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Illumina AI - ChatGPT for your genome...

  Рет қаралды 27,042

Wes Roth

Wes Roth

Күн бұрын

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#genomesequencing
#ai
#deepmind
TIMELINE
00:00 Advancements in AI
00:25 AlphaFold2
05:24 Increasing Interest
08:34 Illumina's PrimateAI 3D
So Illumina unveils AI software to predict disease-causing genetic mutations in patients.
The AI boom has been mostly centered around the big AI companies NVIDIA, GOOGLE, MICROSOFT, OPENAI etc
That’s the space that everyone is watching. That’s where all the institutional money is flowing, but there is something else brewing just out of sight.
First, it’s important to understand how Google’s DeepMind solved protein folding.
And people are noticing this.
More and more attention is being paid to the biotech companies where neural networks can be used to accelerate progress.
People in this space believe that massive progress will be unlocked at the intersection of AI and Genetics.
Neural Networks are great at swallowing large, unmanageable amounts of raw data and spitting out valuable insights.
And that’s what a big part of Genomics is. It’s vast amounts of data.
That brings us back to Illumina.
It’s a massive company that is a global leader in genomic sequencing.
Genomic sequencing, is very basically, the process of making DNA readable.
So let’s say you have a blood sample or a spit sample, you run it through a machine to sequence it and on the other side you get the exact structure of your DNA.
Actual data you can read, print out on a piece of paper or feed into a database.
And there are now global efforts to sequence everyone and use AI to process the data.
And some smart people are taking note
Peter Thiel is a German-American billionaire entrepreneur, co-founder of PayPal, Palantir Technologies, and Founders Fund, he was the first outside investor in Facebook.
And he’s investing in Ultima genomics, a competitor to Illumina.
“Ultima Genomics is coming out of stealth mode after raising $600 million from investors including Andreessen Horowitz, Peter Thiel’s Founder Fund…”
This was in 2022
Carl Icahn, the billionaire corporate Raider launched an attack on Illumina, buying up shares and trying to land some board seats.
This was 2023
Stanley Druckenmiller, who is considered one of the best investors of all time, recently added $25 million of Illumina to this portfolio.
This was May 2023, but this might be a lot more since there is a delay before they have to disclose their positions.
Now, a couple of points I have to make here.
One I own Illumina Shares, full disclaimer.
Two, I can’t predict stock price, I don’t pay attention to the price.
I just think “what would Warren Buffett do” and buy great companies and hold them forever.
With that said, I feel like we are going to start seeing more action in this space.
Bio-tech, specifically bio tech where AI can play a big role, will start growing at a faster rate.
Genomics, personalized medicine, modified organisms etc.

