A description of the pKa and why most drugs are weak acids or weak bases.
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@poojajoshi40136 жыл бұрын
My search for understanding pka ph concept ends here...thnks
@NaDa-vv4nu2 жыл бұрын
+11111
@mattpace4334 жыл бұрын
Current med school student. That means I have had to learn this concept over 10 different times over the years. AND FINALLY! I found an amazing explanation and i clearly understand it. Thank you so much.
@fishribbon8 жыл бұрын
I am an old fan of this man (I like his videos on pharmacology) I like his face: He's like - 'Take it easy, man'
@iBuyBitcoin4 жыл бұрын
This guy is amazing, he genuinely cares about teaching the material
@ahmedassadi92273 жыл бұрын
Trueeeee
@ahmedassadi92273 жыл бұрын
I really need to hug you man, I can’t believe pka is just so simple, my doctors couldn’t get this straight up my head for weeeeeks
@ludyoviedo41215 жыл бұрын
Omg finally I understand this concept. Thank u sooo much
@animeshmisra94674 жыл бұрын
Looking beautiful 😍
@yadabk83783 жыл бұрын
Wow you must be a genius
@supernovachampions6 жыл бұрын
thank you so much for posting this. i am in crna school, and they lecturer was explaining pKa with the assumption that we had a strong understanding of chem - for me that was 10 plus years ago. you put things into plain english for me. i also appreciate your practice of equanimity as you teach.
@Pharmapedia6 жыл бұрын
Thank you! Had to actually google equanimity :) My main youtube page is PHRM203. Pharmapedia is a format experiment.
@yash929512 жыл бұрын
This man explained in less than 10 min what my professors couldn't do in 2 hours.
@andijayy90082 жыл бұрын
the fact that i now understand this in 10 minutes whilst my prof has been trying to explain it to me multiple times the last 3 weeks… THANK YOU
@danamay90814 жыл бұрын
It makes so much sense when you explain it what the hell.. It has taken me months to understand this and I could've just watched this vid to begin with
@myyoutube51574 жыл бұрын
I understood this concept after 5 years of my graduation here thanks Dr
@elsalynn98238 жыл бұрын
Hallelujah! Thank you so much!
@beaono89973 жыл бұрын
loved it. A whole day of class...could have watched this 9min video...
@UtobivbiOghenetega Жыл бұрын
After hours of trying to understand pka, my clarity is actualized.
@yogeshlakshman84882 жыл бұрын
I am very grateful to your way of explaining to the basic understanding
@dhandapani9870 Жыл бұрын
Thank you so much. You’re such a blessing
@DavidSmith-dl2yr6 жыл бұрын
By far the best presentation I have seen on this, thanks!
@harshbirsingh47414 жыл бұрын
i am confused about protonated and unprotonated form🤔
@falakjamil35656 жыл бұрын
Impressive !!Cleared my confusion :) Thnks a ton and stay blessed :')
@doctort.moahmed6459 ай бұрын
This is my second time I saw this video and it's excellent ❤❤
@Random248532 жыл бұрын
Where’s Woody, Taylor, and Kyle?
@paimanehjoohari73914 жыл бұрын
Thanks for these simple definition, I had problems with these elements, but now I understand that, again thanks a lot
@k8reed Жыл бұрын
Thank you so much for sharing your video!
@vibackup3 жыл бұрын
Very good video, just one error at 1:47: HCl is _not_ a white powder, it's a gas above −85.05 °C (−121.09 °F; 188.10 K).
@hannes_mlbx9599 Жыл бұрын
Classic Taylor
@glaydleicaro2562 жыл бұрын
Very clear explanation. Thank you Sir!
@DylanHart8 Жыл бұрын
Kyle really thinks he’s some kind of pharmacist now just because he took little acid.
@ASHTUTORIAL5 жыл бұрын
Best video...thanks sir...great...no words to explain ur teaching clarity
@sabrinadream91782 жыл бұрын
Very good explanation sir
@joycebritto81113 жыл бұрын
excelente explicação. Aprendi mais por aqui do que assistindo em muitos outros vídeos. Grata!
@graceusa39424 жыл бұрын
Great teaching, thank you so much.
@JN-kk4nk Жыл бұрын
this was very clear ! thanks
@priyarajeshanepla94654 жыл бұрын
Thank you so much for explaining it in the best way possible!!
