GABA - The Calming Neurotransmitter

Рет қаралды 43,987

Күн бұрын

GABA is one of the major inhibitory neurotransmitters in the brain - it is the brain's primary brake pedal. Issues with GABA can include things like: anxiety, nervousness, excessive worry, inability to shut off the mind, feelings of inner tension, excessive movement, Obsessive-compulsive tendencies and more. In this video Dr. Holmes explains why supplementing with GABA doesn't always work, and what things can influence your body's ability to naturally produce GABA.
----Content of this video----
0:00 - Intro
0:30 - Are supplements the solution to low GABA levels?
1:24 - How GABA is made: locating possible issues for low GABA
3:24 - Important factors needed for GABA production
4:04 - Hormonal factor to move GABA into cells: progesterone
4:44 - Inflammatory effect on mitochondria and GABA production
5:18 - Indirect way to measure GABA levels: organic acids testing
5:50 - Ways to support GABA production
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Пікірлер: 137

@cynthiaselene1496 2 жыл бұрын

You are an angel for making this video!!!Made a complex process easy to understand :-)

@juliecipolla6732 6 жыл бұрын

Thank you for explaining how all of these elements work together. I find this video VERY important. It's a good overview. What I need is these steps broken down much slower (because I've forgotten the citric acid cycle) and how progesterone and the others help to create GABA. I have subscribed and I'll be looking at your other articles and videos. Thanks again!

@kutay8421 3 жыл бұрын

Even explains why we need girlfriends? = Gaba & Progesteron

@p1dru2art 5 ай бұрын

This looks to be a brilliant group of videos

@katelynmensing9048 3 жыл бұрын

Excellent video!

@KylesBodyandBraintips Жыл бұрын

Love your video on GABA its very important that people get the fight amount to get calm (: for real !!

@netdoc.todaylimited9467 2 жыл бұрын

Excellent presentation on an important topic.

@masterchief5437 4 жыл бұрын

Thanks for the layman intelligent explanation, I got Epilepsy and trying the Ketogenic diet to see if it will help!

@hanyelbanna3673 3 жыл бұрын

Wonderful work Thanks

@celinacerritos1942 5 жыл бұрын

Woooooo beautifully information

@MartinTheBroker 4 жыл бұрын

Thank you

@norbaitijamaludin4728 3 жыл бұрын

Really helpful. Tq so much

@HairGlitter 2 жыл бұрын

Wow. Excellent information. Thankyou

@bertha35100 4 жыл бұрын

Great video 😇

@carolinabergstrom5409 5 жыл бұрын

Really good 👍

@Muuip 5 жыл бұрын

Great concise presentation! Lately I have been supplementing with zinc, magnesium, vitamin B-complex, GABA and polyphenols. It really calms down, best taken before sleeping.

@divined-signcoachingcompan3669 4 жыл бұрын

I love the video..Such good knowledge. I would have liked to see some natural ways to get the vitamins you talked about. (Ex. foods we could eat) Thanks so much for the know how:)

@tracyballard3180 2 жыл бұрын

Thank you. I just started taking Prozac. I have stress gummies with L-thiamine, GABA and lemon balm. Is it ok to continue taking them both?🤷🏽‍♀️

@GoldenGateNum9 2 жыл бұрын

Chlorophyll with Alfalfa is a real dark horse, cant stress that enough. I have been experiencing insomnia for the past 3 years and have tried an Ashwagandha, Passion Flower and Chlorophyll combination which has been helping me sleep like a baby. Breathing meditation, mental attitude, exercise, lifestyle, and diet are also very important to achieve good balanced health.

@Ibrainandbody 2 жыл бұрын

That last statement: breathing, meditation, mental attitude, exercise, lifestyle and diet - yes! 100%!

@Jennifer-gr7hn Жыл бұрын

And killing the 'smart' deVICES. I never liked them, don't have one, and need will. All the rest, yes! And prayer, with purpose for living outside of ourselves. :)

@clivehazell2790 4 ай бұрын

Brilliant

@UHFStation1 5 жыл бұрын

How is gaba inhibition used in the body? I have read inhibiting gaba might initiate certain regenerative processes. Namely the pancreas, and in zebrafish anyway the retinas.

