LEV is inching closer! Rejuvenating mitochondria

LEV is inching closer! Rejuvenating mitochondria - Clinical Trials

Рет қаралды 38,514

29 күн бұрын

There are several clinical trials and research initiatives in Japan focused on drugs and therapies aimed at rejuvenating mitochondria. One notable example is the approval of Imeglimin, a first-in-class mitochondria-targeted reagent for type 2 diabetes, by a French biopharmaceutical company, Poxel SA. This drug has been approved for marketing in Japan as of 2021 and has shown favorable safety and tolerability[2]. Imeglimin targets mitochondrial function, which is crucial for its therapeutic effects in diabetes management, indirectly contributing to mitochondrial health.
Additionally, Japan is involved in various other clinical trials and research projects that explore mitochondrial rejuvenation through different mechanisms and diseases. For instance, the clinical trial registry and research initiatives often include studies on mitochondrial diseases and therapies that could potentially rejuvenate mitochondrial function. However, specific ongoing trials directly targeting mitochondrial rejuvenation in Japan were not detailed in the provided search results.
For a comprehensive understanding of all current mitochondrial rejuvenation drug trials in Japan, one would typically refer to databases like ClinicalTrials.gov or research publications from relevant Japanese research institutions and pharmaceutical companies. These sources would provide detailed information on the scope, stage, and findings of such trials.
Citations:
[1] www.ncbi.nlm.nih.gov/pmc/arti...
[2] www.ncbi.nlm.nih.gov/pmc/arti...
[3] www.nature.com/articles/s4141...
[4] pubmed.ncbi.nlm.nih.gov/33473...
[5] classic.clinicaltrials.gov/Pr...
[6] pubmed.ncbi.nlm.nih.gov/30917...
[7] pubmed.ncbi.nlm.nih.gov/36320...
[8] www.astellas.com/en/stories/m...
[9] classic.clinicaltrials.gov/ct...
[10] classic.clinicaltrials.gov/Pr...
[11] pubmed.ncbi.nlm.nih.gov/30348...
[12] classic.clinicaltrials.gov/Pr...
[13] www.mitomoonshot.med.tohoku.a...
[14] pubmed.ncbi.nlm.nih.gov/26850...
[15] classic.clinicaltrials.gov/Pr...
[16] www.sciencedirect.com/science...
[17] classic.clinicaltrials.gov/ct...
[18] onlinelibrary.wiley.com/doi/f...
[19] classic.clinicaltrials.gov/ct...
[20] www.raddarj.org/en/registry/a...

Пікірлер: 602

@Miresgaldir 26 күн бұрын

I immediately think of tolkins elves, how few children they have, their longevity, and their patience and ability to spend time being artisans rather than rushing their lives. Edit. Like some have said, and I totally agree, there also comes much grief amongst the elves

@JohnSmith762A11B 26 күн бұрын

Yeah but broken hearts always end them.

@ThomasTomiczek 26 күн бұрын

It is actually one example I hand out these days - that humans turn into Tolkien's elves, also because those are very advanced (magic, but still).

@ThomasTomiczek 26 күн бұрын

@@JohnSmith762A11B As depression does humans - at the end one can say they end through some sort of unconscious suicide, loosing the will to live.

@cmw3737 26 күн бұрын

Bryan Johnson is the first true elf

@nyanbrox5418 26 күн бұрын

@JohnSmith762A11B honestly that's one thing medicine can't really cure yet

@markbarks9871 26 күн бұрын

If you've ever been divorced.....we all mourn the loss of those years wasted!!! Bring it on!! Please, please, please give me 25yrs back!

@sadscientist9995 24 күн бұрын

soon we're gonna have "trans age" people.

@faizanrana2998 11 күн бұрын

Heeehehehheeeeee just b gay instead

@Custodian123 26 күн бұрын

I'm ok with the heat death of the universe getting me. That's an acceptable amount of time to me 😂

@thomasruhm1677 26 күн бұрын

And even that will be solved eventually.

@robertlipka9541 26 күн бұрын

I am NOT 😁

@chadwick3593 26 күн бұрын

You say that now...

@khonsu0273 26 күн бұрын

I've always had my doubts about the 'heat death' model - our models of cosmology are still radically changing every decade or so, and there are still big uncertainties about the nature of dark energy & dark matter; I don't think we can have a great deal of confidence in predictions about the far future of the universe given our current state of knowledge. In particular, it's not clear that the 2nd law of thermodynamics applies to the universe as a whole, since it's not clear that it makes sense to call the universe an 'isolated system'.

@andrewwalker8985 26 күн бұрын

You’re right… plenty of time to figure out universe b by then

@vikasbedi82 26 күн бұрын

I am 41 about to be 42. Because of Brittle Bones Disease I could never walk in my life and always lived on crutches and wheelchair. I hope before I reach 50 I get this therapy not only to reverse my age but able to walk normal like the rest. Because of my disability I couldn't marry a decent woman and woman I married to divorced me because she saw I kept breaking and she didn't want to take care of me.

@monchoglu 26 күн бұрын

I hope you can be healed in the near future mate, looks promising

@michaelsimpson9175 26 күн бұрын

that sounds so hard. Hoping that you will be able to walk soon with these therapies.

