While two-dimensional cell studies and animal models provide useful information, they fail to fully replicate the complexities of human biology. In rare cases, they even miss lethal toxicities. One horrific example is fialuridine, a hepatitis B medication that killed five study participants in 1993. Preclinical animal models failed to catch the drug’s effects on human livers.
Emulate Organ-Chips are designed to better replicate specific biological microenvironments, so the cells behave like they do in the human body. Organ-Chips can include tissue-tissue interfaces, blood flow, immune cell interactions, microbes, and mechanical forces, providing a more physiologically accurate model to better predict human response.
This video is presented by Geraldine Hamilton, former President and Chief Scientific Officer at Emulate.
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