Myosin and actin | Circulatory system physiology | NCLEX-RN

Myosin and actin | Circulatory system physiology | NCLEX-RN | Khan Academy

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14 жыл бұрын

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How myosin and actin interact to produce mechanical force. . Created by Sal Khan.
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Пікірлер: 110

@fleshcookie 12 жыл бұрын

Ive came up with a pretty good analogy for this process 1) Think of myosin head as the firing arm of a catapult: this is when myosin head is sitting in the actin filament 2) Then, put the ammo in the catapult, which weighs the firing arm down a bit: The ammo being the ATP, which changes the SHAPE of the myosin 3)Next, cock the catapult,similar to loading a slingshot takes ENERGY: This is when ATP hydrolyzes to ADP+ENERGY (again changes shape) 4)Fire the catapult:Release the Phosphate group

@stephanieclarke6647 9 жыл бұрын

Thank you Khan Academy, for without you, I would not pass Nursing school.

@allikay4263 5 жыл бұрын

Stephanie Clarke THIS

@deryan3364 4 жыл бұрын

I am at nursing school right now and khan academy is more helpful to me than my teachers at school

@ken_vvin 8 жыл бұрын

You guys need to relax. This isn't an easy subject to begin with and Sal did an awesome job at explaining this. If this whole myosin and actin thing is confusing you, watch his next video about tropomyosin and troponin and it'll make much more sense.

@leftright6479 13 жыл бұрын

Wow, I wish I had just watched this video instead of going to class today.

@randomstuffswithrrd 4 жыл бұрын

Wow you made this comment 8 years ago I was in class 6 then

@nachotoast 4 жыл бұрын

Boi do I have news for you

@nadurtha8536 8 жыл бұрын

This is one of my favourite topics of A level biology as you are looking at a fundamental level and it explains how ATP is actually used rather than just learning how it's made (Respiration).

@zaphodbebblebrox7560 3 жыл бұрын

The hardest part about anatomy is visualizing organic processes in a different orientation than what you learned it in

@hamidsaber3121 4 жыл бұрын

Perfect as always! Thanks indeed! BTW I really think your beautiful voice sounds like the voice of Anthony Bourdain!

@froodyartbooks 11 жыл бұрын

These videos are so incredibly helpful. I can understand stuff here immediately. Keep up the good work.

@gmane1531 11 жыл бұрын

Very helpful helped me to clearly see what we have been talking about in class, thank you sal

@SoulReviving786 3 жыл бұрын

Lots of love for khan academy

@11spatel 13 жыл бұрын

I wouldn't understand anything of what my Bio Professor is trying to "teach me" without your help in this video - definitely sharing this with all the classmates I have so that we actually UNDERSTAND for once. Thanks so much!!

@trinipat64 13 жыл бұрын

Well done Khan!...LOVE the way you teach this. I appreciate you writing out EVERY letter...this shows me step by step what you're thinking and doing. I learn best this way. Keep doing it this way- Don't change a thing- everyone else loves it.

@vanillabliss45 10 жыл бұрын

This was so helpful to watch. I didn't really understand much about actin and myosin when my biology professor lectured in class, but this was so helpful. I have learned so much.

@bariatasudan 14 жыл бұрын

thank you so much for all the help......I didn't know where to start and where to finish up until last night I watch the entire video on membrane transport...thank you thank you. your a great teacher!!

@benjaminsayers2293 6 жыл бұрын

Cheers Khan, I find the muscle physiology section of my sports science degree a lot easier now.

@differentstringspodcast 10 жыл бұрын

Thank you! I actually get this now.

@micaelaolivier4180 11 жыл бұрын

These videos are helping me pass biology :D thank you!

@yasmeenkhan8803 8 жыл бұрын

Thank u so much......it was of great help.....

@Existential_Exit 10 жыл бұрын

thanks bro I have a huge biology test tomorrow and this helped so much. But you should also talk about calcium's role in muscle contraction too.

@fleshcookie 12 жыл бұрын

Remember this is muscle contraction, flexing your bicep for example. Think of it when your at full flex of your bicep, myosin is near (but not touching) the end. then when your release your flex, myosin returns to its initial position

@beardownchitown 11 жыл бұрын

I don't know if you're an actual college professor or not, but you should be. As everyone has been saying, you have taught me more in about an hour of watching your videos than I have learned in hours of lecture and hours of studying.