@mrleenudler 26 күн бұрын

Heartbreaking. It's cruel that we have people living with diseases like that. Really hope you can make it to LEV and start your real life.

@ThomasTomiczek 26 күн бұрын

Would that work? I mean, even if the gene is fixed - would you need some sort of bone strenghening (via nanobots or implants) would is there a self healing factor that could be activated?

@vikasbedi82 26 күн бұрын

@@ThomasTomiczek Idk maybe my bones can be replaced by some aluminum or steel metal? Anything that makes me walk. All my life I saw everyone around me walking and with sad heart just sighed. I wanted to dress like a gentleman and walk before I die.

@richardede9594 26 күн бұрын

9:15 the irony of Dave telling us we're going to live for Centuries whilst simultaneously nearly slipping and drowning in a river! 😂😂😂😂😂

@alespider9905 26 күн бұрын

Yeah, I thought the same "we are going to live forev..." /*brokes neck/*

@paultoensing3126 25 күн бұрын

I had the same thought. Maximum universal irony: Having a fatal accident while disclosing a pivotal longevity breakthrough. The universe does have a sense of humor. Good thing he wasn’t driving a Segway.

@richardede9594 25 күн бұрын

@@paultoensing3126 🤣🤣🤣

@christopheraaron2412 25 күн бұрын

@@alespider9905Redd Foxx had a skit, who is smoking cigarettes like mad and he said he wanted to keep smoking for the rest of his life and he had a friend who quit smoking and he told red fox that he was going to live 10 years longer than him and then read said well he was walking across the street one day about 2 weeks after he quit smoking he got run over and killed by a tobacco truck.

@mroctober3657 20 күн бұрын

Reminiscent of the Segue inventor guy who Segued off a cliff.

@Mllet3d 26 күн бұрын

Japan has been Fast tracking a lot of clinical trials for quite some time now and it usually goes nowhere. Just look at all those hair cures and cloning clinical trials. most are based on small animal clinical trials that have a failure rate as high as 99.99%. Possibly a version of Super A.G.I can make the difference. As I believe theirs 9 to 13 Hallmarks of aging. 1. Genomic instability 2. Telomere attrition 3. Epigenetic alterations 4. Loss of proteostasis 5. Deregulated nutrient-sensing (6. Mitochondrial dysfunction, is only one of many Hallmarks of aging) 7. Cellular senescence 8. Stem-cell exhaustion 9. Altered intercellular communication

@mjr7991 26 күн бұрын

Yep...we are not even close to the beginning of living forever even if that is possible (which I dont believe it is).

@shinjiokamura4172 25 күн бұрын

Imeglimin is already available in Japan ! Commercialization just started. I just bought some poxel shares after seeing this video :)

@zvorenergy 25 күн бұрын

This is why Im fascinated by Michael Levins bioelectrics and electroceutical work. What he's doing is more like high-level subroutine calls rather than writing peices of code. Electroceutical in combination with drugs can orchestrate so many things simultaneously. For example, Levin has demonstrated starting and stopping cancer, controlling morphology, etc, all by controlling the bioelectric field. No genetic engineering or special proteins, just altering the bioelectrics only.

@USAtoElsewhere 22 күн бұрын

@@mjr7991to live forever we also need fatal accident prevention but I have reason to believe if we last another 10 or 20 years longevity escape velocity will begin. We need something to give us the amount of time needed to get the following antaging intervention.

@MichaelDeeringMHC 26 күн бұрын

You get your mitochondria from your mother. She got it from her mother. There must be a way to reset them.

@therandommusicguy4773 26 күн бұрын

This is a very interesting way of thinking about it - makes the concept seem not just plausible, but probable.

@popothebright 26 күн бұрын

How does this follow? I'm not getting it.

@mrleenudler 26 күн бұрын

@@popothebright Ageing has a lot of hallmarks. Your body creates new cells all the time, but they deteriorate as they divide and we age. Some magic is happening when a child is conceived. Even though the cells starting the embryo come from aged individuals, the child starts from zero. A lot of the anti-ageing effort is about understanding this process.

@Dygit 26 күн бұрын

@@mrleenudlerI’ve never thought of this before

@shinjiokamura4172 25 күн бұрын

I just bought some poxel shares after seeing this video :)

@DynamicUnreal 26 күн бұрын

I wouldn’t want to live forever. But I wouldn’t mind living 200 or 300 years and seeing all the things that humanity is going to accomplish. If not, then as a male in his mid 30s currently suffering from an undiagnosed neurological illness, I would want to at least live a normal lifespan where I feel healthy all the way up to when I die. What makes aging a disease isn’t that it kills you at the end, it’s that it makes you feel sick long before it kills you. Take it from me, y’all don’t know what pain and suffering is until your health is no longer intact. It’s indescribable.

@ThomasTomiczek 26 күн бұрын

The problem is - once you live 200 or 300 years, will you want it to end? Serious here - you speak from the perspective of a current human. You do not know what you want then. You also do not know what the world will look like. Imagine 1822 - to now. The change will be way more.

