Finally it's here!! For full transparency, during one part of the project my SD card corrupted, causing me to lose some footage. Since I couldn't go back and redo it, I had to record staged footage and reuse older footage. So from 19:45 to 20:58 and 21:40 to 22:17 you see me re-enact what it looked like as closely as possible but without the product actually being there. Then from 20:59 to 21:39 I am reusing footage from before. Also, the structure of m-chloroperbenzoic acid at 17:44 is drawn wrong, it should be the meta isomer, not para. And I realized 'cyclisize' is not a word, I will use the excuse of not being a native speaker. Enjoy this 11 step synthesis!!

there's nothing quite like finding a new chemistry channel to binge

In the beginning of 2020, a large chunk of Rio de Janeiro's water supply was contaminated with geosmin due to an cyanobacteria* bloom in the Guandu river, from which most of Rio's water is pumped. There was nothing wrong with the water, it is obviously treated, but they couldn't remove all the geosmin, and since we can detect it in such small quantities, everyone's water tasted and smelled like dirt for some months. It still happens from time to time, but it usually lasts a few days, nothing compared to the almost three months (iirc) in 2020. * Although Brazilian media just called it an algea bloom, cyanobacteria aren't algea.

17:03 you know you’re not feeling great about your yield when you suddenly feel the need to add a decimal

"after 100 years, it has all filtered through" We're all familiar with that! I do enjoy that anhydrous humour.

As our Aussie friend always says, yellow chemistry is evil lol

"In the end, I am left with.. YELLOW???" What a plot twist haha! Tom really did the chem community right with starting this trend

That's my favourite smell, along with the smell of pine trees and cool, brisk, fresh winter air, as well as burning wood. Just writing this brings back so many memories, it's surreal.

Can’t get over how complicated this process is. In my college organic chemistry labs I’d manage to mess up a 3 step process, so seeing someone carry this out so perfectly is super impressive.

Regarding 13:23 - I'm sure you already know it, but for anyone who wonders: many organic stuff are yellow because they have a lot of conjugated bonds in them (in the case of the imine here the bezene ring is conjugated to the nitrogen via its free electron pairs). This causes the electronic excitation energy to drop, bringing it from the close UV range into the visible range, i.e. the molecule absorbs deep-blue/violet photons, and we're left with a yellowish-looking product. For green we would need to absorb in the visible range both blue and red, which is not very likely.

As a preparative organic chemist I have to say, that is some quality work right here. Congrats to you my friend, I usually mess things up big time when trying to reproduce a paper for the first time :)

Videos like this always make me appreciate the rotary evaporator we have in our lab.

Yellow chemistry :( Geosmin :) This was a fantastic video, the subtle humorous acknowledgment of frustrations among the otherwise professional depiction made me actually physically laugh during a chemistry video, bravo.

Oh yes, yellow chemistry at its finest.

Wow. The patience. The dedication. Not to mention the skill. Mad respect brother.

I love that there are smart people who are happy to share how smart they are, so I can look at all the squiggly diagrams and fancy equipment and feel like I got a tiny little bit smarter. Thanks for taking the time to create, edit, and share.

With a synthesis of so many steps and ever decreasing yields I'd be getting anxiety about having to repeat the whole process just to have enough material for the final steps. Amazing work!

This video is more emotional to me for some reason

This is such a weird coincidence, this morning while getting ready for work I saw I had a sample of 1% geosmin in triethyl citrate sitting on my shelf from years ago and decided to smell it only for you to post this later in the day. It’s a wonderful smell, but you’re right it can get overpowering very quickly. Great video!

I don't know if you did an QaA about this but I was curious about the way you keep up with the things you do in your life and the passion about chemistry? Do you work as an chemist or you keep up another type of work and you make these wonderful videos on your free time? How much did you spent from the start to this day on home chemistry? When and how did you study chemistry (i imagine moreover the school education)? Did someone inspired you? Did someone has incentivated you to pursue this passion at home? Did you received or do you ask for chemistry or practical help from someone? What do your friends or parents think about your passion? Whould you ever incentivate someone to follow this beautiful path which is chemistry and sperimental home chemistry? And do you consider yourself happy? I hope you would answer these questions and remember that we're really happy to be your followers and that your's is one of the best chemistry channels here on the platform!!

Like NileRed, but with a 10x harder product and difficult process. Really interesting to watch, I had never heard of that chromotographic separation process before. I don't know how the closed captions work, but there were many inconsistencies between what was said and what was in the captions. Also, I caught at least one situation where your video text said 1% HCl and you said out loud 10% HCl. This is absolutely insane, and I would have loved to to get my hands on that and smell it.... spread it around the house... lol.

