6 Health & Aging Supplements (and What I Avoid)

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7 ай бұрын

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References:
Video & Studies on Creatine: • The Muscle Supplement ...
Video & Studies on NMN: • I read every human NMN...
Video & Studies on GlyNAC: • Anti-Aging through the...
Video & Studies on Curcumin: • Curcumin: Some should ...
Video & Studies on Omega-3s: • Does Fish Oil (Omega-3...
Video & Studies on Collagen: • Does Supplementing wit...
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#antiagingsupplements #antiaging #agingbackwards

Пікірлер: 780

@Physionic 7 ай бұрын

*1 AMENDMENT & 1 NOTE* NOTE: Some people seem to be under the impression (and upset) that the ratings offered are based on how these supplements impact a person in their thirties. This is incorrect. The ratings consider the totality of the evidence to date, and are not low or high because they relate less or more to someone in their thirties. I added a few personal points of why I don’t take certain supplements, but me not taking supplements has no bearing on the rating. Please listen to the video when I say the ratings are based on the evidence at hand. I say it multiple times and offer context. AMENDMENT: @7:46, I say the rating is out of '10' - that is a mistake, it should be 'out of 5' - I misspoke. My bad for the confusion! Before people ask: this is not an all encompassing list - next year I'll add to this list after I've read more research. 😄

@szlagtrafi9115 7 ай бұрын

Jesus Christ, I may be dead next year. And I'm not joking, I have major problems.

@szlagtrafi9115 7 ай бұрын

Please, only one joke per video :).

@arrowtreewood6836 7 ай бұрын

I thought 2 out of 10 is a euphemism for 1 out of 5🤣🤣

@ballabingoaug9533 7 ай бұрын

There is a high pitch ringing sound that is painful for my ears in the background, same as last video

@matrixfull 7 ай бұрын

thank you so muchhh for this insight on what suppliments help and what suppliments don't help!!! going through allthose studies that is incredible task! i'm very very grateful!!!

@harold18659 7 ай бұрын

Your comments on Glynac are understandable. Got a stroke at 56 years old. Left side impairment/weakness. Balance problems etc. Started Glynac at 64, 1 year ago. After 10 months at 7 grams each I've seen a drastic recovery, almost complete reversal of post stroke symptoms. Another benefit is about 95% improvement of COPD. Now i walk for at least 1 hour each day which was unthinkable for me in the past 9 years. I feel much younger and stronger today. Glynac is a wonder treatment for people like me. Before this i took NMN for 6 months but did not notice any improvements.

@Physionic 7 ай бұрын

Thank you for speaking up - I'm thrilled to hear you've had improvements in symptoms!

@harold18659 7 ай бұрын

Your work helps many like me, thank you!@@Physionic

@Aurla-R2-D2 7 ай бұрын

Thank you very much for sharing your story. Which brand of NMN did you try? All best wishes ^_^

@harold18659 7 ай бұрын

You are welcome. I used Renue by science@@Aurla-R2-D2

@littlevoice_11 7 ай бұрын

Did you opt for 7grams based in weight?

@dcjohnson2208 7 ай бұрын

I’m an old (octogenarian) retired scientist (hard sciences physics, mathematics, electronic engineering, computer sciences). Had an infarct in my youth (65yo) limiting me to bed/recliner cycle. Also noticed brain decline from 35yo to present, getting worse in past decade. I began research on longevity, heart regeneration, etc. NMN 500mg, Organic Extra Virgin Olive Oil, Creatine, Collagen Peptides 10-20g/day, Magnesium L-Threonate 2000mg/day (Brain), Magnesium Taurate 125mg (heart) plus some others have had a major positive impact on my life. My cardiologist of 40 years, says he is “Astounded that the heart has healed itself!”. I like your analyses. I believe you could become a great scientist. Good luck! Post Script: people say I look 60yo, I feel like I’m 50yo.

@lpg12338 7 ай бұрын

Very interesting, thanks for sharing! 👍

@dcjohnson2208 7 ай бұрын

@@enalo6261 I am not a medical doctor and cannot advise anything. I can only share what I experience. I could not detect any bp lowering effect. I take it because it makes the muscle cells stronger. I was in mild heart failure. Proper exercise (with bands), MOST IMPORTANT DIET good sleep follows then…. my bp went down. My weight went from 320 lbs to 195 lbs over several years. It’s difficult but it worked for me.

@lifeislife7199 7 ай бұрын

❤😊

@ReneeRin-mk5fc 7 ай бұрын

I know it is off topic but my dog 14 years and healthy and fit has a genetic heart murmur which has in the last few months become worse and the vet put her on cardisure-would anyone know if magnesium Taurate could help

@lpg12338 7 ай бұрын

@@dcjohnson2208 Yes, lack of use and age rob us of many gifts. ☹️

@tom7471 7 ай бұрын

I'm almost 72, so I take Glycine and NAC at the recommended dosages (2 grams NAC and up to 12 grams of glycine). They are not at all expensive compared to other similar supplements (like NMN). I also take creatine, collagen, D-3, K-2, Magnesium, fish oil, L-Citrulline, Turmeric (natural form), and Taurine with other assorted supplements (not always every day on the others -- ones like Zinc, Vit A, etc -- are maybe 3 times a week). I feel healthy, workout a lot (resistance and cardio), and use a sauna regularly and red light therapy also. It is hard to say if I am getting results from the GlyNac because of all that I include in my regimen. Great video!

@rajanganger5942 7 ай бұрын

NAC and Glycine powder is super cheap.

@rajanganger5942 7 ай бұрын

You missed Berberine in your list and Lions Mane mushroom.

@lpg12338 7 ай бұрын

Sounds like you are doing all the right stuff, congratulations and thanks for sharing. 👍

@2Truth4Liberty 7 ай бұрын

Just FYI I'm 63 (male) and take no supplements or medicines (though have been told I need them). Anyway, I switched to Carnivore diet (more like KETOvore, heavy on the vore) A year later, many aging symtoms were improved or gone, I was down to a more healthy weight (40# less) and long time high blood pressure was now normal.

