Can you do a video on TMG and B12 other supplements that lower homocysteine? Since these supplements and other supplements used to lower homocysteine increase serum methionine and methionine restriction is one of the few proven ways to extend life in many species, I wonder whether these supplements are harming us. So many people are taking them.

This was a great video. I hope you'll get a chance to look at how much is too much. There are countless articles and videos about the importance of exercise and muscle mass and strength, however almost none of the oldest people I've met ever had particularly high muscle mass. It feels like at some point the increase in muscle might become a negative factor, and I've seen some articles that found things like people that run too much or lift weights too much tend to lose some of the benefits of exercise. However for some of these I've met paywalls and haven't been able to find a satisfying answer.

The study "Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults" did not do regression analysis of nutrition, stress, or sleep. An alternative explanation of low muscle mass being associated with low lifespan is that muscle is an excess, after the body has taken care of other metabolic requirements and damage repair. A fancy car may be a sign of being rich, but buying a fancy car won't make you rich. It will do the opposite. The study also defined low muscle mass using definitions of sarcopenia. Those who train cardio, body-weight exercise, weight training, and even walking will all not fit this definition, so the study doesn't support Peter's weight training for longevity hypothesis. Weight training may be reducing lifespan, compared to other activities. Low muscle mass wasn't significantly correlated with lower lifespan unless adjusted for BMI. Which could mean fatter people, have lower relative muscle mass. Excess fat is caused by poor nutrition. Poor nutrition causes lower lifespan. Or excess fat is caused by excess toxins, so the body has a place to store them, meaning the fat is good but the toxins are the problem. Or Also the study said that sedentary time was not significantly associated with all cause mortality, meaning exercise does not help longevity at all, according to this study. One proposed explanation in the study is that muscle mass is a metabolic reservoir to withstand disease. An equally likely explanation is that muscle mass is a metabolic sink that causes disease. Or muscle mass is a excess cholesterol sink that wards off disease. This study is the roshak test of studies, in that you can see any explanation you want to see but it isn't prescriptive. If there are any interventions studies that involved specific kinds of exercise on older adults, and measured lifespan, especially if they were placebo controlled, would be interesting to see a video on.

Can you do a video on the long term effects of sauna use on testicles and low testosterone? Nobody has talked about the potential negative effects of sauna. Some male health influencers who jumped on sauna frenzy all ended up with TRT. Peter Attia recently disclosed his total T is 381.

👍👍

No thumbs up or down. Videos with more views would naturally go to top of lists by algo.

​@@jmc8076yeah sure you're the expert

Indeed!

Double pump ⛽?

Thanks for mentioning this. I thought the risk becomes negative.

There are no such thing as 200% decrease, only increase.

​@@VivungisportThat's what's he saying...

yes true - think there was a mistake there.

Maybe he meant %p?

He looks very weak whereas Attia is strong and muscular 😅... he has myopia as well at a very early age....signs of nutritional deficiencies

Thanks - I work hard to make sure the titles are enticing, but the content delivers. I’m thankful you see that.

And both kinds of exercise is good, I should think. Your heart is a muscle too, after all… but he definitely convinced me about strength training! Now I have to get to work on it! 💪

The thing is before 70 or 80 you have enough / excessive strength to do almost anything. When you get below some treshold, you cannot do things. There are also confounding factors relzted to muscle mass, because mm is kind of flamboyant organ not every body decides to have. A lot of things need to be in order to have it. Hormones, dietary protein and micronutrients, physical activity, enough recovery, low/managed stress. So if people go to 70s with those things out of order and also they have no skills/motivation to make them right, this all leads to sooner death.

I try to work my muscles til tired and tender about 5x a week. Lots of 10 min exercise vid's, A 10K walk with 13.5 lb dog as a weight once a week. She's elderly and won't walk far. day after that, I nap instead! lol. Rest of the week I go round th (20 min) block 2-3x a day. Sitting, watching TV, I work my arms with 2K weights (4.4 lbs). I'm 71 and can out-exercise my friends in their 40's. Keep t fun and easy so you'll keep doing it. Feels so good I crave it! I do red light therapy at Planet Fitness and the 10 min massage bed for recovery benefits.

Another one I should cover.

@@Physionic definitely 👏

In my opinion, the term "all cause mortality" should never be employed in isolation. Clearly, there is never an absolute decrease in mortality. The phrase should only be used in conjunction with the time frame as covered in the research under consideration. No increase in all cause mortality over a 3 month study has completely different implications from no increase over, say, a 3 year study.

