Harvard Chan School Alumni Book Club Discussion with Author, David Sinclair, PhD

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Harvard T.H. Chan School of Public Health

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Harvard Chan School Alumni Book Club Discussion with Author, David Sinclair, PhD
Lifespan: Why We Age - and Why We Don't Have To
Presented by the Office for Alumni Affairs
July 15, 2020
David A. Sinclair, Ph.D. is a tenured Professor of Genetics at Harvard Medical School, co-Director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard Medical School, and Con-joint Professor, at the University of New South Wales, Sydney. He is best known for his work on genes and small molecules that delay aging, including the Sirtuins, NAD precursors, and other epigenetic modifiers. He serves as co-chief editor of the scientific journal Aging and has received 35 honors including being one of Australia's leading scientists under 45, the Australian Medical Research Medal, the NIH Director’s Pioneer award, TIME magazine’s list of the “100 most influential people in the world” (2014) and the “Top 50 people in Healthcare” (2018). He was elected an Officer of the Order of Australia in 2018.

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@josephbach1 3 жыл бұрын

Dr. David Sinclair finally reached puberty with 50 years of age.

@lane1368 3 жыл бұрын

Word😂

@neilsant1194 3 жыл бұрын

Hhhhha.... all his colleagues with same biological age are almost wrinkled like drapery.

@Fearzero 3 жыл бұрын

@@neilsant1194 plastic surgery and botox are awesome.

@ricknash3055 3 жыл бұрын

@@Fearzero Proof?

@Fearzero 3 жыл бұрын

@@ricknash3055 The forehead gives it away.

@HealingSongsAndPoems 3 жыл бұрын

I have so much respect for Dr. David Sinclair. I am so grateful for him and for all the scientists who keep improving our lives! Thank you for making this video available to all of us.

@tomsport4537 3 жыл бұрын

I have been following David Sinclair for many years and have to say that he is developing very positively visually. He definitely looks younger today than he did ten years ago. And he looks much more personable.

@thebeardedseeker5633 3 жыл бұрын

i agree, he does look much more presentable these days.

@stephenkobani334 2 жыл бұрын

I am super excited following Dr David Sinclair research but now can I bet his book Life span in Nigeria.

@miketerhaar773 2 жыл бұрын

@@stephenkobani334 just told

@spoudaois4535 3 жыл бұрын

This research is very exciting! I'm on NMN, resveratrol and a plant based diet, and feel 10 years younger.

@Fefe559 3 жыл бұрын

where do you get NMN and resveratrol ?

@LilianaGrueber 3 жыл бұрын

I am looking to buy these two. Which one are you getting? Pls, save me some time and share with me the reputable companies you are getting the products from.

@patriot20000 3 жыл бұрын

We would all like to know more about which ones you use please.

@megmurphy3270 3 жыл бұрын

How much do you take of each

@soul11134 3 жыл бұрын

even keto diet feel the same may 20 years younger

@falst573 3 жыл бұрын

I'm currently reading lifespan, and it's a life-changing book! Great interview

@MikaelVitalyVyacheslav-bh2fk 3 жыл бұрын

--All meat and dairy in North America and Europe is contaminated with "" prions "" ---> , Virus , bacteria , yeast , fungus , hormones . Blood in the in the blood banks are also contaminated with "prions" avoid blood transfusions if you can ! . Google ---- >""PRIONS and Alzheimer's disease" The " sewage sludge " and wastewater released into the farms and agriculture land are spreading brain disease far and wide every day. DR . Claudio Soto, PhD, professor of neurology at the "University of Texas" Medical School in Houston, and his colleagues confirmed the presence of prions in urine. Soto also confirmed that plants uptake prions and are infectious and deadly to those who consume the infected plants. Therefore, humans, wildlife and livestock are vulnerable to prion disease via plants grown on land treated with sewage sludge and reclaimed sewage water. "Prion" and Virus researcher "Dr. Joel Pedersen ", from the University of Wisconsin, found that prions become 680 times more infectious in certain soils. Pedersen also found that sewage treatment does not inactivate prions. Therefore, prions are lethal, mutating, migrating and multiplying everywhere sewage is dumped. “Our results suggest that if prions enter municipal wastewater treatment systems, most of the agent would bond to sewage sludge, survive anaerobic digestion, and be present in treated biosolids,” Pedersen said. Go read this Article --------> alzheimerdisease.tv/alzheimers-disease-facts/alzheimers-disease-epidemic/alzheimers-disease-risk-by-country/ Most commercial meat and dairy is contaminated with prions and Virus ..prions cannot be killed by heat or by cooking . " prions "go dormant in the body same as a virus ...when the wake up they damage your brain cells and and they damage the nerves in the brain cause many diseases such as Parkinson, Alzheimer disease and cancer . --------- -A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals and are sometimes spread to humans by infected meat products. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease The best is you eat a plant-base diet.Indian has the lowest Alzheimers disease in the world ---> ( they eat a plant-base diet) ...keep your blood sugar below 85 , intermittent fasting and become a Vegan eat a plant base diet and eat organic ! control your stress . Don't dig your grave with your teeth ....watch what you eat and drink . The hospitals and big pharma will make you bankrupt and kill you at the end . The best book on prions and Alzheimer's is called ; Dying for a Hamburger : The Alarming Link Between the Meat Industry and Alzheimer's Disease by Marjorie Lamb and Dr. Murray Waldman ----------------------- kzfaq.info/get/bejne/mr6Tf8Vl1Km9lps.html ------------------------- Vegetable oil and fats ---> damage the liver and slows down the thyroid and you become obese. The pancreas, liver, and Thyroid control your thyroid health . ---> how to get farm animals fat..feed them corn, wheat -------- > and oil or any vegetable oils will damage the liver and thyroid and cause the animal to get fat obese --> the same with humans . -you want to be skinny don't consume any polyunsaturated oils -- no vegetable oil , no fish oils , no avocados. only coconut oil and olive oil in very small quantities...........if you are overweight no oils of any kind . -

