This has to be one of the most thorough explanations of testosterone, estrogen, Anavar and supplements I've ever seen!

Age 49, been on TRT for over 10 years. One thing not talked about is other meds you may be taking and how they may affect Test. If you are on any kind of anti anxiety or anti depressant you may not get the full affect of test as those meds can affect libido, sexual performance and energy levels. Also, I've noticed TRT being way more beneficial for those that lift weights or exercise as that is when you really notice the difference. Not sure if it is worth taking if you just want for libido and/or other health benefits as it is hard to maintain a steady balance of hormone levels without the ups and downs. You also have to keep an eye on RBC's and Hematocrit levels.

Thank you so much for putting this piece of content out. I just turned 40 and have been feeling a drop in energy and libido over the last 2 years. Got tested two weeks ago, and although my total test was 617, my SHBG was was 86 and my free was 6.7! I start 200mg of cyp/week next week and I am beyond stoked. The funny thing is that I still compete in BJJ, surf regularly (2 hour sessions), and stay ripped. People don’t realize that you may look great on the outside but feel like total crap under the hood.

This is why James is the best out there, great content in his videos, and he does a outstanding job of explaining the exercises in his exercise videos, Im 64, and he's one of the reasons I switched to training with resistance bands, thank you again James.

Very interesting video. I'm 55j old and training from my 15j 5 days a week. I never used anything. Now, I am willing to know how to maximize my T levels on a natural way to be the best version of myself. Can you make a topic of that some time. It would really help me. Thanks for all the great videos

I’ll be 55 in June and I’ve been increasing my lifting everyday.I haven’t waked up with erecting for a long time.I don’t smoke or drink.I’m not a diabetic. I’m skinny fat. I eat 4 organic eggs everyday with avocado. With Greek yogurt and organic blueberries. I’ve been trying to get my V shaped look back.

Great video. I'm 46yo, and just started my hormone replacement therapy under my doctor's guidance. For reference, my total T was 320, free T was only 4.6ng/dl, SHBG was good at 30, and my available t was only 100 ng/dl. My doctor started me on gel, but I plan to do test cyp at 200mg/week starting next month.

This is the best thing I've seen on youtube. MUCH respect.

OMG. So glad I found this video. By far, the best vid I've seen for TRT chemistry analysis and monitoring. Very knowledgeable Dr, very easy to follow along. Plane English. Thank you so much!!

This was super insightful. Some of it still went over my head, but the key takeaway for me is that I need to have a deeper talk with my doctor at my next wellness check about my bloodwork. It's something we usually gloss over but I'll be 43 soon and feel like I've been experiencing changes that I've not been able to put my finger on.

Fantastic conversation with a fantastic, ethical and informative doctor. Well done to you both.

Wow! Well done guys! Only wish we had doctors like Dr Brett in Canada!

Bro, this content was next level stuff! Keep asking the right questions! I’ve seen other Doctor’s YT videos and so far none of them have gone this deep on the subject. Thanks for the good content.

