Creatine's Secret Benefit..

Рет қаралды 83,021

6 ай бұрын

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[1] doi:10.1523/JNEUROSCI.3113-14.2015
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Пікірлер: 413

@Physionic 6 ай бұрын

Many people got the correct answer (because you guys are smarties): Oxygen delivery drops, our heart compensates to increase delivery speed of what oxygen is available (and pick up new oxygen at the lungs). Additionally, some extra smarties mentioned expelling CO2 - that's another mechanism that influences breathing. Well done! (and for those few that mentioned these people were simply panicking - as much as you guys were joking, it's actually a viable explanation as well. 😝)

@jeffbachmann7161 5 ай бұрын

CO2 is the number one mechanism that influences breathing. That’s why many free divers have died

@edvedder7835 2 ай бұрын

Where does lactic acid play here? Wouldn't that also trigger an increase in HR and RR? Great content btw!

@CBro4005 17 күн бұрын

Or could it be: chemo-receptors in the pons, sense the change in blood pH (mainly due to higher CO2 concentration compared with Oxygen) lower pH, innervating the adjacent medulla (respiratory centre in the brain srem), to suppress the medulla oblongata's vagus stimulation. The vagus nerve at normal activation, slows the heart rate. Reduced vagus stimulation would increase heart rate.

@baarbacoa 6 ай бұрын

This kind of suggests that in the event you've suffered a stroke or cardiac arrest, creatine might help you avoid brain damage.

@hempwick8203 6 ай бұрын

look up studies on piracetam and other racetams, they have been studied tin preventing damage from stroke. there's a huge amount of drugs that have been studied in preventing damage from ischemic stroke and other types of damage... but starting at piracetam gives you some idea of what I mean lol... And pubmed if you didn't know.. .so "piracetam stroke pubmed" on google will give you the DL

@alexblue6991 6 ай бұрын

My age 71yr old I have just started taking creatine I hope it helps to keep me healthy

@sullentamp9140 4 ай бұрын

It also helps with memory, so u made the correct choice 💪🏽👌🏽

@ReflectionsofChristianMadman 6 ай бұрын

My favorite benefit from creatine is the mental health affects. It makes me feel less depressed and flattened. My lows aren’t as low without any drawbacks of muting highs as well.

@DoctorEyeHealth 6 ай бұрын

Same!

@EdwardsNH 6 ай бұрын

Yeah, I'm useless when I don't get enough sleep, but I've noticed since taking creatine that I do a lot better by taking creatine

@joecool3332 6 ай бұрын

My guess is the heart rate increased to try to deliver more oxygen to the body.

@baarbacoa 6 ай бұрын

You beat me to it. I would think that if the Delta oxygen between blood and lungs decreases, you increase the mass flow rate of blood to maintain the same amount of oxygen transport to the body.

@nimblegoat 6 ай бұрын

My guess is higher C02/CO in the blood . I have heard from memory increased CO2 triggers heart rate - not going to cheat by googling

@jesusjusarez179 6 ай бұрын

Or electric oxygen

@inukithesavage828 6 ай бұрын

This is correct. It's a tell that happens in sleep aponea. If you wake up a lot with your heart rate and a headache......

@jerrywest7068 6 ай бұрын

Yes some people do regularly deprive themselves from oxygen. It's called sleep apnea. After seeing this I would recommend creatine before bed time.

@TheWeirdologist 5 ай бұрын

What's the link of creatine and sleep apnea?

@HansGrob 4 ай бұрын

Sleep apnea causes a fall in blood oxygen saturation, which can damage the brain. Creatine counteracts this. I will try. @@TheWeirdologist

@projectresponsible 6 ай бұрын

Basically: 1. Hypoxia = low production of ATP by mitochondria 2. Creatine --> regenerates ADP-->ATP 3. Na/K ATPase work is maintained (by creatine regenerated ATP) to restore ion balance on both sides of axonal membrane (repolarize towards the resting potential), despite O2 deficit affecting natual ATP synthesis in mitochondria 4. More/better excitation despite hypoxia Great vid. Many thanks (as always)!

@Jay-kk3dv 6 ай бұрын

Yep

@soulshinobi 6 ай бұрын

My father is 82 and was just hospitalized for blood clots in his lungs, I had got some creatine previously because I wanted to see if it would improve his mental state before this and now I'm very excited to try it.