@Fearzero 3 жыл бұрын

@@MikaelVitalyVyacheslav-bh2fk Coconut oil and olive oil are both terrible for the epithelium and stop nitric oxide production eventually causing heart disease, even in small amounts. No oil is good oil. I agree with the vegan diet as whole plant based, zero processed foods and organic.

@toxicrhythmz3718 3 жыл бұрын

@@Fearzero lmao olive oil is extremely healthy

@Fearzero 3 жыл бұрын

@@toxicrhythmz3718 No it isn't. If you want to believe studies brought to you by the olive oil industry then go ahead Mr. Gullible.

@sleepsmartsmashstress740 3 жыл бұрын

By life-changing you mean life elongating? The best way to live long is do longevity research. You cant argue with that

@falcon127 3 жыл бұрын

THANK YOU, DR. SINCLAIR YOU ARE DOING GREAT WORK FOR HUMANITY!

@multi-usede 3 жыл бұрын

Dr Sinclair, you look so young for your age! Super!

@vince_hawk5600 2 жыл бұрын

Great Insights! Thank you Dr Sinclair for inspiring me on the health journey!

@rpatel6461 3 жыл бұрын

Dr. Sinclair... if that hair and beard color is not artificial, I am coming to live with you.

@thebeardedseeker5633 3 жыл бұрын

lol. yeah i was wondering about that myself.

@Marco-bh9im 3 жыл бұрын

@Robert Fiore Yeah but if you look at other videos he's freshly shaven and not all seems dark. I would hope it's true but I think it's artificial. There's a lot of money here at stake and recent studies demonstrate nmn accelerates cancer growth in mice if it's already on the go, but not in healthy people. How accurate this data can be as there is always conflict in data. I wouldn't risk it right now.

@Marco-bh9im 3 жыл бұрын

@Robert Fiore You could win lottery next week and have three wives. :) Never say never, but I understand where you're coming from. I turn 50 next week and I'm blessed to have inherited good genes as compared to most 50 y.o I have only a few grays on my chin. I've been following the progress of testing NMN + other supplements for more than 1 year. Latest results CLAIM to only have aged 10 days in 3 months. So to age 1 year it would take 12 years. Age 5 years in 60 years. I'll take it. ) If that is accurate that's already mega. But although this person testing NMN seems genuine you really don't know if the numbers are true. He could be affiliated as there's $$$$ at stake. If there ever is a miracle pill only the filthy rich will have access. The normal plebs would get the pill that slow things down but the rich will be getting the regenerative/reversing pill. There are claims circulating that some filthy rich already got the technology with CRISPR. I mean just to restore vision he already said half a million. So I guess we should start saving $$$

@user-ky8fh9xl7l 3 жыл бұрын

@@Marco-bh9im it's probably how the light hits in the studios

@Marco-bh9im 3 жыл бұрын

@@user-ky8fh9xl7l Probably but there's always something. There is a video where he has a 5 day growth or close too and you can clearly see it's not dark around his mouth/chin and the light really makes no difference in this case. As said, I'd really like to think it''s real but it's too good to be true. And David has contradicted himself more than once. One day he says don't allow your body temp to drop and in the next video he's says he takes hot showers and then dives into an ice bath. I mean this is a guy that confesses he can't do more than a 4 day fast, he;s not mentally strong enough, yet he can jump into an ice bath? Let me assure from experience it is easier to fast 3 days than it is to jump into an ice bath.