Having high testosterone levels is extremely important, especially in this day and age. Most men today have suboptimal levels of testosterone - a lot less than their fathers or grandfathers had just 30-50 years ago. There are various reasons for this. One factor that is oftentimes neglected is endocrine disruptors in our environment (i.e. xenoestrogens, BPA, phthalates, triclosan, etc), phytoestrogens in food (i.e. soy, which is in almost ALL processed foods), and hypothyroidism (subclinical or autoimmune Hashimoto's disease). There are many ways to increase testosterone levels naturally. Diet, supplements, and lifestyle changes can make a tremendous difference in boosting testosterone, DHT, growth hormone (GH), IGF-1, and other anabolic hormones. Sleeping before 11 p.m. works wonders for your endocrine/hormonal health. Including more cholesterol in your diet which is a precursor to all steroid hormones helps as well - red meat (beef, lamb, bison etc), seafood, eggs, full-fat dairy, organ meats (offal), and saturated fats in general (even plant-based sources, such as coconut fat/oil, cocoa butter, etc). Weightlifting, especially multi-joint exercises, such as deadlifts and squats, have been shown in various studies to increase testosterone, IGF-1, and GH levels. Tribulus Terrestris is a famous supplement that offers short-term benefits, but doesn't address the root cause of low testosterone. No one has a 'Tribulus deficiency'. Concerning supplements, the big 3 are 1) Magnesium, 2) Vitamin D3, and 3) Zinc. Choose a magnesium formula that contains many forms of magnesium as every form carries unique benefits compared to others. Concerning vitamin D, go for a product that is sourced from animal-based sources to maximize bioavailability. Do not use more than 5,000 IU per serving as over the 5,000 IU mark there are malabsorption issues. Break the dose into 2 or 3 servings throughout the day, depending on when you consume a high-fat meal. Vitamin D is a fat-soluble vitamin that requires fat to be efficiently absorbed in the intestines. When it comes to zinc, use zinc picolinate 30 - 40 mg per day taken with a fat-containing meal as zinc picolinate is partially fat-soluble. A nice read on increasing T levels naturally through weightlifting, nutrition, and supplements is 'Vintage Physique' by George Kelly. Old-School bodybuilding diets were very rich in testosterone-precursor compounds, such as cholesterol, saturated fats, monounsaturated fats, zinc, magnesium, vitamin D, B complex vitamins, vitamin E, selenium, boron, iodine, etc. This is one of the reasons why Оld-Schооl bоdybuilders looked like real-life superheroes. If you combine high T with regular weightlifting, the results are compounded (1+1=3). Testosterone also makes you stronger in the gym and more explosive athletically.

James this is second time commenting you are a great influence was 290 now 217 best shape of my life came up with routine using alot of your advice trying to make it to golden gloves in April hope it gets me threw first week matches. Thx again sir!

Great interview with so many questions I had, just prior to my appointment at the VA clinic. Thanks Dr Osborne & James

I have watched SO many videos on the topic and this is hands down THE BEST of them [others are not even close].

Perfect complement to my current book: Testosterone by Carole Hooven - THX James, this trustworthy insides are rare

Thank you for a super informative Q&A with Dr Brett. I have just got my blood test results and the exact scenario highlighted in this video is me. I'm 53, healthy, in good physical shape, I have Total T = 713 (great) but Free T = 7.55 due to SHBG at 90. So Nettle Root Extract and Milk Thistle are my supplements to see if I can lower this and increase my T levels. TRT is off the table until my SHBG is lower and I get some free T pumping, hopefully this will help with my clarity.

This is amazing interview. So calm. So straight forward.

I have been on an all natural BOOSTER for about nine months now, just got mt T levels checked a month ago and I have a total T level of 1060 ng/dl and a free test level of 17.5 ng/dl. Im 55 years old. The product is called Aphro D. Great product and no side effects

I was so worried about going on TRT, I'm 50, had blood work done in november 2022, test level came back low 301, forced myself back in the gym since i had balloned up to 420lbs from my inshape weight of 245lbs, was still tired abnormally weak, like I struggled with 175lbs on the bench, but before I gained all this weight, i could still bench over 300lbs, so now I just had my bloodwork done again and now my test is 199! wtf. So my dr has me seeing a urologist next month, I pretty much know I need test. My previous test levels prior to the weight gain was 989, that was when I was 44. So I'm hoping TRT works for me.

110% great content here. Thank you for taking the time to do this!

I've been on TRT for 2 years, and I'm in my early 30s. So this was a ton of helpful information for something I'll probably be on for the rest of my life.

You missed mood altering estradiol levels. Mine were 81.8 and I have been extremely crabby. They have come down via anastrozole and I feel much less anger and crabby.

Best explanariam about TRT I ever listened.

Doc is very insightful & informative, some the best info I've heard on the Hrt & or Trt subject matter!!

