZfaqr." (Obviously no credit to me -- it's google translate.)

@podemosurss8316 Жыл бұрын

As a biology student, I can say you did an excellent job with this video. The topic is extremely complex, and you nailed what it's important about it.

@SabineHossenfelder Жыл бұрын

Thanks so much for the feedback!

@podemosurss8316 Жыл бұрын

@@SabineHossenfelder There is one entire course at 3rd grade of biology that is mostly about how the nervous system receives and creates information (Animal Physiology part I), and that's on 3rd grade, after having had courses on how the membrane receptors work (Celular Biology in 2nd grade) and on the nature of the different molecules that activate those receptors (Biochemistry I, also in 2nd grade). So, it's basically end of degree stuff, and you got exactly right not only what the facts are, but also the important parts about those facts.

@tubehellcat Жыл бұрын

I came for the astro physics, and stayed for everything else. Thanks for broadening our horizons in yet another direction 👍 very interesting video.

@timjackson3954 Жыл бұрын

I think I'll go with "it's magic". When I was a kid I was scared of the dentist. They gave me a sedative, that made it much worse. Somewhere along the way I realised that the treatment itself it wasn't actually particularly painful, the main component was fear of pain. Once I could understand what was being done and why, and what pains to expect, it ceased to be a problem, kind of like digging a splinter out of your finger with a needle - it hurts but you don't care because you know it will feel better afterwards. That skill became incredibly useful for the rest of my life.

@steveboverie9432 Жыл бұрын

Yes, this also applies to needle injection for vaccines and other medication. I used to get allergy shots when I was young and I learned how to ignore the sort pain, knowing what is going to happen lets me relax and the pain is less.

@SeanBZA Жыл бұрын

Yes, I do not mind my dentist, he has a great chairside manner, and he works to minimise pain at all steps. Simplest thing he does is put a small amount of the injectable lidocaine onto the gum first at the site, and wait a minute, looking at the rest of your mouth at the same time, then going in, putting a small amount in the now numb area, and then another minute of waiting, then finally the full dose. You feel nothing at all, which helps as I am insensitive to the local, so the regular dose normally means I do feel pain, but it is manageable for the duration. Fun thing about the 'caines is that they sublimate, or at least that is what they say in the police evidence room, when the amount they show on trial is half the amount registered at the bust.

@SeanBZA Жыл бұрын

@@steveboverie9432 Who does the injection also is the thing, I learnt from a hard as nails registered nurse just how to administer injections, because she would swab the area, then get ready with the needle, and tap the area a few times with the swab, to get your skin and nerves used to sudden taps, and then slip the needle in instead. You would not notice it. She almost always was the one doing the pediatric work as well, because she would not cause any sudden pain to the infants and children, so they would not cry, and thus not stress the rest of the children in the line out either. Plus she always had a big bottle of sweets, that she gave to them afterwards, as reward. But i did see her inflict needed pain on some, giving them a teaching reminder.

@timjackson3954 Жыл бұрын

@@steveboverie9432 That too. I was in a road accident when I was 11, and had to have daily shots for a week. About halfway though the nurse told me, if you relax the muscle in your arm, the needle won't hurt. She was right. Why did no-one think to tell me that beforehand?

@tissuepaper9962 Жыл бұрын

@@timjackson3954 I learned that one the hard way, when I tensed my arm so hard that the needle bent.

@mpsoxygen Жыл бұрын

The clip of Hawking running over Cox as an analogy for the cox receptors just blew my mind! 🤯🤯🤯 I am now convinced Sabine should be supreme ruler of the European Union!

@Psnym Жыл бұрын

Disagree strongly. We need her to be US President! Change the Constitution, make German the official second language

@terrytartu Жыл бұрын

As someone who has ignored pains throughout my life yet now has accept chronic pain caused by arthritis and, possibly, old age, this video could not have come at a more appropriate time. I have discovered that many prescription opiates do not work well on joint deterioration/friction etc. While diclofenac and similar ketoprofen, ibuprofen etc do. You explained it all very well enabling even my comprehension of some salient points to be satisfied. Great informative video. Thank you. Love the suntan! Estonia has been very hot too!