@imthinkingthoughts 26 күн бұрын

Don’t know how that’s a problem. If I live to 200-300 and want to keep living well hey, it was a great 200-300 years.

@grnbrg 26 күн бұрын

I don't think I want to live forever, either. I do want to remain healthy and mentally fit until such time as decide that I'm bored enough to stop, though.

@DynamicUnreal 26 күн бұрын

@@ThomasTomiczek I don’t think that’s a problem though. Then you just keep going.

@BManStan1991 25 күн бұрын

I think if humans have a choice on when to pass on, we'll know when it's time. If at 300 yrs old you still feel the same way you do now, then that's probably the sign. If you change your mind by that time, well good, the tech by then will give you all the time you'd want.

@Tropical_stories 26 күн бұрын

Your videos give a lot more reasons to live. Thank you for this portion of enthusiasm

@perr1983 26 күн бұрын

David, your videos always give me so much hope. My mother never much cared about her own health, she's 70 yo. But sinse I told her about all this discoveries I found out with you, she has started to change, she's so much more conscious about her health... I told her what you said in this video: hang in there for more 10 years!

@aurisnow 25 күн бұрын

I am just about 58 and spent most of the last 30 years getting high, getting drunk, skateboarding, snowboarding and riding bikes of all kinds. Never spent the time to build anything palpable in life, never bought a house, built a family or a stable career. Yes I would love to stay as healthy as I have being, be it 30, 40 or even 50. I would love to keep riding bikes and snowboarding, plus have the time to find a good companion, build some wealth and maybe go back to school to keep learning about things. Maybe even get focused at the gym and get super ripped. So yes, sign me up for a few more 100 years or so. As far as forever, let's think about that when it comes, hahah.

@zvorenergy 25 күн бұрын

Without significant FDA and government reform, medical tourism is definitely the way.

@russdr0725 26 күн бұрын

It's funny I was having this conversation recently because of your channel and these topics. One of the things that the person I was speaking with had strongly believed was that he thought at some point he would just want to die, if not for anything else then just being on this world for too long. Similar to your grandparents being OK with death during seemingly casual conversation. I responded by telling him it’s because they’ve spent maybe half or more of their lives continuously having a lower quality of life and sometimes becoming completely dependent. Of course they wouldn’t want to live after that? I said have you ever met physically and mentally healthy young people who’ve just casually wanted to die? Probably not and if he did it was rare.

@iamsuzerain3987 26 күн бұрын

I like these walking through the woods videos. Heady days we're living through...filled with wondrous possibilities and hellish horrors. Really hope our species chooses the wondrous🤞

@xJRx7777 5 күн бұрын

Thank you for such comprehensive notes. I wish all KZfaqrs did this.

@Greyalien587 26 күн бұрын

Damn..what a gift to give this drug to one’s mother or father.

@Kingkhan-qk2vk 25 күн бұрын

Yup true...

@MrGriff305 16 күн бұрын

"Indefinite lifespan" was how I said it in my novel in 2009 😊

@helius2011 24 күн бұрын

I love this channel and David's sense of humour. Thank you for all the videos!!

@ScottieAult 26 күн бұрын

David been anxiously waiting for new vid! You are the best

@devlogicg2875 26 күн бұрын

Funniest but = When he speaks of living for eternity and then nearly falls in the river!

@greglhoticom 26 күн бұрын

Yeah, that was great. "Somethin' will get ya". heh. Looking back on my life and thinking about all those times I could have died or been killed (at least 9 times) when a second or two made all the difference.... Cats have nothing on me.

@Leshpngo 26 күн бұрын

I really appreciate this video...keep up the post labor grind :)

@Vancer876 26 күн бұрын

Dude I appreciate your covering this topic a lot, ur doing great work man love ya ❤

@Techtalk2030 26 күн бұрын

I wanna do things i want to do, hobbies, travel, learn new skills, experience new things, maybe see space or other worlds and finish certain tasks. I dont think i would wanna live forever. But 3-5 hundred years possibly.

@jaysilence3314 26 күн бұрын

We could travel by walking there. That would be quite eco friendly.

@oranges557 26 күн бұрын

I will assure you, when these 500 years are over, you will definetly NOT say " ok now i will die." Noone just gives up a decent life.

@macrumpton 26 күн бұрын

Who would want to give up being 27 forever?

@sadscientist9995 24 күн бұрын

20k years max probably then long sleep for a few million and reawaken

@Techtalk2030 24 күн бұрын

@@macrumpton perfect age for me would be me being 20-23 again

@ryvyr 26 күн бұрын

"Except for any Vampires out there in the audience~" **silently backs into bushes like Homer Simpson**

@misterhat6395 26 күн бұрын

I went back to school for my doctorate in my mid 30s in part because I felt that there’s a decent shot of getting an extra ten years on my total lifespan, thus offsetting the fact that I didn’t start my doctorate 10 years earlier. The point I’m making is that increased lifespan can cause people to rethink undertaking things that they previously thought it was too late for.