@jalal0019 3 жыл бұрын

This so nice and wonderful explanation thank you so much you are intelligent

@Ibrainandbody 3 жыл бұрын

Thank you so much for the kind words Jalal!

@vidyas.4531 4 жыл бұрын

1. How does the GABAB Receptor work in contrast to the GABAA Receptor? 2. What is the difference between an Agonist and a Positive Modulator?

@books5808 5 жыл бұрын

I read recently that zinc is actually a blocker for Gaba, not sure about that one. Also I read Phenibut has a tendency to become addictive. The one thing im trying to understand about oxidative stress in relation to anxiety or depression is that its supposed to be corrected through anti oxidents like green tea or blue berries. I dont understand why people say sugar related foods like blueberries are a good idea if sugar is not good for anxiety.

@garyha2650 4 жыл бұрын

Addictive, no. On the other hand of course too much is bad like anything, but in this case increased libido tough to satisfy. Aside from that, in my experience, with tame amount, empathy for others, which I think is simply a return to the natural state. If someone is already fine with GABA-B, it has no effect, or that's what I gather from reading. Pretty sure GABA-A is more frontal cortex and related moreso with alcohol effects by the way.

@Passion535 3 жыл бұрын

I thoroughly enjoyed this video cause I love learning how to improve my life instead of just sitting around and complaining about it! BUT, I got a little confuses with the Progesterone part? Isn't Progesterone a "Woman's Hormone"?? If I'm a man,(and I am), should I use progesterone ??

@cindylandry7856 Ай бұрын

I have an essential tremor-ES. Spasms have been so bad, I have asked family if the bed or house was shaking. It's me! The skin crawling and tendon pains in high gear does have me depressed and anxious. All activity makes spasms worse. Researching since 6 am brought me to GABA.... This: Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABAA Receptors. So I came back to YT to seek more info here on GABA. Having Sjorgrens has not helped. I wonder if it is all related. Hmmm. I already take B complex, Magnesium, D, and Calcium. What doctor should be able to help figure this out?

@tousifk3138 2 жыл бұрын

But i have seen if I take gaba supplement it slightly calms my mind how?

@nickpatuto9809 3 жыл бұрын

I was sober for 6 months off of Alcohol and weed felt good. Then I smoked weed one time and now I feel bad... did this affect gaba production ? And how long until I feel better

@porchlights2268 19 күн бұрын

This was incredibally informative!! Thank you!! My question is what do Benzodiazepines do to this cycle and how to heal from it?

@GawrGurasBathTubPizza 2 жыл бұрын

if you put it under the tongue does it absorb it better?

@mikewagner5855 3 жыл бұрын

You talked about identifying alpha keto gluterate levels in a urine test. Is there a test you recommend?

@Ibrainandbody 2 жыл бұрын

Mike, an organic acids test will give you that information!

@fastnate07 3 жыл бұрын

Would being given valerian root for years as a child cause a shortage of gaba as an adult

@RobertLongM 6 жыл бұрын

Curious is there a possibility that we have a lack of CL ? Since the CL ions are what allows the good feeling, as opposed to GABA that opens the channel.

@raymondysantiagocssm 5 жыл бұрын

Oh honey

@lakid9749 4 жыл бұрын

seesome info

@ddtt958 3 жыл бұрын

I used to drink a lot before. I've been sober about 7 months. I suspect the alcohol has damaged my brain a bit (gaba receptors etc). I feel better now than I did when I first decided to quit but I still deal with some anxiety and depression though I probably had that to a smaller degree while I was drinker also but I just didn't notice it then. I think my brain is slowly recovering. Would I set my recovery back or damage my brain receptors etc more if I were to use benzodiazepines for example in small amounts maybe once a month?