Пікірлер: 88
@rinzler8784
@rinzler8784 Жыл бұрын
So basically AI will take us one step closer to gene engineering ourselves. Solving disease, cancer, Alzheimer's or even engineer ourselves aesthetically once we've mastered it. Im all in i want blue eyes
@matusstiller4219
@matusstiller4219 Жыл бұрын
Me too, I want purple
@nekoeko500
@nekoeko500 Жыл бұрын
You're statistically more likely to not be able to afford it
@gold-818
@gold-818 Жыл бұрын
​@@nekoeko500 the price will trickle down and eventually be included with a standard insurance plan
@nekoeko500
@nekoeko500 Жыл бұрын
@@gold-818 sure, just like GPU prices huh...
@smartduck904
@smartduck904 Жыл бұрын
Why do you want to change your eye color anyway darker eyes means you have more melanin meaning or more healthy That's assuming you have dark eyes You could have any color of eyes I don't know but you want blue eyes
@Lemurai
@Lemurai Жыл бұрын
A team of pharmacologists, biochemists & engineers already worked out the concept of this back in 2000, now that the theory is in place, any company with machine learning capabilities can apply it.
@celestinian
@celestinian Жыл бұрын
It's the field of AI that will solve the problem of cancer in the end
@RickeyBowers
@RickeyBowers Жыл бұрын
Many meaningful discoveries are on the horizon. More discovery and powerful tools will enhance our understand of the language nature writes software in. It's important to emphasize how successful and pervasive this software is! The programs nature evolves operate in the physical reality. Understanding that is not just a revolution in biology, but also in nanotechnology.
@rikvermeer1325
@rikvermeer1325 Жыл бұрын
thank you for the tardigrades
@WesRoth
@WesRoth Жыл бұрын
haha! Glad you liked it!
@carlitosway5204
@carlitosway5204 Жыл бұрын
so basically we can now grow back arms and legs that were missing
@jcfnetwork6768
@jcfnetwork6768 Жыл бұрын
so interesting thanks for covering this more niche application of AI I had no idea about a lot of this stuff
@msidrusbA
@msidrusbA Жыл бұрын
solving autoimmune disorders with a gene therapy program would revolutionize many chronically ill people's QOL. among other insane things, ai driven innovation in the medical field/genes is going to be a two sided coin for humanity to toy with. good or bad im rooting for it.
@jason-sk9oi
@jason-sk9oi Жыл бұрын
The holy grail.
@alexguilherme5652
@alexguilherme5652 Жыл бұрын
Holy shit, i was working in this for a long time now, this is just glorious that our most briliant experts finaly gave a chance to combine the power of AI and biology
@WesRoth
@WesRoth Жыл бұрын
yeah, I feel like this event will be in history books as a starting point of something big
@cmiguel268
@cmiguel268 Жыл бұрын
I want a mullet, six pack and a bigger ... nevermind.
@gothicpando
@gothicpando Жыл бұрын
Nothing can possibly go wrong...
@louielouie9502
@louielouie9502 11 ай бұрын
Build Chloe .Build me a pair of Chloe's. The tech is here. We just need to start building agents to begin innovating it's own biological make up and use it to teach us how to do the same. Imagine the possibilities of an open source think tank of that magnitude. If only we had the balls to collectively make it happen right?
@scottlacey649
@scottlacey649 Жыл бұрын
Hi Wes. Bro, I like you and I like your videos. I just watched the one on tool making using gpt3.5 and gpt4. I loved it and think its very practical. And i like your insights. But a couple of things, possibly controvertial, eg. (if climate change and carbon emmissions in general were a money making scheme - which i believe, and on top of this, diabetes, hypertension, obesity were the product of greedy sugar companies - knowing ful well sugar is a chronic toxin but dont care), and here back to the video, the key point at the end was solving the complicated dilemna of diabetes. and also the actual promotional video by deepmind alphafold said they want to solve climate change. it just strikes me as a tradgedy that these people are just pointing these powerful tools at making money, and ignoring the truth. But i do love the toolmaking. and i honestly kind of agree with your insights. God bless mate. Scott
@louielouie9502
@louielouie9502 9 ай бұрын
Every input has an output component. So any electrical scan can also project yet we are all baffled about why technology hasn't caught up to Utopian levels. This technology has been in use commercially since 1995.
@stephenjimenez6129
@stephenjimenez6129 Жыл бұрын
All good with the exception of access to the tech, which historically has been denied to those below, an or who are not part of the ‘in-group’. Eugenics related policy has become the unspoken drive for those who continue to seek to control the wealth, and thus access to the most valued commodity ,(which is information).
@luminouswolf7117
@luminouswolf7117 Жыл бұрын
Illumina Illuminous
@metakron
@metakron Жыл бұрын
I can't wait to have biological superpowers similar to x-men 😉
@DarkWizardGG
@DarkWizardGG Жыл бұрын
Yeah, some of us will become a fckn mutants soon. But only those chosen one. Lol😁😉😄😅👍