@saxmaster45 3 ай бұрын

How did it go?

@soulshinobi 3 ай бұрын

@@saxmaster45 inconclusive unfortunately, he doesn't want to mix it into anything he drinks so I haven't been able to get him more than one week's doses.

@JeffD14A 6 ай бұрын

As a pilot who flys a light, unpressurized aircraft, I monitor my SpO2 and heart rate to know when I need to be on supplemental O2. The heart rate increases to get more blood (oxygen) to my head. I’ve seen this relationship many times. As an aside, flying at altitude without supplemental O2 leads to a lot more fatigue.

@gf6392 6 ай бұрын

I have noticed this on climbouts from just above sea levels to 12,000 feet, often accompanied by a slight anxiety

@zlmdragon. 5 ай бұрын

Jeff, check this video The Spleen - How To Improve Aerobic Performance

@marcusmoonstein242 6 ай бұрын

The heart rate increase is an automatic reflex caused by the drop in blood oxygen. The reason is that the most common cause of reduced blood oxygen is physical exertion which causes oxygen to be consumed by the muscles (aerobic system). The heart rate then needs to increase in order to get more oxygen back into the blood and on to the muscles.

@user-PaulFedwar 6 ай бұрын

So fantastic and interesting knowledge you shared. Very well vocalized, coherent delivery; Thanks so much!!

@charlesholt8773 6 ай бұрын

Hello Nicolas! Great content. Yes, I am a nerd of long standing but also a sailor and a free diver and so I am intimately familiar with oxygen depletion. I started using Creatine about 20 years ago and noticed a remarkable improvement in my diving ability both in duration and depth. My CO2 tolerance also improved significantly. I now know the nuts and bolts of why my diving improved so significantly. Thank you!

@Physionic 6 ай бұрын

Thrilled to hear it, Charles.

@Dddonalddduckkk 6 ай бұрын

❤ Nic, my MS ridden brain would love you to elaborate on creatine (NAC as well) and its effect on neurodegenerative diseases. Keep up the good work ❤🙏✌️

@Thenext23 3 ай бұрын

Yes, and I’d love to know if Creatine is safe if one has Nephrocalcinosis.

@kenhnsy 6 ай бұрын

Great job because you gave us some textbook edumacation instead of cramming buzzwords down our throats. I am glad I watched the whole video.

@Swenthorian 6 ай бұрын

1:38 Heart rate increases so that the blood passes the lungs more-frequently so it can get re-oxygenated more-rapidly.

@thenecroyeti1 6 ай бұрын

But why

@Swenthorian 6 ай бұрын

@@thenecroyeti1 Because the blood oxygen level is low.

@ArgosySpecOps 6 ай бұрын

@@thenecroyeti1to compensate for the 20% reduction in blood oxygenation.

@gablison 6 ай бұрын

@@thenecroyeti1 Because if your lungs have access to 100% of the O2 from the air and the blood passes through lungs from the heart every minute then it'll get the 100% to go to the vital organs but if the lungs only have access to 80% of the O2 then it'll have to compensate by making the trip every 40 sec instead of the minute to sustain the optimal amount of O2 going to the vital organs.

@pipinggpipingg1487 5 ай бұрын

the why he asked was physically why . After all, heart or your body doesn't think really ,it has evolved or billions of years to have certain physical attributes that creates reactions in your body that helps it survive .@@Swenthorian

@Kevin_Street 6 ай бұрын

Thank you for this video! It's really interesting. I've been shoveling creatine into myself every morning for a couple of years now, and it it definitely does have a mental effect. Now it's time to check out that other video you linked...

@jonb9194 4 ай бұрын

In my experience, creatine levels are possibly low in many cases with runners, especially those who train in hot and humid conditions. If you search on "creatine muscle relaxation time" that should point to some studies on this. I was constantly getting what felt like a "cramp, then strain" reaction in my muscles after less than 2 miles on almost every run, but without the cramp. After taking 5g of creatine per day, I stopped hurting myself within 48 hours. I was probably straining muscles due to poor muscle relaxation during the eccentric phases, and training induced dehydration was frequently degrading the creatine synthesis in my kidneys and liver for hours per day, resulting in very high creatine depletion.