@user-bn9ol6tn2n 7 ай бұрын

Lion’s Mane mushroom can wreak havoc on one’s hormones.

@Joseph-Colin-EXP 7 ай бұрын

I take glycine, and NAC. 43. Work: dusty environments. These were a game changer for.me. sleep better, increased lung capacity, running faster. Complete game changer

@drewmandan 7 ай бұрын

NAC is known to help clear lungs of crap.

@eggbenedict-gt7mw 7 ай бұрын

Nobody talks about nac cancers

@jimb3457 7 ай бұрын

@@eggbenedict-gt7mw Nac cancers?? Supplementation with NAC or vitamin E AFTER the development of cancer was found to increase cancer progression and reduce survival in mouse models of both BRAF- and KRAS-induced lung cancer. This holds true for all antioxidants that suppress ROS. Nac does not cause cancer, but can support already developed cancers by suppressing ROS, particularly lung. liver or pancreatic cancers.

@eggbenedict-gt7mw 7 ай бұрын

@@jimb3457 so most senior citizens, will get cancer if they use nac ,

@eggbenedict-gt7mw 7 ай бұрын

@@jimb3457 yes and people are using it for copd, study claims it reduced senescent cells , later caused cancer in 50 % people

@Panarock 7 ай бұрын

As someone who takes NMN daily and walks through radiation fields. I can definitely say it works!

@creativesource3514 3 ай бұрын

Why take it without hard evidence?

@jamesalles139 28 күн бұрын

☢

@abracadabra6324 7 ай бұрын

Im fairly certain GlyNac is one of the best supplements I have ever used. NMN was good but the effects reduced over time until I was getting almost no effect. GlyNac and NMN also doesn't work for me if I don't get enough sleep. I use Methylene blue, GlyNac, NAC and Tongkat Ali with creatine and I get amazing results in brain function and strength

@lalisa2486 7 ай бұрын

What’s methylene blue for?

@joebartles3986 7 ай бұрын

GlyNAC has been a complete game changer for me. I felt the effects after only a few days.

@chiprichards4668 7 ай бұрын

what brand and where do you source your glynac?

@aminataykanu 7 ай бұрын

I'm 49 and I don't even take gly/nac all the time. I take 1.2g each on and off and I can see the difference in how quickly I recover from heavy lifting as well as how quick I am in aerobic exercise. So I do think gly/nac works for me.

@vladislavroytapel2830 7 ай бұрын

Tongkat Ali / what breand please ?

@graymatters7584 7 ай бұрын

Many of those watching you, including myself, actually ARE older. So what I heard was that I probably should take several of these things. About Omega 3, I take 6 grams of Omega 3 every day - 3 when I rise and 3 when I go to bed. I don’t even take it for brain health. I take it for aches and pains. I’ve found that it drastically reduces inflammation and pain. It makes a great remedy for the muscle/joint pain which comes along with taking statins.

@chrismyers9951 7 ай бұрын

If your on statins make sure you take CQ10.

@EdOConnor 7 ай бұрын

@@chrismyers9951There's no evidence that supplementing CoQ10 has an impact on muscle pain for users of statins. E.g., www.ncbi.nlm.nih.gov/pmc/articles/PMC9495827/

@Gamer3172 7 ай бұрын

Instead of taking Omega 3 , Just eat some fish

@chrismyers9951 7 ай бұрын

@@Gamer3172 Mercury in large fish.

@joey86bu1 7 ай бұрын

@@Gamer3172 Some people don't like the taste of fish.

@garyslavinsky4201 4 ай бұрын

Your comments on Glynac make sense because, at your age, you likely do not have a glutathione deficiency. I, however, at 73, am jumping into that pool with both feet

@Linked2Software 7 ай бұрын

Love your attention to detail. Great work. Please add chapters so when i come back later I can go right to a specific area. TY

@Physionic 7 ай бұрын

Thanks, L2S. I'd like to add chapters to these shorter videos, but they hurt the video performance, unfortunately. I've tested it many times.

@kurtiskunesh143 7 ай бұрын

At 61 I enjoy all those supplements and quite a large Nootropic stack with constant change with time off to notice differences and integrate new research. Thanks for all your heavy lifting research sorting through the misunderstandings in statistical analysis! You're guiding those of us not steeped in a high bar of clinical research excellence for supplemental nutrition! We're navigating a world of nutritional deficiency both in the soil, food, processing and misguided lifestyles.💫 Salute ❤

@NoLimitsNatty 7 ай бұрын

Thanks as always you offer some of the most useful information back by data, your channel needs more exposure so more people can benefit again Thank you 🙏🏽

@gaston. 7 ай бұрын

excellent... always curious about the sups one takes, especially from someone who dives deep into the studies, thanks for sharing.

@sundiataq 7 ай бұрын

I love your content, especially the attention to detail in assessing the quality of the studies you reference in your videos. Could we perhaps get a video on your opinions and insights on various whole food diets, and the feasibility of acquiring all required vitamins, minerals and other potentially beneficial micronutrients from whole food sources? For example there are many healthy, natural sources of collagen and creatine. How do they compare to supplementation? Or for example, I use about half a teaspoon of natural turmeric in cooking each evening, in combination with black pepper and olive or coconut oil. How does that compare to curcumin supplementation? How does total abstinence from ultra processed foods affect the gut microbiome, and how does that affect the bio-availability of nutrients from whole foods, compared to people who eat ultra-processed foods and/or rely on supplements? Those kind of questions...

@wayneherron6511 7 ай бұрын

Thank you for your presentations. I wish I had more time to go through more of your videos. But so far you are helping me understand what I should be taking at my age.

@TheJust22az 7 ай бұрын

Since I am taking almost all of the supplements you mention, I was holding my breath to hear your recommendations based on your recent findings. However, as I am close to turning 70, I will continue to take them as it sounds like I could benefit from doing so.

