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Perhaps as bad as this title is, losing a hand is no joke. But this seems to be the case with one of House's patients when they discover the strange cause of a patient's hands turning purple through a lack of oxygen.
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Season 2 Episode 3 "Humpty Dumpty"
Cuddy feels responsible when her handyman (Ignacio Serricchio) falls off her roof then exhibits unusual symptoms. House's team amputates the handyman's hand to prevent the spread of infection, but when the other hand starts showing similar signs, they must seek out the source before it kills the patient.
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