@SpiderPriestess 6 ай бұрын

Interesting vid glad I watched it ! It explains something I noticed recently. I work underwater so I have to do a lot of breath hold dives . I’ve been able to hold my breath longer with less problems if I push it . I’ve also been taking a creatine supplement so I wonder if this is why …

@drscott1 6 ай бұрын

The mechanism is likely compensatory to increase o2 to vital organs.

@dannymayhem3349 6 ай бұрын

Thanks, Nic. This is a super interesting finding. The lazy part of my brain was like "awwww 🥺" when you refused to give the short, pop science answer lol. I'm not sure of the quiz question on HR increase in this case but I find it super interesting that someone getting "choked out" in MMA will experience a decrease in blood pressure as the signals bw brain and heart are disrupted. Thanks for another banger 🤟

@Mondscheinelfe 6 ай бұрын

An extraordinarily excellent video

@Physionic 6 ай бұрын

Thanks!

@ahnehtub2 6 ай бұрын

As a former swimmer i never tryid if my underwater time will be influenced by creatine supplementation. But it's something i can experiment with. :)

@NanoNutrino 6 ай бұрын

Don't. Shallow Water Blackout is something you don't want to play with

@ahnehtub2 6 ай бұрын

Never pushed to the blackout limit ... usually you know when you have to get out. Also i was never tried that alone. Also it was always measured by distance not by time probably you know the difference :)@@NanoNutrino

@NanoNutrino 6 ай бұрын

@@ahnehtub2 My nephew died last year because of it. I was educated by a free diver on the subject at his funeral, he just happened to be walking by when his body was pulled out of the water. At least you are aware of it, which is more than most people.

@ahnehtub2 6 ай бұрын

As i said i'm a former performance swimmer so i know a bit of everything (including one incident when i hit the buttom of the pool in a flip jump on my back and i was so confused that i had no idea where is the top and where is the bottom of the pool. (got to follow the bubbles to figure it out:)))))@@NanoNutrino

@ahnehtub2 6 ай бұрын

Sorry for you loss in such a tragic way. :(@@NanoNutrino

@anunciata 6 ай бұрын

To answer your question: sinus node and sympathetic nervous system are stimulated by hypoxemia and then increase heart rate and cardiac output. This is to compensate for the lack of oxygen. There are a number of diseases whose symptoms could perhaps be improved by an increased ATP reserve in the nervous system, for example chronic vascular encephalopathy.

@paulwolf3302 6 ай бұрын

One thing I noticed is that I can (surprisingly) run and bike at fairly high altitudes, up to about 12,000 ft and still be able to do it, and feel normal. I am breathing hard, but I would be anyway. But if I just walk around, I can get an altitude headache. I think that when you are running, your heartrate and breathing rate automatically adjust to get enough oxygen. Not so if you are just sitting in a chair.

@hannahdelosreyes2695 6 ай бұрын

I was trying to find out if creatine was safe for pregnant women to take and ran across some info about newborn babies having better outcomes if they experienced hypoxia during birth if the mother had been using creatine. Makes sense!

@jessewallace12able 6 ай бұрын

Nice work.

@dalysea26 6 ай бұрын

"Who is going to be oxygen deprived other than people being strangled or living in the mountains?" Me over here with sleep apnea.

@Physionic 6 ай бұрын

Great point - I missed that one. :)

@robertavanselow9172 6 ай бұрын

Me with copd

@littlevoice_11 6 ай бұрын

And emphysema @@Physionic

@randomlee4308 6 ай бұрын

Hoffers for sure

@marcus_ohreallyus 6 ай бұрын

I've had breathing issues ever since the first time I got Covid a couple of years back. Air is coming in, but it doesn't feel like it's doing the same job it used to.

@Claframb 6 ай бұрын

Great vid. I think the HR goes up to deliver more blood and therefore more O2

@rosaflorpuig3971 6 ай бұрын

Hi. I really enjoy your videos. Thank you for answering my question in a previous video about whether ginger serves as a strong senolytic. I have another question: does Apigenin actually lower CD38 resulting in higher levels of NAD in our cells? Thank you, in advance.

@Handlethis6513 6 ай бұрын

The increase in HR is due to a natural physical response due to hypoxia and an attempt to protect against anoxic brain injury like during OSA and CSA. It would be an interesting study to see if creatine had neuro protective properties during these hypoxic situations.

@mikefrizzell2532 6 ай бұрын

You're a hoot but in a very intellectual way. Great reporting, as always.