@Puerco-Potter
@Puerco-Potter Жыл бұрын
Hqve you watch the movie GATACA? This is how it starts...
@wood9670
@wood9670 Жыл бұрын
Does the electron repulsion of a proteins molecular configuration act as a limiter to what shapes it can fold into or act as a shortcut/driver for the shape it ultimately settles into?
@pattyspanker8955
@pattyspanker8955 Жыл бұрын
This is quite a loaded question! Short answer is both. There are a number of inter-- and intra-molecular forces of varying strengths that arise from deformation of electron clouds (both attractive and repulsive) which guide the conformation of proteins as amino acids are added to their chains. This low-level conformation creates a secondary structure which comes with its own set of interactions guiding the final conformation of the structure. Environmental conditions such as temperature, solvent, and pH will have a large effect on the overall conformation of the protein as these will affect the charge, packing, and kinetics of the macromolecule. Sometime helper proteins will covalently link proteins which can overcome repulsive interactions between proteins, which would be a case that you might consider a 'limitation' of what shapes can be made. The greatest limitation to the shapes you can form would arguably come from the amino acids available to use when building a protein rather than the repulsive forces of electron.
@Mehrdadkh87
@Mehrdadkh87 Жыл бұрын
Nice time to be alive
@Zizos
@Zizos Жыл бұрын
Nuh, we'll die before this gets to the masses. And if it comes sooner then let's hope big pharma and govs are ok with us living a healthy life.
@oranges557
@oranges557 Жыл бұрын
​@@Zizos if you think that this doesnt come well within this century, youre in for a big surprise
@jamesgrey13
@jamesgrey13 Жыл бұрын
Ultima? Illumina? Did these people play too much Final Fantasy 6?
@riftvideos1203
@riftvideos1203 Жыл бұрын
as someone who is playing with small models for fun and seeing the difference a little more power gives, i am stoked someone is putting that much juice into diabetes and such.
@wonkyfug
@wonkyfug Жыл бұрын
Oh look, pharma companies don't have an excuse to not release things now, because someone will just figure it out.
@lostinsydney
@lostinsydney Ай бұрын
AI will eventually create Human 2.0 in distant future!
@michaelrouly6860
@michaelrouly6860 10 ай бұрын
🧬
@damonblade3195
@damonblade3195 Жыл бұрын
Tell it to make Jurassic Park !!! SHUT AND TAKE MY PERSONAL DATA!!!
@tobuslieven
@tobuslieven Жыл бұрын
Ow, my genes.
@Phasma6969
@Phasma6969 Жыл бұрын
Then you never get insurance because they'll do it in utero.
@sbam3139
@sbam3139 Жыл бұрын
This needs much more ethical, cautious approach, checks and balances,much more than AI, generating unknowns to ensure potential irreversible cock-ups leading to 🤷‍♂️☠️
@oumarmuhammad8038
@oumarmuhammad8038 Жыл бұрын
I created a new human genome which includes carbon- based nanorobots with the help of AI
@blackfeatherstill348
@blackfeatherstill348 Жыл бұрын
Mmmm. I wonder if someone might work out how to use this tech in ways that are not good?
@JubulusPrime
@JubulusPrime Жыл бұрын
Ok, So flesh computor? Think about it, using this for organic pc parts, I do not see why you would want to do that but it'd be like Scorn
@hdjwkrbrnflfnfbrjrmd
@hdjwkrbrnflfnfbrjrmd Жыл бұрын
No, seems that you completely missed what this is about.
@JubulusPrime
@JubulusPrime Жыл бұрын
@@hdjwkrbrnflfnfbrjrmd No I got that it was completely diffrent but there is a little thing called imagination
@SearchingForSounds
@SearchingForSounds Жыл бұрын
All I know.. is this can't be open sourced.
@rogeriolisto
@rogeriolisto Жыл бұрын
Bill Gates... Nice we can create mo virus and more money😅
@JStankXPlays
@JStankXPlays Жыл бұрын
😂😂BINGO DINO DNA😂😂😂
@byou934
@byou934 Жыл бұрын
Can you take money and greed out of the equation
@WesRoth
@WesRoth Жыл бұрын
Illumina's leadership does seem genuine in their mission to advance human health. I agree that there are many other forces that would want to squeeze every penny out of this instead of maximizing the benefits to all people.
@byou934
@byou934 Жыл бұрын
@@WesRoth we really have to take our world back
@TrangTen-qk2rt
@TrangTen-qk2rt 9 ай бұрын
ban quyen ❗
@FloridaMeng
@FloridaMeng Жыл бұрын
Can't wait to have photosynthesising skin
@gryphonschnitzel7140
@gryphonschnitzel7140 Жыл бұрын
Ill be bulletproof in the meantime
@takeraparterer
@takeraparterer Жыл бұрын
average in OHIO!
@Karim-vt1xb
@Karim-vt1xb Жыл бұрын
This is the most underwhelming video I’ve watched on AI, so far. Basically, Illumina included AI in a software to do GWAS studies. Duuh!
@user-bp7sy3ii8y
@user-bp7sy3ii8y Жыл бұрын
so, who is the first to turn immortal and cause covid 2.0 for everyone else? ;)
@ToneyCrimson
@ToneyCrimson Жыл бұрын
worth it, i will give it to my mom.
@tiggerbiggo
@tiggerbiggo Жыл бұрын
You need to get a pop filter for your mic, I can hear all your saliva...
@AetherXIV
@AetherXIV Жыл бұрын
post-humanism incoming
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