How do ACE & ARB's Work? (+ Pharmacology)

Рет қаралды 93,030

Күн бұрын

Antihypertensives are a class of drugs that are used to treat hypertension. Antihypertensive therapy seeks to prevent the complications of high blood pressure such as heart attack and stroke.
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Time Stamps:
- Intro 00:00
- Breakdown 00:40
- RAAS System Overview 01:00
- Mechanism of Action 03:23
- Common Drugs 05:25
- When to Use 07:56
- Side effects 09:00
- Contraindications 11:12
- Quick Summary 11:59
- Short Quiz 12:52
Answers:
1.)C 2.)A 3.)B 4.)C
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This pharmacology lecture covers topics such as pathophysiology of hypertension, regulation of blood pressure, cardiac output, systemic vascular resistance, baroreceptors, alpha & beta receptors, vasoconstriction, vasodilation, renin-angiotensin-aldosterone system, bradykinin, nitric oxide. Mechanism of action of antihypertensive drugs and their side effects; adrenergic antagonists; alpha & beta blockers, centrally acting adrenergic agents, dihydropyridine & nondihydropyridine calcium channel blockers, loop, thiazide, potassium-sparing diuretics, renin inhibitors, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor type 1 blockers (ARBs), endothelin receptor antagonist, dopamine-1 receptor agonist, peripheral vasodilators. Drugs mentioned include; Doxazosin, Prazosin, Clonidine, Methyldopa, Amlodipine, Felodipine, Nicardipine, Nifedipine, Diltiazem, Verapamil, Furosemide, Hydrochlorothiazide, Triamterene, Spironolactone, Aliskiren, Benazepril, Captopril, Enalapril, Lisinopril, Quinapril, Ramipril, Candesartan, Irbesartan, Losartan, Olmesartan, Valsartan, Bosentan, Fenoldopam, Sodium Nitroprusside, Nitroglycerin, Hydralazine, and Minoxidil.
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Пікірлер: 150

@DrugChug 4 жыл бұрын

Hope this video helps you out!! Consider Subscribing! 😁

@WadcaWymiaru 3 жыл бұрын

I want ask you: do this drug interact with *serine protease inhibitor* ? (like camostat)

@dwielfirakurniati6333 3 жыл бұрын

thanks for making this video.. very helpfull

@Bylinie 3 жыл бұрын

Thank you so much.... It's really help me..... After spending hours trying to read n understand the concept ... But still I'm not satisfy ..finally your vedio help me alot ,the way u explain its very easy to understand ...And obviously the quiz at last we can ans it without hesitation... Thank you so much.... May God bless u

@abdelmatlubbenmussa9392 2 жыл бұрын

Outstanding presentation and teaching ... succinct and clear... congratulations

@4evauniquelylatoya196 4 жыл бұрын

Omg!!! It's ashame that I'm learning A LOT MORE from you than I did in my pharmacology class that costed me a lot of money! Lol! You are a great teacher and your lessons are FREE!! Thank you so much! PLEASE continue to upload your very informative and understandable videos!! 💖💖💖💖💖💖💖💖🙏🏾🙏🏾🙏🏾

@DrugChug 4 жыл бұрын

Thank you for watching! Glad it helped!! And I truly appreciate the support!😁

@4evauniquelylatoya196 4 жыл бұрын

@@DrugChug you're welcome! 🤗

@rockaidpharmacy1461 Жыл бұрын

Exactly. I have fallen in love with this channel

@gladisrodriguez7764 4 ай бұрын

I’m currently studying pharmacology and this makes so much more sense! I was preparing to fail but may have found a lifeline

@Adaughtersheart-Isa53 4 жыл бұрын

You are a really excellent teacher....I love the methodical way these are presented, organized and it helps to understand "why" which helps to memorize or actually learn the drug categories. You add a brief patho to start helps understand the MOA and the "which patients should avoid " which helps understand and side effects.

@DrugChug 4 жыл бұрын

Thank you so much for your support! @Marlana I'm glad this teaching style is working!

@dalilahreyes3477 Жыл бұрын

It has taken me months to understand blood pressure medications .Finally they all make sense .Thank you

@nicksix71 3 жыл бұрын

This is UNBELIEVABLY great ! Thank you, thank you, thank you!!