@catherinepakenham-walsh234 6 ай бұрын

Hey did you get an answer to this question? I'd really like to know 😊

@cindylandry7856 Ай бұрын

Make sure you have good vitamin D levels or lots of sunshine, B12 is important - eat more beef. All from neurologist. My husband drinks and has vascular issues. Benzos long term can cause memory, dementia, but minimal use should not cause an issue, not temporary. Any Statins over 10 MG is damaging to your body also. Our brain floats in cholesterol. If you add B12 to your vitamin regime, go with B complex. We need all the B vitamins. Vit K helps arteries and puts calcium in the bones, not the arteries. We use that now because statins harmed my husband's brain. Can't get it too low. I hope some of this helps. Not medical advice, but I read a lot and am confident in what I shared.

@senseisoto5013 4 жыл бұрын

Hello thanks for the great information. What is the name again of the urinalysis Please??

@BarryMann 4 жыл бұрын

I could not quite catch the name of the test either.

@islandgirl2355 3 жыл бұрын

Organic Acid Urine Analysis about 5:20.

@catherinepakenham-walsh234 6 ай бұрын

@islandgirl2355 hi thanks for that...what do you mean 5-20 😮

@senseisoto5013 6 ай бұрын

@@catherinepakenham-walsh234 in the 5 min and 20 second is the name of the test.

@ALEXGIBSONCMG 3 жыл бұрын

when can i schedule an appt?

@hollylockman9363 5 жыл бұрын

I took 1/16 of a dose of L-theanjne and it made me sooooo dizzy but did make me calm. Why does it make me dizzy?

@ThiagoDVaz 3 жыл бұрын

It might lower blood pressure making you sleepy.

@keithclark8030 28 күн бұрын

Will fasting help with GABA?

@fredsmith2299 5 жыл бұрын

Excellent. Medicinists will give drugs ro do all this but they fall short and only hits some areas .... but not the whole ...

@Oldtymehockey67 4 жыл бұрын

What would be the best way to supplement while tapering off of lorazepam(which affects GABA production)? Tapering off has caused not only stress, increased cortisol levels, but also severe sleep issues. While undergoing testing to find that ROOT problem(which I currently am), I'd like to find a way to naturally lower the stress & cortisol and increase my sleep.

@GoldenGateNum9 2 жыл бұрын

Hi I don't know if you found a solution yet but In regards to sleeping problems I think that food and herbs which increase GABA activity are a big piece of the puzzle, I have been experiencing insomnia for the past 3 years and have tried an Ashwagandha , Passion Flower and Chlorophyll combination which has been helping me sleep like a baby. Even better than taking Melatonin capsules which is also a very helpful natural sleeping aid. 'Natures Answer' and 'NOW FOODS' have the best quality supplements. Hope this helps, if you need any advice please get in touch. Peace.

@lovelaced928 2 жыл бұрын

Try or look into L-Theanine

@suebrookes7136 Ай бұрын

Can you buy progestogen xx

@zettyhardi 2 жыл бұрын

Why my brain cannot stop thinking even when i sleep my brain still moving. It's like my brain dont have break. I can't control my brain to stop moving & thingking. That is a symptom of low GABA?

@whits6783 2 жыл бұрын

Have you looked into meditation? It's really helped me learn to relax my brain. It's also been very beneficial to stay off my phone for a couple hours before bed. Stay healthy!

@mauricefemenias9752 3 жыл бұрын

I need help ru available im willing to travel

@annwertz8854 2 жыл бұрын

Like to know more about the gaba

@themexicannoodle5655 6 жыл бұрын

So neurons are transmitted to amygdala? What does a neuron look like when a person is anxious or depressed???

@raymondysantiagocssm 5 жыл бұрын

oh honey

@TTBOn00bKiLleR 4 жыл бұрын

If you are anxious it just fires more frequently, GABA is making neurons fire more rarely by altering the potential diferential between the inside of the neuron and the outside

@georgeyacoub6733 6 жыл бұрын

Dr.Holmes , how can you activate the enzyme GAD ?

@garyha2650 4 жыл бұрын

And/or, what are the building blocks of GAD?

@michaelpanichella707 4 жыл бұрын

Take Phenibut. It's GABA with a phenyl group added so it will cross the blood brain barrier.

@juanperez-ni2iw 4 жыл бұрын

Where did you get it...does it have another name?

@everettjohnson265 4 жыл бұрын

Its absorbed through the gut

@pamalatrynovich4817 8 ай бұрын

So then why is GABA supplement being sold if it doesn’t do anything.