@jpe1 Жыл бұрын

I have similarly ignored pains throughout my life, and I had quite a bit of joint pain, but several years ago I stopped consuming any and all dairy products and the joint pain essentially ended, and to a small degree the damage has been reversed. It’s never to late to make healthy changes to one’s diet!

@adammillwardart7831 Жыл бұрын

You might look into "wild lettuce". It's a weed that's more or less common all over the world except really dry areas. A guy named Mike Reed has a bunch of videos on KZfaq about how to use it for pain relief. He uses it for arthritis and joint pain. Good to know, in case pharmacies are ever closed or out of stock from supply chain issues etc...

@95rav Жыл бұрын

If you had asked me last week what Estonia was, I would have said it was an enzyme, hormone or something. (Also, and totally not PC: how do you make a hormone? Don't pay her!)

@allangibson2408 Жыл бұрын

Ibuprofen and aspirin actually treat the cause of arthritic pain - because they are anti inflammatories.

@esecallum Жыл бұрын

look up d3

@TristouMTL Жыл бұрын

OMG you've outdone yourself with the humour in this one! I'm managing to still pay attention and learn something, but I'm laughing so hard that it's making it difficult! Thank you to everyone who makes these videos -- so educational, so entertaining!

@Memfys Жыл бұрын

Pharmacist here. Great video! Surprisingly deep and thorough given the limited time. Already sent the link to several friends. Thanks!

@dmh20002 Жыл бұрын

I had a injury and received iv morphine. for two hours I had no worries in the world, I just floated on a cloud. Occasionally I think about how it would be nice to have it again. Now I understand why addiction is so powerful.

@wishingonthemoon1 Жыл бұрын

I hated being on morphine, I was blatantly aware that my mental capabilities were lowered and it was miserable. But hey, didn’t have pain 😆

@dennisbrown5313 Жыл бұрын

Not every one has that experience; for me, it reduced pain but had no more effect then aspirin. So, I was lost why people liked it - had it twice (two different surgery's) and no difference. Ditto codeine

@duggydo Жыл бұрын

I researched the different types of painkillers a lot when I was taking them regularly. After I changed my diet and cut out bread, sugar, almost all carbs, and started drinking a LOT of water, I don't have pain anymore unless I over exert. It's amazing what diet can do.

@winsomehax Жыл бұрын

Same here. You'd imagine this kind of info would be huge. Costs little, no risk. Very strange why more people don't just try it.

@michaelblacktree Жыл бұрын

Congrats on your success! The saying "you are what you eat" is so true. So for example, if you eat foods that promote inflammation, you're going to suffer. Heavily processed foods with lots of carbs are highly inflammatory.

@jpe1 Жыл бұрын

Yes! After I cut all dairy products from my diet the joint pain I felt every morning when waking up (that I thought was simply part of life) all went away. I tell people to stop consuming dairy, your body will thank you (and so will the cows!)

@rickstorm4198 Жыл бұрын

Yeah that's not gonna fix a nerve impingement and many other injuries.

@oakpope Жыл бұрын

I stopped eating completely and inside my grave, I can assure you, I don't feel pain at all. Actually, I don't feel anything...

@nziom Жыл бұрын

My jaw dropped twice when I heard the cases of those two construction workers, the brain is truly the most complex and mysterious organ to ever exist.

@MattAngiono Жыл бұрын

It's amazing what the brain is capable of! Pain is all about perception!

@TheAngelsHaveThePhoneBox Жыл бұрын

It's the only organ that named itself.

@agxryt Жыл бұрын

The title of this video really undersells the depth and quality of it. This is a great review

@kurtmueller2089 Жыл бұрын

Great video, thank you. And also a sponsor I can get 100% behind. Tried them out with students and not only do the experiments always work (contrary to several other science experimental kits) but you can do each experiment twice. Also, the results are generally visually impressive.

