Multiple Sclerosis - B Cell Depleting Medications - Q&A
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Күн бұрынIn this video, I answer YOUR questions about B cell Depleting medications to treat Multiple Sclerosis.
The Boster Center for Multiple Sclerosis is accepting new consultations and actively enrolling several MS clinical trials. www.BosterMS.com or call 614-304-3444 to schedule!
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COMMENT with your thoughts and questions below! I look forward to reading and responding!
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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS to help educate others. These videos do not provide medical advice and are for informational/educational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!
@kkaci5 10 ай бұрын
I’m a new person taking Kesimpta. I’m doing better than I have in 10 years. It’s remarkable! Heat intolerance, fatigue, cognitive issues and energy much improved. And super easy dosing. Many in group doing better than when on O. I’d love to know why!
@321joback 10 ай бұрын
I think, personally, it's just less load for our bodies. Like, carrying 100lbs all at once vs carrying 20lbs 5 times. It's why I went with K, it just makes more sense
@Jerusalem_Warrior 10 ай бұрын
I know from experience why some of the people on Kesimpta may be doing better than those on Ocravus: I'm on Ocravus, and around 1.5 months before my infusion, I guess my wayward immune system starts coming back to life and I feel like 💩. After that, it's ANOTHER month till I get back to myself. I guess that this phenomenon wouldn't occur if my doses of B cell depleater were given regularly, once a month. Makes me consider switching to Kesimpta as a solution to the "crap gap", because Lord knows my new neurologist has been turned down by the insurance for anything else she's tried to prescribe. Food for thought. Thanks for asking.
@klburke 9 ай бұрын
@kkaci5 That's great to hear! I just started Kesimpta and will take my third shot of the initiating dose series tomorrow. Thank you so much for sharing!
@atanamorell2 9 ай бұрын
Glad it is working well for you! I am just switching from Tysabri to Kesimpta and am hoping it also works well for me. Thanks for sharing your experience and best to you 💕
@amomaba5763 4 ай бұрын
@atanamorell2 hey hope it works out well for you. May I ask what made you switch from Tsyabri from Kseimpta?
@eileensmollen8641 9 ай бұрын
My mother has been treated with Rituximab and chemotherapy when she was 78 and had Non-Hodgkin (cancer). After the chemo she still was treated with Rituximab for a period of time. She had no side effects of this drug. Maybe this helps to get a more positive opinion about this succesfull treatment with this drug, bc she is now 92 years old.😉
@giorgismama8024 Ай бұрын
Thanks for sharing this with us! I am glad your mom had positive results! May she continue to live a good life! Blessings!
@RenEBerry. 9 ай бұрын
Thanks, Dr. Boster! Very informative as always. I appreciate these videos. I’ve been on Ocrevus five years, but will be de-escalating or stopping. My compromised immune system, including very low IgG levels has caught up with me. In the hospital right now for the third time this month with severe covid pneumonia and organizing pneumonia that keeps progressing. I am very grateful for the five years on Ocrevus. Other than this final infection, it has been a wonderful DMT for me. I don’t at all want to scare people. I would do it all over in a heartbeat.
@RenEBerry. 9 ай бұрын
I’m on my way to a full recovery now. Yay!
@CypeltResortAustralia 10 ай бұрын
I’m on Ocrevus infusions. It’s a day in out patients here in Perth Western Australia. I go in for the day, every 6 months. I’m one of the lucky ones. It’s my 1st meditation and we have seen lesion shrinkage. Absolutely fabulous results! 😊
@sourenamehr6087 10 ай бұрын
I am in Perth too and use Kesipmta. Very easy to administration and super effective it is also on PBS
@martinm8991 10 ай бұрын
Another perfect dose of highly relevant and useful information. Thank You very much, Dr.Boster
@glitterwheels 10 ай бұрын
On kesimpta and this video just reminded me I really need to do my blood tests! going next week.
@silviopoggi8193 10 ай бұрын
I am in my 70's and was diagnosed late onset PPMS and was put on Ocrevus with great results, no new lesions, shrinkage of existing lesions, and no problems of secondary infections of any kind. Blood tests were always fine. Dr. retired, new doctor will not let me continue Ocrevus because of my advanced age. Furthermore, trying to find a neurologist willing to even speak with me about returning to Ocrevus infusions is impossible. I have called multiple doctors with the same response - not taking new patients (never mentioned but I'm sure a deciding factor, age). I am now beginning to see accelerated deterioration in my walking and strength. Last MRI showed the possible beginning of new a new lesion. Angry, doesn't begin to describe my current outlook. Sorry for the rant. Wish I lived in Ohio!