@ludmilamanna612 8 жыл бұрын

Was shown this in class today :D Nice video. (Unfortunaly, none of the smaller sketches could be seen from far away XD) I think it would be even better if you could show some animations. It's a bit hard to imagine the process with still pictures.

@syume16 14 жыл бұрын

awesome video!!! really good for reviewing before test! :) Thanks!

@ABuddhaB 13 жыл бұрын

You saved my life, again. Thanks !

@kostaskiriakidis2892 5 жыл бұрын

hell yea bro!!Totally understood! thanks!

@BlackGhost574 11 жыл бұрын

Really nice presentation :D! helped me with my report your awesome man thanks!

@sal-nr6jt 11 жыл бұрын

I can see clearly now. Thank you sir.

@daythink 13 жыл бұрын

totally understand, very enjoy for your explaining ,thank u so much

@mdmetodiev 14 жыл бұрын

fantastic! can't wait until the next video comes out!

@Lorena-mr4qz 6 жыл бұрын

Salll yay i havent heard one of your own lessons in soo long

@campr723 11 жыл бұрын

Is there anything that you have yet to master Sal? All kidding aside, your videos are absolutely wonderful, and very helpful. Thank you so much. -A Molecular Biology College Freshman.

@loganlowkey6044 5 жыл бұрын

Phillip Dalessio from STCC brought me here, and I'm glad he did.

@Andorianin 11 жыл бұрын

Brilliant videos!

@Duncanpulse 11 жыл бұрын

You have no idea how much this helped me with a biology assignment. thank you

@rudytan2914 3 жыл бұрын

wonderful reactions: adenosine triphospate to bind with adenosine diphospate plus phosphate group to cock with the high energy to produce the actin was the best reaction the myosin when bonded.👬👥👊😂

@samsalla2381 5 жыл бұрын

Very good video Sal. Thank you

@vipansharma8337 3 жыл бұрын

These videos are very much helpful for me to crack NEET🙏🙏👌👌👌😁😁😁😁😁👍👍

@feisalalrubaei9157 7 жыл бұрын

you're amazing !

@chipchocolate2718 10 жыл бұрын

Thank you sir

@mistershe4688 4 жыл бұрын

I was on the Khan Academy website but i just had to copy url to come here and give it a like.

@longbelao 10 жыл бұрын

Great video!

@greendayy710 11 жыл бұрын

Thank you!!!

@destineydavis8999 2 жыл бұрын

Glad I knew the mechanics before watching this. You know exactly what you’re talking about, but the way you portrayed it has deff evolved through the years. The drawing and clutter was a bit distracting here

@kinleywang3109 5 жыл бұрын

step 4 ADP released is also called the power stroke.

@orbsandtea 14 жыл бұрын

Awesome! I still have a question though... What happens when the myosin has crawled to the tip of the actin? :/ Thank you for any help! :)

@randomstuffswithrrd 4 жыл бұрын

You're intelligent

@nadinchees 13 жыл бұрын

you just saved my chances of passing my exams!! thanks

@EclipZeMuzik 6 жыл бұрын

wonderful work!!

@orignialsounds9364 3 жыл бұрын

11 years ago this came i was in middle school Now im in 1st year of med school watching this

@yujeissi 13 жыл бұрын

Love how you simplify the topic my putting into simple steps.

@rudytan2914 3 жыл бұрын

Good explanation sir. You're definitely the best professor or even better than a school dean. 😂👥

@decemberdolphin1 12 жыл бұрын

r u a bio professor? my teacher has been trying to teach us for weeks what you taught me in 9 mins....idk if u r awesum or if she is just bad at teaching, but yeah! I LOVE your vids they r sooooooooo much clearer!!!

@ThePurpleWasteland 10 жыл бұрын

Finally..! a nice simplification of the cross bridge cycle!

@stellasmammacita9028 10 жыл бұрын

Thank you so much. Your videos are so extremely helpful.

@red619619 14 жыл бұрын

last years ap essay question was on something like this. Muscle contraction. Actually how atp is used throughout the body. well awesome vid.

@eleanorpr328 7 жыл бұрын

Why does the myosin release the actin when the ATP binds to it? I study physics, and this is on my biophysics course, Im worried its for a biological or chemical reason that I have missed

@brendenshea1312 2 жыл бұрын

Khan academy, keeping county jail inmates entertained on their tablets since 2014

@stephenvastardis8720 5 жыл бұрын

I love Sal Khan.