@willemvandebeek Жыл бұрын

You gave me a scare there for a while, because I thought there was a chronic pain issue in your personal life. Glad to hear this isn't the case. :)

@anatomicallymodernhuman5175 Жыл бұрын

“...though this risk also exists.” Favorite line. Listening to music can help you ignore pain. But what really does it for me is making music. It has been my chief way of dealing with gout pain when ibuprofen wasn't enough. Thankfully, though, my gout symptoms went away when I switched to low carb diet. Was this episode edited on a plane or similarly noisy environment? There are numerous awkward edit points - clicks, caught breaths, and so on. Great content, though, as usual.

@MyMy-tv7fd Жыл бұрын

suggestion (as I had acute gout in the little finger once) - avoid high levels of purines (type of amino acid) in food, eg offal like kidney. Also increase vitamin C and take joint support supplements containing chondroitin and MSM

@anatomicallymodernhuman5175 Жыл бұрын

@@MyMy-tv7fd , mine is chronic, and over the years, I’ve cut out red meat, shellfish, and a lot of other high purine foods. But symptoms kept returning anyway until I started intermittent fasting and cut way back on potatoes and white rice. Pain free for weeks now. Dr. Berg on yt explains why.

@JanicePhillips Жыл бұрын

Try adding Youngevity's 90 for Life to your life and wow. I'm off my massive doses of all meds and almost completely off my opioids that I've been on since 2003. Thank God for Dr. Joel Wallach! But he's not as sexy as Dr. Sabine. lol

@chriswebb1935 Жыл бұрын

This is by far the most educational yet entertaining channel on KZfaq that I've seen yet. Sabine I just love your explanations on topics not only pertaining to physics but also the world at large. This channel is extremely invaluble to me as I am a total dunse when it comes to math. Thank you for everything.

@IIMrOhII Жыл бұрын

"Magic! Thanks for watching" had me. Loved it.

@jehl1963 Жыл бұрын

Your best video yet Sabine! I even watched through the ad!!! Why? I think it was because you were learning about the subject as much as the viewers. I encourage you to please continue this in future videos. 👍👍

@jehl1963 Жыл бұрын

Hi. I don't know if that was the real Sabine Hossenfelder or an imposter responding above. Either way, I don't have an Instagram account.

@nanorider426 Жыл бұрын

5:34 "Magic" 😆 I love when you do that Sabine. You talk at great length about something interesting and suddenly a joke appears. Bravo. By the way, I'm a former military medic so I have a slightly professional angle to this subject.

@riadhalrabeh3783 Жыл бұрын

Brilliant Sabine.. I watch a lot of medical videos but this one is by far the best.. please continue the good work. Yes science has no boundaries.

@JamesKintner Жыл бұрын

As an anesthesia provider, this is an excellent and concise overview of a pillar of our practice.

@Veerorith Жыл бұрын

This was incredibly helpful, I had bariatric surgery recently and was told I can basically never take NSAIDs again, but they didn't really explain well why, except that it would increase ulcer risk. Understanding the mechanics behind it is really interesting and makes a ton of sense now!

@MattAngiono Жыл бұрын

If you find you're struggling with pain after you've healed, check out the book THE WAY OUT, by Dr Alan Gordon... It solved everything for me once I had the knowledge!

@kinggzz Жыл бұрын

very good. as i was laying here with extreme back pain i got comfortable and watched your video. i realized my pain level had decreased dramatically and wondered if i had somehow found a good position to lay in which was partly true or was it that my brain was distracted by being interested in what you had to say. very interesting, thank you.

@MattAngiono Жыл бұрын

Get THE WAY OUT by Dr Alan Gordon.... It's invaluable for dealing with pain, as it's all about perception! I was part of the highly successful study in the book, and almost everyone saw immense benefits, most were completely pain free by the end.... No medication needed, just education!