@DrugChug 3 жыл бұрын

Wow, thank you! I appreciate the support

@shavetadevesar 6 ай бұрын

Great explanation thank you so much sir for your time and efforts

@lilym8451 2 жыл бұрын

I'm a visual learner and this is amazing content you have!! It actually makes sense and I can follow along! Already subscribed, I'm trying to memorize the top 200 for the ptcb this is gold!

@speaksoftlylove7988 Ай бұрын

Best pharma channel ever !!!!

@starzthelimit3563 4 жыл бұрын

This is the best explanation of these 2 drug classes. Thank you!!

@DrugChug 4 жыл бұрын

Thank You! Appreciate the support!😁

@lykebila 3 жыл бұрын

the best explanation, this is just awesome. You made it so easy to understand something that looked so hard for so long

@DrugChug 3 жыл бұрын

Thank you so much for watching! Glad it helped!😁

@TheMonnybonny 2 жыл бұрын

WOW. AMAZING. so many different videos..but your video was the only one I felt was made it extremely simple to understand. Thank you.

@maryhasaballa4052 4 жыл бұрын

This is amazing! I hope there will be more episodes coming up soon!

@DrugChug 4 жыл бұрын

Thank you for the support! More videos are being worked on as we speak! 😁

@jacquelinekelman1065 5 жыл бұрын

Really awesome video! Helped me a lot, wouldn't be able to pass pharmacy school without this! Thanks!!!

@sunrunnernge560 4 жыл бұрын

absolutely love your channel! top notch

@DrugChug 4 жыл бұрын

Thank you so much for the support!😁

@christinajoanne8177 4 жыл бұрын

Absolutely love this! Thank you so much for your hard work! Would absolutely love if you could do more on vasopressors or inotropes! Thanks again my friend :D

@DrugChug 4 жыл бұрын

You're welcome @Christina ! More videos are planned and will be released soon! Vasopressors and ionotropes are on the list!

@gloriac9994 3 жыл бұрын

ugh i love you sm. u are saving my butt for this exam

@yuliakogan4160 Жыл бұрын

Thank you! Great content!

@goahead3654 3 жыл бұрын

wow I am so happy I found this channel!!! Such precise information and beautiful explanation!! Thank you so much sir! I wanted to hear a lot more explanations from you, but your channel seems to have only few videos.. Please make more videos!!!!!!! I would love to learn from you.🙏🏻🙏🏻

@DrugChug 3 жыл бұрын

Thank you so much for your support! More videos to come!

@100lanka 3 жыл бұрын

Excellent teacher, what a clear lecture.

@MrNick11177 2 жыл бұрын

Your Videos are a God sent!...Thank you soooo Much, it is much appreciated!!!

@adal8653 Жыл бұрын

This is the best video in all the videos that explained ACE& ARB❤❤❤

@tedbear6083 3 жыл бұрын

Thanks so much for these videos! I'm a second year medical student and these have been really helpful

@DrugChug 3 жыл бұрын

You're very welcome! Glad to help! Now go ACE those exams!

@lahirudissanayaka-mk8sq Жыл бұрын

superb explanation & I really love this channel ❤❤❤

@esterindahkusumaputr 4 жыл бұрын

Thank you so much, and now i'm getting ready to write my thesis!

@DrugChug 4 жыл бұрын

Woohoo! That's awesome to hear! Good Luck😁

@IsabelRodriguez-nv2ue 3 жыл бұрын

Formidable!!! Thanks a million!!!

@patriciahess-goetz4552 4 жыл бұрын

I am going back to get my ARNP at 52!!! and at Duke!!! and you are my new BFF!!! Helping this old brain break it down!!! THANK YOU!!!!!

@DrugChug 4 жыл бұрын

No such thing as an "old brain" ! You got this! And I'm glad I can help!

@patriciahess-goetz4552 4 жыл бұрын

@@DrugChug Everybody is getting a drug chug t shirt for xmas this year :-) I love the antibiotics one

@DrugChug 4 жыл бұрын

I appreciate the support 🙂

@RajwinderKaur-pm1pb 3 жыл бұрын

I have pharmacology exam on Tuesday and this helped me a lot. I love it 🥰 Thank you so much Sir!!

@evangelinelawrence9783 2 ай бұрын

11:58pm thank you for explaining

@rebeccagonzalez2407 3 жыл бұрын

Amazing explanation! Thank you so much!