They do not discuss the effects on hemocrit and hemoglobin. Not all people respond the same but I was TRT for a year and my hemoglobin and hemcrit levels went through the roof. Just know if you have this issue you are signing up for regular blood donations to keep those in check.

Excellent and very informative video! Thank you guys kindly for bringing this information to the public!

I never comment on vids, but I'm getting desperate. In 2 months I'll be 40. Always have dealt with depression and not able to keep weight on until a few years ago. Now I have fatty tissue in my chest that is basically like an adolescent girl. For a couple years I used muscle shirts to descise it, but now I'm so depressed and am giving into the fact that I don't have the energy, or even desire 90% of the time, to try an work it out. I've never gone to doctors much and don't know my levels, but I can only think I must have low T. My testicles have nearly disappeared, and I have no sex drive, even though I had always had a very very active sexdrive. I just went through a relationship with a woman that is SO beautiful and was very sexually active only to be completely disfunctional. I'm a fairly tough guy at heart. Will do absolutely anything I must no matter what the danger is to take care of my family, but just feel like crying all the time. Who can I see and where do I need to go to get help? As a man, I am ashamed of how I feel and act. I want to be a man that will take care of my sons and daughter, but I'm so lost right now... I hope this actually reaches someone that can help and not just be a stupid comment for everyone to critisize..

Best explanation hands down. Well done Dr. Osborne.

This is the best video I’ve seen on the TRT subject in the 8 months I’ve been on it. I’m working on nailing down the right dosage. I think 200 mg a week may be a bit much for me. Thank you for all the information!

Love the videos man. Extremely informative. Thanks for the great content.

At 47, I've been involved in CrossFit, powerlifting, calisthenics, and general fitness for over 20 years. When I hit 46, I started on TRT (Testosterone Replacement Therapy) due to feeling lethargic, unmotivated, and constantly tired. After 2-3 weeks, I noticed significant changes: my mood improved, cognitive function increased, and I woke up with abundant energy. It's important to note that throughout this period, I remained committed to my workout routine, hitting the gym six times a week despite lacking motivation. The benefits I've experienced from TRT include increased energy levels, improved libido, and I believe it has also reduced my recovery time. While I'm not actively pursuing personal records in strength anymore, my strength levels have remained consistent. Overall, I feel good, and fortunately, I haven't experienced any acne issues. I maintain a clean diet and supplement regimen, including creatine, zinc, spirulina, glutamine, omega 3, Nitirc oxide with caffeine, lion's mane for cognitive function, and glycine with bone broth every morning. Im a gym rat so I do calisthenics 3 times per week, legs and some upper body twice per week, crossfit saturday, and light cardio with sauna on sundays on a 16-18h fast. if youre over 40 I believe TRT is a must IMO, workout, eat healthy... thats my 2 cents

Thank u and Dr Osborn for sharing this. Gotta have a deeper talk with my Dr and probably find a specialist in this.Wish I lived closer.

I’ve watched a lot of videos on this and this by far was my fav. Thank you!

I take .3ml of test cyp every 4 days and my total test is 1300 give or take a tiny bit and my Free Test is 48-54. Super sensitive.

I enjoy the info in this video a lot. I have taken some points to heart indeed. I do have trouble with one point made: The doctor had stated that with estrogen levels being too high, that libido would become so affected that sex would not be possible. I had taken a test blend as a bodybuilding supplement. I was taking 6000mgs weekly, and for reasons not clear to me, my total test shot up to above 3000, and my estrogen was 142. My sex function was significant and I had no issues at all. I still had the other symptoms of high estrogen- night sweats, hot flashes, nipple sensitivity. I have been taking zinc daily for several months. I have been taking D3 with K2 for a couple months, as well as DIM complex for a couple of months. I cut my dose in half. I have not had a new blood test taken yet. However some symptoms have receded and my sex function has gone from enhanced, as it was with my estrogen at 142, to greatly enhanced to the point of being troublesome to my current relationship. Just wanted to share my experience.

Love the video and information! Can't wait for the next video!