@kinggzz Жыл бұрын

@@MattAngiono well, when you have pinched nerves and herniated disc and degenerative disk disease as well as arthritis, diabetes, carpol tunnel, migraines, multiple bone spurs, everyday is full of pain.

@MattAngiono Жыл бұрын

@@kinggzz well, I wouldn't want to make promises, but that's exactly what I thought before coming across this stuff. The truth is that the body can heal, and even "pinched" nerves or slipped disks, or whatever kind of issue you might be having is still being processed by the brain. And if you can recalibrate the signal, the pain can go away. It's not like I'm invested in this, but it really did work for me, and I know how agonizing it can be to have chronic pain. Just try the book, keep an open mind, and see if you can reprogram the neuropathways that are stuck in pain mode. Like any other pattern in the brain, these things get stuck and stagnant. Some of the people in the study described in the book, which I was one of, had terrible seemingly incurable pain, decades of it, until we met Dr Gordon. Just give it a try and see what happens! I'm only spending time commenting here to try and help because I know the misty all too well

@kinggzz Жыл бұрын

@@MattAngiono i assure you that if it were possible to touch another person and transfer my pains listed above and my 239 kidney stones, and my diabetic neuropathy as well as the bone spurs in my hip sockets, THAT PERDON WOULD SCREAM IN AGONY AND FALL ON THE FLOOR passed out from the shear agony. so my brain does help mask/ignore the pain but it does not fix the problems. thank you for the conversation. peace to you and your family.

@MattAngiono Жыл бұрын

@@kinggzz how about the Buddhist monk who set himself on fire? I'm pretty sure that would be worse and he didn't even make a face. I am only trying to help. You can check out a cheap book with an open mind or continue to pay who knows how much for meds that don't sound like they are working. What have you got to lose? Anyways, I'm not arguing, just suggesting what worked for literally every person in the study, one woman even had scoliosis and healed it. But it's totally up to you..... ✌️

@michelebriere9569 Жыл бұрын

I have chronic pain, and found this video very instructive. Thank you.

@michaelesplin529 Жыл бұрын

Thank you Sabine, I watch your videos as often as I can. I sometimes struggle with the math and concepts, but enjoy them all the same. Your demeaner and steady even pace often fills in the blanks.

@n-steam Жыл бұрын

I had both hands covered in 2nd degree burns, the pain was about as bad as you can imagine. When I got to hospital, nurses applied a silver-based cream, and almost instantly the pain went from 110% to 1%. The mechanism behind it has yet to be studied though.

@wkj-dk8wv Жыл бұрын

Silvadene cream!!! That stuff is awesome. I ended up with 2nd and 3rd degree burns on my foot (long story, me being barefoot and a grease fire in the kitchen). After getting it cleaned up, I was given that cream. Like you said, from 110% to 1%. That stuff is amazing.

@allangibson2408 Жыл бұрын

The mechanism is very well understood. Burns are painful because neurons are exposed. Covering them reduces pain. Silverdene controls bacteria that just loves burns - people with burns mostly die of infection.

@n-steam Жыл бұрын

@@allangibson2408 I don't think that would explain my experience. By the time I got to hospital it was already blistering. The outer skin unbroken, had died and had separated from the skin underneath. I had a small (square inch) patch that actually had skin broken, but that was 3rd degree and was completely painless already. I really doubt any living neurons were ever in contact with the cream.

@allangibson2408 Жыл бұрын

@@n-steam Third degree burns are painless because the nerve ends are destroyed totally. Second degree burns are painful because the nerve ends are exposed to air (which was why butter was traditionally applied to relieve pain - it unfortunately also accelerated bacterial growth).

@n-steam Жыл бұрын

@@allangibson2408 Yeah, I know about third degree burns. Experiencing them makes you want to read up on them. My point was about the blistering. The skin is separated. There's fluid between the layers of skin. I had blisters the size of each finger, 4 on each palm. Nerves on the exposed skin have no way to pass their signals through the blister.