@DrugChug 3 жыл бұрын

Thank you for watching! :)

@sarmadali8172 Жыл бұрын

You are the best teacher of the pharmacology

@rashidchak8945 8 ай бұрын

fantastic explanation sir,requesting to continue your fantastic explanation.

@keemyam9408 3 жыл бұрын

Amazing video so simple and understandable thanks to you ♥️

@DrugChug 3 жыл бұрын

Thank you for the support!😁

@muhammadadil1948 4 жыл бұрын

I really love your simplest and easiest way of teaching. Please teach to University professors who lack professional knowledge and getting salaries what they don't deserve

@DrugChug 4 жыл бұрын

Thank You for the support! Unfortunately, loving to teach comes within, and these professors who dont care will never teach effectivly.

@user-os6rs1gh3g 3 жыл бұрын

Thank you so much for your hard work

@DrugChug 3 жыл бұрын

Youre very welcome. Thank you for watching!😁

@dannielibby7412 3 жыл бұрын

Learning Pharm for Dental Hygiene - thank goodness I found this!

@naj1450 3 жыл бұрын

Very clear explained. Thanks

@DrugChug 3 жыл бұрын

Thank you for watching!

@shahadf2844 6 ай бұрын

I just clicked the like button before even watching the video❤️

@rashidchak8945 9 ай бұрын

Wonderful lecture,

@beawesome5090 4 жыл бұрын

Perfectly explained. Thanks

@DrugChug 4 жыл бұрын

Thank you Razin! Appreciate the support!😁

@yulimedrano818 3 жыл бұрын

Amazing videos! Helping me study in nursing school!

@DrugChug 3 жыл бұрын

Thank you so much! Feel free to share with your class! 😁

@hardik8191 3 жыл бұрын

A very well explained video. Thanks

@DrugChug 3 жыл бұрын

Thank you so much for watching! 😃

@shahmirhosseinzadeh3122 4 жыл бұрын

I love this video. Thank you very much

@DrugChug 4 жыл бұрын

No problem!😁

@27capricia 3 жыл бұрын

This is so awesome. Thank you so much for your time. Do you have a video on ABGs? Would you please consider making one ? As a nursing student your videos are saving me right now. Thank you.

@DrugChug 3 жыл бұрын

Thank you 27capricia, keep studying hard! There are more videos planned such as ABGs. But due to the time it takes to make these videos, it may take some time to make!

@knight8821 Жыл бұрын

Very helpful knowledge with someone just diagnosed with high blood pressure

@Mohammed-dd8jm 4 жыл бұрын

very interested video thank you please we need more interested video

@cjreddy2607 2 жыл бұрын

excellent lecture, thank you Sir

@kellymudford7635 4 жыл бұрын

love all these, find it so helpful can you make one about NSAID's

@DrugChug 4 жыл бұрын

Ofcourse Kelly! More videos coming out in the future, and NSAIDs are definitely on my list!

@jaylee842 11 ай бұрын

Wow... Thanks a millions. 🎉

@musikaaffection8570 Жыл бұрын

Thank you soo much sir 🥰✌️

@user-nw3ze8jq2y 5 ай бұрын

Your are a amazing teacher ,it is easy to understand .ur all vdeos are amazing. I requesting u to make a vdeo of cholinergic drug sir.

@bobrags1976 2 жыл бұрын

I am an old woman pharmacist and I am thankful for the reviews

@TT-el8vn Жыл бұрын

Thank you!

@dianewema7642 3 жыл бұрын

You are amazing!

@mnwu2n 2 жыл бұрын

Nice presentation..❤️❤️❤️

@sanatombikhumanthem1246 2 жыл бұрын

Sir please upload more 🥰

@ethelrizarri2614 Жыл бұрын

Very knowledgeable, OMG now i know

@user-hc9kc2oq6g 4 ай бұрын

Your videos are way to effective. Why did you stopped uploading pharma videos.please upload more & more like those videos😢

@Karla-xu9dh Ай бұрын

I agree!

@tishabrown9576 Жыл бұрын

Your the best ❤

@omkarkalaskar3009 3 жыл бұрын

I like the way u explain and I fully understand this concept,pls make video on drug used in CHF and it's pharmacology

@DrugChug 3 жыл бұрын

Thank you so much for watching!😁 yes more videos are planned!