Awesome video. Thank you. 🙌🏼

Great information 👍 what an interview 👏 thank you for your content.

Without a doubt, the most insightful deep dive on male hormones out there

Great info! Cleared up a few tiny things I was confused about thank you

You found a shirt with sleeves. Honestly, you look good. Nice job.

For me the biggest concern is hair loss. Seems like everyone I know on TRT is bald

THANK YOU!! amazing video, I looked everywhere for this type of information

Great "inside perspective!" Thanks guys

Thanks for the video. Very interesting information that deserves to be viewed several times to capture it all.

Great video!! Very informative and helpful, thank you!

80mg twice per week Test C gave me hair loss and bad hormonal acne. Saw Palmetto and Finasteride did nothing. I went off TRT completely and am still struggling with hormonal acne.

Best video I have seen on trt, thanks for that.

Great content.

Thanks for this vid James I’ve been thinking about getting my T checked so timing is right on

great conversation

Great vid, very informative.Thanks

Great video. Just wondering if Doc has ever dealt with an patients that have a mutation in AR gene, leading to androgen insensitivity syndrome? There would definitely be some sort of genetic component to your question about receptors…

There's so many factors. Are you working out while you're on the TRT? If so you can spike your testosterone faster. Are you drinking heavily while on TRT? If so you'll convert it to estrogen faster. No two guys are the same

I have had prostate cancer and did the five radiation treatments a week for nine weeks along with six weeks of female hormones. That was 9 years ago and still holding at 0.2 PSA. My Urologist said I could take TRT and the PA said I shouldn’t take it because it can bring the prostate cancer back.

Im 45 and my Testosterone has dropped by 360 pts in the last 7 yrs. I was at 890 now at 530 and they have started me on T cream twice a day. I have also started Sermorline once a day at bed. My liver function was very good but my main concern is my estrodial number is at 13.9 and my DHEA was the lowest she said she’d ever seen at 75.9. I will also be supplementing DHEA. Should I be taking something to keep my estrodial numbers down or do they need to increase? I have been taking finasteride for 20 yrs do to hair loss in the family. I am a little concerned that my hair loss will increased by the Test therapy.. I should note my Free T is 93.2. Any recommendations are greatly appreciated

So much awesome information, thanks mate!

My T is at 340 and I am in my 50s. My Dr. said its in the normal range will not give me any and won't budge. He said it wouldn't be covered anyway. I feel like I'm swimming against the stream trying to get it.

Gyno and nip sensitivity does happen before 12 weeks. Don't let that fool ya

How about breaking it down so us ordinary people can understand

I took high does testosterone Cyprionate trained hard and heavy and to failure and eat bags of protein yet I hardly made any muscle in the 12 cycle it was barely 5-6 lb and I lost it all within 4 weeks I came off

Man I this gentlemen was my doctor! My doc is a joke he has me on 200 mg every two weeks I had to adjust it to 100 mg a week on my own when I asked him about doing that he told me it’s no different and I won’t want to do double the shots! When really I could care less I do a shot every day to optimize my levels and how I’m feeling! My total was 27 ng/dl before I started at 29 a heaven opiate addiction crushed my natural test production! I’m 5 years sober now and still struggling with getting dialed in due to how bad my doc is! I have an appointment with an endocrinologist coming up hoping they can help me! I’d go to a clinic but it’s hard to pay 100$ or more a week when right now I’m paying 4$ for my two vials of test cyp 200 a month! Idk something has to give though my total came back at 480 my last blood work and he’s like yea that’s fine your in range but it’s not I still don’t feel great I need to get dialed in! Sure my training nutrition all that could be better but it’s vastly improved from what it use to be something has to give for sure! I feel good the first 3-4 days after my shot last 3 I’m down again the Roller coaster ride sucks! Have no idea what my cortisol levels and estrogen levels are either I’ve asked him the last 2 blood works to check my estrogen and hasn’t put it on either test he just doesn’t seem to care and doesn’t listen to me! I’ve told him I’ve done hours or research online and his response was I went to medical school 4 years and had 10 plus years of schooling overall smh!