@user-wk4ee4bf8g 26 күн бұрын

Seems like the stress of getting your doctorate would reduce your lifespan

@klammer75 23 күн бұрын

Having children has been the greatest joy of my life! If I could afford it I’d have dozens🤩🤔😍

@rgonzalo511 22 күн бұрын

Well you definitely should be excluded from the longevity treatment then

@Doctor_Sex_0 19 күн бұрын

@@rgonzalo511 lmao

@croneyr Күн бұрын

I think most people will continue to have children. Children bring too much personal fulfillment for it to just go away. Kids aren’t like 8 tracks.

@7TheWhiteWolf 26 күн бұрын

Also, David Sinclair said his therapy was dirt cheap and that you could make it with common household products.

@the42nd 26 күн бұрын

which therapy was that?

@dbSurfer 26 күн бұрын

Having your children live at home until they are 352,689 years old

@christopheraaron2412 25 күн бұрын

I'm 68 years of age never been legally married and never had any kids the woman I lived with had a hysterectomy when she was 29 and she didn't want kids anyway. If we have near indefinite lifespan well then most of us don't need to have any kids. All the money I saved by never getting married and divorced and paying child support will more than pay for the therapy.

@robotheism 26 күн бұрын

i love your videos! ❤️💯

@MaillonRecordz 24 күн бұрын

Damn I like these future bio/medicine vids/talks. They are really a preview of all the cool things that will come soon

@phen-themoogle7651 26 күн бұрын

Amazing news! Hopefully the trials go well and they help a lot of people manage their chronic diseases, even if it takes a few years before we see progress. But this gives me a lot of hope by 2030 that maybe I'll be able to try some rejuvenating treatment of some sort.

@FriscoFatseas 26 күн бұрын

Great video and loved the nature walk vibes

@mckitty4907 26 күн бұрын

When do you think this will be available though?

@dockdiscus3693 26 күн бұрын

David is one of the few people to leave Plato’s cave

@fire17102 26 күн бұрын

The air and view from outside are just not comparable 🌸

@SalamAnuar 26 күн бұрын

We're in the plato cave watching him touch grass on our phone screens

@michelchaman6495 26 күн бұрын

@@SalamAnuar the grass is also in plato's cave but it might be closer to the entrance.

@mrmortima3761 26 күн бұрын

Ever since David's nature videos I get the vibe of Luke Smith wandering through the woods talking to us dear viewers, all over again :)

@doubletapm4 26 күн бұрын

The new camera looks amazing!

@greenjackle 26 күн бұрын

Hello Fellow Humans, Being permanently disabled due to Bone Cancer. I desperately want something that helps me walk again. Then to get my life back would be amazing. Because since 2016 when I was 32 years old I have had my life stolen from me by cancer. Technology is the inly reason I have not ended my kife already. I hate being poor and being in pain 24 7 and not being able to walk and run. I want my life back so badly. So this science cant come fast enough.

@nav4200 26 күн бұрын

Hey man I’ve just started to watch your videos, lemme tell you’ve been answering most of the questions that have been bothering me thanks for making these videos.also any advice for a 20 year old to be financially prepared for AGI?I’m currently a finances analyst.

@titostake967 22 күн бұрын

Definitely a lot of questions

@hhhhhh9792 26 күн бұрын

It is also possible to inject new mitochondria into your body. A study came out this year that found that that transplanted mitochondria migrate into cells on their own and they preferentially migrate into cells with damaged mitochondria.

@mrleenudler 26 күн бұрын

Ooooh, that's exciting! You got a source for that?

@hhhhhh9792 21 күн бұрын

@@mrleenudler I read about it on a longevity website called Lifespan

@croneyr Күн бұрын

Yea source please and I’ll google it too.

@alexellerbee9378 26 күн бұрын

Where do you look for most of your information and research?

@snorremortenkjeldsen6737 26 күн бұрын

Thanks, that definitely provides hope for the future! Does anyone know what the name of the drug/company is?

@panicraptor2837 26 күн бұрын

As a molecular biologist and computer scientist, I'm not too optimistic about pharmaceutical therapies. The biology of a single cell is multitudes more complex than anything humans have ever built, and for any pharmaceutical there's already a counter pathway in our biochemistry. I've been following the longevity science for a decade, and most of the therapies are designed to attract VC funding. Few clinical studies have ever confirmed the findings of in house trials. While it is true that all cells can rejuvenate, and technically the first cell never died, the flip side of unhinging those mechanisms is cancer. Gene therapies, on the other hand, look far more promising to cure genetic diseases. Because we are working from 2 known states.

@theWACKIIRAQI 25 күн бұрын

Do you think advanced AI coupled with advanced imaging could produce a novel ways of dealing with cellular aging? I guess what I'm asking is, do you see a way of cutting edge bio-research getting de-coupled from the human element? we're slow, prone to errors and easily distracted (among other things) so :)

@panicraptor2837 24 күн бұрын

@@theWACKIIRAQI There's simply not enough data to apply machine learning to solve the problem of cellular aging. You can apply ML to sub-problems like protein folding or drug discovery. The AI we have today is not intelligent, it can't work from a few data points. And getting good data is the hard part.

@theWACKIIRAQI 24 күн бұрын

@@panicraptor2837 exactly. so ( bear with me ) if we could create an AI that could learn from first principle like us humans do and given that electronic systems think at the speed of light, non stop. Then a curious, self-taught AI could in theory arrive at a new theory of cellular aging by noon and devise, say, a complete therapy to mitigate its effects by dinner time, no?