@sean_vikoren Жыл бұрын

RE: Hypnosis I went through some training as a Hypnotherapist, and I can tell you that there is certainly something there. In one student-student exercise, my fellow student forgot our key intro phrase (something like "You may choose to remember any part of this experience at any time."). After sitting there for a bit, I asked her if she wanted me to go first. She blinked, and then explained that we had already done the exercise. In the end, I did not feel comfortable wielding that much power over another person.

@richarddawkinsatheist9289 Жыл бұрын

I am glad that I came across your youtube channel. Thank you for all the hardworks behind every video! Keep up this good work!

@johnnyboy4428 Жыл бұрын

Sabine I love watching and listening to your videos it takes away my pain

@doggedout Жыл бұрын

Third time this week I have seen that clip of Hawking running over Cox with his wheel chair. Still cracks me up every time. Also: A good treatment for sunburn is topical procaine. Just thought of that for some reason.

@DoctaOsiris Жыл бұрын

Fun fact: Acetaminophen and Paracetamol both come from the full generic name for the drug: Paracetaminophenol 🙃 Also - Heroine was just the brand name for Diamorphine Hydrochloride which is still available on Prescription in most countries 🙃

@xESOTERlC Жыл бұрын

Absolutely love her type of subtle, dry humor Great videos. Glad I found her in my feed.

@KalebPeters99 Жыл бұрын

This was so informative, thanks Sabine! I hope this one gets some more views cuz this should definitely be more general knowledge 🙏

@Paulkjoss Жыл бұрын

When unboxing, don’t speed up the unwrapping part - the sounds of tape, ripping, and peeling are the audio analgesics that KZfaq loves 😀👍🏼

@hyperzzzzz1 Жыл бұрын

Dr. H. Can't thank you enough for this. So clear, and after several viewings I think I will really understand my pain/pain relief battle. I know your a phycist (I'm a subscriber) but I wonder if you might br8ng your intelligence and clarity to tinnitus. Thanks.

@mirkocaserta Жыл бұрын

I second this. My mom has tinnitus and all the doctors have done so far is recommend white noise apps. I wonder how much we know about it and how long it's gonna take to develop an effective treatment.

@MattAngiono Жыл бұрын

You must get the book THE WAY OUT by Dr Alan Gordon! You don't have to suffer, if you get the right knowledge. Worked for me after chronic suffering for years

@andyx6766 4 ай бұрын

An extremely helpful breakdown of the chemicals, mechanisms, and body parts involved. Good balance of detail and examples.

@danwb5916 Жыл бұрын

Knew a woman years ago who was taught , by a professor at UBC to block her chronic pain through hypnosis . Her husband said she became so good at it that she could immediately stop any pain -stubbed toe or kitchen accident . The nature of hypnosis would indeed make a great video. )

@JimGobetz Жыл бұрын

Thanks Sabine for this vid, it was informative. I have been on opioids for several years due to cancer and am starting this month on a 10% MED (Morphine Equivalent Dose) reduction. Nice to know it's the accepted method. FWIW I did not have good results with Cannabis.

@BRUXXUS Жыл бұрын

Hope your cancer has been taken care of! Coming off opioids is no fun... :( I hate unsolicited medical advice, but I will just say that kratom helped me quit opioids incredibly fast, with no withdrawal.

@MattAngiono Жыл бұрын

You've got to get the book THE WAY OUT by Dr Alan Gordon! It's the best tool for chronic pain, as perception is everything. I can tell you from personal experience, it really works! I was actually in the study the book is based on and it was very successful, more so than anyone expected, even the doctors involved!

@PamSesheta Жыл бұрын

Wow! That explains why aspirin was a preferred migraine medication to others, it just took a lot of the pain receptors out of commission; my migraines can have aftershocks and follow up migraines, so an abort that acts as a preventative is important. Very cool, but good reason to be wary of it, I have found other medications to manage migraine but I will have a new respect for aspirin

@Rationalific Жыл бұрын

Excellent explanation about how these painkillers work, what their downsides are, and how these drugs compare to each other. I haven't seen tons of videos about painkillers, but I'm pretty sure it would be hard or impossible to find one as concise yet informative as this one!