@Physionic 6 ай бұрын

Thanks!

@alzero4621 6 ай бұрын

My guess is that since oxygen is restricted, heart rate increases to compensate for that (each pump carries less oxygen, so you need more pumps per unit of time to reach the same oxygenation level as before).

@ashleyparker1203 6 ай бұрын

Sympathetic nervous system will trigger increased HR in a decreased O2 environment to better circulate remaining O2 to your muscles to give you the best chance to get away from the psycho strangling you!

@abcde1054 6 ай бұрын

Physionics grandma: Why does that kid never visit? Physionics grandma after the creatine talk: Why does that kid visit? 😂

@jellybeanvinkler4878 6 ай бұрын

If I had a physionics grandson, I'd listen to him all day long! While I baked him a pie. LOL J/K We'd walk the farm together and later I'd take him to dragon boat practice. 🥵😅 Then have a steak and eggs together.❤

@Physionic 6 ай бұрын

😂

@evelynbayna8824 6 ай бұрын

My son and I discuss all the bro science. He who was never interested in science in school.

@mrfoodarama 6 ай бұрын

Very cool!

@amj864 6 ай бұрын

Fascinating, Is it dose-dependent? Will 20gr be more effective?

@Physionic 6 ай бұрын

Unknown at this time

@duke605 6 ай бұрын

Heart rate increased to deliver more oxygen. It's like when you drop the amperage (blood oxygen). If you want the same wattage (oxygen delivered) you increase the voltage (speed of the blood)

@sal7024 6 ай бұрын

Not related to video topic but do you think there is a benefit taking collagen peptides over just taking glycine powder which is the main aminoacid in collagen? Glycine having other possible health benefits aswell and a lot cheaper. Speaking mainly in terms of skin health.

@stephenwillis9571 6 ай бұрын

I suggest it has to do with blood pressure - artieries widen in the oxygen deprived state to allow more O2 to reach organs - this in turn though reduces blood pressure (as can be seen in the chart) because the arteries aren't as narrow which is then countered through increased heart rate: more "heart pumps" are needed to maintain the blood pressure in dilated arteries, than narrow ones.

@brandongreen1177 6 ай бұрын

Which supplements do you take?

@eduardozamora1947 6 ай бұрын

Great info. I have an anecdote regarding creatine that might be interesting for some. I've been struggling with insomnia for years, and it's getting worse every month (I'll start treatment soon, don't worry). I been trying different changes in my nutrition to help me out and I realised that I had been supplementing with creatine for pretty much as long as I have insomnia, so even though nothing should relate the two things I stopped taking creatine a while ago and just for the sake of experimentation I've been cycling in and out of it. My results: creatine is of course not the cause or the trigger of my insomnia, but it does make it worse. My hypothesis, creatine helps you function better with less sleep, which when you are actually trying to accumulate sleep drive it can be a bad thing. It's like caffeine in a sense, although non stimulant, it helps you cope with sleep depravation so you can function, but it can make the problem worse by messing with your sleep drive and cycle. Well, that's my take on it anyways. I would like to see more content about sleep in the channel as well :)

@cristianrosescu2914 6 ай бұрын

Thanks for your comment. I’ve also been struggling with insomnia. What treatment are you doing for insomnia?

@rvpvela911 6 ай бұрын

Check out Chris Masterjohn PHD. He discusses creatine effect on insomnia that occurs sometimes.

@mattsmith1440 6 ай бұрын

@@cristianrosescu2914 Every body is different, and I don't think these are 'miracle cures', but I use some specific essential oils to help in sleeping myself. There are studies on lavender (compare with lavandin) and ylang-ylang oils showing effects on heart rate and hypertension, and I have also found clary sage oil to be quite powerful (not sure if this has studies to support it yet). A couple of drops of pure essential oil in water, using one of those cheap sonic vapourisers really helps. Also, try not to try to go to sleep, if that makes any sense. We say all the time 'try to relax', but if you think about it it's absurd. If you're trying, you're not relaxing. Relaxing, like sleeping, does not only *not* require effort, but putting effort into it actually works against your goal. I know it sounds obvious, but once I corrected this attitude, and in doing so the anxiety that comes with the issue, I remembered how to sleep again, and you can too.

@lgnd-lm6ug 6 ай бұрын

I once took creatine just before bed and noticed my sleep was actually better so I kept doing this ever since

@biohack9540 6 ай бұрын

I had to quit creatine because of insomnia.

