This can vary greatly. As a default, we'd always recommend checking with your instrument manufacturer's guidelines. These are generally around every six months. How much you are injecting, how much is your split, how dirty are your samples can all impact this. Cleaning split vent lines is generally reserved for a situation where you feel it is needed, such as seeing some ghost peaks or other evidence of contamination. In an extreme case, when you notice incorrect flow rates and may suspect some clogging.

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