I love it when people map out science in a visual manner, and this diagram is really neat and well-drawn. Makes it way easier to understand and is also nice to look at!

a thing to point out. Naive T Helper cells cannot be activated by a macrophage, they can only be activated by mainly dendritic cells or potentially, B cells

2019 and we are still here watching and LEARNING from your videos! Thank you so much for sharing your wealth of knowledge and it breaking down.

Thank you for doing this, by far the best videos out there on this subject are yours. It is to late to help with my current class, but it would be nice if you could do similar vids while delving a little deeper, cause it seems like every professor out there picks and chooses what parts to teach and what to leave out from there lectures. Example: going into B7.1(2) binding to CD28, and even talking about the cytokines needed for T cell maturation.

Also, Interferon-gamma increases the expression of HLA-DM. HLA-DO is a negative regulator of HLA-DM by binding to it and inhibiting the release of CLIP

Thanks mate, I was searching for a material which could help me understand this problem and the only one was your video, keep doing. Great Job!

this is extremely well explained and mapped out keep up the good work Armando!! you saved my life ^_^

Day after tommorrow is my immunology viva, well i had some concept, some doubts which you cleared!!!!!! Thank you soo much! YOU ARE A LIFE SAVER!!!!!!! Stay blessed!!!!!!

amazing! the level of detail is just right :)

Really great video, thanks! I snore halfway through when reading these in books, so this was really helpful.

you are honestly suchhhh aaa legend, all your videos have made immuno so easy for me

Sir, I think CD4 molecule binds with beta2 fragmant of HMC-ll molecule, according to our book.

this is brilliant.. very well explained in a way that any student can easily understand.

was highkey stressed learning this topic but you made it sm easier on me, thank u

wow, you've saved my life tonight, ¿thank you so much. Please keep doing this beautiful, excellent work

This was extremely helpful .Usage of drawing to explain the concept is the best way. thankyou sir.

Your videos help so much! Thank you!

Thank you so much for your videos.

you are makeing medisn subject more easyer ,, thannk you very much bro

your art is wonderful!!

This is so helpful. Thanks for this really easy to understand video.

Amazing video... great job!

Excellent video!

Always great stuff thank you :)

Very detailed. Thank you.

Thank you Armando!

Same as my comment for MHCI video - I believe MHCII binding site is not so specific for particular peptide, rather a range of peptides. Only the T cells have the very specific selectivity for antigen due to the genetic rearrangements of the receptor.

Thank you. God Bless you.

Thank you! This was very helpful!

so helpful...thanke you you made it so easy for me to understnd

Awsm video n great explanation!!!

Really awesome video 👌👌👌

Awesome video.

Is there somewhere I can download your illustrations?

You sir, are amazing

Thank you so much this is very helpful 😍

Thanks, cool video really helps! However, I think that CD4 actually binds to alpha 2 and beta 2 portion. what do you think?

What happens when the peptide isn't specific for the MHC 2 molecule in the endosome?

y re a lifesaver thank u!

Great video but I noticed that you said that CD4 binds to the MHC II alpha portion. I know for a fact that this is incorrect and that they bind to the B2 portion specifically.

great video. thanks a ton again

thank you very much....awesome... very nicely explained

thank you very much

Thanks Armando

very good .Yes you r right CD 4 binds only beta 2 chain at a constant domain of mhc class ll

thank you so much

thank yoou for this nice demonstration , i'm having a hard time with this class

Thank you!

Thanks, really helpful

could you please describe what is the process after this ? like what's exactly the function of binding MHC-2 with the activated T Helper cell?

Thank you to much

Sir ap great ho explain krne m it was very helpful to me

Great job

you are amazing

thank you sir

Wooooow You are genius thanks so much 😍😍😍😍

What will happen if phagolysosome will fuse with a wrong mhc2 molecule endosome .. I mean if peptides of bacteria are not specific for that mhc2 molecule ???? Please reply

I thank you, man

amazing explain

Perfect thank you

Alhamdulillah... Very nice

So the Ii or CD74 protein is the invariant chain that becomes CLIP?

thank you so much ^-^

와... Thanks sooooo much😭😭👏🏻👏🏻👏🏻👏🏻

At 4:34 he mentions only a specific peptide will bind MHC-II, can someone clarify if he means a given MHC-II molecule will only bind a single peptide -OR- only certain peptides are capable of being bound (if so what dictates this specificity) -OR- if a given APC will only present one epitope of an antigen

I thought the CD4 binds to the beta domain of the MHC class II molecule?

Please do a video on B cell development!!

What about co-stimulation which is essential for the activation of naive CD4 T-cells

Hello what is the difference between HLA ( human leukocyte antigen ) and MHC ( major histocompaticbility complex ) ?

Great video. Could you please upload the diagrams at some platform?

Thankyouu!

Do dendritic cells use the MHC I processing pathway or MHC II? My textbook says I but my professor says II ._.

Is the Ii protein also known as the invariant chain??

I not sure about the Ii protein - i'm sure it was the 'Li' protein instead?

Thank uuuu

Awesome

can you please do video on transplant reactions - gvhd

Armando you are awesome! Are your complete drawings available online?

impressive!!!!!!!!!!!!thnx

wow thankyou:)

But is DC that activate naive CD4 T cells, right? not macrophage. so maybe don't use macrophage as an example of APC, because it can be quite confusing...

Why is the groove closed in MHC class2🤔

Gracias :-)

keep up

nice!

really nice teaching. but i think the CD4 binds to the B2 part of MHC or both of B2 and Alfa 2. and what about the role of calnexin and catepsin s here?

Good

shokran :) شكرا

thanx allot

I fuck with this MHC II Processing animation. 😎

Lu beneran orang batak lu? Gw orang batak, bangga banget gw hahha jadi pengen liat muka lu, logat lu, asli internasionale ahhaha anyway, makasih videonya keren banget

10. The role of the HLA system in immune reactions

CD4 binds with beta not alpha

Alpha chain is of 29kD and beta is of 34kD. Kindly correct

Made my life easier :p

is this the exogenous process ?

Correct me if I'm wrong but, the part where the HLA removes the clip, then the peptides fuse with the endosome, The way that they taught me was, that in order for the HLA to remove the clip, it has to first fuse with the peptide-carrying vesicle. The video is amazing btw (:

Correct 'Golgi' pronunciation