@coogee126 3 жыл бұрын

This is a very useful presentation. thanks for sharing

@jerseystotler3615 3 жыл бұрын

Very good interview The Doctor looks to me to be in his 30s even though his age is 51 he says . I have not ate red meat or drank milk in almost 40 years I am usually guessed in my late 40s when I am 65 years old. I take Metformin for diabetes and fast but I have always done this just to maintain my weight. I am going to start takeing Niacinamide. I also dont take vitamins but do take a aspirin a day. Not really not to age just basically to maintain health I also have always cooked with olive oil and eat alot of eggs. Thank you Dr Sinclair for more ideas on how to age healthy

@NiekKuijpers 3 жыл бұрын

Is milk actually that bad for you? I always thought it was really healthy. but as someone who lived in the Netherlands, i drink A LOT of milk haha

@SI-ln6tc 3 жыл бұрын

Don't forget resveratrol.

@zahidhossain8410 2 жыл бұрын

Do Metformin effects enlarged Prostate???

@yuliaschannel6288 2 жыл бұрын

Your diet can’t be good if you have diabetes and have to take pills to control your weight. May be try animal based keto instead - you won’t need pills or supplements, will fix your diabetes as well.

@rahilakhadem5753 3 жыл бұрын

he is the best phd in the world

@davidjlaurie370 3 жыл бұрын

Dr. Sinclair, I'm curious, what is 78c and can I buy it to boost nad+ ?

@oliviamiller8187 2 жыл бұрын

Life expectancy has jumped, mainly because infant survival rates are much higher than they once were. Poor hygiene and nutrition, less advanced medicine and more communicable diseases meant that newborns in Ancient Greece and Rome had a much lower chance of surviving their first few years. But by combatting age-linked illnesses, we can extend our life and live until a hundred and fifty. I too have spent a lot of time confused with the push back to ending death and extending human life. As more people see it as a true option, I hope they’ll move past the fear of death and see it’s all really quite possible! It’s through Dr. Sinclair's podcasts I learned about Vitruvin Anti-Aging Supplements and ever since I am taking this NMN supplement, it radically changed my life.

@Gi-Home 3 жыл бұрын

Excellent chat session, always good to hear about David Sinclair's work on healthy aging (oxymoron in my view), life extension or health span.

@WooHooLaLa 3 жыл бұрын

@peterz53 3 жыл бұрын

@33 m. Recent work out the Conboy Lab shows that simply doing plasma exchange, replacing a large fraction of the plasma in old mice with saline, also rejuvenates some tissues. So it may very well be that the effect attributed to young blood may simply be removing detrimental factors from old blood. Another good reason to donate.

@nicksmith-chandler458 3 жыл бұрын

I would love Sinclair to study monoatomic elements.

@ttfan3257 3 жыл бұрын

LECTURE NOTES FOR MYSELF: No one has explained why Caloric restrictions and HIIT contributes to longevity and 'reversal' He folows the 16/8 fasting Breakfast = Yoghurt + Resveratrol Dinner is normal alcohol and meat Drives a Tesla Talks about his dad, who started a new career aged late 70s As fit as David Cannot live 21century like 20th Global Pop ( except Africa) is at risk of decline A lil (physical) stress helps us live longer Hormesis: What doesnt kill you makes you STRONGER Mental stress is NOT good Metformin triggers AMPK He lifts weights to prevent muscle atrophy Olive oil activates Sirt1 just like Resveratrol When our fat breaks down, we make olive oil ! So olive oil mimicks fasting ! 14:00: Sauna people tend to have less heart attacks. Curr researching a molecule in add to NMN Researching Covid19 which depletes NAD+ Reseveratrol is an antiocidant but it's beneefit comes from the fact it is a signalling molecule that turns on natural defences against antioxidants Antioxidants can blunt the ebenfits of exercise. We need oxidants and free radicals to benefit from these life style changes In nematode worms, antioxidant shortened thier life All patents expire eventually The older u live, faster one dies The genes that control sleep are intimately connected to those that control lifespan Exercise ensure blood flow to brain to prevent dementia Pets and social life Centenarians: Red wine, Olive oil and humor, doesnt get stressed out Constant (high) cortisol levels not good Inner spiritual healing affects our aging process Age associated diabetes senolytics Senescent cells accelerate aging folded proteins WHO recently declared aging a medical condition Telomere length can b used to estimate aging, but they also vary in length Horvath clock more accurate It measures methyl on DNA and est bio age. Blood transfusions ( tweaked) from young to old mice reduce heart age by 74% His reserach focusses on turning on 3 'embryonic' genes that tend to b switched off with age. Religion Switching on longevity genes is a better way to fight cancer than antioxidants NMN given to old mice or horse improved fertility Metformin helped some infetile women mTor senses amino acids and on sensing a steak, turns on ability of body to make protein. Need to keep mTOR off everynow and then to allow/ help it clean out old proteins thru autophagy This is the prob in Alzheimers , accum old crystallised proteins Rapamycin ( Rapalogs) have greatly extend lifespan of mice, worms & yeasts mTOR, Sirtuins and AMPK talk to each other...they are just diff pathways 3 sirts in nucleus, 3 in mitochondria and 1 more floats around in between, they care for telomeres, cell survival, repair DNA damage, control how much fat to put on Mice w more sirtuins live longer Sirt 6 is v effective Skin of 50yo has 50% of NAD+ of a 20yo Got into trouble for saying 1st person to live to 150 already exists...quoted by Oz PM, told to keep mouth shut, wants respect of peers Just doing 5 simple things gives extra 15 years Prev they only cd slow down aging, in last 2 years they believe in resetting age of body Doctors may need to change medicial philosophy and regard aging as a treatble islilnnesses b4 they will prescrible Metformin for non diabetics His doctor is conservative and did not prescribe him Metformin