@waltercolnaghi9177 6 ай бұрын

O2+ATP->AMP+C3H6O3+Energy. (If a persone is well fed, O2 is the shortage compound in the chemical reaction). Creatine provides additional Phosphate therefore “Energy” for longer exercise. As an adaptation mechanism to the prolonged stress there’s an increase in metocodrial number therefore more O2 available in the above reaction. As simple as that.

@scottvanmatre2507 6 ай бұрын

Fick equation: Cardiac Output= total O2 consumed[VO2]/the difference in arterial venous O2 content [Ca-Cv]. Cardiac Output is also equal to the stoke volume * HR. In the context of experiment, Stroke Volume and VO2 are constant. So we can now have the formula: SV*HR= VO2/(Ca-Cv) Once again SV and VO2 are constants so as the Ca-Cv gets smaller, HR has to increase.

@sdunca4864 6 ай бұрын

We are seeing it used in Chronic pulmonary patients as well (COPD, Long term Covid, CHF) mostly where respiratory drive has shifted. Nutritionally it seems to be assisting in recovery and rehab time. No studies as of yet- Wonder if the O2 drive chronic patients (vs CO2 driven "normal" patients) would have the same outcomes as the study as these metabolisms have shifted and compensated long term... Interesting review- thanks for sharing

@littlevoice_11 6 ай бұрын

Thank you for sharing. Do you have any external links to and research, early findings or resources for copd and creatine please?

@sdunca4864 6 ай бұрын

@littlevoice_11 not currently- nutritionally it was noticed in 2020 with covid patients- I am only aware of nutritional supplementation being added to the intake questionnaire and specifics of creatine were added later due to effects w renal clearance- but the correlation w chronic resp patients is an area supplements are big as well- thus my question.

@santosvella 6 ай бұрын

Heart rate increases to counteract reduced arterial oxygen content and match oxygen delivery to the tissue.

@avalanche9142 6 ай бұрын

Whenever I use Creatine for several days in a row I end up getting pain and discomfort in my joints. Over the years, I have tried different brands, tried to drink more water with it, etc. but ended up with the same results for some reason

@CHill-td6lz 6 ай бұрын

Do you think this may help ppl with sleep apnea conditions?

@homesignup 6 ай бұрын

Very interesting stuff. The other thing to remember is that creatine is only good for short term neuro stimulation but not long term memory. It is primarily due to increased ATP. Note that it also decreases NREM deep sleep (which is an important time for when your brain cleans out your toxins). The other issue is that it can in some folks cause greater water retention in muscles causing weight gain and a puffy squishier look (rather than sinewy) depending on dosing. There are other side effects as well on GI, liver and sometimes kidney in older patients. In younger folks it is perfectly fine (and most people take it for the extra energy it provides for working out and faster short-term brain activity) but in others it has some larger side effects including hair loss (which stops as soon as they stop taking it). I know people who love it, and others who do not. It really depends on the individual.

@christoph4977 6 ай бұрын

One mechanism would be the cartoid body and baroreceptors sensing the decreased oxygen levels and sending signal through the carotid sinus nerve, the vagus nerve and the sympathetic trunk to the the vasomotor center in the brainstem to regulate blood pressure and cardiovascular activity.

@gwhizz8922 6 ай бұрын

So in the end, what is a natural source/supplement of creatine that your body will use? What do you think about methylene blue as an anaerobic "bridge" for ATP generation in the mitochondria?

@Quixote1818 6 ай бұрын

I have mild sleep apnea. Seems like this could explain why I have more energy since I started talking creatine.

@popanator7759 6 ай бұрын

Can you explain creatine and kidney function interactions. When I was in hospital for kidney stones, they said to stop taking creatine...

@Dan-dg9pi 6 ай бұрын

I have a suggestion for the next Physionic contest: at what time in the video will the phrase "powerhouse of the cell" be uttered?

@Holy.HannaH 6 ай бұрын

Do I have to pick an exact time or can I just call dibs on any timestamps that are palindromic?🤔🤷‍♀️

@nicktube3904 6 ай бұрын

Does this also apply on people with autoimmune disease like post covid or Q-fever?