@samuelofosu2231 3 жыл бұрын

How u relax n speak make me understand well

@aliarahaman4998 Жыл бұрын

Very good

@minashah8168 3 жыл бұрын

OmG you are so brilliant 🌸

@DrugChug 3 жыл бұрын

Thank you for the support! 🙏

@saeedbadar3224 2 жыл бұрын

Thank you Sir

@bahjatabuhamdan4838 3 жыл бұрын

So nice presentation .

@DrugChug 3 жыл бұрын

Thank you for watching!

@larajayebarron1393 2 жыл бұрын

I find these videos so helpful! Could you do one on potassium channel blockers if you get the chance please, I’m struggling with the antiarrhythmics

@lnperez3043 4 жыл бұрын

Excellent !!! Please make videos on anti-arrhythmias drugs . Thank you !

@DrugChug 4 жыл бұрын

Thank you! and Yes! Those videos are already in the pipeline!

@dipeshmaladkar 4 жыл бұрын

Very nice video.

@DrugChug 4 жыл бұрын

Thank you! Appreciate your support!😁

@JOHNNIEUSA 4 жыл бұрын

do You Have reveiw COURSE FOR usmle step 1... the level of teaching is amazing and loud and clear.. GREAT VOICE

@Celtic_Iron 2 жыл бұрын

Thank you for the amazing video. I managed to have an case of angioedema from 20mg of Telmisartan. It was mild and managed with histamines but does this mean all other ARBs are out for treating high BP ? Im an endurance athlete so trying to avoid cardio effective medications and was considering Losartan.

@louisemcelhill5748 2 жыл бұрын

Excellent video. I would have liked to hear more about side effects of ARBs. Ive been on Telmisartan for one month and am having a few issues. But what is really more than a nuisance, is dry eyes, which I assume is d/t this drugs effects. I wear RGP contact lenses so this is very annoying.

@sarezhmohammed1103 3 жыл бұрын

Thanks for sharing this amazing video, it was really useful. As a nurse, I benefited from this. But there is a question: you say that our kidney has Angiotrnsin one receptor, but how can Angiotensin two bind to it?

@mobayoakin899 3 жыл бұрын

The receptor is actually called angiotensin 11 type 1 receptor

@MustReason 2 жыл бұрын

The primary BP lowering effect of ACE/ARB is achieved by interfering with vasoconstriction. The loss of sodium and water is secondary.

@Emily-if4wi Жыл бұрын

Was wondering why this wasn't mentioned in the video--thanks for building on!

@nataliewilson3957 3 жыл бұрын

more videos please

@MicheleMancusoishere 4 жыл бұрын

Excellent video but I don’t understand why you only talk about the effects of angiotensin on the kidney without mentioning the effects on the arteries, heart and nervous system

@linkim4157 4 жыл бұрын

Thank you for the great video! Ive learn a lot from this video! Question! So if ACE inhibitor/ARB reduce the sodium and water retention, does it mean these medications can also be diuretic? If so, then why would they make hyperkalemia if they can be diuretic? Thank you!

@DrugChug 4 жыл бұрын

Thank you Lin for the support! ACE & ARBs do reduce some sodium and water retention, however it isnt a main mechanism. When compared to Thiazide and Loop diuretics-ACE's & ARB's are negligible so we cant consider them as a diuretic. When we talk about diuretics, there are 3 types and they focus on 1) different parts of the kidney and 2) Different electrolytes. One class of these diuretics are called "Potassium sparring diuretics", meaning they let go of all other electrolytes (Na, Ca, Cl) and hold onto potassium (K+). The reason I bring this up is that just because something is a diuretic or has diuretic-like properties, it doesn't automatically indicate hypokalemia. These ACE and ARB medication just promote the holding of potassium specifically. Thats why we see hyperkalemia! Hope that clears somethings up for you!

@almadiaz3236 4 жыл бұрын

Tank you

@DrugChug 4 жыл бұрын

You're very welcome!😁

@beningembun7719 4 жыл бұрын

Please make video about drug interaction,how to classify it pharmacodinamic or pharmacokinetic

@DrugChug 4 жыл бұрын

Great idea! More videos are planned and I will add this to the list!