@SI-ln6tc 3 жыл бұрын

Thank you. You should get more thumbs up.

@nixodian 3 жыл бұрын

40m40 mTor, autophagy

@janelawrence6627 2 жыл бұрын

I have always been grateful of the works of these scientist in slowing the aging process. When I came across Dr. Sinclair's book, I became very positive about how everything works. I tried and get the results that many people are talking about. I am 50 on my next birthday, but people still think I am 30+. Overwhelming! Thanks to NMN by Vitruvin.

@aaliyahlee1265 2 жыл бұрын

I wish I still have your age and know NMN earlier. I am already beyond the retirement age, but I am still grateful that I'm taking it even just over a year. I wish all people would know the results. By the way, I am taking Vitruvin as well. Do you also purchase through their website?

@katewilson5269 2 жыл бұрын

Didn't expect I'd come across in a comment from a Vitruvin user. I've seen many popluar NMN brands in the market but only few are proven effective. My parents switched to Vitruvin as well after figuring out that I had the most effective results more than the brand they're using...

@leeway777 3 жыл бұрын

Using adeno-associated viruses to transfer OCT4, SOX2, KLF4 into the cell, what is the dosage? Do the 3 gens (transcription factors) need to be activated? What does the antibiotic doxycycline do?

@nicolevonw8101 3 жыл бұрын

Yes to the beard!!! Tell your wife to make you keep it! LOL!!!!! 🙃😊

@ulysseamer2942 3 жыл бұрын

Please, where can we buy NMN , resveratrol? I heard that metformine has many side effects. I heard also that there are some plants which have the same effects than metformine BUT WITHOUT ITS SIDE EFFECTS. Can we take these plants instead of metformine and will these plants have the same anti aging effects?

@mr.sportcoat1651 3 жыл бұрын

What kind of plants?

@jimsutton9407 3 жыл бұрын

@@mr.sportcoat1651 check out berberine... read some of the research papers.

@cassanova9322 3 жыл бұрын

Someone please time stamp this.

@dougcane4059 3 жыл бұрын

the interviewer seems to have missed to opportunity for Sinclar to expand on the NEW information about reversibility of aging - - - the first question should be - "what do you think is the most important information currently and would you expand on that?"

@synewparadigm 3 жыл бұрын

Any thoughts about the last Recall of Methamphetamine because it gives cancer?

@royzlatanestevez9843 2 жыл бұрын

Fascinating developments are happening much faster than I anticipate, but I'm still very sceptical of it. I'm not too sure it will work or it's too optimistic. BUT I would not want to live until 150! I'd prefer to die at a humanly possible age, but stay young and fit until that age - like centenarians, except much shorter. As you can't get away in the end and the world of Death awaits us all, I see no point in trying to avoid it for a few years.

@Zura_Lanch 3 жыл бұрын

Why no one ever mentions Paul Bragg when they talk about longevity?!

@patriot20000 3 жыл бұрын

He died at 81 for one thing. And Bragg's aminos? It's like any other soy bean extract - it's an excitotoxin that actually kills brains sells. No thanks.

@katarinahinsey3931 3 жыл бұрын

What are the long term risks of NMN supplementation? Unknown.

@Fefe559 3 жыл бұрын

Digging the beard dr :).. meow !

@kaoanthonco8770 3 жыл бұрын

I actually wanted to buy NMN life span in Australia but I don't know if it is effective or legit to buy Life Span NMN and resveratrol. Anyone here did already buy Life span NMN and resveratrol online?? They sell it online.