@user-po2bh4kj9q 7 ай бұрын

I thought I would give my experience using NMN. I am 54 years old and in pretty good shape. At 50 I rode Lotoja, which is 207 miles in one day. Averaged 19mph. For the next 2 years I was injured and that kept me off the bike. At the beginning of 2023 I started taking NMN. In March I was riding my trainer and was achieving higher watts then the year before. Got injured. Off for a month. I started riding without NMN and forgot about taking it. I was riding terrible. Did a relay through Utah in June and I struggled. In June I almost hung up my bike. Then I remembered the NMN. Started taking it again. In July I was riding up the mountains without tiring out. My times were close to my 2019 times when I was riding 100 miles every Sunday. In August there is a tough ride we do. I counted 21 very small climbs but they are between 9-13% incline. I went from 44 minutes to 36 minutes. The only explanation is the NMN. So now I take it all the time. I take 1000mg of NMN, 1000 Rostvertol, and 500mg of TMG. Its the ProHealth Complete. I have had others take it and they all said it gave them energy. But some had digestive issues and stopped using it. I don't know about Age Reversal, but it sure seems to have helped my endurance.

@saschawilliams1 Ай бұрын

I'm 62. I had very similar results in martial arts training, much of which for me consists of leg raises, kicks, high speed strikes, crunches, push-ups. The difference of taking nmn versus not is huge! Particularly regarding my leg muscles. Definitely more flexibility, more muscular endurance, much less soreness, etc.

@mihaelafrincu8732 23 күн бұрын

Brilliant job!! Could you suggest some brands,please?

@gregpalac 7 ай бұрын

Good stuff man, thank you for the videos and the info, it's been very useful.

@godofthecorn3011 7 ай бұрын

Rather counterintuitively, my favorite part about this video is that lots of the conclusions you come to are kinda boring. Thanks for taking such a level-headed approach to relaying the info you gathered and not cherry-picking positive data for clicks. Love it!

@glowaves 4 ай бұрын

Good point.

@minemilx2702 7 ай бұрын

Please do more ranking lists like this one with more supplements!

@jmc8076 7 ай бұрын

Great to have this type of info video based on trusted objective research. I take 500mg/d (split) turmeric for GI issue (one new OK study but seems to help). Now I’m worried it may impede muscle rebuilding after a long phase of illness and chronic pain. I’ll look into it. Thx. FYI Physionic emails are good summaries of new videos.

@richfuller 6 ай бұрын

Awesome I'll keep taking all of those since I'm 55 and not in great health. You totally convinced me to keep taking them all!

@felicisimomalinao1981 7 ай бұрын

Much thanks for the regular updates.

@DavidPaulNewtonScott 2 ай бұрын

Watch out for the mood flattening of NAC

@c-eagle 7 ай бұрын

Thank you for that summary. :) I sometimes think, an issue with studies is that average-based results is the only thing that's mostly being looked at. In quite a few cases (too many, in my opinion), a specific substance only affects specific groups of people which can't always be categorized (ie. if it's due to specific genetics required for a certain substance to work in a specific way). A study like this would not necessarily tell them that a substance they would benefit from is actually good for them. For example, for about 20 years I've been doing frequent double-blind-studies together with a few friends, just to find out what individually affects us and how. And for me personally, we found that GlyNAC does wonders. I am just 41 and we were repeatedly able to show that it helps me get out of extended phases of chronically missing motivation or of "mental inactivity". BUT this simply doesn't apply to everyone. I know people who don't benefit from GlyNAC at all, EVEN in this exact situation. So in my humble opinion, even though quite a few of those substances do benefit most people (and average-based studies shows us this), people need to individually find out what they benefit from. They may have a rare genetic detail that helps them benefit from a specific substance more than the average person. Average-based studies can't tell them everything, though they are a good starting point.

@deansusec8745 7 ай бұрын

NMN did have noticeable effect. GLYNAC had huge effects. No more inflammation in any joint or muscles. Never any after hard core gym workouts. I am 54 and not in shape. Started going to the gym after a 3 year pause.

@BitZapple 3 ай бұрын

NAC is a huge and obvious booster for lung capacity. It enlongates breathing capaticy a lot and very noticably. I'm 32 and regularly train at the gym. It actually helps getting more reps in some exercises because getting out of breath is much less of a limiting factor.

@mihaelafrincu8732 23 күн бұрын

Brilliant job! Please suggest the brands,thank you.

@landoishisname 7 ай бұрын

my early mid60s dad started taking NMN on a whim and he jokingly said he was worried he'd accidentally ordered something like cocaine that's how profound and fast the positive effects were, says he feels 10 years younger

@Physionic 7 ай бұрын

Haha, that's amazing!

@Aurla-R2-D2 7 ай бұрын

Wow, that's wonderful :) Which brand is he taking? Cheers ^_^

@stargazerbird 6 ай бұрын

Me too. The high doesn’t last though. But that first week was amazing.

@Aurla-R2-D2 6 ай бұрын

@@stargazerbird ~ Do you take it with TMG? Cheers ^_^

@tomlongam7653 4 ай бұрын

Many thanks for this video!

@WhereNerdyisCool 7 ай бұрын

I am in my early 50s and take NAC and its been super helpful (not sick much this year!). I've also been using NR (Niagen) for 2 years and while I don't feel any big difference, much like a daily vitamin. However, I don't feel or look my age and I think, in addition to my fitness and diet, is a big part of it. I also do collagen peptides and hyaluronic acid. Creatine HCI works great for me, it helps with DOMS - monohydrate made my face feel bloated. Be well!

@victoriawhite3662 6 ай бұрын

I had a Dr suggest NR to me, within a few months my numerous dark leg scars began to fade quickly. Although I didn't have relief from symptoms of issues we were working on, it obviously is doing something to heal tissues!

@joelsombroek 7 ай бұрын

NAC also helps a lot for detoxing from heavy metals in your food / environment, so that’s not age related.