@panicraptor2837 23 күн бұрын

@@theWACKIIRAQI Contrary to physics, biology is an experimental science. There is not much to reason about from first principles, it all comes down to meticulous and careful experimentation, and multi year clinical trials to follow up. Emergence is why our models of the world will always be incomplete, and given the complexity of biology even small errors have massive consequences.

@croneyr Күн бұрын

We are in an exponential growth curve on aging. I think we will start seeing a doubling soon.

@USAtoElsewhere 22 күн бұрын

So sorry to hear about your bone disease. As he said, stay alive another 10 years. Stay alive longer if possible just in case its late.

@simoneromeo5998 26 күн бұрын

What study are we talking about? Is there a link to check the details?

@antoine.- 26 күн бұрын

Indeed it gives immense optimism tysm

@JohnSmith762A11B 26 күн бұрын

GPT-4 on some risks: "While rejuvenating mitochondria in aging cells holds promise for potential therapeutic interventions against age-related diseases, including cancer, it's essential to consider potential risks and unintended consequences. One concern is the possibility of enhancing the survival of damaged or mutated cells, including those with cancerous potential, by improving their mitochondrial function. This could theoretically increase the risk of cancer development or progression. Moreover, mitochondria are involved in cellular processes related to apoptosis (programmed cell death), which is crucial for eliminating damaged or abnormal cells, including cancer cells. Altering mitochondrial function could potentially interfere with these processes, leading to dysregulation of cell death mechanisms and promoting tumor growth."

@josephboomtv7811 26 күн бұрын

I follow this sort of thing, and mito /aging is pretty general, perhaps you could mention the details of this prospective Japanese study - I’m really interested to know what substance is within the study..

@StevieMoore 25 күн бұрын

I'm skeptical. Very, comically optimistic, about so, so much.

@propeacemindfortress 25 күн бұрын

on a related topic, do you think it is possible to train an ml model to accurately predict the results of genetic modifications without first getting huge amounts of data on directed and random changes to not only further investigate the insane amount of interaction between genes and the wide ranges of effects but to also gather as many data as neccessary to enable the prediction of everything else that could go right or could go wrong. Also asking bcause I would be interest to explore your expectation on the decission making in regarding to get the amount of data necessary in light of the economic, military and scientific possibilities in an technological arms race paradigm. What is your expectation regarding the amount of constraint taken at the risk that someone else will run large scale (and undisclosed or unconsented to) genetic experiments on the population for the greater good and the preservation of ones own economic or cultural peer group?

@Empyish 26 күн бұрын

Is this Japonese science based on the Yamanaka transcription factors ? I read some research like 4-5 years ago, showing full "regression-rejuvination" at the cellular level, but timing of treatment was the major limiting factor.

@Wild_Clash_ 23 күн бұрын

I like the walks in the woods, gives peter Zeihan vibes

@kindaovermyhead 26 күн бұрын

Do you think longevity medication should be open-source? (If that is even possible.)

@sunlight8299 26 күн бұрын

At the end of a recent video David welcomed feedback on whether the video is better. I wonder if there are some details there in the description or comments 🤔

@geordi-gabrielrenauddumoul449 26 күн бұрын

I mean, if it's published it's open source. The means of production is not open source tho. It takes capital to make

@glenthegoalsguy 26 күн бұрын

If you follow the current recommendations on nutrition, health and lifestyle then an individual may live an additional 12 years with good health span, so this type of research seems plausible to achieve for most of us.

@xingzhexin8843 26 күн бұрын

Unrelated comment, what camera/mic system are you using in this vid?

@faizanrana2998 11 күн бұрын

NO COPYING

@joshd265 26 күн бұрын

Great vid!! Love these walks but prefer the wider angle with the background in focus. Getting a bit travel sick with the closeup.

@jamesfehlinger9731 26 күн бұрын

Re: "The heat death of the universe will get you" -- by all means, if you haven't already, check out Isaac Asimov's 1956 short story "The Last Question". The text is available on-line, and there are a number of audio versions on KZfaq. It's a classic, and was recognized by Asimov himself as perhaps his most memorable story.

@davidx.1504 26 күн бұрын

Not to knock the Japanese experiment on mitochondrial rejuvenation, but isn't David Sinclair already working on rejuvinating whole cells/tissues in vivo?

@popothebright 26 күн бұрын

David Sinclair is a career scam artist. I have one word that says it all about that fraud: Resveratrol.

@mrleenudler 26 күн бұрын

Lot's of controversy around Sinclair. Hard to know what's real and what's hype. Both resveratrol and NMN results has issues. Notwithstanding his effort to monopolize NMN.

@markbarks9871 26 күн бұрын

I'm skeptical about Sinclair's motives. I hate saying this, but I think his focus is on profit. I would love to be 100% wrong....and I hope I am!