@Lostpanda1237 жыл бұрын
Great explanation and a great tutor!
@elvinahandini6456 жыл бұрын
omg your videos saved my life many times :') thankyou so much
@jalaluddinnasim83286 жыл бұрын
Elvina Handini Can you explain,why most of the drugs are weak acid or weak base? In the video I found that it is because small change is required to shift between ionized or non ionized form But I don't understand how?
@elvinahandini6456 жыл бұрын
Most drugs are weak electrolytes, may be weak acids or weak bases. In water, this weak electrolyte will be ionized into its ionic form. For weak acids, a high pH (base atmosphere) will increase its ionization and reduce its nonionic form. In contrast to weak bases, a low pH (acidic atmosphere) that will increase its ionization and reduce its nonion. Only nonionic forms have fat solubility, so only the nonionic and ionic forms are in equilibrium, then after the nonion form is absorbed
@jalaluddinnasim83286 жыл бұрын
Elvina Handini,so,they are weak acid or bases,but why are they not strong acid or base?what is the benefit of that?
@elvinahandini6456 жыл бұрын
Drugs that are weak acids will easily penetrate the cell membrane in the acidic atmosphere. Because in an acidic atmosphere, the drug is relatively unionized or the ionic form is small enough to penetrate the cell membrane more easily. strong acids or strong bases will be easily ionized which is cannot be penetrated to the cell membrane.
@user-si7sk4iz2c3 жыл бұрын
@@elvinahandini645 thank you ❤️
@hajernt7833 Жыл бұрын
Amazing
@harshitagaur63946 жыл бұрын
Thank you sir...so easily explained
@jazewang35433 жыл бұрын
This guy is the best!
@minabish17833 жыл бұрын
Thank you very much
@vibehealth682811 ай бұрын
God bless you
@RomajaneAbrenio5 жыл бұрын
This is a really good video. Thank you, Sir! 💓
@steveharris17404 жыл бұрын
Humm, this is "basically " (haha) acid-base equilibrium.
@sainidhi56173 жыл бұрын
Finally understood it.... Thanks Alot!
@Simran-jd4wi2 ай бұрын
Thank you man ❤
@fredred4764 жыл бұрын
awesome vi. subscribed, thanks!
@trickjacko84824 жыл бұрын
Thank you
@johnmiller3236 жыл бұрын
I understand the concept now... thank you so much
@jalaluddinnasim83286 жыл бұрын
William can you explain why so many drugs are weak acid or base,not strong?
@jyothishk75574 жыл бұрын
Thanks for the video.❤️❤️
@damemochi33226 жыл бұрын
Quick question. In the example with aspirin, when it's either in the acidic (HCl) or basic solution (NaOH), does it COMPLETELY dissociate into its respective lipid/water soluble form since aspirin is a weak acid??...or is it more so that in an acidic environment aspirin is MOSTLY lipid soluble while in a basic environment aspirin is MOSTLY water soluble?
@Pharmapedia6 жыл бұрын
GREAT QUESTION! I googled it and came across this. www.ausetute.com.au/aspirin.html They show complete dissociation. But your question is not only outside of my clinical knowledge base, it is outside of the point I want to make. Most drugs are weak acids or weak bases because change in pH change their water solubility. This is an essential concept for drugs that cannot be mixed in the IV lines. So running a drug through a piggyback running normal saline as the maintenance solution can cause that drug to come out of solution and form particulates if it is incompatible with the pH of the maintenance solution. Major med error issue in some hospitals. Hope this helps. Thanks for the great question!
@marceloovg18735 жыл бұрын
Suppose you have a closed system like the beaker shown in this video, with a finite amount of plain water , you measure ph and it comes at 6.5, and then you add say 1 gram of powdered HCL and it completely dissociates , it gets the pH of the water to an acid 4, then you add 500 mg of Aspirin (pKa is 3.49) what will happen is Aspirin will slowly dissociate (slowly because the pka is very near the current total solution ph which is 4) until the pH reaches more/less 3.49, then at this moment roughly 50% - 50% of the aspirin will be in the uncharged : ionic (charged) form and right here it will stop dissociating. how much of the aspirin will dissociate? 90% ? 10% it depends how much quantity of it you added , if 500mg was enough to donate enough aditional protons to the already acid solution then ir will stop right there, if not, it will keep dissociating until it reaches the thermodynamic equilibrium constant and will stop dissociating and keep at 50% - 50% no matter how much more aspirin you add it will not lower the pH more. thats what pka means.
