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MAOIs are a class of antidepressants and include the drugs isocarboxazid, phenelzine, and tranylcypromine. These drugs are used to treat depression, although they are not first-line treatments due to their side effects and dangerous food and drug interactions. Notably, MAOIs can cause a hypertensive crisis, especially if patients consume foods containing tyramine, like wine, cheese, and processed meats. MAOIs can also cause serotonin syndrome, a life-threatening condition resulting from overload of serotonin signaling. As such, MAOIs should not be given within 14 days of taking any other serotonin-altering drug.
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