@beningembun7719 4 жыл бұрын

@@DrugChug i'm so looking forward for it..thank you

@tigerkahoy3822 4 жыл бұрын

Bravo

@DrugChug 4 жыл бұрын

Thank You!😁

@neetukaur8517 3 жыл бұрын

Ans1-diovan Ans2- ACE Ans3-losartan

@anjayyadav6735 4 жыл бұрын

Sir plz make more videos on drugs.

@Pharmakonacademy1 4 жыл бұрын

Make video on antivomiting drug

@emmelinejulien711 Жыл бұрын

Wich medication naturel you can take for lawyer blood pressure

@healthandsprituality Жыл бұрын

Angiotensin 2 binds to receptor of angiotensin 1? 2.32

@anthonynchabeleng2664 11 ай бұрын

What about headache as a side effect?

@happyamoah6241 3 жыл бұрын

I wish you explained the hyperkalemia side effect.

@DrugChug 3 жыл бұрын

This side effect requires more explanation in the hormonal process of the body. But in general, ACE's and ARB's effect the hormone level of aldosterone with make the kidneys hold on to potassium more, causing hyperkalemia Hope that clears things up!

@BigTough 4 жыл бұрын

I do not see Perindopril here on your list of prils. (or Perindopril Erbumine?) Mine is an 8mg combo with Indapamide 2.5mg. Can you make a video on ACE Inhibitors and how to avoid lifestyle habits that may work against the medication straining the heart or perhaps what might even amplify it dangerously? Like diets(certain foods), types of exercises, and how much, certain supplements, other medications like anti-depressants, particularly SSRI medication, benzodiazepines, metformin, Salbutamol, and even how certain drugs and /or alcohol may affect the body while taking this medication? I read somewhere that ACE inhibitors are very powerful, powerful enough to completely stop even certain methamphetamine processes in the body. And is it true that if you have been taking a Pril for years and then stopping it, the effects of the medication can last nearly a month or longer? Anyways, thanks!

@edoc431 3 жыл бұрын

Does long term use of ace inhibitors cause ckd?

@sivareddy7781 4 жыл бұрын

Why can’t I like 100 times

@DrugChug 4 жыл бұрын

Thank you! I wish you could too haha!

@marieminani6978 3 жыл бұрын

How bradykinin naturally cause increase in BP

@comcfi 3 жыл бұрын

Would there be a reason for a doctor to prescribe an ACE inhibitor with an ARB?

@DrugChug 3 жыл бұрын

Always discuss with your doctor first when making a plan to treat. But typically No. There shouldn't be an ACE plus an ARB because it can dangerously lower blood pressure.

@killogram1ful Жыл бұрын

❤

@lydiapereira1942 Жыл бұрын

Excellent Video . I have a condition called Atrial Fibrillation and I experience heart palpitations only when I have high Blood pressure . I am 82 years old. I take Bisoprolol 2.5mg. I was prescribed 4 different types of blood pressure drugs and I have very serious side effects. I tried Amlodipine, Candisartan, Indapamide Felodipine and Ramipril. I have been on Bisoprolol for over 3 years but for the last 6 months my blood pressure reading is over 150/75 The only drug that I don’t have any side effects is Ramipril. But my Doctor says it is affecting my kidneys. I don’t have diabetes. Could you suggest which drug I should try ACE Inhibitors that are safe for kidneys. All the above drugs cause increase irregular heart rate and arrhythmia, dizziness. Only Ramipril works on me but Doctor is not in favour.I should be very grateful for your reply.Thanks.

@Emily-if4wi Жыл бұрын

Healthcare professionals can't diagnose or prescribe medications on KZfaq, but given your health history, you might benefit from finding another doctor in your area and getting a second opinion. Best wishes!

@dipadebnath5734 2 жыл бұрын

Why don't you post new videos?

@missfatima7829 4 жыл бұрын

where are answers to the quiz?

@DrugChug 4 жыл бұрын

In the description below!

@Mannydingo30 3 жыл бұрын

Bro you are the shit

@anjananeupane1721 Ай бұрын

I don't found what I actually search for

@WadcaWymiaru 3 жыл бұрын

There is something wrong with the video. See: kzfaq.info/get/bejne/Z9yKd7mT1rjMqYE.html there is two "receptors" for angiotensin-2? Or maybe only one, and the other is just a proteine? Or this is the serine protease stuck to receptor?