Your videos are always amazing, but this one is probably the best. Very well done! Keep it up :)

"Oh wow, seems to be going good, glad he did it first tr-" "I ADDED BROMINE"

Pure Geosmin solutions are a part of many sensory kits! At the food company I once worked at they did taste tests of some water samples. The testers were trained by drinking highly diluted chemicals such as Geosmin or DMS.

Best chemistry youtuber on the platform, love all of your videos, always excited when a new one comes out. Keep up the great work

What always amazes me is how mother nature creates the most complex molecules with ease (apparently). Just think of all the fruit flavors for example. And here, she just let's it rain on soil and voila... Petrichor. This makes me wonder if scientists have found out how this all is achieved (especially flavors) naturally.

I have no clue what's happening or what he is doing but it's satisfying to see all that chemical work turn into something

I am physics lover but now I can see my mind going in arms of chemistry.

I see explosions and fire is not alone in his opinions regarding yellow chemistry

One of your best videos,outstanding reactions and an unusual compound. Very nice of giving samples of product too!

This was an awesome video!! Thank you. I loved the chemistry, I loved the humor, just an all around perfect video.

Love laid back style of your commentary dude, makes this very enjoyable and approachable 😀

So sad there is no more sample, I've almost touched by the tip of my fingers one of my dreams,. This fragrance is like smelling life, its really therapeutic for me, just few breathes of it and it's like a big calm ocean with blue clear sky, take place all over my inner self. No more knots in my guts. only feather-light state instead. This a definition of a really peacefull sent. Thank you and bravo to you dear Chemiolis.

As an organic chemist I can tell you that this is some very nice work. Very impressive. Congrats!

I always thought it was the lack of smells that made the rain smell. You learn something new every day

truly an underrated channel. Watching you make this was so interesting

I love the smell of rain right before it starts pouring down lol thanks for sharing

There is nothing like a simple straight forward synthesis, and this is nothing like a simple straight forward synthesis.

This is not a video about chemist. This a journey through the most deep sentiment of science.

Ah now I get the smell referrence!

I LOVE the smell of petrichor! Gonna have to make it!

That was a very technical and laborious process, and you crushed it! Good job

What an amazing synthesis. Congrats!! I cannot imagine the time all those steps took. Truly impressive.

i’m taking organic chemistry right now and learned the general forms of a bunch of these reactions last week ! i love it when i can start to understand what’s going on in long syntheses

Can we just appreciate how mother nature just does this naturally and so quickly. Thats insane!

I like to watch your videos when I'm tired and want to take a short nap in the armchair. I'm not a chemist, nor am I too interested in chemistry, but I enjoy listening and watching a bit of video until I fall asleep for a short time. 😃❤️ And of course Im always awake at the end to see the result!

This looked like so much work, thank you for doing it, love the video!

I was always told the smell of rain was from O3 (rather than the regular O2 we breathe) but I never really looked into it! Thanks for the video

I think another good reason to add athylene glycol during the bromination is to disfavour deprotection of the ketal, since that will also yield ethylene glycol (le Chatelier principle). Oh yeah the deprotected one is probably a pretty strong lachrymator too lmao

my friend your videos are only getting better and better, very enjoyable

it's the best scent when one heads out- weird how one molecule (though likely a group) can bring such calm and clarity to the mind

So complicated that I lost track this time. 😵‍💫 It's a miracle that so much product could be obtained at all in the end. Sending smell samples was invented by labcoatz - a good idea to profitably compensate for the missing sensory impression. How about the sent of wet dog next time? 😉

Damn, that's impressive and awesome. You deserve to get a rotovap.

Short path vacuum destilation and yellow. Thats all I understand but I think thats the essence of this video.

i have no idea why i watched this video the entire way through without understanding a thing. There is just something very satisfying about it. Hope it helps me in my chem final a few days from now.

Love u

I really wish I had picked o-chem instead of cybersecurity...

It took this man maybe months to prepare it. While it took rain literally seconds I guess. Rain is the goat.

Of all the excellent KZfaq chemistry creators including Nile Lab, Nurd Red, and Cody's Rage, Chemiolis is one of them.

A long time a holy grail of fragrance molecules for me! But never had the balls to go all nuts and make it from scratch... Also: MgSO4 tends to "complexate" with ketoesters and diketones, which can partially explain low yields in some of the steps. I've gotten into this pitfall a few times in my practice in the lab...

