I finished this video several weeks ago already, but I had to wait before I could publish it, so this is not the only thing I have been working on since my last video! Expect more (hopefully) soon.

Bro literally combined the two worst types of chemistry in existence and got an actual, measurable yield which is really impressive

Reject complicated organic catalysts, embrace electrons

You are constantly raising the roof in YT chemistry community… mad respect

You’re basically the only organic chemist on KZfaq who still makes legitimate chemistry videos! Please keep it up, your content is amazing!

I am so happy to see a video regarding my field of research! Just to make it clear the Electrasyn is not the best set up to start synth. electro organic synthesis. There is a lot of literature regarding galvanostatic reactions from other groups only using a lab power supply and simple electrodes. I would be super happy to see more of electrosynthesis videos on your channel. You could contact me for some easy synthetic procedures or literature to show on your channel!

Electro organic chemistry sounds fascinating and all, but what really blew my mind in that video was this showerhead funnel you used to fill your column with solvent at 8:00 . I haven't run a column in 8 years but where was this piece of glassware when I did? I've never seen this anywhere. Our glassblowers could have easily made this. I feel like i missed out on something important.

Always improving brother! Good video! Also this is black magic

I once asked a professor who is specialised in organic electrochemistry why they don’t use the Elektrasyn. He told me that it is a nightmare to work with because the magnetic stirrer tends to break the electrodes. I forgot the other points but people like to jump on trains when it comes to high impact research

This kind of chemistry is incredibly exciting. Can’t wait to see how it evolves and grows

I was always interested in electro chem and I’m finishing up my second semester of ochem. This video really got me hyped to see how vast electro chem can be! I don’t think I’ll end up doing this in the future, but it still looks amazing!

You took your already top-caliber chem KZfaq content to a new next level with this video. Keep it up with testing frontier chemistry like this!!

Man, I absolutely love these creative synthesis videos. While I do think you a have a lot of talent as an experimental chemist, what I appreciate the mosts out of your content is your apparent theoretical knowledge and the way you share it with the public. As a new PhD student in org chem, it's amazing to finally have youtubers such as you and Chemdelic doing not only the experimental work on video but also showcasing the theoretical aspects of planning a synthesis, figuring out reaction mechanisms and ultimately pushing the boundries of science. I couldn't enjoy it more, keep up the good work❤

This made my day! Please don't stop uploading chem content. I need my chemistry fix over the break.

thank you for your contributions to the community!!

Echem is awesome! Thanks for making a great video showing the emerging practicality of electrosynthesis :)

Yay electrochemistry! I just got done running a chlorate cell with mmo electrodes and an old pc power supply at 4A for 60 days ❤

Love your work.... ❤ your opening words were very apt...

Electrasyn!

Ive been thinking about this topic and I'm not any type of chemist but really find it interesting

I am writting a paper on this right now. Organophosphorus electrochemistry :) cheers

Organic electrochemist right here! Great video. I use electrasyn quite often and can say it changes the game for good. Electrochemistry introduces more variables besides that of organic chemistry, which can be a nightmare for some but also an advantage as you can get different outcomes from the pure electrochemical optimization. Gladly electrasyn handles that very well and not much electrochemistry is required for one to get to know the field

Oh man, I just caught a very cool flashback. I studied organic electrochemistry in my last year, when I was studying to be a chemist. It was a very cool job lasting many months, which taught me almost everything I need to be a good specialist. A lot of what is shown here was routine for me. And even more than is shown here...

Very cool appreciate your time.

Hate to admit, but I usually don't focus on the actual chemistry. I come here to just watch mixing of odd stuff and its outcome which feels therapeutic enough to calm my weary soul.

Great video! I'd love to see more electro organic synthesis!

Ozonolysis is the latest "new" tool in organic chemistry. The old oxidizers such as permanganate or chrome get left in the dust. Uses 95% Acetone. It streamlines the process, leaves .HCl intact. Under 1 hour to completion. 90% yield. Pale yellow colour. Amazing!

It's good to see electrochemistry expand into organic chemistry. Thanks!

Dsng thats huge would expect nobel prize on this kind of research

I remember reading a write up for clandestine d amphet in a book by uncle fester back in the 90's. It called for a palladium electrode using a lambskin condom as a makeshift semi permeable membrane.

great video dude, respect

Awesome chemistry! I want to try some electrochemical organic synthesis now!

Sweet!!! Never seen one of these devices! Maybe I'll understand enough to use one soon 🎉

Thats brilliant. I always wondered if that was possble, not that i enjoyed electrochemistry. I just figured it would somehow work to perform organic chem one day.