@marcoss1622 6 ай бұрын

The heart rate increases due a compensatory phenomenon to the lack of oxygen. Incidentally, blood pressure would also increase. This is because mitochondrial “breathing“ should remain constant in the face of said hormetic stimulus. Apneas and snoring are oxygen depriventions, too

@enstips 6 ай бұрын

Yes so I wonder if creatine can help with sleep apnea. Maybe with the mechanism explained in the video creatine can improve the reoxygenation after an apnea. What do you think about this?

@ldjt6184 6 ай бұрын

What if my BP is 96/58 and my heart rate is 82-85? Is that heart rate too high? BP too low?

@stephanygates6491 6 ай бұрын

HR increases with low O2 to relieve buildup of CO2 in the blood, cycling through alveoli faster.

@JustShort338 6 ай бұрын

Decreased partial pressure of oxygen to the end organs causes vasodilation. This decreases Blood pressure. As a compensation, medulla oblongata is stimulated, which via vagus nerve causes an increase in the heart rate.

@antonc81 6 ай бұрын

I wonder whether there could be some risk mitigation benefits for adults and especially children who are prone to asthma attacks, or even sleep apnea.

@RealJonzuk 6 ай бұрын

i get oxygen derived from chain smoking and i take creatine and ive noticed i can breathe better and i feel better when i smoke instead of sicker lol its crazy every hit is like spitting stuff out when i take creatine they shoudlve had me in the study

@roqclimber 6 ай бұрын

Creatine could be very beneficial for Mountaineers.

@a18ttc 6 ай бұрын

Lots of comments already regarding increased HR and hypoxia. Stress response and horrmone response to increas sympathetic drive. If HR increased and stroke volume maintained or increased then cardiac output increased. Increased flow to deliver to vital organs and make best use of low already low P02.

@JackClayton123 6 ай бұрын

My adult daughter had a mild concussion in a car accident several years ago. I had her load up on creatine for similar reasons (a concussion is not a brain bruise).

@warner36207 6 ай бұрын

Each individual body has its own O2 volume requirement. Volume is dependent upon O2 saturation and rate of flow. If saturation drops, then rate of flow must increase.

@johnpritchard9753 2 ай бұрын

Fascinating - my biochem degree is 55 years old now 🤣but I enjoyed that

@SergejPanic 6 ай бұрын

When strangled, the heart rate increases to support glycolysis, which produces lactate. This lactate needs to be transported by blood to the liver, where gluconeogenesis converts it back into glucose. The glucose is then transported back to the cells, and the entire cycle starts all over again. On the other hand, I assume a higher heart rate also facilitates faster transportation of glucose produced by the liver during the breakdown of glycogen in the process of glycolysis.

@Vogeln 6 ай бұрын

You mentioned that creatine helps mitochondria with creating more energy via "phosphorylation". I take that to mean, in the most simplistic terms, that creatine donates something to the mitochondria to help it along. Doesn't methylene blue do something similar by donating an electron, to help the mitochondria produce more energy?

@debjordan4399 24 күн бұрын

It's also been shown to improve bone density and strength in people over age 55 years.

@angelalee3681 6 ай бұрын

Does this mean I would benefit from taking this on high altitude hikes like the Inca trek ? Thanks

@abdeliribas6247 6 ай бұрын

Hi Nick, i have a fantastic question. Is there maybe a link between Creatin and Parkinson Disease ?

@Holy.HannaH 6 ай бұрын

Current research, unless I've missed something along the way, suggests the answer to that question is no. Some patients have a slight drop in the year prior to diagnosis whereas some have a slight raise after several years. A 5yr study of creatine monohydrate proved to be an ineffective treatment. Edit to add: I'm clearly not Nic, just sharing what I've learned in my own research.

@littlevoice_11 6 ай бұрын

What makes you wonder this please?

6 ай бұрын

Probably not, because Parkinsons comes from the destruction of grey matter areas that produce dopamine. Its not that the cells have a hard time signaling, it's that they don't have the signaling substance. But I could be wrong

@PhilTomson 6 ай бұрын

People with sleep apnea are deprived of oxygen often several times per night. Maybe creatine could be helpful for people with sleep apnea?