@pamscott1321 9 ай бұрын
Who that is unbelievable that 0 is was working so well and your doctors won’t continue with what’s working. I was well take O and it working just fine for me. Maybe you could find a doctor out in a different area from where you live. I hope you get the O you need maybe try contacting your Medicare and your insurance provider and see if they can help you. I wish you well and prayers.
@klburke 9 ай бұрын
That's horrible. It's ageist and cruel. I am so sorry this is happening to you. It's inexcusable. Rant away! 🫂❤
@Terricharmedackles 10 ай бұрын
I’ve been on Kesimpta for 6 months. Really hoping that it works for me 🎉
@margauxpeck9975 9 ай бұрын
There’s a rumour swirling on one of the Facebook support groups for Kesimpta that taking probiotics is contraindicated for anyone taking a B Cell depleting DMT. Meanwhile, probiotics seem to be recommended generally for those with MS for improving the microbiome. I would love to know your thoughts on the issue.
@themilkman7367 9 ай бұрын
what is their reasoning? considering there are more bacteria in your gut than cells in your body, therefore this seems like a rumour.
@martinallenuk 10 ай бұрын
I'm waiting to move over to Ofatumumab. Can't come quick enough.
@aarongray503 10 ай бұрын
It's great
@HacquardGMMS 10 ай бұрын
Thank you, Dr. Boster!!
@cloressagoldson7518 10 ай бұрын
Happy Monday and thank you!❤
@colleensmith3374 9 ай бұрын
Thank Dr Boster for this community
@hackett1181 10 ай бұрын
Excellent information!! Thank you!😊
@jackielavelle7974 10 ай бұрын
Thank you, Dr. Boster~😎
@kharrison7629 10 ай бұрын
Thank you for this information.
@arthurmiller9103 10 ай бұрын
Incredibly enlightening Thank you Doc Be 🙏well
@mistycross3844 9 ай бұрын
I just started Kesimpta just a little over 3 weeks ago. I'm already seeing a big difference!
@colleensmith3374 9 ай бұрын
I hope you have success with Kesimpta! I have been on it for 1-1/2 years since my diagnosis. Thankfully, I can still do most everything I want to do from before diagnosis. I was diagnosed at 54. I do try to prioritize sleep and exercise and eat well even though I love sweets! Cutting out dairy & much gluten makes me feel better. I don't really drink alcohol much anymore and it's good. Lots o & lots of water and yoga too help me. Also, very important to keep stress as low as possible. love from Colo
@kelliebutler24th 10 ай бұрын
I just started my first brumvri on Saturday and I'm going back to get the booster on the 13th
@lshinkle5 5 ай бұрын
Is funny you made this video, I was just thinking about this very subject, our blood tests. My MS sister or brother had my same thoughts it would seem! Thank you Dr. B 🧡🧡🧡
@FUMSvideos 9 ай бұрын
I’m about to start on Briumvi. I’ve been on Vumerity and have a new lesion and 2 old lesions have grown significantly in the last year so - we’re changing meds. Ugh. Here’s hoping. 🤞🏻
@jeanpetrillo6038 9 ай бұрын
Very timely video! Thank you! I had been on Ocrevus for 3 years. Dose changed to every 5 months due to crap gap. Thought I would try Kesimpta, because it was a B cell depleter and seemed so much easier. Big mistake. Feel like I’ve fallen into the crap gap continuously for the past few months. I’m switching back to Ocrevus next month. I know these meds have not been studied head-to-head, but has your anecdotal experience been that patients do about the same? Thanks again!
@stonz42 10 ай бұрын
Thanks Dr. B! I've been on Ocrevus for a year now and it's been great for me. I got my second full infusion 10 days ago at the faster rate, but overall still took 4 hours. All of my symptoms went silent within a few months after the first infusions and I didn't have much fatigue during the "crap gap" before my last infusion (I did before the one 6 months ago). If BTKs show similar efficacy and safety, I'd switch as a long term plan to restore my full immune system and eliminate the infection risk factors. Can you post a video discussing the current state and prospects of BTK inhibitors?
@ntaliantalia7448 10 ай бұрын
Can you please make a video on the -so called- "inverse vaccine" which is under trial..?