@AnalyticalReckoner Жыл бұрын

I have reoccuring pain from old injuries from manual labor. It wasn't the heavy things that caused problems, it's the repetitive motion.

@hunterG60k Жыл бұрын

I love that you branch out from physics now and again because the quality of the information is still excellent. I studied medicine at uni and after doing pharmacology I am in the same boat as your friend; not many drugs make me nervous but paracetamol does. If you take a couple of pills more than you're supposed to each day, over a period of time, you can have killed yourself and wont know about it until your liver completely shuts down so without a transplant you're gone. I had toothache recently and was taking ibuprofen, codeine and paracetamol; I made sure to write down what I took and when so I definitely didn't overdose on paracetamol. It's scary stuff.

@reggiep75 Жыл бұрын

Now this is one thing I've always read into and not got a definitive answer.. THIS VIDEO WILL GIVE ME MY ANSWER, where others have failed... 😊🤘

@paulspice4717 Жыл бұрын

As usual amusing and educational. Thanks Sabine

@DjoumyDjoums Жыл бұрын

Very happy to hear you talk about various scientific subjects, thanks for the video.

@nomizomichani Жыл бұрын

I have allergic reaction to many drugs including some pain killers. I don't usually take pain killers except when I went into a surgery. When I was younger when I was in pain, I taught myself to think the pain away. I guess it was somewhat akin to meditation. I think I am more sensitive to pain now than when I was younger.

@monsieurVi Жыл бұрын

Same here. I was curious if someone mention this “self-induced Somatic Deamplification phenomena”. From my own experience, It’s something that our brain is capable of and can be trained (or should I say fooled?). Kind of magic actually. ;)

@sapelesteve Жыл бұрын

As a retired health care professional, I found your video about pain very interesting. It would be good if you could do a video about the benefits of "medical hypnosis" as opposed to the theatrical hypnosis that most people are familiar with. 👍👍😉😉

@dewiz9596 Жыл бұрын

Awesome stuff, Sabine!

@HENRYIII003 Жыл бұрын

Perfect timing! Yesterday, I listened to a fantastic lecture about The Ethics of Pleasure.

@LadyAnuB Жыл бұрын

Sabine, Pain is only a part of the flu I currently have. (Got tested for COVID and I am negative.) I am curious about how decongestants, expectorants, and cough suppressants work on a molecular level now. 😅

@THX..1138 Жыл бұрын

I think a person's pain response varies quite a lot from person to person and that difference probably determines both how effective and addictive pain killers are. I would not be surprised if more pain sensitive people have more phycological pain as well because they are more rightfully fearful of pain. I would bet those people are also more likely to become addicted to painkillers because they have more of those receptor thingies. ...Myself, I'm person who has a very low pain response. And no history of drug abuse. I've injured myself many times and though having been prescribed them I've only ever taken a single pill of a prescribed pain killer because I didn't think I needed it and honestly it didn't seem to have any effect on me. Same goes with over the counter stuff. I often go years without even taking an aspirin. Recently while barefoot I banged my foot on the leg of a couch so hard my toe began to bleed. The leg was round and smooth so couldn't understand what cut me. It was a fairly large and deep looking cut. It didn't hurt that much, but it also wouldn't stop bleeding so I went to the emergency room figuring I needed stitches. There I was asked first by the nurse, then the nurse practitioner, then the doctor I'd say a good 6 or 7 times what my pain level was using their little pain chart that ranged from 1 to 10, 10 being the end of the world. I answered it was a 1 or at best a 2. The doctor ask how I did it, looked at it some more then said he needed to do an Xray. I bucked cuz I didn't want a dose of radiation just so he could pad the bill. That's when he told me it was a compound fracture. That my bone is what had caused the cut and he needed see what the break looked like to be sure it was okay to just stitch the toe back up. He then also remarked he was surprised and maybe a little concerned I didn't feel more pain. I believe my high pain threshold is due first not feeling pain as strongly as most people and because of that lack of feeling my brain also hasn't learned to be as afraid of pain as some people.