@PlatinumLemur 6 ай бұрын

I've been learningbice skating spins and have been taking creatine for about a month without loading and have noticed reaction and balance adjustments. It's a small differnce but I have un medicated asthma, under control & a high hemogloben level (within normal) but I have for the past month experienced less fatigue and a greater sense of ability to learn. Sadly I have has a psorisis flare up.. I know my heart rate is usually slow intil I am doing some physical activity, so the need for the body to increase blood flow to supply oxygen (& breathing more) seems to ho hand in hand but I might assume too much.😮

@kmkvladne 6 ай бұрын

Thia could be applicable for the patients with ME/CFS. One of the discussed underlying mechanism is restricted blood flow especially in the brain and therefore hypoxia! They also suffer from brainfog so this could be potentially a real help!

@dianetheone4059 6 ай бұрын

68 yo started creatine for the New Year. Good so far. I'll let you know how it goes.

@leondevries478 4 ай бұрын

And how did it go? After two months..

@dianetheone4059 4 ай бұрын

@@leondevries478I-think-it's-helping.-Hard-to-tell-as-the-effect-is-small,-but-I-do-feel-stronger-and-more-focused-mentally.

@joeboxter3635 6 ай бұрын

Compensatory response of the sympathetic nervous system. The brain detected drop in 02 and started hyperventilating. The hyperventilation caused the heart rated to also go up. Yes, in part that helps to increase 02, but the 02 wasn't there! All this is a fancy way of saying: panic. Interestingly, while the average heart rate went up there were some extreme data points where the rate eventually went below.

@SoulsaverNlife 6 ай бұрын

With out oxygen in our blood the blood clots up&can't move freely to the heart which causes heart attacks

@ethimself5064 6 ай бұрын

Your Top links took forever to load for some reason?

@electricalien 6 ай бұрын

Would we not be experiencing reduced oxygen during high intensity trianing especially in activated muscles? I am very surprised you didn't make the comparison of the reduced oxygen state to an excercised one.

@ChadCilli 6 ай бұрын

Is this excitatory effect the reason why creatine disrupts sleep and interferes with sleep quality?

@shaunhutchison4049 5 ай бұрын

It could be useful for high altitude mountaineering?

@jagleaso 6 ай бұрын

Decreased saturation of hgb = decreased oxygen carrying capacity of blood therefore cardiac output has to be increased (HRxSV) to meet the metabolic demands of the tissues.

@czarcoma Ай бұрын

Sharp increase in HR happens all the time.... In the ER... When an accident victim is loosing blood volume. Not surprised creatine improves nerve function. I understand creatine basically energizes cells. So any energy hungry cell (nerves and muscles) shouls benefit

@koyamogodztv550 3 ай бұрын

Oxygen deprivation is more prevalent than people think..many people who suffer TMS and anxiety related physiological symptoms actually experience oxygen deprivation hence the manifestation of symptoms. It will be nice to know that perhaps supplementing with creatine can alleviate these episodes by allowing the body to have a more consistent O2 saturation in the blood.

@littlevoice_11 6 ай бұрын

I wonder if this has potential benefits for copd/emphysema sufferers?

@drytropics 6 ай бұрын

Is it true that creatine doesn't readily cross the blood brain barrier and guidionic acid is a far better way to boost neuronal creatine levels? I have Hyperhomocysteinemia Accelerated Atherosclerosis and began getting dementia symptoms which improved greatly with 2g of guidionic acid and 2g of creatine. Hypomethylation due to the Hyperhomocysteinemia likely depleted my neuronal creatine as nearly half your available SAMe methyl donors are used to make creatine from guidionic acid. It's important to boost methylation with B vitamins (esp. B12, B9, B6 and B2) and trimethylglycine if taking guidionic acid as it can be a big draw on available methyl donors. When I have a coronary artery blockage (currently on my 7th since 2017) my main symptoms are breathlessness/ nocturnal dyspnoea and tachycardia. I've noticed at night when my blood oxygenation drops to around 80% my pulse rate can rise from around 50 bpm to 80 bpm, sometimes waking me up. I assume it's my heart trying to maintain oxygenation by speeding up a bit. Or else it's just stressed from forcing blood through a small arterial opening, or stressed from lack of oxygen to the heart muscle itself. It's the latter I feel is the case as my cardio-surgeon said the feeling of breathlessness is likely due to the heart muscle suffering hypoxia, as my blood oxygenation can be at 98% and I still feel breathlessness when I have a coronary artery blockage. It's good to know creatine could help in my situation. I will get back into taking 5g daily as it could help protect my brain a bit from my current hypoxic state.