@bubblegumbitch 10 ай бұрын
was about to ask the same thing would love to hear his thoughts :)
@lemonpeelangelfish 9 ай бұрын
Thank you Dr Boster excellent informative answers to some great questions from the fabulous MS community. 🔥🔥💖🔥🔥
@AaronBosterMD 9 ай бұрын
Glad it was helpful!
@paulahall1700 10 ай бұрын
I will be receiving the Riabrii in a week or so. I have received Rutuxin but that was before the pandemic. Out of caution I did not receive any since 2020. I am 67 y/o and what my neurologist described as “ an outlier). I as diagnosed at the very beginning of 2018.
@desiredecove5815 10 ай бұрын
Great information Doc- these answer a lot of questions I’ve heard. #Sharingiscaring
@AaronBosterMD 10 ай бұрын
Great to hear!
@pamscott1321 9 ай бұрын
Ditto
@user-kt4yb5gb7o 10 ай бұрын
I'm on teciferda now
@brendadouglas4868 12 күн бұрын
I was taken off Ocrevus after my first full dose, because I had diarrhea for more than 4 months following that dose.
@MysticalDreamFire 10 ай бұрын
Ty for letting explaining this! Helps alot! Question: how about surgeries and taking these meds? I ask because I'm taking Kesimpta and I probably need a hysterectomy
@JaimeIngram 9 ай бұрын
He answers that question in this video at 10:28
@sarahtexasyall 10 ай бұрын
I have MS, Trigeminal Neuralgia, Chiari Malformation (Surgery 2012) and Addisons Disease. i had plasmapheresis to start. Then multiple hospital stays for Soli-Medrol within the last year, i was on Tysabri for 8 months & continued to develop lesions. I just had round 2 of Ocrevus & im Praying it works..I went from being at the gym to in a wheelchair within a year. 💜
@colleensmith3374 9 ай бұрын
I hope and pray that Ocrevus works very well for you! love from Colo
@jswanson1272 5 ай бұрын
Hugs I’m a zipperhead as well 2020
@sundaisycake3372 2 ай бұрын
I took my first Briumv B shot and had minimal side effects like chest tightness, muscle soreness. And 10 days into it, I am feeling extremely tired, fatigued, and even more muscle soreness, but I noticed it wears off the more I rest. Then the full 450 mg dose is in two weeks. 🙏🏼❤️
@Bonny-Coco 9 ай бұрын
Thank you for these very informative videos. My son (35 years old) was diagnosed 2 years ago with MS. Ocrevus has been a miracle. He has had no flare ups while on it. Previous medications did not work. At his last visit his neurologist said if his anitbodies drop lower, he will have to come off Ocrevus. She did not tell us about the infusion of IvIg antibodies so he could stay on it. We are very scared of trying a different medication, as others did not work. Should we find a new doctor in light of her not giving us all the choices you explained?
@deel2435 9 ай бұрын
You have a printing press!
@vaske5753 9 ай бұрын
What do you think about the clinical trial that suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients? Would be really interesting to cover this as well
@christinefarmer5938 9 ай бұрын
Hey Doc! Urgent, important QUESTION: Are you going to address the unspoken but obvious change you've made??? The big metal Brain Games toy over your shoulder looks like an interesting conversation piece...😉 Excellent topic!!
@Veestar88 10 ай бұрын
This is appropriate to wake up to, I just spent most of last week in hospital after a really bad reaction to Kesimpta and was told I can no longer take it. I’ve been wondering if I’ll be able to take any of the B cell depleters or if I’ll have to switch to a different type.
@Annenigmatic 9 ай бұрын
If it turns out you can't take them, I really recommend Gilenya
@johndeaux83 9 ай бұрын
How far along were you on it?
@freethinkeralways 9 ай бұрын
I'm so sorry... What kind of reaction put you in the hospital if you don't mind sharing?
@mbl36 10 ай бұрын
PPMS. Can't take ocrevus due to having breast cancer, 2018.
@charlesvan13 7 ай бұрын
My medical insurance has been switching to the B-cell depletors. I asked my doctor if there was any difference in efficacy between Ocrevus and Rituxan and he didn't think there was. He seems to think Ocrevus was developed to cash in on the success of rituximab, which is much cheaper, being a generic.
@justinbrady9502 10 ай бұрын
Kesimpta holds my cd19 level at 0, but ocrevus only held the number at 0 for around 4 months, so it wasn’t powerful enough I’m assuming. It seems I need the monthly treatment regiment.
