Multiple Myeloma has a low Anion Gap…Ever wonder Why?
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Күн бұрынMultiple Myeloma has a low Anion Gap…Ever wonder Why?!
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@LittlePurpleBook 3 жыл бұрын
Fantastic video! Isn’t medicine beautiful? Everything in medicine has an explanation.
@martyapo 4 ай бұрын
In the last 6 years, 6 of 8 anion test have come back low (4's and 6's). Over the same time period, chloride has been normal, wbc trend low end of normal, rbc trend high end of normal, and both total protein and albumin are middle of normal. I'm in generally good health but overweight, prediabetic, and a history of kidney stones. Should I be concerned?
@unniroshan 2 жыл бұрын
Thanku so much for the video... Explained it simple with basics ❤️
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@testos2701 5 ай бұрын
Great and Dandy I think I got it, is that the cure for cancer?
@hajaraks3165 4 ай бұрын
But why the increased M-protien ( which is a cation ) is not added to the equation of unmeasured anion (WHICH INCLUDES DECREASED ALBUMIN) - Unmeasured cation ?
@ThatsWhy- Жыл бұрын
Yes. At first, when the liver is busy in inflammatory producing proteins, the ALBUMIN (anion) will decrease and (HCO3-+ CL-) will go up to compensate. That is metabolic alkalosis where AG is low. At second, when the IgG (cation) goes up, 2 things will appear. 1) when IgG goes up NA+ will go down to maintain electropositivity but this leads to hypovolemic. 2) when IgA (anion) goes up (HCO-3 + CL-) will go down to maintain electronegativity. As a result, multiple myeloma are protein which secret (acids) which will lead to HAGMA later on when hypoxia and even high AG metabolic acidosis which will trigger an instant respiratory compensation hence (hyperventilation) respiratory alkalosis . Later, I am afraid if the drop in Na+ will precipitate Ca++ or Mg++ stones with phosphate in kidney. Why? Because ALDOSTERONE will be inhibited due to hypertonicity but ADH will kick due to hypovolemic but severe vicious cycles of hyponatremia
@drketanpatel6401 3 жыл бұрын
First i liked video and then start to watch the video, because i know video will be awesome as always........
@arshadhussain8797 3 жыл бұрын
👍...pls make videos on bone marrow transplantation and x rays,ct ,mri, histopathology slides interpretation...thanks
@MedicosisPerfectionalis 3 жыл бұрын
Thank you so much for letting me know!
@knzay 3 жыл бұрын
thanks king
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@quintonkettell5436 Жыл бұрын
Question (27M) - I have an anion gap of 2 - Chloride is 109 - normal albumin - Is this worth investigating? Platelets have been steadily dropping since 2019.
@thewholetruth5473 Жыл бұрын
A published review found that out of 67,000 calculations of anion gap, a low anion gap was calculated less than 1 percent of the time. Within this small percentage, *_over 90 percent of the results were due to laboratory error in calculating one of the electrolyte values._* Clinical Journal of the American Society of Nephrology 2(1): p. 162-174, January 2007. So settle down.
@Missauthentic716 Жыл бұрын
I’m not a pathologist but I love this video.
@MedicosisPerfectionalis Жыл бұрын
I appreciate you os much, Stacey! I am a big fan of people who like learning!
@allaboutmovies4821 3 жыл бұрын
But if that's the case chloride is being used so not increasing burr decreasing
@MedicosisPerfectionalis 3 жыл бұрын
I am afraid I didn’t understand!
@aspencooper8495 7 ай бұрын
I had on my urine test abnormal below average anion, could that mean that I could have the disease multiple Myeloma? How can you test for this?
@MedicosisPerfectionalis 7 ай бұрын
This video is about the serum anion gap. Urine anion gap is a different concept.
@heatherscancerjourney Жыл бұрын
My anion gap is 0 and high globulins and low white blood. I just finished chemo 4 months ago. I haven’t got my m protein result yet this month but my total proteins jumped and are high . My RBC are in normal limits .
@janetgonzalez3064 10 ай бұрын
Does this mean you still have cancer?wht was your m protein result?
@heatherscancerjourney 10 ай бұрын
@@janetgonzalez3064 yes I was only in remission for 5 months and I’m going through treatment now and a stem cell transplant in December. My m protein was 3 g/dl this time abd it went to that in a month
@christyschmelz884 Жыл бұрын
Anion Gap is 2, chloride is 109, and WBC is 4.5 (has been decreasing for 8 months). Your video answered some questions and now wondering if multiple myeloma is a possibility
@thewholetruth5473 Жыл бұрын
Probably you should ask your doctor. When you do, please let us know.
@thewholetruth5473 Жыл бұрын
A published review found that out of 67,000 calculations of anion gap, a low anion gap was calculated less than 1 percent of the time. Within this small percentage, *_over 90 percent of the results were due to laboratory error in calculating one of the electrolyte values._* Clinical Journal of the American Society of Nephrology 2(1): p. 162-174, January 2007.
@christyschmelz884 Жыл бұрын
Albumin was low as well, doc doesn't think there is a problem.
@ghaffarkhalili5801 5 ай бұрын
Mine the same you does your doctor told you anything? Can you share
@glitterysweet 3 жыл бұрын
Medicine makes sense when YOU teach it. Thank you!
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@UnviversalLaw33 Жыл бұрын
So i have normal albumin level but zero anion gap no diagnosis anyone can help
@thewholetruth5473 Жыл бұрын
A published review found that out of 67,000 calculations of anion gap, a low anion gap was calculated less than 1 percent of the time. Within this small percentage, *_over 90 percent of the results were due to laboratory error in calculating one of the electrolyte values._* Clinical Journal of the American Society of Nephrology 2(1): p. 162-174, January 2007. Also, maybe you could see a doctor and ask them if you have questions about your lab values. That could probably be at least as helpful as asking random people for medical advice in the KZfaq comments. Just saying.
@WhyTheHorseface 4 ай бұрын
My anion gap is 4. Am I dead?
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