@fugslayernominee1397 Жыл бұрын

Wohhh! So much information cramped up in just 20 mins, got to learn so much from this thank you Sabine.

@andrewroberts5988 Жыл бұрын

Amazing video and great humor. This is an awesome vid. It is very rewatchable. Well done!

@zlamanit Жыл бұрын

13:15 "I'm not a doctor" I'm sure that a PhD in particle physics counts.

@dstern54 Жыл бұрын

I imagine lots of us noticed that. To be technically correct she could have used medical doctor or physician instead of doctor.

@wktodd Жыл бұрын

Careful of that sun Sabine 8-)

@rodisopamsu Жыл бұрын

Careful With That Axe, Eugene 8p (Pink Floyd)

@xx_z.bruh_xx6916 Жыл бұрын

The deadpan "Magic, thanks for watching" had me rolling

@stub1116 Жыл бұрын

That was a brilliant video, well thought out and presented. Thank you.

@youtubeoppressivecensorshi8047 Жыл бұрын

Opioids are best pain killer. It’s my human right to have as many opioids as I want. I don’t want anything else

@marielawrence6100 Жыл бұрын

Your videos are always the best I do receive a notification each time you post a new video.we will have regrets for things we did not participate in. Investment should always be on any Creative man's heart for success in life and I'll advise you do little glimpse of that on your video*

@guspelletier3079 Жыл бұрын

That's through investment should be on every creative man's mind due to the economic situation

@jacksonjack6594 Жыл бұрын

At the moment now I'm a bit confused about this investment stuffs because I don't know what to invest in perhaps Crypto, Forex or even stock.*

@johnjoe9660 Жыл бұрын

I Will advice you invest on Crypto and let go of Forex and Stock trading

@jeremyvernon1825 Жыл бұрын

The be>st strategy to use when trading bitcoin,is to trade with an expert who understand the market as their own farm and makes maximum profit.

@eugeneweaver5392 Жыл бұрын

Mr Michael Taylor is the right person to start trading cryptocurrency with.. he knows he's way around the crypto world.. he has been helping me increase my investment every day for over months..

@RuntotheMovies Жыл бұрын

That dentist overlay picture gave me full body shivers.

@bastiangugu4083 Жыл бұрын

Great video and very interesting. Thanks Sabine.

@sp277 Жыл бұрын

Very good summary and well explained. Thank you.

@jdz9115 Жыл бұрын

Thank You for this very informative and light hearted look at this subject. I am on several of these drugs, and now have more information to ask why.

@Quenchcar Жыл бұрын

Thanks, Sabine, it's very much interesting subject and presentation.

@holdinmuhl4959 Жыл бұрын

Usually I don't like advertisements in the video(Who does?). But this time I have to support Frau Hossenfelder's ad for MEL Science. I don't know MEL Science at all. Once, many years ago I was an East German boy who had a young aunt who had had no own family yet then. From her first self earned wage she bought a chemistry experimental kit. I was way to young for it then and my mother immediately removed the hydrochloric and nitric acids as she feared that I could do me a harm. But as she had no chemical knowledges she had left caustic soda, ammonia and such weird things like copper sulphate, so that I could make some of the fine experiments, however had not understood them then. To cut it short at least: This was one of the very decisive gifts of my life I suppose. It made me very curious to learn a lot. I became interested the in everything from chemistry to zoology, electronics. Finally I became a banker.😁 But this very broad interest remained all my life and has stretched out to philosophy, sociology and genetics. If I had young children today I'd make such gifts to them.