@BitZapple 3 ай бұрын

It's one of the most obvious supplements with how it instantly just extends my breath at 32 years old.

@blink182bfsftw Ай бұрын

@@BitZapple what do you mean?

@ewertonsalles 5 ай бұрын

Another amazing vídeo, thanks for that. I wonder if you have done any analysis on Berberine to reduce glycose levels. Thanks

@NotThatKindOfKiwi86 7 ай бұрын

Nice bicep flex my dude. You're the most buff nerd I know and I absolutely love it!

@albertcamus5970 4 ай бұрын

needs to hit his shoulders more. Unless he flexes - he looks weak.

@lisamacdonald8579 Ай бұрын

@@albertcamus5970omg are you serious? What a shitty thing to say.

@Solmyr1234 7 ай бұрын

So interesting, thx man!

@nick68231 7 ай бұрын

One more comment about Glynac. I am hypothyroid and one thing I noticed after taking it is that for the first time in decades my thyroid function tests were coming in totally normal. I have never had them come in normal. I have an older friend who is hypothyroid and has been for decades. She takes thyroid meds unlike me. She started glynac supplementation and her thyroid tests are now coming in on the hyper side, which has never happened for her. Her doctor basically told her to decide between the glynac or her thyroid med. I know the thyroid is super sensitive to toxins and toxins can affect it's function. I know that glutathione is an excellent detoxifier. So I am wondering if glynac supplementation can correct thyroid dysfunction that is linked to environmental toxins? My best guess is that my thyroid was over burdened by environmental toxins and the glutathone helps to detox it. Or maybe glutathione levels helps boost thyroid function in other ways?

@joen.8364 7 ай бұрын

Excellent analysis. I was wondering, I am 60 and do need some antioxidants it seems for chronic inflammation as the body struggles to exist with all the stuff that happens. What would you think would be a good time/strategy, just basically thinking, to take it (time and in relation to working out that we still have to do or wither away). Thanks a million, keep up the good work and happy Christmas season to you!

@gregoryphillips3969 6 ай бұрын

NMN is of GREAT benefit for people 50 years old and beyond. Someone younger doesn't need it. I am over 60 years old. I started taking it and had incredible results. As a tennis player who competes one is always looking for an advantage. With NMN l can honestly say that l became lighter on my feet and noticeably faster along with an overall improvement in well being. It's been really amazing. I have also seen improvements in lean body mass. Others whose stories l have learned of have experienced things like healthy weight loss and gray hair turning back to it's natural color. NMN is not meant for people under 50. But for anyone 50 and beyond it's a godsend. Many times evaluators of things like NMN have other alterior motives. Anyone over 50 should try NMN themselves for 3 months and then make a decision.

@user-uk6db3mb2f 5 ай бұрын

What about NAD+ ? Always confused about NMN and NAD+

@ChasTerran 3 ай бұрын

NMN is a pre ursor which helps your body increase the amount of NAD+ @user-uk6db3mb2f

@lisamacdonald8579 Ай бұрын

What dosage are you taking please? Thank you for the intel :)

@GregWalp 7 ай бұрын

Great information as always. How about berberine, and TMG, and blue methyline?

@EntrepreneursInCars 7 ай бұрын

Great summary Nick, appreciate your work.

@Physionic 7 ай бұрын

Thanks, Rich!

@littlevoice_11 7 ай бұрын

Already looking forward to your collagen deep dive. I am hoping for content on bone density, osteoarthritis and gut health

@_negentropy_ 7 ай бұрын

Thanks so much for this! Can you recommend a brand of creatine?

@_zantetsuken_ 15 күн бұрын

You can't do anything wrong because it's just one ingredient. Creatine-monohydrate and you are way to go.

@federicolois3344 7 ай бұрын

I have started with Glycine + NAC a few weeks after the study was published. 40yo male, BMI borderline to obese. As you noted taking NAC is a pain in the ass, so I started encapsulating the powder in 1g pills. That made it better but it made it complicated to take. I decided to not change my routing for the first 3 months (no change in diet, no change in exercise). The first side effect I seen was that it essentially killed a chronic knee inflammation that I have been carrying for 8 years after a LCA surgery. That's said I never went over half of the dose (50mg/kg daily). I also found that my 1-hour week tennis sessions would not leave me exhaust to the level of having to take a nap after it. Fast forward 6 months I started strength training 1-hour week, I progressed as expected, but everything changed after changing the protocol to add Taurine into the mix. Including Taurine and even diminished the amount of NAC the difference was absurd. My personal trainer had to start adding weight every single session. The max weight was just not enough every 2 weeks apart (not enough time to do everything on a single week, so my rotations takes 2 weeks). I went from 25kg to 60kg in press bench in a matter of 2 months, 70kg for leg press to 130kg and so on. I first investigated Taurine because my wife wanted to take it, but doesn't tolerate well NAC, so I was looking for something that could make the amount of cysteine she already eat in food to have a larger effect. As hepatocytes would react faster to the availability of cysteine, I decided to go the Taurine route. Then I said, what if I do that with mine too? The rest is history, I haven't lose a kg, but the amount of muscle (fat/muscle ratio change) and health benefits were massive. My current protocol is: 33 mg/kg Glycine 33 mg/kg Taurine 25 mg/kg NAC Would be interesting for you to look into how those 3 may be linked together to have provided such a boost.

@MyBeautifulHealth 7 ай бұрын

Check out the channel Pottenger’s Human- he does an excellent job informing about all three supplements you listed. 🙂

@vladislavroytapel2830 7 ай бұрын

NAC ...whai was amount for you?

@eggbenedict-gt7mw 7 ай бұрын

What about liver health

@federicolois3344 7 ай бұрын

@@vladislavroytapel2830 I am 90kg, therefore 2g

@cravarc 6 ай бұрын

I take L-Citrulline along with Taurine for the nitric oxide. As we age, we produce less of it kind of like Taurine. L-Citrulline is pretty cheap; I wonder if it would extend your results even further.