@ED-ez8yd Жыл бұрын
So legit. Thanks.
@dane30308 жыл бұрын
This helps a ton, thank you.
@drsheikh6 жыл бұрын
FAN-tastic.. Thankyou so much
@TMTeeandEmm-uc6si10 ай бұрын
From galala University thank u ❤️❤️
@pain_is_ultimate3 жыл бұрын
Nice
@arshithgowda87282 жыл бұрын
Oh god finally i understand thank u sir 🙏🙏🙏
@naghmeazadi82948 жыл бұрын
It really helped.thanks
@thaslima86883 жыл бұрын
Thanks a lot completely clear
@dojrajkhanal94175 жыл бұрын
Will the same case be applied to phenol?..just like for aspirin?
@syedataliahaider65783 жыл бұрын
thanks to u i understood the concept
@JC-xk8vh2 жыл бұрын
The 33 dislikes are 33 Professors that couldn't explain it any better.
@mithunvb6854 жыл бұрын
Thank you boss!
@ThePedroCordero6 жыл бұрын
It helped me a lot...I couldn't understand this shit from books! Thanks a lot!
@MrKrishanpatel8 жыл бұрын
Amazing video and explains everything very clearly! Thanks
@aizayy36582 жыл бұрын
Om gash Thanks Love ❤️ u🤧🤧🤧🤧🤧🤧
@jaskaur78858 жыл бұрын
Thank you so much!!!
@olalaolala44008 жыл бұрын
thank you so much ❤️
@yoaimou9798 Жыл бұрын
I love u man
@netspirit793 жыл бұрын
"Hydrogen chloride is a white powder" - WTF?
@Peace-fo1vx4 жыл бұрын
thank you
@sameraahmed71567 жыл бұрын
amazing
@iqrabuzzamanshoumik32845 жыл бұрын
Thanks
@6sixFace3 жыл бұрын
0:22 That's Based.
@robertamorgado69084 жыл бұрын
thank you!!!!
@RenasAb5 жыл бұрын
Thanks 🙏🏻 ❤️❤️
@lukehe86637 жыл бұрын
Thanks!!
@abdallarohi54296 жыл бұрын
such an intelligent guy👍
@brittanym13264 жыл бұрын
You’re going to get me thru school
@zainjafry26584 жыл бұрын
thank you for make so easy
@artherdoland10505 жыл бұрын
thanks
@luvurenemies61274 жыл бұрын
Well, let's take this assidic solution, similar to the asssid in our stomachs. Let's put an ASSSSspirin in. This proton wants to come off the aspirin. BUT IT CAN'T. WHY? because of proton mass AACCtion! ...watever u r having, i need it XDDD
@jeevidhabalasubramaniam23414 жыл бұрын
Sir y does that substance release the proton instead of releasing electron.. since electron in the Valence is easier to remove than the proton in the nucleus...@0.10 min
@RahulSharma-ew5zp4 жыл бұрын
Jeevidha Balasubramaniam h+ ion is considered as proton
@RahulSharma-ew5zp4 жыл бұрын
Acid base concepts are based on h+ and oh- and not on electron
@dp-mason3 жыл бұрын
Woody looks really different
@himanshudutt51624 жыл бұрын
HCl is white powder??
@damntravis6056 Жыл бұрын
RSK
@keeskruithof11235 жыл бұрын
HCl is at atmospheric conditions a colourless gas. Painfull to eyes.
@pricilladisuang16903 жыл бұрын
I completeeeelyyy understand nowww
@collinsulanja33334 жыл бұрын
💪👌
@countrysafari2308 жыл бұрын
#Pharmapedia Thank you for this amaizing explaination. I am confused about quinolones, how do they have good absorption from gastrointestinal tract despite that they have a carboxyl group at position 3 and amine group at position 7 which will make them ionized in acidic as well as basic fluids ?
@BrandonSLockey8 жыл бұрын
vielen dank
@saurabhbhansingh26116 жыл бұрын
Thank you sir it's was really helpful
@smokecurl94374 жыл бұрын
Nice lecture. My personal favourite Pharmacology channel is: Dr. Junaid Asghar. Have a look at this topic there and thank me later.