@christydavis6114 9 ай бұрын
I was on Ocrevus for 2 years and went into secondary progressive MS, switched to Kesimpta. Had to miss 3 months of it due to an initial hospitalization for an MS flare with a fever, they treated the fever as if there was an infection, as I would expect (I’ve been a nurse for 30 years), 2 more hospitalizations after that because the initial hospitalization they gave me strong antibiotics which caused CDif, then I had a rebound case of it which really messed with my MS. Been on kesimpta for about 1 1/2 years, this was my first big flare. I know Ocrevus and kesimpta are the newest meds out there . Are there any new meds, that show promise, coming soon for secondary progressive?
@freethinkeralways 9 ай бұрын
So sorry... Oh my! You are going through a lot! I got side effects + rate reactions from every DMT I tried before Ocrevus became available. Now I'm thinking I'm better with my original MS dx vs. all the potential side effects of new meds.
@sewlovemydogs 10 ай бұрын
My neurologist has asked me to research and consider the bi annual Ocrevus infusion, after a recent MRI shows two new lesions on my spine since the last MRI three years ago. Looking on Google, the good, the bad and the ugly has become very confusing. For the most part it seems to have some very nasty side effects - which is a bit disconcerting. I’m currently taking a daily Gilenya capsule which has been very effective in stopping the yearly relapses I was having while on daily Copaxone injections (and a far more pleasant way to fight MS). With Gilenya I’ve only had one relapse in several years and was surprised to hear of the new lesions. Could you please share your valuable experience with what to expect and the scenarios you have witnessed. Thank you for all you informative videos, it’s wonderful to hear your no nonsense and learned opinions. ❤
@sewlovemydogs 10 ай бұрын
P.S. I live in Australia so may or may not have access to all that is available in your country.
@ecarlson4987 10 ай бұрын
If you have new lesions then the drug is not really working.
@ScottyRosencrance-dq4pj Ай бұрын
@@ecarlson4987no it’s not. I’ve been on 5 DMTs and failed at them all but Lemtrada has me at over 8 years. With no treatment. Since 3 days at the end of year 1
@johnr4510 9 ай бұрын
Hi Dr B - Is Kesimpta more humanized also? and is it tolerated as well as Ocrevus?
@user-kt4yb5gb7o 10 ай бұрын
❤❤❤good morning
@thigmotrope 9 ай бұрын
RE: colitis - my guess is that it's not as uncommon as stated. keep in mind that no IBD patients were a part of the Kesimpta (another CD20 antibody) clinical trials. not only does ocrevus now have a warning (thankfully) but Therapeutic Advances in Neurological Disorders published guidelines for treating MS and other autoimmune disorders in 2021 specifically stating to avoid cd20 antibodies for those with IBD. I spent the last eight weeks in pure hell because of that contraindication. definitely not worth it, more neuros need to understand the risks for their patients that have IBD. I know that wasn't the original question. I think the original question was talking about the risk without IBD, but I can't help make this point.
@aineoloughlin 10 ай бұрын
Hi Aaron, at a later Q and A session, could you address Ocrevus infusion times. I am on the IV drip for approx 8 hours because my body can only tolerate a full doze at a certain speed. I get dizzy, nauseous and have blinding headache despite having taken pain relief and an antihistamine before the infusion as well hydrating and eating throughout the process. Is this something I should be concerned about? Does it mean I am not tolerating through drug? I had a similar reaction with Rituximab.
@Jerusalem_Warrior 10 ай бұрын
Sounds like it means you do lousy on infusions in general. I'm also always telling them not to speed it up. 😏
@jbell987 10 ай бұрын
So if O has less infusion reactions, do you think O will be used in place of R for cancer chemo treatments?
@paulahall1700 10 ай бұрын
Correction it’s.Riabni.
@sandyhebert3613 9 ай бұрын
Is this anything like IVIG treatments
@amiraheikal193 10 ай бұрын
Next month is my second dose of ocrevus, but I feel so tired these days. Is this normal? Will these symptoms disappear after taking the medication? Thank you
@gwensimpson4448 9 ай бұрын
Mavenclad depletes B and T correct? Only 2 times a year.Have you had any good luck with this?
@Sharla1213 9 ай бұрын
Will I turn into Mighty Mouse?
