EPIGENETICS and GENE EXPRESSION A-level Biology. How methyl and acetyl groups control transcription

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4 жыл бұрын

Epigenetics is the heritable change in gene function, without changing the DNA base sequence. Learn the impact of methylation and acetylation on inhibiting and initiating transcription (turning genes on and off).
Learn how epigenetics can lead to cancer.
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Пікірлер: 45

@leahlester2620 4 жыл бұрын

Thank you!! You make this topic seem so simple now☺️

@MissEstruchBiology 4 жыл бұрын

Thank you Leah :) Glad you have found your 'subscriber choice' video helpful😁

@AndrewIu-jq3rt Ай бұрын

Revision for next week yay

@menerrs 3 жыл бұрын

thank you so much, when i learnt this in school I was overwhelmed by the new vocab but you explained it perfectly!

@MissEstruchBiology 3 жыл бұрын

Hello 👋🏻 That's great 😁 So pleased it helped you understand this topic and the key words

@ethancheung114 3 ай бұрын

such a hard topic ngl

@user-en7mn5wy6u 2 ай бұрын

This was really helpful

@qaisarsbiology5267 3 жыл бұрын

I was searching for a simple explanation on epigenetics and finally, i got it here.Thank you again

@MissEstruchBiology 3 жыл бұрын

Glad it was helpful! Thank you

@itsarmie3162 3 жыл бұрын

i return again to thank you, bless you! :)

@MissEstruchBiology 3 жыл бұрын

You are very welcome! I hope the videos continue to help you.

@sea5205 2 жыл бұрын

You have really helpful videos thanks!

@MissEstruchBiology 2 жыл бұрын

So glad you find them helpful 😊

@mostafaelboghdady8653 2 жыл бұрын

thank you doctor for this helpful video ☺☺☺

@MissEstruchBiology 2 жыл бұрын

You're so welcome, hope I helped 😊

@tryingtolearnn 5 ай бұрын

3:57 is there a mistake because it says transcription is going to be hard as there are stronger association of dan and histone but then you say the exact opposite?

@kingd1738 2 жыл бұрын

Oh my lawd im finished tomorrow

@imamalilover968 Жыл бұрын

😂😂😂😂 how did it go

@Lil_rousey 4 ай бұрын

😂😂😂😂😂

@shazmeertv44 4 ай бұрын

Cry about it mate

@jeddy2925 3 ай бұрын

Jesus is Lord btw 😁

@marckessler3662 3 жыл бұрын

Excellent videos, I am going to show this one to my AP Biology students. Given the quality of your videos, you should have many more views :)

@MissEstruchBiology 3 жыл бұрын

Thank you so much. I hope it helps them. Hopefully one day I will 😊🤞

@gregorysmith1134 Жыл бұрын

Most people know nothing about molecular biology. This is not a video for the general public, but, rather, for that small percentage of the population who has the background knowledge to understand the subject matter.

@rubiksworld2170 4 ай бұрын

@@gregorysmith1134lol this is just an a level biology video so for 16-18 year olds. And a lot of ppl do a level bio!

@mathur932 2 жыл бұрын

thank you

@MissEstruchBiology 2 жыл бұрын

You're welcome 😊

@angelumeokaleo1859 2 жыл бұрын

hi I was wondering , if there’s decreased acetylation of histones does that make then bind to DNA Mir tightly or do they bind loosely ?? :)

@tania-vq8di 2 жыл бұрын

i think they bind more tightly due to stronger association!

@gregorysmith1134 Жыл бұрын

More tightly. The less acetylation, the more methylation.

@missgirl7879 5 ай бұрын

Im finished for my mocks 😢

@gregorysmith1134 Жыл бұрын

Like your British accent. You pronounce certain words differently than we do in America.

@MissEstruchBiology Жыл бұрын

ahh yeah! Which words? I know in ecology niche is pronounced differently

@gregorysmith1134 Жыл бұрын

@@MissEstruchBiology words such as Methyl. We give it an "eh" sound, whereas you place your accent on the "e". It is difficult to explain in writing. While I have your ear, if I wanted to convert a virus into a retrovirus, would I need to create an operon to code for my Integrase, Protease, and Reverse Transcriptase? It would seem I would need to insert an operator to allow repression until these enzymes are translated and ready to carry out their functions.

@winniethepooh8766 Жыл бұрын

@@gregorysmith1134 smart guy

@rmzfbrmz Жыл бұрын

Summary: Adding a methyl group to the tail (methylation) maintains the positive charge, making DNA more coiled and reducing transcription. Methyl group isn't positive. Adding an acetyl group to the tail (acetylation) neutralises the charge, making DNA less tightly coiled and increasing transcription.

@MissEstruchBiology Жыл бұрын

Nice summary notes 😁

@sujansvault 2 жыл бұрын

m lmk

@Diedieimmerlacht253 2 жыл бұрын

The acetyl group is not negative. It just masks the positive charge of histones. Anyway, your videos are awesome.

@MissEstruchBiology 2 жыл бұрын

Glad you liked the video. Thanks for your point. For AQA that is the accepted the level of detail. As is often that case with science, GCSE and A-levels are taught at a particular level rather than all the exact details to prevent the courses becoming waaayyy to detailed and too high a standard.

@atrappy2077 2 жыл бұрын

if you're such an expert then why u watching bio videos