Okay, faraday's per mol is completely insane. COMPLETELY. I had to walk down a long path to even figure out how the hell any scientist thought up this unit of measure. First, you have the SI unit for electrical charge, which is coulomb. Then you have a constant called Faraday's Constant which is the amount of coulombs in 1 mol of electrons, expressed as coulombs per mol. Then you have a goofy NON STANDARD unit of measure called the faraday (little f) which is an amount of coulombs equal to Faraday's Constant times Avogadro's Number, expressed as coulombs. Then finally you have faraday's per mol which is actually... COULOMBS PER MOL AGAIN. But its worse than that! its an AMOUNT of coulombs per mol!! Only a chemist could come up with such a foul non standard usage of SI because it contains Faraday's Constant and Avogadro's Number in such a way that it likely makes some basic algebra simpler down the line. JUST USE COULOMBS PER MOL. My brain hurts. Oh and don't confuse this with the SI unit farad! that is 1 coulomb per volt! And you will likely deal with farads doing electrochem because they are how capacitors are characterized.

Kinda got me excited about the progesterone synthesis... any chance you're gonna do a video about prog or maybe estradiol? 🤠

Amazing stuff! Probably the first video of an electrasyn being used outside of a university lab on youtube?

I'm surprised its not more common considering chemistry is all about the electrons.

Respect from a pharmacist dude cool to see technology helping to explore new methods

I've been saying this for years, electrolysis for REDOX reactions makes so much more sense from an energy input standpoint and removes the need for high activity reagents. Only issue to be worked out for manipulation of organic compounds is finding a suitable polar solvent. Changing the anode/cathode material may allow for more selective reactions, i.e. partial reduction and targeting certain functional groups of a molecule.

Great work! Would love to see you attempt making phenylpropanone from benzaldehyde and butanone using ultrasound and copper chloride as a catalyst. I've pondered it for years but never got around to actually working out the details.

This topic is my favorite. RedOx with wires is awesome.

Great video!

It looks promising. As a related note, there is a lot of active progress in BIOSYNTHESIS of various chemicals using genetically-altered yeasts.

F/mol is… such a weird unit. I guess it makes sense when you consider the substance like a capacitor being charged up by the apparatus, but it still smells strongly of unit crimes.

I see that someone watched Baran’s intro to his seminars multiple times 😂😂 excellent work lad

Yey electrochemistry ty

Amazing job well done how are you it was super amazing

Just like biochemistry. E chem is black magic as well

this is part of the magic of reality; thank you

needs more amps for atleast 100g of product to be made after some time. They gotta make it bigger and use larger electrodes and atleast 10-15 amps of current available for the particular electrosynth.

Uh, you lost me at short bath distillation. This synthesis seems intense. There are a lot of steps and a new machine. You didn't even break a sweat. You understood all of it! That's truly awesome!

Great column chromatography you will rarely find someone on youtube who does it the right way!

can you do this with an aryl dihalide? or can you use formic acid in situ as the carboxylic acid?

5:52 If you have free flowing silica I find you can use much less to adsorb your crude material than if you used celite.

Hey there sorry if I sound stupid here but in the first step of the reaction at 4:57 I do understand the mechanism but isn't it all possible using the n bromo phtalikide and the potassium or sodium salt of the acid you used? thanks if you reply in advance

Aren't we a fancy lad, using DIC in stead of DCC :3

I think I'm good at chemistry but I had no chance of following this but I still found it interesting anyways for the bits I did understand.

I wonder if such a method could be used, instead of LAH, to reduce a nitrile to an amine?

Literally just submitted my post-lab for electrochemistry in biochem today

That remaining grain of hydroxypthalimide, so finely contrasted with the black plate of the heater, has ignited in me a level of anxious frustration that I believe is only experienced by OCD sufferers. Thank you for diagnosing me. XD

Video suggestions can you turn acrylonitrile to polyacrylonitrile and then carbon fibre if possible ❤ love your vid btw.

It's a bit spooky to me to put a clamp on your air hose when doing flash. I prefer just pressing it on by hand and it plopping off if the pressure ever gets too high (sometimes product starts crystallizing in the column suddenly when it becomes "too pure", clogging it) rather than having the column itself potentially blowing up.

Okay but that three d print lab stand is everything ring stands want to be I mean I'm doing chemistry like a caveman with my awkward rust ridden clamps and your clamps adjust this video has unironically reshaped my view of what the future of chemistry is.

Hi, very nice video! I have a curiosity, what's the Seebach's stain that you used in your last TLC?

@ 7:34, if the air bubble editing you spotted was that big one in the center about 1-2 cm up, I wouldn't worry about *that* at least... 😅 It looks like it's in the glass itself, which would be worrying in itself, since it's a weak spot. 😕 You can see it before you loaded the column (7:17), and also on the second column (19:13).

Key challenge is obtaining high yields. Isn’t it??? Large scale industrial applications have been achieved but they’re as rare as hens’ teeth.