@rui-9-cs315 3 жыл бұрын

💕

@johnlucich3496 3 жыл бұрын

10-4 DAVID SINCLAIR KEEP ON KEEPING ON. . .& ON & ON ! ! John Lucich 916-260-6700

@rustybolts8953 2 жыл бұрын

"I don't say that anymore.! What? That.!

@BlueSkies360 3 жыл бұрын

I did not get the Tesla comment, someone explain me please

@edword7195 3 жыл бұрын

I think he means because they are fast, so fast cars more dangerous. The people that drive them here in Scotland typically drive much more safely than regular cars.

@aleksandrazurek1767 3 жыл бұрын

A Gin therapy??? 😂😂😂 Im on it!!!!

@xtian384 3 жыл бұрын

How to address methylation problems with NMN?

@itsamodernmess 3 жыл бұрын

TMG supplement to support

@xtian384 3 жыл бұрын

Alexandra Marks Thanx!

@aaliyahlee1265 2 жыл бұрын

I only know one product that my overall health can rely the most. It's NMN by Vitruvin Health. Cost-effective!

@bhocatbho 3 жыл бұрын

Niacin is chaper then NMN. It seams that niacin is a precursor of NAD+. I wolld have liked to ask dr Sinclair if Niacin is a valid substitute for the more expensive NMN.

@thexeesus 3 жыл бұрын

NR not niacin

@bhocatbho 3 жыл бұрын

thexeesus no, I mean specifically niacin vs NMN, not Nicotinamide Riboside.

@SS369 3 жыл бұрын

To become NAD+, most of the Nacin will be first converted to NMN. Niacin is a big molecule so it has a harder time entering cells.

@thomasham130 3 жыл бұрын

@@SS369 Think there was a study done earlier this year about Niacin, back in April? Can't find the link right now. But showed that over 10 months a 1 gram dose of niacin doubled NAD+ in mussel tissue, and a 4 fold in blood. This was a human study. Main thing was it need to be the instant release, not time released. Also it started at a dose of 250 mg and worked up to 1 gram dose.

@SS369 3 жыл бұрын

Falkris I would Google this: “niacin” AND “nicotinamide mononucleotide” AND (“metabolism” OR “pharmacokinetics”) This search will give you all the studies that contain the first two words and either one or both from the latter two. Make sure to research it thoroughly, because there’s forms of niacin that have not been proven effective.

@zahidhossain8410 2 жыл бұрын

Do Metformin effects enlarged Prostate???

@marikohayashi-hall884 3 жыл бұрын

I always finish my shower with cold water

@whiteninja9481 4 жыл бұрын

I just picked up this new book yesterday. Looking forward to reading it soon. I have been wondering . . . any collaboration with Dr. Aubrey De Grey and Dr. David Sinclair on any research projects?

@pakau 4 жыл бұрын

i dont know really, but they met each other and they keep in touch often.

@falst573 3 жыл бұрын

Imagine if Peter Attia joins them... The dream team of longevity

@alkeegan9915 3 жыл бұрын

They do crossover but Aubrey approaches it from a different perspective. A cure to aging rather than preventing it.

@MikaelVitalyVyacheslav-bh2fk 3 жыл бұрын

@BennyAshurov 2 жыл бұрын

where a good places to buy Quertcin apigenin, theaflavin, curcumin,Fisetin please help

@judestritzinger3059 3 жыл бұрын

Christian Slater is looking young these days...lol

@ijazgoindi1496 3 жыл бұрын

Does the combination of both Resveratrol and NMN is essential to get back younger cells , or NMN is enough? People beyond medical field need to know the exact function of this combination.

@beegee1894 3 жыл бұрын

what is him driving a TESLA have anything to do with aging or not aging?

@TikiTokSTREAM 3 жыл бұрын

I think is was a glitch unclear not beyond that

@youngdaggerdick8146 3 жыл бұрын

i think he means he`s contentful

@Sa-fd7ih 3 жыл бұрын

Someone mentioned he said in another interview that he likes driving fast. Teslas are fast.

@MikaelVitalyVyacheslav-bh2fk 3 жыл бұрын

@1000BabyRage 3 жыл бұрын

“I drive a Tesla, I’m not trying to live forever.” Does he mean that he bought a Tesla because he doesn’t have a lot of time left so he’s making the most of it while he can? Or does he mean that the Tesla is shortening his lifespan? Electric cars do expose people to more EMF’s... I don’t know.