Beautiful synthesis! I really see Chemiolis perfume line a thing XD Maybe just not in carbon tet XD I understand so well yellow... yellows and oranges, most hated colours Keep good work!

So, it's a raining down to earth upload. Thanks, I really needed this, honest. ;-)

OK, I just watched this and couldn't resist. The smell of rain is one of my favorite things so I subscribed. Hope I get a sample!

You’re hilarious in this video

It was not a good idea to watch this before my report deadline. Now my brain doesn't even work. Man, those were a lot of steps there lol. The videos are getting more complex day by day. I can't imagine how complex videos will be in a year from now.

I always wanted to make that compound. Thanks for sharing

Love the idea of giving back to the community, supported

Oh, a nice smell :). We all thought you were going to make some cursed tellurium compound or something lol

Awesome video as always! I was wondering, though, why does the enamine form a more substituted alkene? I was always taught that it prefers to form a less substituted alkene because of sterics. Perhaps it has something to do with the fact that the nitrogen is only monoalkylated, not dialkylated? Thanks!

Love you! Finally I found someone who makes videos in NileRedlike quality and fashion. Continue making videos and great content❤

this is so cool, petrichor is my favorite smell ever and i used to have a bottle of ESO that had geosmin in it and the company that sold it ran out of business and i've never been able to find anything quite like it since.

I love your style of humor. Nothing against explosions and fire, but I can't really get into it because there's so much screen shaking and gags. You have the perfect amount of funny stuff timed just right along with 95% actual chemistry.

I wonder if it'd work as a perfume

man you are an absolute legend for making this ♥ this has to be the best "amateur" orgsyn channel on youtube and I am so happy somebody is still making content like this. So many steps, great videography, narration, YELLOW memes, smell commentary. made me super happy to watch ☺ you've guaranteed a Patreon supporter as soon as I land a job. one note - audio could be louder. was hard to understand on full phone volume while showering 😆 don't judge me, that's when I got to it 😆

this is type of content that I wanted. I love smell of rain so much.

The most impressive thing about Geosmin if you ask me, is the fact that we humans can detect it at as low as 5 parts per trillion. That’s about equivalent to a bloodhound’s ability to track prey. We know that dogs have been reported to track scents at distances of 20-150km away, sometimes even longer depending on weather conditions. This goes to show how deeply engrained agriculture is in our biology.

Processes like this are why I had to quit chemistry. This level of focused complexity and crippling ADHD do not mix. I'm writing this about halfway through the video and I already forgot what you're making. IIRC you're turning rubber gloves into McDonalds Special Sauce?

Is there a proper scientific explanation why it is always yellow and not some other goddamn color? 😅

As a NileRed enjoyer, this channel is such a great discovery!

Impressive stuff, take my hat off to you, amazing the process you have to go through yet after rain nature just produces it!

hell yeah this is my type of 2 am content

This thumbnail is genius. Usually thumbnails are poorly made or clickbait, but this thumbnail perfectly captures the idea of the video and how we think rain SMELLS

Mooie video! Je wordt nog een keer een grote youtuber. Je videos zijn nu al geweldig

Love how you show every step. Reminds me of college. Sorry about the yield, it happens.

Holy shit! This synthesis is epic in the literal sense... Bravo Sir.

Yes, make rain smell science man

Your synthesis skills are impecable 😍

This video is so long with so many steps. I love it! I knew you had a good sense of humor. Keep it up 😉.

My favorite smell. So cool someone recreated it

Everybody needs a hobby. After listening for a while, I jumped to the end for the dramatic conclusion!

That’s an extraordinary amount of patience and dedication! I couldn’t do it and would wait for the next rainstorm lol

i randomly got this recommendation altough my youtube page is almost only gaming and I dont regret clicking on this! thank you for this fascinating video

This is so satisfying

I really enjoyed this extraction. 😊

Wow what commitment! Bloody amazing stuff mate 👍

And thats one heck of a long synthesis

Now that my dear friend was an enormous amount of work. Well done

I’m learning about these in college nowww so very exciting and helpful applications of knowledge thanks

This is the first video I’ve ever seen from you and you’re so cool. Subscribed. Can’t wait to see your future videos!

I always thought the rain smell was something unique to my area. Because we have creosote bushes everywhere it makes a unique rainy smell when it rains lol. People always say that rain here doesn't smell like anywhere else in a good way, so I always thought.