@@johnkellett2893 As a math/stats guy, I tend to agree. BUT, as a KZfaq viewer I've learned to be less pedantic about the little details and try to absorb the context and meaning of what's being shared. Also I sometimes need to remind myself that YT is a global village of sorts, and the best communicators are those who can use simpler language and concepts that is easier for things like machine translation. As for ACM...I see it being used everywhere as a stand-in for "risk of you dying from something, somewhere". No end date on that. So I am often shaking my head when someone says, "using X is associated with a 12% decrease in all-cause mortality in men". OK. ACM against what control, and over what time (for starters)? The "control" appears to be the "average guy who lives to 78; the average woman to 82". Or something like that.

Thank you, David.

why havnt you been searching on your own?...why do you wait for others to tell you what to believe?

​@@jadezee6316 Two assumptions, neither of which are correct.

Me, too!! We’re all aging as we speak. I wzn

I think that would be a fair argument, Nikk.

Why not both?

@@mstr293 because I believe preserved mobility is the reason strength factors into longevity. While upper extremity strength is great too, lower extremity strength ultimately is what will preserve your mobility into old age.

@@mstr293 Most people do. I'd say, most sports require a bit of both, even if a little dominant one way or the other. Even skateboarding which one would think is all lower body. If you dip your board, you have to catch yourself. And of course, your flailing your arms around trying to balance and such. You learn to move your whole body as one. But without a solid upper body, if you DO fall and we all do, then the upper body strength, balance and such definitely comes in to play...firstly, you can catch yourself. Secondly, you can brace your fall (which I've had to do a few times when I did fall off my skateboard). I'm a bit older now but still ride my Penny skateboard around from time to time. It's definitely risky learning to skateboard but once you have it down pretty well, it teaches you not only leg balance, situation awareness, reaction time and such, but it also teaches you how to deal with a split second "oh crap" moment...and oftentimes, you are using your upper body...it usually starts with arm flailing...but if you hit a pebble, your using your upper body for positioning. And if your going down, your bracing (or trying to grab a tree maybe ;). Definitely an overall amazing longevity type sport (I'd say similar to skiing). I think the best part other than helping with balance is that split second reaction training you get when dealing with an actual body-in-danger situation. I know I went a bit off topic...but I did have a family member once go to fall, they tried grabbing the TV and it broke...they managed to be ok, possible by bracing the TV. But honestly, it's not always the pure strength aspect. If you have really good body kinetics, you could grab that TV and know how much pressure and such is needed to not only not break the TV but not pulling it down on yourself and having it break your fall appropriately. I don't feel this is actually fully a strength thing here when it comes to preventing injury, but I do feel the muscle mass protecting against health markers is a real phenomenon and is, to a point, equally as important for falls and such but body awareness is very crucial and that transcends strength.

@@jeffschultz4168 They’ve looked at lifelong endurance athletes that did not train strength and they were no different than sedentary folks in the strength domain. I wonder how you might separate body kinetic awareness from strength as many endeavors like gymnastics will have a strength component. Maybe skateboarders/surfers. Not sure what supply of elderly ones we’ll have for a while though.

Thank you, Christoph!

If that is completely true the men should live longer than women. Clearly strength is important and working on that is key.

@@mpoharper I wonder how much of men dying before women on average is their propensity to take more risks that end their life early? Also, grip strength correlating with longer life could work for both sexes if it is based on the average per sex (I'm not sure if this is what it meant though).

@@travv88 I think estrogen is protective. You look at heart disease risk; it starts later for women. Perhaps risk also plays a role. All we know for sure is each of us will eventually go. Women are strong but in a way that differs from men. I have much better lower body strength than my husband but he has me beat in upper body and grip strength. I think the key is to keep working on strength as we age. You feel better and look better.

Get a grip! Lol.

@@jamesbyrne9312 😂😜

Yeah, well the bodybuilding thing is because all of the substances they abuse to have such muscle mass.

I can guarantee that study did not look at natural bodybuilders. For all we know enhanced bodybuilders are protected by their muscle mass from some devastating affects of the copious amounts substances they take (often not taken as wisely as they could otherwise be too).

Absolutely. See the pinned comment. One of the variables accounted for was physical activity.

The causation can also be the otherway round. Unhealthy people are not able to move a lot and that is why there strength is low. Also after illness the elderly cannot bounce back to where they were, hence sarcopenia. Sometimes this happens even to the younger (long covid etc. )

Right on man. I am 56 and started lifting when COVID shut down the climbing gyms. Used to lift in my early 20’s. Really enjoying the strength workouts.

Shoot for the middle and lift a 50 pd weight, say, for 5 to 10 reps and it will do you more good than a single rep of a heavy weight or lots of junk reps on a too light weight. You are only secondarily lifting to burn energy at the gym. You are lifting to provide a stimulus for your muscles to get bigger so they burn more 24/7 and provide sinks for blood glucose etc.