@vinsibil2520 3 жыл бұрын

I was trying to figure that out

@garlic5955 3 жыл бұрын

Interesting

@bperez8656 3 жыл бұрын

I think it was a joke about negative impact of batteries with radiation

@Jessica-kk1cz 3 жыл бұрын

Hi All, David Sinclair said in another interview that he has a penchant for speed. When he was younger, he actually lost his drivers license in two countries, in both Australia and I think the US. I forget the interviewers name but the interview was in the past two months, posted on KZfaq, and I think she’s involved in race car driving somehow, but I couldn’t swear to it. (I had the interview on in the background). In any case, he made similar joke in that interview that he is not trying to live forever if he is driving fast.

@Earwaxfire909 3 жыл бұрын

Oleic acids seems to have a greater effect than NAD+. What are your thoughts on the recent data?

@williambernz7806 3 жыл бұрын

I dont know if you have studied monoaramic gold but what I have found is that it repairs you DNA and extends the talomers.I hope you will read the comment cause it is important to your research

@lucci6142 3 жыл бұрын

Any more info or links?

@shirleywilliams5397 3 жыл бұрын

Metformin is prescribed (off label) for PCOS (polycystic ovary syndrome). This is a complex endocrinological and metabolic disorder that can cause infertility in young women and diabetes in post menopausal women. There seems little research on healthy women taking metformin as there is no medical reason to prescribe it. The caution in taking metformin off label for anti-aging is that it can cause or worsen vitamin B12 absorption in the gut and that it changes the gut biome so that folate absorption is lessened and folate digestion is impaired. The severity of this varies between people and the effects are seen mostly in people who use it long term...perhaps 5 years or more. The deficiencies caused have serious consequences. Therefore B12 and folate levels should be regularly monitored by blood tests when metformin is used. Hence do not attempt to take metformin without medical supervision. My knowledge comes from personal experience of all of these medical issues.

@Brancoveanu450 2 жыл бұрын

Thank you. You appear to be a well informed person ,possible with a medical training. Any opinion on taking NMN ?

@cindyradison8324 2 жыл бұрын

Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number.

@rachelstark8002 2 жыл бұрын

This is exactly what I am telling to my family, especially to my husband who just recently take Vitruvin NMN with me. We imagined how amazing it will be to still hug and kiss our lovely grandchildren when we reach 90. So grateful to this supplement! Thanks to Dr. Sinclair who adds more years to our lives!

@angiep5216 3 жыл бұрын

I wish someone ask what are the side effects of nmn , it is a chemical like all medicines and all comes with many bad side effects .

@SI-ln6tc 3 жыл бұрын

7:15 meal skipping 8:49 declining population 18:20 antioxidants. In history of longevity research has been disappointing.

@beegee1894 3 жыл бұрын

nice beard doc

@danbaron9094 2 жыл бұрын

Dr. Sinclair looks a little like Gary Oldman from the movie The Professional.

@chrislong1287 3 жыл бұрын

My daughter died at 6 from a cruel neurological disease. now may wife has been diagnosed with stage 4 brain cancer at 50. This is unbearable. I hate death. Please put death off as long as you can. Death is what makes life sucks

@AxxLAfriku 2 жыл бұрын

My haters throw rocks at me and IT hurts. I hope they don't throw The Rock at me because I like him as an actor. GAGAGAGAGA!!! I am funny!!! I am the funniest KZfaqr EVAH! Please agree, dear ax

@crapschamp9986 3 жыл бұрын

I think taking the taking the healty 2.0 pack 90 for life im not so hungry.started eating eggs 8 a day have been lifting boxes forty years .eat about once or twice a day.no nuts bread oats wheats rye barley no nuddles bear or whisky.i gess rice is ok rice socky is ok.red wine ok.butter real ok its hard to cut bread and pop out no sugar.

@patriot20000 3 жыл бұрын

I don't remember the specifics but I know he said eggs are not great because they inhibit something we need more of. Bummed me because I usually eat 2 a day.

@Daggerworda 3 жыл бұрын

Wait why aren’t we striving for immortality? Surely that should be the ultimate goal, why think small when you can think big?

@Sa-fd7ih 3 жыл бұрын

Too controversial for many people. His research relies on funding, which he could lose a lot of if he’s not careful with what he says out loud.

@beanbash7072 2 жыл бұрын

You have repeated something frequently something like Nnm . But you say it so fast that I am not certain t.what has been said could somebody reply with the correct letters.in text? thanks

@benkim2016 2 жыл бұрын

Nmn can accelerate the rate of cancer and it is only safe for someone who no cancer! How does one know for sure he doesn’t have?

@janelawrence6627 2 жыл бұрын

by going under lab test.