@sundaisycake3372 2 ай бұрын
😆 thanks, made me laugh
@spacecat2195 Ай бұрын
😂
@zaraobscure 10 ай бұрын
(From Montreal) Hello Aaron. I'm on Ocrevus infusion (every 6 months). I would like to know why I must wait 4 and a half month after the infusion, and 1 before the next one, to receive a vaccine. And thanks so much for your videos and such useful information :)
@Fishbone8891 10 ай бұрын
I had this question as well and what I was told pertains to the the actual B-cells. Most vaccines function from a B cell response, meaning that the dead virus that's injected via vaccine needs B cells to generate antibodies against that virus. So when you are taking a B cell killing medication, you don't have the B cells in your system to create the antibodies, meaning the virus has a lower efficacy. I'm on Ocrevus as well and this was the simple answer and understanding I have of the situation. Hope this helps!
@Harold_Blackwell 9 ай бұрын
I recall he did a video addressing that specific question previously. He should have that video on his channel.
@zaraobscure 9 ай бұрын
@@Fishbone8891 Thanks :)
@Sharla1213 9 ай бұрын
How long do I have to wait after Covid to start Rituximab? Nervous.
@dawaunsmith8134 10 ай бұрын
I take teridlumide what does that do? I tried ocrevus had a reaction
@NYNC88 10 ай бұрын
All my MS symptoms were much worse in the days after my 2nd half dose of Ocrevus. Should I expect this every time I get Ocrevus? It's very difficult to deal with.
@Jerusalem_Warrior 10 ай бұрын
No, no, you'll get used to it and your future infusions will surely be tolerated well. Best wishes from Jerusalem!
@2009gameel1 10 ай бұрын
WHAT ABOUT IF QUANTIFERON IS WEAK POSTIVE , CAN I START OCRIVUS?
@ranakhouja9315 10 ай бұрын
Please can you tell me if i can take Rituxan instead of Ocrevus ? ( i have primary progressive ms )
@ScottyRosencrance-dq4pj Ай бұрын
Rituxen isn’t approved for PPMS
@veselafilipova6788 10 ай бұрын
Witch medicine would be compatible for JC virus?
@pamscott1321 9 ай бұрын
Ocrevus that’s what my neurologist put me on when I was diagnosed in 2020 because I was positive for JC. O has worked wonders for me. I wish you well…!
@rowenahibler7372 9 ай бұрын
❤
@taracostanzo5198 9 ай бұрын
Question: if lemtrada is an IRT by killing b and T cells, such that only 2-3 doses are needed in most patients, why are the B cell depleters not also considered an IRT, such that they need to be taken indefinitely? What’s the difference?
@ScottyRosencrance-dq4pj Ай бұрын
I don’t know but Lemtrada is the most badass treatment In my Drs opinion(The Dr Aaron Boster 😊) Ocrevus and Lemtrada have had the best patient results. Hands down. I’m at 8 years of no treatment after doing Lemtrada No new damage of any kind. After 20 years of progressive disease course, I’m officially in remission, 5 years of no treatment and no disease progression
@cherylterrell3199 Ай бұрын
I’m scared because I’m jvc positive and neuro recommends Briumvi ,PML risk?
@falconwarrior7306 9 ай бұрын
Wow I've got frickn mouse protein in my system 😢smh man this sooo gross I've got progressive multiple sclerosis had absolutely no idea what I was being injected every six months
@spacecat2195 Ай бұрын
😂
@michelleburns168 9 ай бұрын
What kind of human portein??
@Sierravernee87 9 ай бұрын
Hello, what do you think about TYSABRI?
@ScottyRosencrance-dq4pj Ай бұрын
He has many videos talking about his fav 5 DMTs and videos on Tsabri
@Serifair 10 ай бұрын
And where are they getting these “human proteins”?
@josephvered3991 9 ай бұрын
Hi from Israel as usual interesting data I hope to have more information about taking vaccinces during taking treatment to theMS especially on Tysabri and Ocrevus thanks what is the best time to get them
@homespunluxury 4 ай бұрын
If Rituxan is a cd20 depleter, then why isn’t it checked in blood work? My cd19 is low (zero), but cd20 isn’t even checked. Cd16, cd56 above normal. Others normal and IGG and IgM normal. It seems strange these other CD types are checked, but not cd20. Is there a reason for this? I don’t care if answer is “nerdy.” 😂
@rx6389 10 ай бұрын
🔥🔥🌄🔥🔥
Dr. Chanu Dasari, MD (@DasariMD)
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Aaron Boster MD
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Aaron Boster MD
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