@jakefields8018 21 күн бұрын

if I could just live to 200 yrs old id be grateful

@Jonnyicey 24 күн бұрын

Im 38 as well, it's amazing how aging catches up with you.. my poor knees 😬

@vincentl2060 26 күн бұрын

we can Buy this Poxel Biotech on french market

@v.zacarovitch928 26 күн бұрын

Can you share how to order it? I am an MD myself.

@weredragon1447 26 күн бұрын

I'm 53. I'd take ten years of life and be ecstatic. 43 is a universe of difference, even if you are active like I am. But 33 or 23? I think I might faint.🎉

@phen-themoogle7651 26 күн бұрын

Hi, I'm in my late 30s but been dealing with autoimmune diseases since my early 20s, so would be awesome to get younger too lol btw, is your icon Yakumo Ran? (⋈◍＞◡＜◍) sorry for random question.

@weredragon1447 25 күн бұрын

@phen-themoogle7651 I believe it is Yakumo Ran. I never played the games, but when I was researching the background for my D&D character, I modeled some of her traits and history. 😁

@Kingkhan-qk2vk 25 күн бұрын

@@weredragon1447im 25 i never thought 50's would be physically exhausting i thought it happens in 70's or something

@weredragon1447 24 күн бұрын

@@Kingkhan-qk2vk 🤣🤣🤣🤣

@kevinedwards7182 24 күн бұрын

Yea, I think maybe in 10 years time we might start to see some benefits. LEV isn't around any corner.

@wedding_photography 26 күн бұрын

Many biological treatments can be replicated very cheaply. It's the research, testing and FDA approvals that are freaking expensive. The actual production, especially on a small scale, can be dirt cheap. As long as the method is published. Overpopulation is not really a problem, we can always limit birth rates with severe fines. One mistake David makes is assuming birth rates will be so close to death rates naturally that the population will plateau. The odds of that are basically zero. Most likely, birth rates will outpace death rates by orders of magnitude. Which means the population will grow exponentially if left unchecked. The benefits however are crazy. Almost nobody wants to die tomorrow, just because their age reached some number X. As long as you're healthy, you should be able to live indefinitely. And yes, it's just biological immortality. If your brain is destroyed in a horrible accident, there's no coming back from that. Other organs we will be able to rebuild. I remember seeing a death calculator that estimated your odds of death from various causes. I think car accidents kill half the people at around 40 thousand years, assuming modern car crash rates. But that can be fixed with AI driving. Heck, I wouldn't mind living 40K years. Much better than the current 75-80 expectancy.

@ThomasTomiczek 26 күн бұрын

"Overpopulation is not really a problem, we can always limit birth rates with severe fines." - you are aware that we just hit peak and population levels are supposed to fall - FAST. South Korea faces a 75% population DROP in the next cycle as their birth rates are 0.48 children per woman. The fix is already in - and we likely expand a lot soon, space wise and then insanity.

@JohnSmith762A11B 26 күн бұрын

It would be great if AGI could end the livelihoods of bureaucrats and speed up the testing and approval of novel treatments. If all AGI does is propose loads and loads of new drugs and therapies with the same old regulatory snail's pace we are not gonna see much useful progress; simply an endless backlog akin to a 700-mile long line at the DMV.

@ThomasTomiczek 26 күн бұрын

@@JohnSmith762A11B Supposedly it already does. Sounds stupid, but there is a TON of statistical analysis and document preparation involved - clinical trials are not what actually determines the outcome, but the analysis of them - and AI is supposedly ALREADY being used in that. There was something about a major medical manufacturer having 750 internal GPT instances for - in many cases - exactly this. The idea of getting rid of many of the beaurocrats and replacing it with automatic fast processes - a dream. Sadly, lot of career idiots there.

@andrasbiro3007 26 күн бұрын

"limit birth rates with severe fines" - that's a horrible idea. China tried something like that, and they got tens of millions of brutally murdered babies. And I'm not talking about abortion, but killing actual born babies. They also got an aging population that is crippling their economy. Banning something that most people really want is a recipe for disaster in general. Like the Prohibition or the War on Drugs. And it's completely unnecessary, birth rates naturally plummet with rising living standards. It's because on a farm children are cheap labor, in a city they are very expensive pets. People are not animals, we understand consequences and able to plan. And it's a vicious cycle. If we choose to have less children, we start to care more about quality, we spend more resources on them, which raises the "barrier to entry" for the next one. In a few generations we end up with less than one child per family. And then we don't even date anymore, there's a fast growing loneliness epidemic.

@dr.emmettbrown7183 25 күн бұрын

11:22 That is an absolutely undesirable dystopian future.

@MasamuneX 26 күн бұрын

even if its 100$ a month anyone making minimum wage would still buy it

@ScottWilliams324 26 күн бұрын

As of the latest information available, Japan has made significant progress in mitochondrial rejuvenation research, but widespread human trials specifically for anti-aging or mitochondrial rejuvenation therapies have not yet commenced. Research is still primarily in the preclinical or early clinical stages, focusing on understanding mitochondrial dynamics, improving delivery methods, and ensuring safety. However, some related clinical trials, particularly those targeting mitochondrial diseases, may be ongoing. These studies focus on techniques like mitochondrial donation or replacement therapies, which are closer to application in humans for specific medical conditions rather than broad anti-aging purposes. The transition to human trials for broader anti-aging applications will depend on the outcomes of current experimental studies, regulatory approval processes, and ethical considerations, especially given the complexity of mitochondrial manipulation.