@dwight7793 3 жыл бұрын

Heres looking extremely noticeably younger even his eyebrows are thicker and that's hard to get them to grow back

@dotboutwell2877 2 жыл бұрын

FDA- give me a break😁

@chickensandw1tch 3 жыл бұрын

Tou can see that he wants to day more but he’s restricted by society and the science community

@sleepsmartsmashstress740 3 жыл бұрын

You Can Slow aging by not shaving That helps women live a decade longer Look at your idol David Sinclair

@dotboutwell2877 2 жыл бұрын

FDA- give me a break😁FDA

@neilsant1194 3 жыл бұрын

Dr. David has no wrinkle at 50... omg

@Fearzero 3 жыл бұрын

Botox, moisturizer and dermal fillers.

@Lulu-kt6gr 3 жыл бұрын

He’s taken Resveratrol for years. I still think Resveratrol is the best supplement.

@neilsant1194 3 жыл бұрын

His & his team found out something in oleic in olive...

@Fearzero 3 жыл бұрын

The studies do not support resveratrol as being anti aging. Look up Dr Michael Gregor taking apart several studies on it. Sinclair had a patent on resveratrol so he's basically shilling by saying he takes it.

@Fearzero 3 жыл бұрын

@@neilsant1194 Ya the downside is all refined oils damage the epithelial layer of our arteries.

@ricknash3055 3 жыл бұрын

@@Fearzero Dr. Gregor seems to be a complete opposite in everything.

@Fearzero 3 жыл бұрын

@@ricknash3055 He dissects the studies and says it like it is. He doesn't have a stake in the biz like Sy Sperling, I mean David Sinclair. 🤣

@ET-oq9mg 3 жыл бұрын

Dr Sinclair looks like he is in his 20s

@chickensandw1tch 3 жыл бұрын

Its so lit

@xtian384 3 жыл бұрын

no he does not

@Fearzero 3 жыл бұрын

He looks younger than 50 but so do I. I just avoid too much sun, get plenty of sleep and exercise and eat super clean all my life. Oh and use facial moisturizer daily. His botox and dermal fillers help him look younger too.

@xtian384 3 жыл бұрын

Fear Zero I do think, though, that the point of his research goes beyond the idea of ‘youthful looks’. Looks is just something people focus on the most

@Fearzero 3 жыл бұрын

@@xtian384 Yup but there is zero evidence any of it works in humans.

@AE0N777 2 жыл бұрын

I cannot believe this man is 51. He looks like she’s 30

@manuelojeda9144 3 жыл бұрын

TAKE A LOOK AT THE AUSTRALIAN CAROLYN HARTZ YOU WILL BE SHOCKED SHE DOESN'T LOOK 70 YEARS OLD. SHE IS A BEAUTIFUL GRANDMA. HER SKIN IS THAT OF A 45 YEARS OLD LADY.

@nightrunner14 3 жыл бұрын

Had my life restored by WFPD eating lifestyle, strength training, good solid sleep, and intermittent & prolonged fasting. It's not rocket science. People want to live & eat like the standard Westerner & take a supplement to erase the damage are missing the mark... why not achieve the same results & NOT get sick in the first place? The pharmaceutical industry looses when we don't need their meds anymore. When looking at people who are on metformin & noticing their improvement on overall health by taking metformin... realize the population you are studying... type 2 Diabetics. They have shortened lifespan by 20 years on average... bec of poor diet & lifestyle choices. Pills are NOT the answer. Address the root issues: Diet & Lifestyle.

@abuhanzalaabdul 3 жыл бұрын

You are looking more handsome in beard. #drdavidsinclair

@joshuagilmore8692 3 жыл бұрын

NMN cheap? I don't think so.

@Fearzero 3 жыл бұрын

$3.00 a day if you buy in bulk. The problem is it's all frozen which damages its effectiveness. I took it for over a year, 1g a day and noticed no difference. Then again I am already super healthy on an oil free vegan diet and exercising and fasting.

@joshuagilmore8692 3 жыл бұрын

@@Fearzero Fasting will be boosting autophagy but presumably even with your diet NAD+ will still decrease with age. $3 a day is still a lot when Nicotinamide costs me about $0.2AUD per day.

@Fearzero 3 жыл бұрын

@@joshuagilmore8692 Well there are zero human long term studies on NMN or NAD that show it's effectiveness. In rats yes, humans no.

@vinsibil2520 3 жыл бұрын

@@joshuagilmore8692 could you point me to where you bought the nmn?

@joshuagilmore8692 3 жыл бұрын

@@vinsibil2520 I've never purchased it myself mainly due to the price.

@ogungou9 3 жыл бұрын

People who live more than 100 years have their longevity much more influenced by genes than by the environment, they have a genetic peculiarity. For the rest of us genes only play 25%, the influence of the environment predominates. People who live over 100 years have on average had a much less hygienic life than people who have a normal longevity. They live long because of their genes really. So there is that ...