@yodamaster757 6 ай бұрын

I assume their heart rate increased due to the additional stress on their organs getting a lack of oxygen. They begin to breathe heavier and that gets their autonomic nervous system to ramp up production of circulating O2 hoping it gets to the surrounding tissues to preserve them as fast as possible

@pandemik0 2 ай бұрын

Interesting potential applications here. Creatine for altitude sickness?

@michaelgolden8255 6 ай бұрын

It is critical for the brain to maintain high oxygen perfusion. The heart rate increases to compensate for the restricted supply.

@TheAlexfrascari 6 ай бұрын

Very interesting. My brother said he is taking creatine and It helped a lot with his brain fog. But he said you need to take a double dose than usual or It has no effect

@xxskolxx1 6 ай бұрын

Is this single dose a day or multiple?

@m.b.593 6 ай бұрын

Maybe I should try this as the typical 5gm never did jack for me…EXCEPT the time I gained around 6 lbs after a month on some creatine I got from Amazon that I’m thinking had to have come from China…no joke!

@chadrichards8930 6 ай бұрын

@m.b.593 if you only take 5grams a day it will take a month or more to fully saturate your muscles. That's why a lot of people do a load phase to reach maximum saturation quicker. Example taking up to 20 grams a day for a week or two

@ketogenicvegan4970 6 ай бұрын

Heart rate ^ to maximally circulate blood / distribute RBCs to oxygenate body.

@zealman79 6 ай бұрын

I guess creatine is the way you can push through your gym session for longer given the aforementioned functionality, but also if you were studying for finals or something too? maybe...very interesting :)

@FuturesInPastTense 6 ай бұрын

About to fly on a Boeing aircraft, so it's kinda nice that since I supplement creatine it will help a little if the door blows off at 38,000 ft.

@Physionic 6 ай бұрын

😂

@user-iz4yg7qg2w 5 ай бұрын

Does creatine affect the prostate ?

@Chaotic313 6 ай бұрын

With less oxygen in the blood, the heart rate increases to deliver more blood to adjust for the oxygen deficit?

@t2p5g4 3 ай бұрын

Halfway through I began wondering if creatine can help sleep apnea. I asked Perplexity, and was told " A study published in the Journal of Clinical Sleep Medicine found that creatine supplementation led to a significant reduction in the apnea-hypopnea index (a measure of sleep apnea severity) in a group of overweight and obese adults with sleep apnea. The proposed mechanism is that creatine may help improve muscle function and reduce upper airway collapsibility, which is a key factor in sleep apnea. However, more research is still needed to fully understand the relationship between creatine and sleep apnea." Then again, I could be comparing apples to oranges.

@Santa-ny1yp 6 ай бұрын

I would guess that your body recognizes low oxygen and engages fight, flight, or freeze. The downstream would be to obtain more oxygen.

@SpiritMatter-qo3jj 6 ай бұрын

Creatine might be beneficial to cancer cells which have a high non-aerobic metabolism?

@angelic8632002 6 ай бұрын

So whats the best way of getting creatine into the brain? I kind of want to try this out due to some personal health reasons.

@earx23 6 ай бұрын

I heard that you need to take a lot to get serious brain benefits. But from other sources I hear that lower doses are also OK. It's about the difficulties in crossing the brain blood barrier.

@Always-xl9db 6 ай бұрын

It will also be gender specific most likely. Men have larger creatine capacity but for women lower doses, several times, is a better way to go.

@blaze1148 6 ай бұрын

The Heart Rate increases when there is less oxygen available through the lung Alveoli to increase the blood flow hence increasing the O2 transfer to the cells to as near normal a level as is possible - the less O2 transferring through the lung Alveoli to the blood the faster the heart will pump the blood around the body servicing the cells. The lack of O2 stimulates the production of Adrenalin which increases heart rate.

@Musika1321 6 ай бұрын

Serious question from a dad whose son takes Creatine and has a severe heart condition palliated by a TCPC (a Fontan circulation) whereby his univentricular heart already beats considerably faster than other hearts and his oxygen sats normally sit at 95%. Should he be taking Creatine? At 18, he's obsessed with weight training at the moment. He seems really happy because he's doing what he loves, which is great, but he needs advise on taking the Creatine and no one (least of all NHS cardiologists) seem willing or able to give it. Hope someone can help. Thanks