100mg brings my free test from 300 pmol/L to 880 pmol/L (range 170-660)

Thank you. Informative, particularly for me about the supplements.

James you are my fitness idol. I'm in my 30s so not quite at the level of needing to worry about TRT but such great information in this video and very candid. Gonna give stinging nettle a try for a few months and see if I notice a difference. Thanks for the years of great content.

Great Educational Video my friend. I wish all youtubers would follow suit 👍🏼👍🏼

A lot of answered questions. Thank you!

Hey I’m 21 years old. I have 945 ng/dl total test. And 109 pg/dl of free test. But what worries me is my high shbg and albumin at 44 mnol/L and 5.0 g/dl respectively. I notice some brain frog. And find my motivation and high testosterone like behavior in consistent and almost cyclical.

Thank you so much for this video!!! I learned so much! 👍👍👍

my shbg is 56.6, ordered 5mg boron straight away, thanks :D

Can you or the doc tell men the best ways to control cortisol levels? Stress reduction, chemical elimination, foods, etc… thank you!

I took nugenics and it didn't work 😕 I guess i'm a non responder !!

So .... My Tess total is : 96.46 L and 1.30 L is my Free Tess. Lol So with a score that low, I can safely bet the reason why I feel like dog s*** is because of of these crazy low levels right? Lol .... We went over my blood work on Friday but I have to wait till this coming Friday to start the treatment. I'm dying to get started. I'm so sick of feeling this way.

Wrong about SHBG. SHBG is the primary transport protien. The binding to a T molecule lasts roughtly 2 hours. T is always released back into the blood from SHBG. That's how all carrier protiensw work, including TBG, CBG and DPB.

My doctor put me on bioidentical testosterone troches. 50 mg twice a day and 50 mg Dhea. What do you think about this? Been on this for 6 weeks now. The only thing that l have noticed is that my libido is some what better. I am 60

What if both free and total numbers are very very low of testosterone

Killer video James! Thanks.

Amazing, amazing video, thank you!!

this is awesome info.. thank you so much

52 here is my protocol 100mg Test E 50 mg Masteron E 125 mg Anadrol Weekly Anadrol is 8 weeks on 16 off ..

Wow these doses seem high to me but everyone is different. Im 50, on 110 a week and at >1599

This video is pure gold

I was told by an MD that Testosterone is like food for cancer after being told I have Prostate Cancer.

Great video and great questions, but it would be even better if you asked him about what is an optimal free testosterone range like you asked him about total T in previous video!) Thanks a lot guys!👍🏻

Wow..great information,..thank you

What do you mean state law says we really aren't supposed to be prescribing more than 200mg / week?

How much does trt raise blood pressure? I’m on a beta blocker can I get on trt safely?

It pisses me off when they shout out all these pissin numbers without saying whether it’s in pmol/l or ng/dl etc. the list can go on

These Drs in Canada refuse to put me on trt or hrt and it does not matter what my numbers are. My t sits at 300 and they insist on calling it normal even though I have ALL the classic low t symptoms. I dont know what to do.

At 8:10, cortisol levels were discussed. Could stress from work elevate cortisol levels enough to have the same effect?

The guy on the left does sign language the whole time that is pretty cool for the hearing impaired

The Dr says he likes estrogen between 20-30, but isn't the best ratio for libido... total testosterone to estrogen 13-18:1?

Excellent information.

Interesting information... thanks ❤

I didn't see mentioned what happened to me. I'm a 64 year old male,my test was 162 and over a 5 month period it went up to 612. At first it was great then slowly i was totally paranoid at night. i couldn't sleep i had to have the light on ,i was fine till i put my head on the pillow then the nervousness kicked in.Why did this happen.

I just got tested. Im 62 and my total test was 17.9 or 516 NG. Wondering what the doctor will say

Such a informative video james.. appreciated 🤜🤛