@@billking8843 Thanks for the input... While your advise may be good for a young person with time to spare, my view is that the "training" aspect of muscle care is far more important than the "bulking" aspect -- especially for those who are very young and just starting out and for those who are fighting against the trials of old-age. The research Nic points to seems to support my view, in that longevity is supported more by trained muscle then by bulked muscle, and either is better as opposed to couch-potato muscle. Additionally, it is my experience that muscle based glucose banking is far more effective in higher repetition exercises like running than in power exercises like lifting; with such perhaps being just based on time. Anyways, join us in the growing conversations on Nic's site; great stuff!

Body building for extreme bulk, is not the example. Think of a lean well rounded athlete

See latest video , where over training with strength.resistance lessens many benefits except diabetes. Which makes sense muscles grab sugar . But useless bulk muscle mass outside of PR in gym or comps - is more tissue that can get cancer, more stress on a heart getting older , less energy for immune system , less recuperation time , more ocd behaviour etc . Calenthistics - strong lean body mass gets all the benefits with less downsides - with proviso plenty of rest. VO2 max is also quoted as great indicator of life expectancy . But again as we age you can to get VO2 you need HIIT to boost it - tradeoff to get it high , may not be worth it . Pushing heart too much with little though, or while fighting an illness can cause heart problems - namely atrial fibrillation. So get your muscle up and then work on maintaining strength . When older 80/20 rule 80% light cardio to intense , warm ups and warm downs . Listen to your body , fighting a flu - rest up - see folks with long covid -one cause was not resting . Plus increase risk of injury. Stay hydrated - when older muscles may let you know you need a break with twitching etc , go from intense to light or stop with warm down . Plus high strength to lean muscle mass , least stress on joints , with huge reserve to squat , lift , carry etc . Also work on movement , control, balance, flexibility I understand those running marathons at 80 may want that sub 3 hours - their choice, just know pros and cons for older heart . Don't see many weight training channels showing downside , just hey this is best way for max big muscles like that's the wonderful end goal . TBF the average gym goer is not ending up with big muscles . as needs crazy dedication plus don't think most people want crazy arms , or thighs that affect everyday life - like walking normally , buying clothes

@@fitcwebb Jack LaLanne is the best example I would guess

​@@user-yl7kl7sl1gguess who will end with very low muscle mass? The people who didn't want to have much muscle mass...and they lose more as they get older

First off. You are using the extreme as an example - that does not make sense comparing to a normal person. Elite endurance athletes risk ending up with too big hearts even though their cardiovascular health was peak during their younger years. Secondly we dont have have a blue zone combined with lifting weights, which could give even better results than what we are seeing in those zones. thirdly disease and genetic disposition is also a thing, people living longer in blue zones could be a combination of genetics and diet, rather than diet alone. As a conclusion I would argue that you are wrong to say studies differ from real life observation, because you dont know all the co-correlations in real life observations.

Well said.

It's possible. I think that's why he mentioned that they are associative. Nevertheless, that it is possible does not mean that it is as you say, it could be that higher strength really reduces risk.

Thanks, Jonathon - hope you've been well!

Thank you, Simon!

Thanks, Cheryl!

Thanks! 😃

The muscle runners pledge: "Less than 3 miles per day, then the muscle will stay".

@@travelguy1564 i run 25+ miles per week. 4 times- 10k each.

@@richiprosadmistry414 If that is what you want to do, then keep doing it. Four runs plus two resistance sessions plus a rest day might work for you. But nobody has more than four intense sessions a week of anything so with 4 X 10km runs, your resistance sessions couldn't be too hard.

@@billking8843 thanks. I agree. I need to make more effort on resistance. I feel it.

Try doing body strength exercises, you can take a break while you're running to do them. Resistance fans are also wonderful, use them while you're watching TV or you can take them with you anywhere

I'll take it!

​@@PhysionicI have a bias for bridges and handstands.

@@markaguilera493 Used to love the idea of handstand push ups, been decades since I did them. I can't do them with out a wall at 61, but often toy with the idea of putting them back into workout rotation. - Cheers

Didn't drink tea? teas are one of the healthiest habits there is! I include ginger, green tea, cinnamon, oolong, dandelion...the list goes on almost endlessly. Coffee's also a life extender.

:-P

Thanks, Jeanie!

😝

I plan on covering cardiorespiratory fitness, as well. Yes, calorie restriction is no doubt a factor, but if you want to optimize health and lifespan simultaneously, having high strength and high cardiorespiratory fitness are the better goals. If a person wants to just extend life, regardless of the quality of life, calorie restriction might be better (I need to look into this more), but there are consequences to being in a calorie deficit 'indefinitely'.

I would need to read some more literature on it. I don't feel educated enough on the topic, yet, Mitchell.

Any compound movement and routine that includes some form of progression will do. Better keep things simple and concentrate on improving on the few exercises you do.

Anything that builds your strength is good. Also do cardio!!!! Very important to do cardio! 😀

Great to hear!

Thanks, Paulo!

Watch til the end... :)

@@Physionic oh that was you? LOL fooled me. You did good. Not annoying :)