@laurikorpela5670 26 күн бұрын

Just imagine the amount of responsibility you have to take over your choices when there is no naturally occurring escape from the consequences.

@altagraciaadames3483 26 күн бұрын

David, all you have to do is stay alive for the next 10 years, then you are golden. My new anthem, Bee Gees. STAYIN ALIVE STAYIN ALIVE HA HA HA HA STAAAAYYYYYYIINNNNGGGG AAAALLLIIIIVVVVEEÈ

@Dojimanoryyu 26 күн бұрын

Imagine 200 years mortgage...

@ifrag9215 26 күн бұрын

If I could turn back the time from 60 years old to 30 years old, strangely enough I would look forward to continuing that same job that I say I hate so much. I'm guessing that although I hate my job, I really like my co-workers and look forward to the socialization and the purposes the job brings.

@user-nn4jy9hi1y 26 күн бұрын

Such an interesting perspective

@thebeezkneez7559 26 күн бұрын

I can't find this specific treatment, help anyone?

@aryannaidu5966 4 күн бұрын

Resveratrol is awesome

@josephcler3299 26 күн бұрын

Interesting youtube though it was highly spectative and optimistic in my opinion. 10 years seems like a very short time span considering the glacial pace that medical research normally progresses. But we will see.

@anonymissed3611 25 күн бұрын

There still will be a problem of taking care of elderly/infirm. If not enough births, the problem persists. Its just pushed down the road.

@Freakei 26 күн бұрын

So If this actually Happens (Immortal biological Body), the question is If our brains can keep up. Any neurologist who may chime in about whether rejuvenated mitochondria would also positively affect the brain? I could also imagine there being hidden Interactions Not yet discovered.

@I-Dophler 26 күн бұрын

Great news! Rejuvenating mitochondria is a considerable step forward on the path to a longer, healthier life. Let's hope these clinical trials succeed and get approved worldwide soon.

@ifrag9215 26 күн бұрын

Can you make a video on the new and delicious crops (vegetables/fruits) that will be created.

@deanburke9107 26 күн бұрын

imagine the subscription fee

@InstaxxPOV 26 күн бұрын

Anyone has links to resources regarding the trial he is talking about?

@DaveShap 26 күн бұрын

In the description

@armadasinterceptor2955 26 күн бұрын

Im going to put it out there. Alot of these do called extreme advanced, will not require AGI, just an ability to think, and problem solve with our getting tired, and creatively putting it all together. We are literally leaning over the edge of a cliff with everything we wanted at the bottom, and were only holding ourselves up with a pinky finger, that is getting tired. The age of A.I is the equivalent of every single person on earth having Einstein in there pockets, the potential from that alone, is insane. Were talking about the age of custom tech, were you can design a bot in mid journey, 3d print the parts, and install your desired LLM. This is we are right now.

@JohnSmith762A11B 26 күн бұрын

This is true and interesting, and I agree we can do so much already with simple integration, but even there things are moving so fast right now I think most of us in the tech space feel ourselves unsure about what value we can really add that won't be obsolete in weeks or months. I really wish the geopolitical situation would calm down because we are indeed near to the precipice of an entirely new world.

@Tom_Bombadil3000 25 күн бұрын

It doesn’t matter if the cost of production ends up being zero. They will price a drug such as what you’re speculating about higher than you or I will ever be able to afford, mark my words

@ct5471 26 күн бұрын

What might that mean for someone being 30, 40, 50 … at the time of LEV, or perhaps when this mitrochondria drug is released (at 20 rejuvenation therapies might not be relevant yet, and after that more for cosmetic reasons for a time, after 50 mostly for health/ longevity reasons) . Like all 30 year olds look and feel 20 again, all 40 year olds like 30 and so on? Might it be that the impact is larger for old peoples, like for an 80 year old person it an equivalent of 20-30 years while for a 30 or 40 year old it’s more only 10 or so. Eventually we might all end up with more or less zero self inflicted accumulated molecular and cellular damage (what aging is) and all be 20-25 again more or less for ever, but how will the initial rejuvenation tipping point will look like for someone at this initial point, also depending on his current age at the time. Functionally as well as in terms of optics

@JuanMacrame 26 күн бұрын

I could be wrong, but isn't the mitochondria about energy efficiency, and true longevity about telomeres?

@mrleenudler 26 күн бұрын

Telomeres is one aspect among many of longevity. We either have to find a master control knob, or create a load of different rejuvenation interventions.

@ThomasTomiczek 26 күн бұрын

No. Those are essentially 2 axies you must both fix - supposedly mitochondria and some other low level hanges can rejuvenate the body, but then you still run into the telomere problem that makes cell incapable of replicating at some - WAY LONGER - point. Point is - that is also fixed and, again, I think that is a 150 year problem, not a 90ish, i.e. it hits later. By then... given how we play ow in labs with DNA,.... it likely is no problem in 20 years.

