Great explanation!! I've found many of your videos extremely helpful during my studies. Just wanted to thank you for that and know that it is appreciated.

Thank you this is truly excellent, you are a great teacher!

I've been watching your whole GI series at 1.5x speed to review for my exam next friday, and so far it's going great! Thanks so much!

fabulous explanation and great video! so interesting :) especially where you mentioned about the sympathetic function.

Great lecture very helpful. Thanks !

Greetings from Germany, your video is far better than every german video on KZfaq. I am studying animal science and we need this knowledge as well :)

Excellent, thanks Andrew

Thank you so much sir for this video , i wouldn't have understood if it wasn't for you .

Clears out many gaps jn understanding 👏 helpful !

thank you sir , very informative and easy to understand .... keep doing the good job

Thank you Mr.Andrew :))) i love it

Brilliant Explanation. This helped me tremendously

excellent video mr.wolf, ı have been investigating the gastrointestinal motility for a long time, ı am a medicine student, ı have some questions; if there isnt slow wave potential in smooth muscles, wouldn't peristalsis be? what is the importance of slow wave potentials?

Good stuff professor! thanks. Question: CNS, parasympathetic via vegas is only involved to extra stimulate the interneurons that otherwise function normally on its on? If there was a lesion to Vegas right at the entry point to the GI it wouldn't stop peristalic reflex? Thanks - Med student.

amazing explanation, thank you so much, so is it safe to say that in the fasting state the GI motility is generated by cajal cells, and in the fed state stretch receptors will stimulate the postprandial GI motility?

this explanation helps tons! thank you

brilliant explanation.

Great video thank you so much!

great video, very thorough!

Thanks so much! Great explanation!

Outstanding lecture!

This was so good! Why so few views?

You are amazing ! Thank you very much ^^

thanx.god bless u....

i love this

Very clear explanation!

great job there keep it up bro

Good overview of the topic... Thanks

thank you soooooooooooooooo much!

helped a lot!! thanks!

Hi andrew, thank you for this great video. Could you possible go through the churning ontractions in the GIT as well? That cause mixing of the food, especially in the stomach

thank you so much for the video sir...

Thanks for this video....sorry to ask but could you perhaps explain the pelvic muscles coordination for defecation?

great lecture :) but i have a question that if there is no external stimulation like if there us no food or chyme in the GIT, will GIT produce spike potential ?

Do you recommend any book for licence certificate of hematology? thank you

Thank you for the video !! I have a question about Cajal Cells. What I understood from lecture is that Cajal cells are constantly producing slow waves and they are NOT action potentials. Therefore, we can infer that a hormone or Neurotransmiiter is going to have no effect on slow wave amplitude and pattern?

You make me feel such a paralizedcperson of knowledge

too good..but isn't myenteric plexus situated in between circular and longitudinal muscle layers? and 1 thing i wanna understand is- the slow waves r generated in cajal cells,and how r they transmitted to the muscle fibres? is it like cajal cell to muscle cell?

Very well explained ))

very good video, but i have a question? the longitudinal muscular layer is the external layer and the circular one is the internal, thats what i had unsderstood, from the book of pathofisiology mcphee

You rock Mr.Wolf! But I got one question... How do the circular muscles infront of the bolus relax? I mean what's the mechanism? Thanks.

BEAUTIFUL 👌🏻👌🏻👌🏻👌🏻👌🏻👌🏻👌🏻

nice explanation . thankyou very much. i have one question, by which enzymes or receptor or factor circulatory muscle and longitudinal muscle's contraction happen ? thankyou in advance ..

Hi! Thanks for this amazing video thus i have a question about the contraction and relaxation in the circular muscles during peristalsis, which neurotransmitters are used? What does VIP?

Lecture is very helpful

Thanks you 're fantastic

Thanks for the Vid But Let me ask if i got this correctly: 1- Sensory receptors relays to MYENTERIC plexus( upon Stretch or chemical acting on them) 2-.. the Interneurons of'' Myenteric Plexus'' Relay send '' Efferent'' Signal to Smooth muscle for contraction . 3-At same Time Cajal Cell are doing their thing with BER up and down spike,(slow Rhythm contaction ) , that are NOT enough to create Action potential but can make it easier by allowing Hyperpolarization state 4-the Afferent Signal Coming from the ''Myenteric Plexus'' , will Cause Threshold Crossing (In hyperpolarized state ) leading to Action Potential-------> Causing Smooth muscle to contract. -------->Leading to peristalsis ? All Above is Done Purely withing the ENS '' Enteris Nervous system'' however the CNS can act via Parasympathetic ( Acetylcholine ) as stimulatory and inihibitory via Sympathetic (noerpinehphrine )? Sorry for such a Long Question , But there are very few good sources that can explain what you did :) Thanks Again.

Please give me hope. I have airway reflux as a consequence of damage to vagus nerve from a virus. Can it be reversed? Should i take acetylcholine supplements? Thanks.

Some sources say that the longitudinal muscle relaxes above the bolus, allowing it to stretch, but you mentioned that it contracts. What are your comments on this?

How longitudinal muscle contraction occur and pushes the bolus forward

How do you start peristalsis once you lose it due to pain injury disease Etc?

Nice Video

circular mus. is the closest to lumen i think there is a mistake

great!

Sir, I have an doubt.....Is peristalsis an involuntary or reflex action ?????

thanks

Thankyou

1. excellent i have already liked it on the icon side 2. minor revisions recommended - a) the slimy Jamaican English accent could be changed, b) not a semi-audiobook, coz i don't want to be seeing the videos whilst hearing to his good english

thank you,but you are not showing details.

we are hollow worms :D

Its called syncytium…

Great video, but worms are NOT our fucking cousins thank you :)