@bramfran4326 Жыл бұрын

I really enjoyed this one. Interesting subject, structured and complete presentation, plus can't remember of any similar video.

@letterheatst1459 Жыл бұрын

Great video on a topic I was curious about.

@rtt1961 Жыл бұрын

Much more informative, and straight talk, than the huge majority of so-called "pharmacology experts". Only a physicist, only Sabine. As usual...

@FritsvanDoorn Жыл бұрын

There is also acupuncture. I have once used it as acupressure to have a tooth removed at the hospital otherwise they had to wrestle me down by a couple of very strong persons because I can fly out of the window only by thinking about having a tooth pulled out. Total panic here but not using only two pressure points. The first one was Pe8 and the second I forgot.

@MeppyMan Жыл бұрын

I hate to tell you this. But acupuncture is all based on pre-science magic. No two acupuncture practitioners use the same pressure points or can even point to them being in the same place.

@ironcap2050 Жыл бұрын

I am vaguely interested in pain medication but like always I learned something and of course the wit is perfection. thank you

@wngimageanddesign9546 Жыл бұрын

"It's a box!" I love your dry sense of humor! Another great video!

@stanweaver6116 Жыл бұрын

Thanks for the primer, very helpful.

@JelleDeLoecker Жыл бұрын

That was a great video! Super clear explanations.

@shannonmcconville4337 Жыл бұрын

This was a great video. As always full of accurate information

@seeyoucu Жыл бұрын

This is fantastic. Great explanations!

@protoword10 Жыл бұрын

Simply, thank you Sabine!

@veeeeeedub Жыл бұрын

Great video Sabine! A really good summary in a concise and easily understandable way. Perhaps you can look into phantom limb pain for amputee patients and the effects of mirror therapy and graded imagery to relieve pain

@tiemiahu9947 Жыл бұрын

Awesome! Very informative, thank you Sabina....

@IncompleteTheory Жыл бұрын

Chapeau for finding and using that clip with Brian Cox to show how to block Cox enzymes.

@samdog_1 Жыл бұрын

Nice job! I think your explanations were right on target.

@christalrising Жыл бұрын

Savine, I could watch your videos forever thank you for the gift of knowledge you are amazing and I love how you explain it. Keep up the good work we love you from Arizona

@TheSkystrider Жыл бұрын

I love your sense of humor, Sabine!

@robertellershaw Жыл бұрын

Did anyone else notice the two video lights reflecting in Sabine's eyes giving the seldom seen effect of two bright lights reflecting in her eye's. Good educational video, Sabine Thank you

@donovangmike Жыл бұрын

Anesthesia next please; and goes without saying you have the most comprehensive, intelligent and succinct science channel on the tubes.

@gopro2804 Жыл бұрын

I absolutely love you sense of humour and your manner. I love you smart brain. Please keep making these videos. I nearly spat out my drink at 5:35!

@elck3 Жыл бұрын

Dr. Hossendelder’s videos are constantly getting better, and it’s clearly due to painstakingly (no pun intended) researched videos.

@billyt8868 Жыл бұрын

this is one of my favorite videos for sure

@liliancalo3518 Жыл бұрын

Sabine, I loved your English jokes, and seriously, I appreciate very much your science about the physiology of pain. I spent two years in Germany as a post doc fellow in a Biochem lab (I'm Brazilian) and it was amazing, professionally and as a life experience. Your accurate explanations reminded me the group discussions we had every week. I've already subscribed to your channel, Danke Schön!

@WindowsOnWindows Жыл бұрын

Thank you for a really fascinating video!

@tamirmichael1265 Жыл бұрын

@sabine Excellent video. Thanks for making it !

@HarryLewinASR Жыл бұрын

Your pain (relief) presentation was masterful and wonderfully concise. I never finished my Ph.D. thesis on the role of acupuncture in the management of chronic pain, buy my discomfort at revisiting pain management was moderated by the audio-analgesia you generated. Dass ich in Ulm an der Donau geboren bin, ist relativ nebensächlich.