Seems 4-(4-(3,4-dimethoxyphenethyl)phenyl)morpholine is a high value chemical. What is it primarily used for commercially?

omg electrasyn, i wish to play with it one day :00

I wanted to do this in my thesis 20 years ago but couldn’t find literature and a supervisor that would back the idea.

i always loved synthetic organic electrochemistry. Problem is indeed: standardized equipment; cell construction, quality low-resistance diaphragms (they will charge you an arm and a leg for a few dm^2 of Nafion® sheet, which is just sulfonated polystyrene), efficient cooling of both anode and cathode, and expensive platinum electrodes. A lot of it is overkill though, when you see how pre-1960s chemists approached it with cheap unglazed porcelain diaphragms but of course resistance will be high making efficient cooling a hassle. BTW electrocatalytic hydrogenation using a sacrificial catalytically active anode (like nickel) in a single, undivided cell is an understudied subject, the old approach usually was electroreduction on cathodes with high hydrogen overvoltage like lead or mercury, in divided cells. With electrocatalytic hydrogenation, through the sacrificial nickel anode a continuous, fresh and highly active spongy layer of nickel saturated with hydrogen is deposited on the cathode, eliminating even the need of a diaphragm. Of course due to the nature of the setup it will be limited in scalability, but it could be an elegant alternative to the classic hydrogenation with skeletal (Raney) nickel.

I suspect to convert plastics in a renewable source. The key are the electrochemistry and the electrocatalysis.

Amazing trying to inspire the way to utilize microwave assisted synthetic chemistry. Thinking you can detail more regarding as I still feel, just like electrolysis and other RF assisted reactions, there are many areas of opportunity for the devices and the methods.

16:24 which paper did you use to establish that mechanism?

as a simple mechanical engineer my head is destroyed by this content, very nice:)

where did you get the perforated funnel at 8:00 from?

I've been interested in electrolytic reductions for years.

I DO SYNTHETIC ECHEM AT MY LAB OMG THIS VIDEO IS FOR ME

Ah, but what are the PKa's and energy used .. Furthermore, can the chromatography be enhanced by 'holding' the impurity to the top with a magnetic field or light charged grid?

That's a cool way to make another jar of white powder

i still think HHO gas generators is my favorite application of electrochem. or does that not count because its just breaking a bond and not really synthesizing a compound? i think we will see HHO gas an energy storage or energy transportation in the future, or possibly just H2 gas. transporting HHO gas is kind of insane because of how unbelievably explosive it is and how energy dense the gas is, but if you have a container that isn't leaking than you can store energy essentially forever. i could only imagine the blast from a huge tanker car full of HHO going up in a rail fire though. just propane or butane is bad enough when they go up

Looking to buy the system youve got for mounting glasswear, you said better basics but sadly i cant find them? anyone got a link to the website?

Would like to know the availability of videos and literature for electro synthesis of possible industrial chemicals

Would be interested on any work on Organic Electrochemistry and 5Meo-dmt or what is often known to be far more complicated, A psilocybin synth.

We add some ethyl acetate, and then add some celite, which I washed with ethyl acetate, and on top of which i added more ethyl acetate, and washed the setup with ethyl acetate, extracted the product with ethyl acetate 3 more times, took the ethyl acetate solution and then added more cealite and sand into it, and added more ethyl acetate....

Do you have any interest in molten salt electrochemistry? I always thought it was interesting that you could theoretically melt a eutectic mix of NaOH and KOH in your oven. I never tried it because those things can cause nasty burns if they have any water trapped in them

IKA sells great rotovaps too....

How do people figure out what that wild mixture of chemical had to be to react favourably to the anode/cathode material and electricity to get the product? Almost looks like magic or alchemy to me!

I haven't found any literature or papers that have tested this specific compound, but based on substances with similar structures (substituted 4'-arylethyl-4-phenylmorpholines), you likely made a blood thinner, tyrosinkinase/NPM-ALK inhibitor, HIF-1alpha inhibitor or potent ribosomal kinase 1-3 inhibitor. In any case, I'm quite sure that it's very unhealthy if ingested. Also, PubChem is great :D

I love your vedios so much brother

love the video like always, but i really have to mention how the column is sagging over time. maybe they can make some different kinds of holders but it scares me so much how the column moves over time. personally i wouldnt feel confident leaving it alone for even a bit lol

I didn't understand anything of this but still enjoyed the video

Can we get an NMR spectrum or something to see that the product is what you say it is?

Try doing the same reaction but using microwave energy. ❤

Hmm I should hire a personal chemist to make my favorite recipes 🤔😃

Cool, I love drugs 0:54 I can replace expensive catalysts by instead just hooking a car battery to it??? Wtf I love electric organic chemistry now

Awesome video but there should probably be some advertising disclosures in there. And if the products and services that you are talking up are not affiliated with you in any way you should say that. Tiss the law my friend and you should look into it before you get yourself in trouble. Again Awesome work :)

I think it will revolutionize it. Yes

I thought you said that device came from Ikea at first ... and was soooo confused lol.

I don’t get what’s going on but it looks cool