@gordonwho 7 ай бұрын

Great review! How about TMG?

@Floating-Cows 7 ай бұрын

Do you have a video on antioxidants and muscle growth because both are important! How do you use both and maximize their benefits?

@avrilpetersen5486 5 ай бұрын

I love your humour 😂 Thank you for your analysis 🙏🏽

@lortorial 7 ай бұрын

Another excellent posting, thank you. I wonder if fitbit or some other provider will ever create a bio implant that can analyze your levels of NAD and other things. Just picture how much data could be produced globally, which then could aid studies.

@donnabeaudin9114 4 ай бұрын

Was looking down taking notes when you mentioned nmn, I thought you said m&ms..had me going there for a minute.😆

@theshadow8008 7 ай бұрын

Informative.

@ZappyOh 7 ай бұрын

My current stack: Fishoil - 2gr. GlyNac - 1gr. + 1gr. Glutamin - 1gr. Curcumin - 0.75gr Palmetto - 0.6gr. VitaminD - 1500iu Half a multivitamin-pill. ... Thinking of adding both NMN and Taurine, while retirering Glutamin. I'm 58, in good shape and slender, but with a recent diagnose of psoriasis and no less than 4 stents in my heart.

@VisionCapitalist 7 ай бұрын

Glutamin forms more glutimates in the brain skip that get D from sun and butter oil

@ChopperChad 7 ай бұрын

Look into vitamin K2(the MK7) version as well.

@venicebeachsurfer 7 ай бұрын

Why the stents? Were you always slender...or a smoker?

@ZappyOh 7 ай бұрын

@@venicebeachsurfer I was always fit and slender, but also a heavy smoker from around 16 y.o. I quit after my first massive heart attack at 48, giving me three stents. At 56 I had another, less severe attack, giving me a stent more. Doctor says, that I'm genetically inclined, and it runs in my family. Not much I can do about that. So, I'm aiming for healthspan rather than lifespan :)

@Mark-nx7mr 7 ай бұрын

@@ZappyOh Smoking..Shrinks blood vessels like crazy.

@rosetyler4801 7 ай бұрын

Thanks for the list. Only thing I take at the moment is collagen. I might try the creatine. As far as strolls though radiation fields, if I don't keep taking them then how will I keep my youthful glow?

@Sid-bc8pn 7 ай бұрын

Great. That helps. Perhaps it makes sense to split the rating for old and young...when I listen to you....and thinking of many studies. I know how hard it is for a scientist to give compressed advice, thanks for doing it. Thousands other things to say and hundred thousands that are unknown, but in the end we need advice. And we'll never know enough or test in a 'complete' way. Or as aunt sally says: I went to the forest to look for mushrooms and didn't find any. Therefore, there are no mushrooms in forests.

@sheradenart7907 7 ай бұрын

I have been taking glyNAC for autoimmune symptoms and have seen great results but I am looking to find another solution because I am starting to feel better and it is for removing the reactive species. It has also help to improved my menstrual issues, though I am also taking selenium and collagen for support for my extracellular matrix.

@geraldjarosch536 7 ай бұрын

Being in my 40s, GlyNAC might be the only supplement where I noticed an immediate improvement. I have more energy, metabolism is up, on a diet I lose more weight while supplementing GlyNAC. I tried a month worth of NR (should be similar to NMN) once, noticed literally nothing and it was also the most expensive supp I ever took, so I stopped.

@planttheseed2129 7 ай бұрын

What brand do you consume? Could you share?

@geraldjarosch536 7 ай бұрын

@@planttheseed2129 NAC is from Now Foods, Glycin is a German brand I don't remember and you won't likely be able to buy anyway. I just look for 1g capsules for a good price.

@eggbenedict-gt7mw 7 ай бұрын

What about cancer and nac nobody talks about it

@brianwnc8168 7 ай бұрын

@@eggbenedict-gt7mwwhat about in NAC and cancer?

@eggbenedict-gt7mw 7 ай бұрын

@@brianwnc8168 there is study on the web where nac reduced sensecent cells , for anti aging, but later in 50% people the same cells turned cancerous, i want to take nac , bcoz here in india it's very cheap, bcoz of the study i have not bought nac, i want a clear utube video on nac and cancer

@photo200 7 ай бұрын

This came up in a different comment thread, but I thought I'd post a separate comment on it. The take-away is that when evaluating these supplements based on outcomes, it might make sense to divide them into two categories: The first (and probably most common) category would be supplements that have expected direct measurable outcomes, such as reduced insulin resistance, increased muscle-building ability, triggering autophagy or reduction of senescent cells, etc. The second category would be supplements that have the intended outcome of restoring levels of certain important substances that change with age, which could be either increasing them (e.g., NAD, glutathione) or decreasing them (e.g., oxidative stress metabolites). In this case, it's those changes that are the direct outcomes, and other outcomes are indirect results of these changes, which may or may not be noticeable in daily life or levels of health in the near term but have been shown, usually in mouse models, to have longer-term benefits for healthspan or lifespan. In the case of GlyNAC, there have been more demonstrated indirect benefits on health markers than with NMN, albeit from a limited number of studies so far. Nick is correct that these supplements don't have much value for younger folks, but should possibly not be written off for older folks. Since evaluating lifespan and healthspan is difficult and time-consuming in humans, trusting these supplements to be worth what you spend on them, even if they're considered to be safe, is inherently going to be more subjective and dependent on your assessment of the data, and possibly on your current physical condition.

@Physionic 7 ай бұрын

I really like this suggestion. Wonderful idea. Thank you.

@teddyrobert1105 7 ай бұрын

Excellent explanation for those of us who like to supplement ourselves. Could you please make a video about the supposed health benefits of consuming DMSO (dimethyl sulfoxide) orally?