@benjibenji9653 3 жыл бұрын

How does he keep.his hair dark ?

@DarekBirton 3 жыл бұрын

He dies it. Look at his eyebrows which is always darker than the hair on people heads but his beard was darker and one time it was different darkness, His manipulation will be revealed because he could still show his hair as it true color than to pretend it is dark when in reality he has a head full of gray hair.

@lindahansen32 3 жыл бұрын

In another interview, he said it had stayed dark, but his brother and father have gray hair, so it's not genetic. He said he does not dye it.

@changechannel1036 3 жыл бұрын

This topic came up on one of his Joe Rogan interviews. I believe it was the first time Dr. Sinclair was interviewed by Joe.

@unpeacedralberteinsteinsze6395 3 жыл бұрын

Google topdoctor Yola Lol

@vickybiagini8623 3 жыл бұрын

He looks 51

@vickybiagini8623 3 жыл бұрын

45 plus 6a

@thinkandquestion5156 3 жыл бұрын

It is not about appearances, aging as it relates to diseases, weakness, muscle loss, etc. Yes, physical appearance matter too.

@vickybiagini8623 3 жыл бұрын

Physical appearance is the most important besides atrophy of muscles. If one makes such a bold claim as we can all stay young, then one needs to look young himself. Hes aged just like the rest of us. It doesnt matter though, because most die in their sixties. Life is short, so enjoy every day that you have. Nobody will ever change the fact that we all leave it.

@alkeegan9915 3 жыл бұрын

I always thought he looked early 40s myself.

@chickensandw1tch 3 жыл бұрын

He don’t tho

@kpzcbttp 3 жыл бұрын

Tesla had hit on this about eating less years ago.

@dandelion1627 3 жыл бұрын

Chinese wisdom about eating less for health and longevity was stated several centuries ago.

@changechannel1036 3 жыл бұрын

/ Ben Franklin too.

@DarekBirton 3 жыл бұрын

Why is he taking a drug for diabetes if he is suppose to be so healthy and why do he need to take all those supplements?

@RaulEdu33 3 жыл бұрын

Biohacking with metformin, NAD+, Resveratrol 💪👨🏻‍⚕️

@Sa-fd7ih 3 жыл бұрын

That drug is one of the things he found in his lab to be good for health. Lots of good info on how he found out about all that stuff in his book Lifespan.

@dewittbeaucater 3 жыл бұрын

Yeah, but Cheetos tho....

@nixodian 3 жыл бұрын

Ttfan below

@bekithomson 3 жыл бұрын

It's frustrating that you have to have special friends to get metformin for these purposes.

@henryclark4588 2 жыл бұрын

SOB

@Shams-xr8lv 3 жыл бұрын

? how to grow a new teeth

@z.deutch1334 3 жыл бұрын

Stem cells

@ajjones734 3 жыл бұрын

The mysterious exhaust sicily analyse because bassoon logically satisfy beneath a medical rooster. disillusioned, zippy syrup

@DarekBirton 2 жыл бұрын

He believes in taking all these drugs but does not understand food can replace those drugs if he eats right. He needs to get sleep. He looks tired. He never raises his eyebrows. He never likes to smile. What the heck. Look at him promoting a high blood pressure medication and all those supplements over better eating habits.

@togenicha 3 жыл бұрын

He does not look younger than his age. AT ALL! Amazing how gullible, obsequious, and stupid people are. They accept everything he is saying without thinking.

@EVMacD 3 жыл бұрын

Yeahhhhh, ‘I drive a Tesla’ like that’s so dangerous. Tesla’s are the safest cars on the roads. Nice try.

@DarekBirton 3 жыл бұрын

His beard is dyed. His eyebrows should be darker than his beard. It is obvious. He has diabetes and takes a prescription drug.

@shirleywilliams5397 3 жыл бұрын

He does not have diabetes. He takes metformin as an anti ageing medication. I take it for pcos. It is not only for diabetes.

@missunique65 3 жыл бұрын

Nice Botox injections Davey, a load of this stuff isn't doable for us. So we get to watch you take your injections, and all that stuff you have access to while you hawk a concept that IN PRACTICE is not available to a measurable degree to the layman.

@Fearzero 3 жыл бұрын

Yup he is definitely botoxed up and probably dermal fillers too. Also resveratrol is not proven to work at all in humans.

@kpzcbttp 3 жыл бұрын

I totally agree.

@jasonhewett9070 3 жыл бұрын

@@Fearzero nonsense

@jasonhewett9070 3 жыл бұрын

@@kpzcbttp nonsense

@Fearzero 3 жыл бұрын

@@jasonhewett9070 You have a tremendous vocabulary. I think your vocabulary is nonsense.