@YESHUASlave 5 ай бұрын

Woe. Wait. If i taught that in the class room at the College ('University') today, the other way around... wonder how that would go‽-) j/k 'progesterone'; lol-) Real Question: What is similiar in Men, or does less of Our Glutamate get turned into GABA??

@jorgeingle3526 6 жыл бұрын

@MartinTheBroker 4 жыл бұрын

Where are you located? Can I visit your office?

@necessaryJustice_4all 6 жыл бұрын

What about pharmagaba?

@pratikgandhi8168 6 ай бұрын

Yes...pharmagaba will do wonders for anxiety ...750-1000 mg daily.

@pratikgandhi8168 6 ай бұрын

Regular GABA does nothing.

@bbcraz1226 5 ай бұрын

Why would someone take a gaba inhinitor?

@Rommie26 4 жыл бұрын

Are GABA supplements good for porn induced erectial dysfunction since watching porn weakens the neurotransmitters

@Antaeres 5 ай бұрын

So what happens if your methylation is fucked

@bobobrien8968 2 жыл бұрын

How does a guy get progesterone?

@shenko225 Жыл бұрын

This video about the calming neurotransmitter got me super stressed out

@garyha2650 3 жыл бұрын

Took me just a few seconds to fall in love with her

@GleKar69 6 жыл бұрын

Yes, you are BEAUTIFUL. :-)

@keithrichard391 5 жыл бұрын

She is mine buster

@adventureescape1929 5 жыл бұрын

creepy

@pratikgandhi8168 6 ай бұрын

P5p (100 -200 mg) - b6 does wonders - not pridoxine...

@beverleycumming1876 Жыл бұрын

So most of us if healthy don’t need a supplement

@Jennifer-gr7hn Жыл бұрын

Another thing people need to do? Kill the "smart" deVICE. It's a pink elephant in the room to people like me.

@MrHandoverfist 6 жыл бұрын

lithium...that is lead...NO.

@pratikgandhi8168 6 ай бұрын

Need pharmagaba....regular gaba does nothing ..

@mitramoso 6 жыл бұрын

Rapid fire talk. What is the hurry. Slow down and there will be enough GABA. .

@joshyard5113 5 жыл бұрын

adderall

@reggiereg2989 5 жыл бұрын

Back off of your BABA your brain is not able to process the info...I suggest moving into the realm of Adderall lol

@shanemike3070 6 жыл бұрын

will you marry me?

@syedali-le6ii 3 жыл бұрын

She's such a cutiepie 😘

@hvbuitenen 6 жыл бұрын

Sorry, you talk way to fast and your pronunciation isn't to good neither

@hvbuitenen 6 жыл бұрын

Sorry, i can deal with an accent, but really fast spoken texts, that are only partially pronounced is hard. This is not an easy chat, as you say it's science so there is a limit to what you can hear, fill in the missing parts and understand. Some can easily do this, but not everyone it that good with language.

@takforalt 6 жыл бұрын

Have you tried slowing it down in the settings? I find her articulation fine, however, I can see that she speaks rather quickly and rushed. No one is perfect my friend.

@hvbuitenen 6 жыл бұрын

Hi, indeed, no one is perfect, that goes for both the speaker and the listener. And i do not expect her to be perfect. But because not all listeners are completely without linguistic flaws, the public you will reach vary greatly depending op your speech. That's why people go to training's and that's why feedback can be useful. i just think she can do better is she pays a little attention to this. But maybe my comment was a little too brief. It just portraits the effect it had on me.

@hkgs_knight4216 5 жыл бұрын

Slow down the speed

@reggiereg2989 5 жыл бұрын

To us Americans that have grown up speaking English it is actually Perfect Pronunciation, Take more English classes...

@books5808 5 жыл бұрын

@Jennifer-gr7hn Жыл бұрын

blueberries are HUGE....very important. Fruits that have the skin that matches the color of the fruit inside, are good. Time of day matters too. Don't eat fruit after 3pm. Berries are good! So is Hyperbaric 02 chamber. IV ozone, etc.