@aalliaandreadis5109 7 ай бұрын

I've been taking MSM which is a more refined version of DMSO and I love it. Lots of new spiky hair on my head and general wellness. Just be careful and buy a reputable brand cos a lot of it comes in bulk from china and isn't pure.

@Mind69420 10 күн бұрын

Be careful with DMSO I'd only orally ingest if my life were horrible already with nothing to lose.

@karenbrummond8507 6 ай бұрын

You are a sweet, funny nerd. Thank you for your info.

@patrickhayes6022 7 ай бұрын

Thanks, I find your videos very educating and interesting, at least the parts I can understand! Could you do anything on Long Covid?

@Physionic 7 ай бұрын

That's a tough one, Patrick. I hope to cover it, however. Thanks!

@patrickhayes6022 7 ай бұрын

Thanks. I have no doubt anything you cover would be more informative and useful than 90% of doctors I meet@@Physionic

@ritamargherita 7 ай бұрын

I have long covid, was severely bedbound at my worst for months. What helped me was LDN, Korean Ginseng 2000mg, and Glynac. I'm able to work part time again, but resting mostly in between work days. It's a long game. Good look to you!

@LaHReetaLays 7 ай бұрын

What should we look for when buying quality collagen?

@alvaromd3203 7 ай бұрын

Such a character! 😂 great videos, with lots of personality. That matters lot.

@checkmecare 7 ай бұрын

Thank you so much for sharing. It really made us feel very helpful.

@abc_cba 7 ай бұрын

NAC helps me with my Asthma especially the Mucus part. Plus, it adds Cysteine and sulfur to the body which helps to raise Glutathione. Thanks for your perspective, though.

@sarahrosen4985 7 ай бұрын

How much does magnesium help? Helps (prevents) my asthma and migraines tremendously.

@abc_cba 7 ай бұрын

@@sarahrosen4985 well, I had been a gym freak since the past 10 years and I would get these tremors or weird shakes on any part of my body and I showed it to many doctors who thought that it was a neurological or a spinal issue and these tremors would come out of nowhere, shake me and disappear so I never had it persistent enough to show to anyone as a proof. I came across a video of Dr. Eric Berg about Magnesium's role in that. I started with Magnesium Citrate every night and believe me, the tremors vanished. Whenever, I get those now, I know for sure that I have to take my Magnesium supplement. For my asthma, I rely on modern medicine but I also dose on Ayurvedic herbs like Adulsa, Andrographis and even Boswellia Serata for my asthma. Helps me immensely.

@jmc8076 7 ай бұрын

I’ll pass this on. Thx

@abc_cba 7 ай бұрын

@@jmc8076 nobody asked you to pass or hold on to it. This is a community to share our experiences. Keep your rant to yourself 🙏🏻

@eggbenedict-gt7mw 7 ай бұрын

@@sarahrosen4985magnesium doesn't help astahama, and nac worsens asthama that's the side effects written on it

@VeeKayGreenerGrass 6 ай бұрын

For collagen I buy heavy beef leg bones with lots of bone marrow and boil them at home for bone broth. You can reboil the bones as many as 7 times before getting fresh ones.

@thehungergames8918 7 ай бұрын

Nattokinase, Astaxanthin and Kurkuma for Spike Protein protection 🕵️‍♀️

@CD-gh1uf 7 ай бұрын

Good stuff as usual

@Minisquid100 7 ай бұрын

Please keep us updated if you come across any new studies on Taurine 🤔

@Ronlawhouston 6 ай бұрын

Damn, nice muscles! Thanks for wading through all the data. Can you sometimes do videos for older people?

@vagomaniac 7 ай бұрын

About NMN: Energy, I feel I can walk or perform many tasks non stop. And that’s on demand. I don’t have to wait for three or five days for it to start working it just works every thousand grams. People that are not active won’t harvest benefits except at a molecular level.

@zhilahaghbin4766 7 ай бұрын

Thanks' Nick, as always science based and your interpretation is Gold, like a cup of M&M :)

@jonnull 7 ай бұрын

41 years old here. I noticed great results from NMN, 500-1000mg per day. Daytime drowsiness disappeared, more clean energy, more desire to move and do stuff. Sadly, very expensive. Solution? Plain old flushing Niacin. Same results for $3 a month, works just as well, and I actually enjoy the flush.

@eggbenedict-gt7mw 7 ай бұрын

Bro what about liver health

@tomdebevoise 7 ай бұрын

NMN is also very expensive a cheaper alternative is Nicotinamide (B3), which is the precursor to NAD+, or acts higher up in the process.

@videoagogo1 7 ай бұрын

Niacin (Nictotinic Acid) is 'better' in that regard and unlikely to inhibit Sirtuin generation

@aalliaandreadis5109 7 ай бұрын

@@videoagogo1been taking 500-1000mg of nicotinic acid to raise my HDL and after the first couple of days of intense flushing cos of immediate vasodilation, I feel amazing. My face always looked very young and I'm convinced I look even younger within a week. Amazing stuff but of course no one can patent it or overprice it so no one talks about it even though it was the standard doctor treatment for high LDL and high blood pressure till the early ninenties when statins were created.

@eggbenedict-gt7mw 7 ай бұрын

Niacinamide bro

@pip5461 6 ай бұрын

Well done...

@ricorix3439 7 ай бұрын

Just a warning, do not take GlyNac at the amounts they used in the papers if you are relatively young. I made that mistake a few years ago (I was about 36/37) when one of the main papers came out, and after a few days my body was full of bruises. Granted both Gly and Nac are blood thinners, but the issue was probably also that i already had healthy levels of those and it must have been a big overdose for my body. Once I reduced the doses the bruises went away, but eventually I stopped taking it, especially NAC. I still took 1g of glycine for a a couple of years and recently I switched to collagen which is rich in glycine anyway so no longer take it. Might be great for people that are depleted and/or have low protein diets (that's another thing, my diet is protein rich, so the amounts were even higher), but not for a healthy, young(ish), well fed person.