@marcosalamanca8742 7 жыл бұрын

Awesome video. Just a quick question. What happens when the muscle "relaxes"? This lecture explains beautifully how the myosin "pulls" the actin filament, but I think after step 4 something should happen to bring back the myosin head to the initial position. Let me rephrase it. I think if the cycle ends in step 4, the muscle will be in a state of "Perma contraction". Am I right? Sorry for bad english, I am no native speaker and started to approach the subject just recently. Thanks a lot ;)

@thedisintegrador 7 жыл бұрын

Yeah, I am having the same question. Maybe it just slides back, given that there is tension in the muscle

@thedisintegrador 7 жыл бұрын

well, apparently he explains in the next video :D

@deliads5377 11 жыл бұрын

if u were ma lecturer for each course i'm doing i'm sure i'd graduate wit first honors!!!!

@Ellything 12 жыл бұрын

really good explanation but im just bad at science & i still sort of don't get it =\ but i understand all of your math videos so still thumbs up to you sir ! :3

@haddadelizabeth 10 жыл бұрын

Cool!!!!!!

@skylethon1170 10 жыл бұрын

(please clear my doubt) Where does the myosin head get the ATP molecule from? Thank you very much SAL for this awesome video

@vitalyievlev9692 8 жыл бұрын

He said depending on how we view it, its either actin pulled by myosin or myosin "walking" along the actin. he also said there are thousands of myosins "walking" on every actin filament. if the myosinsare are not synchronized, that means some of them at any given time will be constraining either actin from sliding along the myosin filament or vice-versa. its like when you trying to pull something when somebody is holding it. if you guys know what's going on, can you explain?

@mastermo666 8 жыл бұрын

+Vitaly Ievlev they are synchronised

@vitalyievlev9692 8 жыл бұрын

+mohammed shatwan, he specifically mentioned that if they were all synchronized they would all detach from actin at the same time and the actin filament would move back. it's like a stretched spring.

@devianbomb 12 жыл бұрын

Outdone yourself

@brittanyrenae100 12 жыл бұрын

I agree

@SalmanKhan-uv8tu 4 жыл бұрын

I'M very weak in physiology sir give me idea that what should I do

@kleihasanaj9689 12 жыл бұрын

but how myosin goes to the first place at actin molecule? because is one way movement, and myosin will get to the end of actin with a few reaction

@fleshcookie 11 жыл бұрын

Sal, I always think your right, and i think your right right now. But, my Anatomy and Physiology textbook sites that ADP and Pi are released simultaneously.

@hussainahmed8117 7 жыл бұрын

How to download these informative videos???

@deliamalone 13 жыл бұрын

@CherryPi420 #1--the guy has almost 2,000 videos a free information so maybe he doesn't have time to script everything perfectly #2--people need time to absorb ideas, process them and put them in our memory. If everything was written out this video would be like 2 minutes and you'd have to watch it like 10 times to absorb it.

@Andy-km1xp 6 жыл бұрын

Delia Malone true

@susan7363 9 жыл бұрын

kind of confusing.

@KellyACrawford 10 жыл бұрын

Please help cure Dystonia. Maybe were not producing something so our synaps are not fireing. So much info and no one can figure it out. Maybe its caused by a bacteria no one can detect.. and I found out nerve 4 in the brain can't be seen.. it seems so simple. All it takes is to get them foreign again. And when you have a focal dystonia a few years later another shows up. Help!

@GoldenP51 12 жыл бұрын

@passikg his other videos cover that

@GBart 11 жыл бұрын

Intertwound?

@hatoridenzo6685 8 жыл бұрын

hello all please could anyone tell me what program is he using making this explaining video ?

@jackiexiong5120 8 жыл бұрын

+Hatem Kaabi Khan Academy

@hatoridenzo6685 8 жыл бұрын

jackie xiong thnx alot

@KellyACrawford 10 жыл бұрын

Could a bacteria stop one of these functions?

@annasdr4780 6 жыл бұрын

Nikkel Farm yes

@stewartbrands 3 жыл бұрын

You mean chemical energy to mechanical work.

@VoteRohan4VP 6 жыл бұрын

The AAMC is getting more than enough money to be able to sponsor a basic animation for this. Idk why we dealing with two google search images...

@joerandom9489 8 жыл бұрын

I still don't understant how chemical force is transformed into mechanical force to drive the heads to walk specifically. Could anyone explain step by step please? For example,a car engine is that piston pushed by fuel explosion push the crank to produce torque or a jet engine is that fuel mixed with pressed air is burnt to jet to produce backward force.