@JuanMacrame 26 күн бұрын

@ThomasTomiczek Telomeres aren't fixed, to my knowledge. DNA can either repair or replicate, and it's the replicate mode that is prone to telomere shortening. The repair mode is better at maintaining telomere length. It's been a while since I've read this stuff, but that's how I remember it! :)

@JuanMacrame 26 күн бұрын

This is why they say you must keep your body in flux: cold/hot, fast/famine, etc. DNA copies in repair mode.

@ThomasTomiczek 26 күн бұрын

@@JuanMacrame We have the tools to do DNA manipulation - and as I said, in 10 years or so it is EXTREMELY Unlikely we have not solved that. Given the the Tolemeres are a longer term problem - we do still have time, as I indicated.

@AleksandrVasilenko93 26 күн бұрын

At this point the FDA should just create an automatic approval process for anything developed inside Japan, South Korea, Taiwan, the EU, the UK, Israel, and Australia. If it got approved by our developed nations peers than it will get approved by us most likely. Why delay?

@Tom_Mroz 26 күн бұрын

Biological immortality is the only solution for achieving environmental care: discontinuing pollution and genuinely prioritizing the protection of Nature. While we often state that we must conserve nature for future generations, do we truly mean it? No, we simply lack concern. We may have a moment of idealism, but ultimately desire material possessions like a new house, car, or vacations to exotic locations that involve travel. We seek new experiences, knowing that death is inevitable, so we disregard the environment. Ultimately, greed triumphs. However, once we acknowledge that the consequences of our actions will impact us directly (since death is not an escape as it once seemed), we will approach environmental issues with the gravity they deserve.

@quaterman2687 26 күн бұрын

I hope we will live it. I studied a second time pretty late and finished with 37. I did not make my PhD because I felt too old and I wanted to make money. If I could live e.g. 1000 years, it would be nothing! You could study whatever you want!

@UltraK420 26 күн бұрын

Right, and it puzzles me when people say biological immortality is a bad thing. Why? Just because the idea of living indefinitely seems boring or meaningless to _some_ people doesn't mean it is absolutely meaningless. I'm looking forward to it. There's also the side benefits of reversing disease like you mentioned. Of course I'm gonna want that! It would be the biggest regret of my life if I never seized the opportunity to live life the way I've always wanted to, like when I was a kid and my time felt meaningful.

@phazerave 26 күн бұрын

kinda wondering, what does a starving person on mitochondrial rejuvenation therapy look like?

@q2w8i9o 26 күн бұрын

10 yrs Wow. I like you ! if I can stop aging at 60 yrs, I'll be happy. Still fit in my 50th. Hopefully, infinty life will come true...

@pandemik0 26 күн бұрын

You should engage your community with questions. What projects would you undertake knowing you would live to complete them? What would you do differently knowing you will live to see the outcomes? Things like that. What would feel different in centuries of life? As a many century year old person returning seeing that tree you planted as a kid, is now a old giant, and a forest has come up of what used to be a field, how would you regard that? We'd sure take better care of our planet.

@Voorhees94sg 26 күн бұрын

LEV in 2030 still sounds like total sci-fi to me and I very much doubt it, but I wish you were right Dave. If your prediction is correct, I will send you some good wine. :D Well, anyway, it's a very interesting topic and I hope you will make videos about it from time to time. :)

@maxxflyer 26 күн бұрын

maybe they referred to telomere? or maybe there is something I miss

@onepunchman4ever168 18 күн бұрын

Love Altered Carbon First Season !!

@vanhillephilippe8868 25 күн бұрын

The delicate question is: is it better to take Sumitomo's medicine or buy Poxel shares, in France....in the first case you may be better, in the second, it will be your financial health which could improve ....!🤑

@jasonp.1195 26 күн бұрын

Other fictional examples which to explore the concept of hyper longevity. Of them Pandora's Star hits closest to Altered Carbon's scenario, though I'd judge it a bit less grim. 'The Gentle Seduction' Short story by Marc Stiegler from 1989. Quite hopeful, core concept of making transitional steps acceptable. 'Pandora's Star' and 'Judas Unchained' by Peter Hamilton (Commonwealth Universe) Longevity via periodic rejuvenation treatments. Lots of perspectives explored in the society. 'Freiren:Beyond Journey's End' (Anime/Manga) Fantasy adventure setting focused on the perspective of a particular long lived elf with no clear limit on her lifespan.

@AtomicSlugg 26 күн бұрын

I'm creating a personal knowledge and emotional database. It'll track how I felt at different points, the reasons behind those feelings, my understanding at the time, and my perspective on things. with LEV in mind, memory presents a challenge. Unless we record everything and utilize a BCI for flawless recall, how much can we truly remember from our early lives? Even if I live to 200, there's little chance I'll retain clear memories of my thoughts and feelings in my 20s, which would be quite a shame, what's the point of a long life if you can barely connect with your past self?

@manslaughterinc.9135 26 күн бұрын

What were the results of mitochondrial rejuvenation in animals?

@TiagoTiagoT 26 күн бұрын

I remember reading about a study a long time ago that found that statistically, the average life expectancy of an otherwise biologically imortal human would be about 500 years, due accidents and such that would at some point result in irreversible physic damage.