@aubreyelf87 7 ай бұрын

Thank your for the warning. I'm 36 and just getting into supplements. It's easy for me to want to rush out and take everything. Videos like this make it tempting.

@eggbenedict-gt7mw 7 ай бұрын

@@aubreyelf87i am also new to supplementation,

@user82938 6 ай бұрын

It's very difficult to eat a protein deficient diet if you are eating a normal amount of any food every day.

@_zantetsuken_ 15 күн бұрын

Collagen + hyaluronic acid is fine enough. Each collagen dose gives you 4-5gr. Of glycine.

@bvaccaro2959 7 ай бұрын

Thanks for your analysis/overviews here. I would though definitely disagree with the age at which one might consider NMN for sure. I'm turning 49 next week and can say it makes a rather large difference for me at least. When I started taking a few years ago prior to the pandemic I was riding my bike into work everyday from (Clinton Hill in Brooklyn into the Lower East side of Manhattan in NYC). I noticed a rather striking improvement within like only a couple days. That being when riding up the incline side of the Manhattan Bridge(going to work and then the opposite side coming home), my stamina was hugely improved and I felt like I would have 10 or 15 years prior. - I used to play basketball in my 20's so at that age I was more fit then nearly the entire population - I did some small amount of wieght lifting and a lot of plyometric training for hoops in my 20's - I rode my bike a lot in my 20's on up Caveat's - at the time I started NMN I still drank 1 or maybe 2 beers most days - I ate grubhib/seamless orders for dinner way too much during that time as well But's - I also ate a lot of Pasta(I'm Italian American), with a lot of Olive Oil and absolutely only use Pasta from Italy(Or my ancestors would haunt me... LOL) - I'm naturally skinny/lean I think the biggest BUT is that of human variability because anecdotally at least NMN is working amazingly for some and rather lackluster for others. The other is of course what you mentioned. We need much better trials of NMN which are not so general and more specific in age groups and a whole cohort of lifestyle variabilities IE: diet, exercise, work stress, family stress, income level stress.

@Physionic 7 ай бұрын

Totally fair. I'm just guesstimating.

@bvaccaro2959 7 ай бұрын

No worries, and I do appreciate you diving into these things. Still early days for some of these supplements @@Physionic

@markbeiser 7 ай бұрын

I knew why you were going to say you don't take GlyNAC when you mentioned it at the beginning!🤣 I'm far from an expert, but just reading about what it does I figured it wouldn't be beneficial to anyone that isn't over 50 or so. I'm 55 and take it, but not in the quantities used in that study. It is kinda cheap in smaller quantities, but I'd sure like to see more studies.

@MrSymbolic7 3 ай бұрын

I am 64 and soon to be 65 years of age , I just started taking GlyNac twice a Day at the dosage a Doctor recommended for my weight about a Month ago and have already started getting improvement with my joints all over but especially my right hip which would keep me up at night ( especially when cold fronts were approaching my area ) I also started with magnesium that has 7 different types, but that stuff is worse than Ambien for trying to wake up , I can sleep from 10 P.M. to 10 A.M. and still have to force myself out of bed and avoid it all together if I have to get up before 8 a.m. !

@jefflane8508 4 ай бұрын

Thanks for some wonderful and interesting videos. Very helpful. Don't understand all of it but I'm trying! I'm now taking Curcumin (Meriva) because diabeties runs in my family. But a thought on your comment on Curcumin reducing muscle building potential... I've seem some recent studies that show that Curcumin has an anti-catabolic effect so it helps in keeping your body in an anabolic state which of course is great for building/keeping muscles! The studies showed the end results of those on Curcumin gained more muscle than those not. Thoughts on this seemingly contradictory effect?

@Ibanezyt 7 ай бұрын

My stack: NMN (Energy), MSM (anti-inflammatory), creatine, whey protein, Vit: (K2, Magnesium glycinate, D3). Sucks getting old 😬

@lokyh5635 9 күн бұрын

Thanks

@user-ik7rk7lz9p 7 ай бұрын

I use Curcumin every Meals,2Meal a day 18 hours fasting every day.

@iggytse 7 ай бұрын

I am on the wrong side of 50. NMN and 1000mg does help remove age related fatigue to make me feel, umm l, late 30s. I also stack it with TMG so I don’t deplete my levels plus Creatine and O keep moderate levels of carbs in the diet. I have also substituted the NMN with Vitamin B3 with the same stack. Seems to work the same.

@gilgamesh..... 7 ай бұрын

I've been taking collagen for about a year now. I was just starting to wonder if it was actually worth it. Nice to hear it hasn't been a waste of money.

@lpg12338 7 ай бұрын

Do you take vitamin C with your collagen?

@afronrg 6 ай бұрын

@@lpg12338 would that be the right way to take?

@psiga 7 ай бұрын

5:26 "Better to have a little than to have nothing. Except cyanide. I'd prefer 'nothing', when it comes to cyanide." Folks should be careful about taking B12 supplements that have Cyanocobalamin in them. The "cobalamin" part is the Cobalt, which is the real vitamin, and the "Cyano" part is the _cyanide_ which is acting as a cheap carrier. A "better" form of B12 is Methylcobalamin, but about ten percent of the population are prone to _overmethylation,_ which can cause agitation and severe mood cycles (ask me how I know...). At that point, the more expensive Adenosylcobalamin is needed.

@filo2517 7 ай бұрын

Yes I have to use the adenosyl/hydroxy mix as well

@jjperry3995 7 ай бұрын

I used you video on GlyNAC to start supplementing. 72 yo and supped for 6 mths. I had good results initially but ended up with very cold hands and lower legs n feet from what appeared to be constructed blood vessels. I was taking a copper supp at the time and on ceasing both I recovered a couple of months later.

@BitZapple 3 ай бұрын

B-Vitamins, Iron, B12, folate for blood mass and Citrulline, Glycerol, Taurine, Ginkgo for circulation.

@BitZapple 3 ай бұрын

I get circulation issues stemming from low thyroid, mainly Tomatoe Juice and Citrulline seem to have a big alleviating effect on it. And of course working on the thyroid itself. But Tomato products and Citrulline can be a more quick fix for it.

@N330AA 7 ай бұрын

I mostly take Berberine, Fish Oil and Multivitamins, mostly.

@davidrojas5319 5 ай бұрын

One more comment about this subject of cregaatine. This is what I found online about it. Guanidinoacetic acid (GAA) is a nutrient that has been used in human nutrition since the early 1950s. Recommended for its role in creatine biosynthesis, GAA demonstrated beneficial energy‐boosting effects in various clinical conditions.Jan 11, 2023 Guanidinoacetic acid in human nutrition: Beyond ... - NCBI

@allehelgen 4 ай бұрын

NAC seems to be very powerful at reducing my blood creatinine and ALP/AST blood levels, so I'm not sure if it only applies to older people (I'm 34). Maybe for other outcomes, but on biomarkers NAC (so I bet GlyNAC) seems to be good.

@masonmmmmunch847 7 ай бұрын

Could you do a video on Ca-AKG? I find everyone who talks about it only has positive things to say, yet I find it hard to find any concrete evidence to believe its actually worth taking.

@antoniomarti3322 6 ай бұрын

Instructivo y orientador vídeo, gracias. Aunque el susto del GLY NAC fueron dos angustiosos segundos. El dato de la edad cronológica es importante. Por supuesto, el tema de las dosis suficientes (1000 mg de Omega 3 me parece insuficiente) y si se toma o no con comida y a que hora del día. Habría que valorar si la persona sufre o no enfermedades. Y, algo que siempre echo de menos en todos los estudios sobre suplementos o nutrientes, por no hablar de fármacos, es el estudio de sinergias, combinaciones de varios de ellos. Saludos cordiales.

@jonathonmills3563 7 ай бұрын

Fish oil is mostly consumed for cardiovascular health, in the 3g per day dosage. You should look at that versus just brain health which only the DHA fraction is important for.

@BitZapple 3 ай бұрын

Try to take them 3x1 gram each morning, noon, evening separated because they are also blood thinning. When I take multiple ones and then I might also take some other supplement that thins the blood I might get a racy heart. I don't when I spread the Omega 3 doses out and be more careful of Ginkgo, Garlic and liquorice for example.

@itsnotu-its-me 7 ай бұрын

Can you take a look at sulphorafane? I get it from broccoli sprouts.

@SargeMaximus 7 ай бұрын

I'm 35 and adding glycine has given me a huge boost in my physical stamina and heat tolerance on hot days

@Physionic 7 ай бұрын

Interesting - is that the only supplement you've added?

@SargeMaximus 7 ай бұрын

@@Physionic it was but I’ve added a lot since then because I was like “how else can I improve my health?” That’s around the time I found you btw

@Physionic 7 ай бұрын

Cool! Thanks for sharing.

@SargeMaximus 7 ай бұрын

@@Physionic oh but I should clarify: I DONT use GlyNac. NAC seems to give me brain fog. I use Glycine powder stand-alone

@lpg12338 7 ай бұрын

Can I ask what is your daily dosage?

@grainiac7824 7 ай бұрын

Curcumin is an excellent anti-inflammatory and helped my husband's thumb arthritis a lot

@jude-ln1ut 7 ай бұрын

Extra strength turmeric did a little for me. However I definitely had improved arthritic symptoms after taking high molecular weight hyaluronic acid 200 mg for 6-8 weeks. Introduced it to 2 others who also had same positive effect.

@davidperfette1425 5 ай бұрын

Regarding NMN. I think there is so much hype around it that the real benefits are getting lost. I exercise a lot, both in weight training and running. It has not helped me build muscle, but it has noticeably helped in my recovery. I continue to be much less susceptible to soft tissue injuries from running than I had in the past, and I've been pushing harder because of it. I also have noticeably more endurance. The benefits I have noticed are recovery and endurance. I'm 57 years old.

@ptlovelight2971 7 ай бұрын

Im in my late 30s and took NAC over the Spring and Summer. I definitely noticed an improvement, but i was already compromised after a bout with COVID and the subsequent post viral syndrome. I think younger people can take GlyNAC, especially those who smoke/vape, and have a unhealthy diet/lifestyle. But like you said, if you are in relatively good health it may not give you much benefit

@Dieblauesau 7 ай бұрын

I heard an interview with Professor Charles Brenner, he said that in studies NMN has shown to not going into the cells and that they therfor dont work, he says instead one should use NR and that this goes into the cells. What do you think about that?

@bruceharkness4497 6 күн бұрын

My experience with Gly/NAC at 68. I lost 3-4 inches of my waist without changing my current decent diet and exercise profile.

@patcusack6252 7 ай бұрын

I’d like to find one of your videos on bernerine Will keep watching. A new viewer - keep up the good reviews. Without practice I find it hard to stay awake while rebut hear kinds of pApers

@alex_montoya 7 ай бұрын

What do you think about Berberine for a 50 year old with high cholesterol who takes 20mg simvastatin daily? Do they work well together?

@doreenlane2370 7 ай бұрын

I consume collagen powder and it works for the skin for sure.

@legendted6237 6 ай бұрын

What kind of doctor should i consult if im interested to take meds like these?

@ross9263 7 ай бұрын

Can you cover the effects of taking ‘common supplements’ for relatively healthy individuals ? Like should i take methyl b-12, fish oil, vitamin c, etc. or will it not do anything for me.

@EduardQualls 7 ай бұрын

Please consider that the huge effects of GlyNAC at older ages may be the result of decades of underproduction/limited production of glutathione, just as the deleterious effects of cerebral fructose accumulate over time, through its metabolic disruption of AMPK, leading gradually to mitochondrial-mediated cell death and degenerative nerve-disease and dementia. Small improvements earlier in life could actually reduce those large, beneficial effects later in life.